Article
Dermatology
Claire Mangez, Pierre-Francois Roux, Georgios Stamatas, Thierry Oddos, Cecilia Brun
Summary: Despite starting development early in utero, neonatal skin is still immature at birth compared to adult skin, undergoing a maturation process in the first years of life. The differences between the two include thinner and dryer stratum corneum, less natural moisturizing factors and lipids in newborns. Baby skin shows a higher epidermal cellular turnover, with specific molecular and metabolic characteristics still poorly understood.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Plant Sciences
Long You, Ting Shen, Weicheng Hu, Jae Youl Cho
Summary: By activating growth factor receptors such as EGFR and HER2, protopanaxatriol (PPT) can regulate skin moisturizing factors and multiple signaling pathways, thereby protecting and moisturizing the skin.
Article
Biochemistry & Molecular Biology
Wesuk Kang, Bomin Son, Soyoon Park, Dabin Choi, Taesun Park
Summary: This study demonstrates that ORs are highly expressed in HaCaT cells, especially under UV or inflammation exposure. Activation of specific ORs by odorant ligands can downregulate skin barrier genes in HaCaT cells, indicating the potential of ORs as markers for skin barrier abnormalities and the need for further research on their role in barrier dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ilekuttige Priyan Shanura Fernando, Mawalle Kankanamge Hasitha Madhawa Dias, Dissanayaka Mudiyanselage Dinesh Madusanka, Eui Jeong Han, Min Ju Kim, Soo-Jin Heo, Kyounghoon Lee, Sun Hee Cheong, Ginnae Ahn
Summary: The study found that fucoidan derived from brown algae can alleviate the effects of fine-dust on skin inflammation and restore skin barrier function. SHC4-6 exerts this effect by reducing ROS levels and inhibiting inflammatory cytokines.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Kyung-Ha Lee, Hwan-Kwon Do, Do-Yeon Kim, Wanil Kim
Summary: Chlorogenic acid is a polyphenol found in human diet that impacts human cells, promoting procollagen type I production and skin barrier gene expression. It can be used to restore impaired dermal matrix network and epidermal skin barrier.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Dermatology
Jie Zhou, Gaopeng Liang, Lu Liu, Shujing Feng, Zhengni Zheng, Yaguang Wu, Xiaoling Chen, Xiangqian Li, Lina Wang, Li Wang, Zhiqiang Song
Summary: This study conducted an in-depth transcriptome analysis of atopic dermatitis (AD) in the Chinese population, revealing heterogeneity and highly expressed keratinocyte activation and pro-inflammatory genes. The study also identified an increased IL19(+)IGFL1(+) subpopulation in AD lesions, which may be associated with disruption of the skin barrier, amplified Th2 and Th17 inflammatory responses, and mediation of skin pruritus. Additionally, progressive activation of multiple immune axes dominated by Type 2 inflammatory reaction occurred in AD chronic lesions.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
James V. Gruber, Robert Holtz, Jed Riemer
Summary: The impact of different molecular weight fragments of hyaluronic acid on normal human epidermal keratinocytes has not been deeply explored. This study demonstrated the influence of HA on the expression of CD44 protein, showing a molecular weight-dependent effect.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Review
Cell Biology
Pamelika Das, Pappula Mounika, Manoj Limbraj Yellurkar, Vani Sai Prasanna, Sulogna Sarkar, Ravichandiran Velayutham, Somasundaram Arumugam
Summary: Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by rashes, itching, and pruritus. The pathogenesis of AD is closely related to immunological factors, including the role of the epidermal barrier and abnormal cytokine expressions. Disrupted epidermal barriers and the abnormal release of pro-inflammatory mediators from keratinocytes, as well as the role of immune cells, contribute to the pathophysiology of AD. Specific biomarkers for diagnosis are lacking, highlighting the need for further research in this area.
Article
Dermatology
Jos P. H. Smits, Noa J. M. van den Brink, Luca D. Meesters, Hadia Hamdaoui, Hanna Niehues, Patrick A. M. Jansen, Ivonne M. J. J. van Vlijmen-Willems, Diana Rodijk-Olthuis, Celine Evrard, Yves Poumay, Michel van Geel, Wiljan J. A. J. Hendriks, Joost Schalkwijk, Patrick L. J. M. Zeeuwen, Ellen H. van den Bogaard
Summary: This study demonstrates the phenotypical and functional consequences of FLG deficiency, showing its crucial role in epidermal barrier function and differentiation. The results provide insights into the exact role of FLG in skin biology and disease.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Dermatology
Jaehyung Kim, Min-Gyu Kim, Sang Hoon Jeong, Hee Joo Kim, Sang Wook Son
Summary: The study revealed that STAT3 plays an important role in the skin barrier, influencing the expression of KLK5 and SPINK5. Loss of STAT3 leads to cutaneous inflammation and other abnormal phenotypes, suggesting that STAT3 may play a crucial role in maintaining skin barrier homeostasis.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Cell Biology
Peter Seiringer, Stefanie Eyerich, Kilian Eyerich, Daniela Dittlein, Anna Caroline Pilz, Emanuele Scala, Johannes Ring, Heidrun Behrendt, Andrea Cavani, Claudia Traidl-Hoffmann
Summary: The study found that keratinocytes partially inhibit T cell proliferation and cytokine production, with this effect depending on the keratinocyte/T cell ratio and soluble factors. This shows that keratinocytes play a critical role in controlling inflammatory processes in the skin.
Article
Pharmacology & Pharmacy
Mike Walker
Summary: As the largest organ, the skin plays a crucial role in protecting the body and regulating various functions. However, aging and environmental factors contribute to the deterioration of the skin, leading to various issues and imposing a significant burden on individuals and the healthcare system.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Jian-Xiang Liu, Dao-Lei Cui, Dan-Lei Yang, Jing-Ya Li, Zi-Yue Yang, Jin-Zhou Su, Cai-Xia Ren, You-Ya Niu, Ping Xiang
Summary: Tris (1-chloro-2-propyl) phosphate (TCPP) is a commonly detected organophosphorus flame retardant in the environment. This study investigated the detrimental effects of TCPP on human skin keratinocytes and found that it decreased cell viability, induced reactive oxygen species generation and DNA damage, arrested the cell cycle at the G1 phase, and caused cellular senescence through the p53-dependent DNA damage signal pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Tian-Ning Yang, Xue-Nan Li, Yu -Xiang Wang, Xiang-Yu Ma, Jin-Long Li
Summary: The toxic effects of DEHP on the duodenum in quails were investigated, revealing that DEHP exposure leads to duodenal barrier defect, breakdown of antimicrobial defense, activation of TLR4 receptors, and oxidative stress, which further promote duodenal damage.
Article
Dermatology
Mika Fujikawa, Hiroko Sugimoto, Rie Tamura, Koki Fujikawa, Ami Yamagishi, Yuhki Ueda
Summary: The moisturizing agent MPS can repair TJ barrier dysfunction and improve the reduction caused by histamine in AD patients, suggesting it as a new therapeutic option.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ryan Dickerson, Jaideep Banerjee, Adam Rauckhorst, Douglas R. Pfeiffer, Gayle M. Gordillo, Savita Khanna, Kwame Osei, Sashwati Roy
ANTIOXIDANTS & REDOX SIGNALING
(2015)
Editorial Material
Dermatology
Ralph S. DaCosta, Kathryn Ottolino-Perry, Jaideep Banerjee
ADVANCES IN WOUND CARE
(2016)
Editorial Material
Cell Biology
Jaideep Banerjee, Savita Khanna, Akash Bhattacharya
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2017)
Article
Endocrinology & Metabolism
Savita Khanna, Cameron Rink, Reza Ghoorkhanian, Surya Gnyawali, Mallory Heigel, Dayanjan S. Wijesinghe, Charles E. Chalfant, Yuk Cheung Chan, Jaideep Banerjee, Yue Huang, Sashwati Roy, Chandan K. Sen
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2013)
Review
Hematology
Yuk C. Chan, Jaideep Banerjee, Sang Yong Choi, Chandan K. Sen
Editorial Material
Cell Biology
Jaideep Banerjee, Amitava Das, Mithun Sinha, Sudipta Saha
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2018)
Article
Multidisciplinary Sciences
Sashwati Roy, Jaideep Banerjee, Surya C. Gnyawali, Savita Khanna, Guanglong He, Douglas Pfeiffer, Jay L. Zweier, Chandan K. Sen
Article
Multidisciplinary Sciences
Jaideep Banerjee, Piya Das Ghatak, Sashwati Roy, Savita Khanna, Emily K. Sequin, Karen Bellman, Bryan C. Dickinson, Prerna Suri, Vish V. Subramaniam, Christopher J. Chang, Chandan K. Sen
Article
Multidisciplinary Sciences
Jaideep Banerjee, Piya Das Ghatak, Sashwati Roy, Savita Khanna, Craig Hemann, Binbin Deng, Amitava Das, Jay L. Zweier, Daniel Wozniak, Chandan K. Sen
Article
Multidisciplinary Sciences
Ximena Leighton, Alakesh Bera, Ofer Eidelman, Lukas Bubendorf, Tobias Zellweger, Jaideep Banerjee, Edward P. Gelmann, Harvey B. Pollard, Meera Srivastava
Article
Dermatology
Daniel Zurawski, Chad C. Black, Yonas A. Alamneh, Lionel Biggemann, Jaideep Banerjee, Mitchell G. Thompson, Matthew C. Wise, Cary L. Honnold, Robert K. Kim, Chrysanthi Paranavitana, Jonathan P. Shearer, Stuart D. Tyner, Samandra T. Demons
ADVANCES IN WOUND CARE
(2019)
Editorial Material
Cell Biology
J. Banerjee, J. Ghose, M. Sinha, S. Sen
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Article
Multidisciplinary Sciences
Jaideep Banerjee, Shanmuganathan Seetharaman, Nicole L. Wrice, Robert J. Christy, Shanmugasundaram Natesan
Review
Gastroenterology & Hepatology
Shuyun Rao, Sobia Zaidi, Jaideep Banerjee, Wilma Jogunoori, Raul Sebastian, Bibhuti Mishra, Bao-Ngoc Nguyen, Ray-Chang Wu, Jon White, Chuxia Deng, Richard Amdur, Shulin Li, Lopa Mishra
HEPATOLOGY COMMUNICATIONS
(2017)