Journal
IUBMB LIFE
Volume 62, Issue 12, Pages 859-868Publisher
WILEY
DOI: 10.1002/iub.399
Keywords
cancer biology; microRNA; noncoding small RNAs; oncogenes; tumor suppressors
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Small noncoding RNAs are key controllers of cellular function, and their deregulation can lead to cancer development and metastatic evolution. This review summarizes the most important examples of small RNAs involved in human cancer and discusses their clinical use as biomarkers and drug targets for diagnosis, prognosis, and treatment of cancer. We also describe the possible mechanisms underlying small RNA-mediated transformation and outline the future describing new small RNA families with great potential in cancer biology. (C) 2010 IUBMB IUBMB Life, 62(12): 859-868, 2010
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