AIF-mediated caspase-independent necroptosis: A new chance for targeted therapeutics

Caspase-independent mitotic death (CIMD)

(2011) Katsumi Kitagawa et al.   CELL CYCLE

Necrostatin-1 ameliorates symptoms in R6/2 transgenic mouse model of Huntington's disease

(2011) S Zhu et al.   Cell Death & Disease

Severe X-Linked Mitochondrial Encephalomyopathy Associated with a Mutation in Apoptosis-Inducing Factor

(2010) Daniele Ghezzi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Role of apoptosis-inducing factor (AIF) in programmed nuclear death during conjugation in Tetrahymena thermophila

(2010) Takahiko Akematsu et al.   BMC CELL BIOLOGY

Systemic administration of lipopolysaccharide induces molecular and morphological alterations in the hippocampus

(2010) Grzegorz A. Czapski et al.   BRAIN RESEARCH

A phase 1B dose escalation trial of Scutellaria barbata (BZL101) for patients with metastatic breast cancer

(2010) Alejandra T. Perez et al.   BREAST CANCER RESEARCH AND TREATMENT

BZL101, a phytochemical extract from theScutellaria barbataplant, disrupts proliferation of human breast and prostate cancer cells through distinct mechanisms dependent on the cancer cell phenotype

(2010) Crystal N. Marconett et al.   CANCER BIOLOGY & THERAPY

Histone H2AX: The missing link in AIF-mediated caspase-independent programmed necrosis

(2010) Mathieu Baritaud et al.   CELL CYCLE

Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons

(2010) S Tobaben et al.   CELL DEATH AND DIFFERENTIATION

Necroptosis as an alternative form of programmed cell death

(2010) Dana E Christofferson et al.   CURRENT OPINION IN CELL BIOLOGY

AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX

(2010) Cédric Artus et al.   EMBO JOURNAL

Activation of mitochondrial calpain and release of apoptosis-inducing factor from mitochondria in RCS rat retinal degeneration

(2010) Sayuri Mizukoshi et al.   EXPERIMENTAL EYE RESEARCH

Alternative cell death mechanisms in development and beyond

(2010) J. Yuan et al.   GENES & DEVELOPMENT

Necrostatin Decreases Oxidative Damage, Inflammation, and Injury after Neonatal HI

(2010) Frances J Northington et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Sorafenib induces growth inhibition and apoptosis of human chondrosarcoma cells by blocking the RAF/ERK/MEK pathway

(2010) Xinchang Lu et al.   JOURNAL OF SURGICAL ONCOLOGY

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Apoptosis-inducing factor mediates dopaminergic cell death in response to LPS-induced inflammatory stimulusEvidence in Parkinson's disease patients

(2010) M.A. Burguillos et al.   NEUROBIOLOGY OF DISEASE

Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis

(2010) G. Trichonas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardioprotective effects of a novel calpain inhibitor SNJ-1945 for reperfusion injury after cardioplegic cardiac arrest

(2009) Yoshiro Yoshikawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

AIF: Not Just an Apoptosis-Inducing Factor

(2009) Nicholas Joza et al.   Annals of the New York Academy of Sciences

Outer Mitochondrial Membrane Localization of Apoptosis-Inducing Factor: Mechanistic Implications for Release

(2009) Seong-Woon Yu et al.   ASN Neuro

Mitochondrial m-calpain plays a role in the release of truncated apoptosis-inducing factor from the mitochondria

(2009) Taku Ozaki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The proapoptotic activity of C-terminal domain of apoptosis-inducing factor (AIF) is separated from its N-terminal

(2009) YONG ZHANG et al.   BIOLOGICAL RESEARCH

RIP Kinases at the Crossroads of Cell Death and Survival

(2009) Wim Declercq et al.   CELL

Redox-Linked Conformational Dynamics in Apoptosis-Inducing Factor

(2009) Irina F. Sevrioukova   JOURNAL OF MOLECULAR BIOLOGY

Calpain activation is not required for AIF translocation in PARP-1-dependent cell death (parthanatos)

(2009) Yingfei Wang et al.   JOURNAL OF NEUROCHEMISTRY

Bobel-24 and Derivatives Induce Caspase-Independent Death in Pancreatic Cancer Regardless of Apoptotic Resistance

(2008) M. Parreno et al.   CANCER RESEARCH

Identification of a Molecular Signaling Network that Regulates a Cellular Necrotic Cell Death Pathway

(2008) Junichi Hitomi et al.   CELL

The molecular archaeology of a mitochondrial death effector: AIF in Drosophila

(2008) N Joza et al.   CELL DEATH AND DIFFERENTIATION

Bid-induced release of AIF from mitochondria causes immediate neuronal cell death

(2008) S Landshamer et al.   CELL DEATH AND DIFFERENTIATION

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

(2008) G Kroemer et al.   CELL DEATH AND DIFFERENTIATION

Loss of Apoptosis-Inducing Factor Results in Cell-Type-Specific Neurogenesis Defects

(2008) R. Ishimura et al.   JOURNAL OF NEUROSCIENCE

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology

A novel calpain inhibitor, ((1S)-1((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl) carbamic acid 5-methoxy-3-oxapentyl ester, protects neuronal cells from cerebral ischemia-induced damage in mice

(2008) A. Koumura et al.   NEUROSCIENCE

Necroptosis contributes to the NMDA-induced excitotoxicity in rat’s cultured cortical neurons

(2008) Yanli Li et al.   NEUROSCIENCE LETTERS

The Variability of the Harlequin Mouse Phenotype Resembles that of Human Mitochondrial-Complex I-Deficiency Syndromes

(2008) Paule Bénit et al.   PLoS One