Structural Heterogeneity and Dynamics of the Unfolded Ensemble

Single-molecule spectroscopy of protein folding dynamics—expanding scope and timescales

(2013) Benjamin Schuler et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A quantitative measure for protein conformational heterogeneity

(2013) Nicholas Lyle et al.   JOURNAL OF CHEMICAL PHYSICS

Interplay of non-Markov and internal friction effects in the barrier crossing kinetics of biopolymers: Insights from an analytically solvable model

(2013) Dmitrii E. Makarov   JOURNAL OF CHEMICAL PHYSICS

Exploring the role of internal friction in the dynamics of unfolded proteins using simple polymer models

(2013) Ryan R. Cheng et al.   JOURNAL OF CHEMICAL PHYSICS

How Kinetics within the Unfolded State Affects Protein Folding: An Analysis Based on Markov State Models and an Ultra-Long MD Trajectory

(2013) Nan-jie Deng et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Different Degrees of Disorder in Long Disordered Peptides Can Be Discriminated by Vibrational Spectroscopy

(2013) Reinhard Schweitzer-Stenner   JOURNAL OF PHYSICAL CHEMISTRY B

Intrachain Contact Dynamics in Unfolded Cytochrome cb562

(2013) Nicole D. Bouley Ford et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Experiments and simulations show how long-range contacts can form in expanded unfolded proteins with negligible secondary structure

(2013) W. Meng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toward an atomistic description of the urea-denatured state of proteins

(2013) M. Candotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformations of intrinsically disordered proteins are influenced by linear sequence distributions of oppositely charged residues

(2013) R. K. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microsecond dynamics of an unfolded protein by a line confocal tracking of single molecule fluorescence

(2013) Hiroyuki Oikawa et al.   Scientific Reports

Towards the physical basis of how intrinsic disorder mediates protein function

(2012) Jianhan Chen   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The Conformational Ensembles of α-Synuclein and Tau: Combining Single-Molecule FRET and Simulations

(2012) Abhinav Nath et al.   BIOPHYSICAL JOURNAL

Exploring the top of the protein folding funnel by experiment

(2012) Lisa J Lapidus   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structural Ensemble of an Intrinsically Disordered Polypeptide

(2012) Jeetain Mittal et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Backtracking due to Residual Structure in the Unfolded State Changes the Folding of the Third Fibronectin Type III Domain from Tenascin-C

(2012) Swarnendu Tripathi et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Slow Unfolded-State Structuring in Acyl-CoA Binding Protein Folding Revealed by Simulation and Experiment

(2012) Vincent A. Voelz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure and Dynamics of an Unfolded Protein Examined by Molecular Dynamics Simulation

(2012) Kresten Lindorff-Larsen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Peptide Chain Dynamics in Light and Heavy Water: Zooming in on Internal Friction

(2012) Julius C. F. Schulz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Measurement of energy landscape roughness of folded and unfolded proteins

(2012) L. Milanesi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multimolecule test-tube simulations of protein unfolding and aggregation

(2012) M. E. McCully et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Folding of the four-helix bundle FF domain from a compact on-pathway intermediate state is governed predominantly by water motion

(2012) A. Sekhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of the H4 tail binding and folding landscapes via Lys-16 acetylation

(2012) D. A. Potoyan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantifying internal friction in unfolded and intrinsically disordered proteins with single-molecule spectroscopy

(2012) A. Soranno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polymer scaling laws of unfolded and intrinsically disordered proteins quantified with single-molecule spectroscopy

(2012) H. Hofmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Localizing internal friction along the reaction coordinate of protein folding by combining ensemble and single-molecule fluorescence spectroscopy

(2012) Alessandro Borgia et al.   Nature Communications

How Robust Are Protein Folding Simulations with Respect to Force Field Parameterization?

(2011) Stefano Piana et al.   BIOPHYSICAL JOURNAL

Unstructural biology coming of age

(2011) Peter Tompa   CURRENT OPINION IN STRUCTURAL BIOLOGY

Residual structure in unfolded proteins

(2011) Bruce E Bowler   CURRENT OPINION IN STRUCTURAL BIOLOGY

Optimizing Protein−Solvent Force Fields to Reproduce Intrinsic Conformational Preferences of Model Peptides

(2011) Paul S. Nerenberg et al.   Journal of Chemical Theory and Computation

Energy Landscape Analyses of Disordered Histone Tails Reveal Special Organization of Their Conformational Dynamics

(2011) Davit A. Potoyan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Microscopic events in  -hairpin folding from alternative unfolded ensembles

(2011) R. B. Best et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid Collapse into a Molten Globule Is Followed by Simple Two-State Kinetics in the Folding of Lysozyme from Bacteriophage λ

(2010) Alexandre Di Paolo et al.   BIOCHEMISTRY

Balance between α and β Structures in Ab Initio Protein Folding

(2010) Robert B. Best et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Evidence, from Simulations, of a Single State with Residual Native Structure at the Thermal Denaturation Midpoint of a Small Globular Protein

(2010) Gia G. Maisuradze et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Time-resolved FRET between GPCR ligands reveals oligomers in native tissues

(2010) Laura Albizu et al.   Nature Chemical Biology

Net charge per residue modulates conformational ensembles of intrinsically disordered proteins

(2010) A. H. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA search efficiency is modulated by charge composition and distribution in the intrinsically disordered tail

(2010) D. Vuzman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein functional landscapes, dynamics, allostery: a tortuous path towards a universal theoretical framework

(2010) Pavel I. Zhuravlev et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Sequence and Crowding Effects in the Aggregation of a 10-Residue Fragment Derived from Islet Amyloid Polypeptide

(2009) Eva Rivera et al.   BIOPHYSICAL JOURNAL

Linking folding and binding

(2009) Peter E Wright et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Measuring distances within unfolded biopolymers using fluorescence resonance energy transfer: The effect of polymer chain dynamics on the observed fluorescence resonance energy transfer efficiency

(2009) Dmitrii E. Makarov et al.   JOURNAL OF CHEMICAL PHYSICS

Coordinate-dependent diffusion in protein folding

(2009) R. B. Best et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Function and structure of inherently disordered proteins

(2008) A Keith Dunker et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Protein folding studied by single-molecule FRET

(2008) Benjamin Schuler et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

ABSINTH: A new continuum solvation model for simulations of polypeptides in aqueous solutions

(2008) Andreas Vitalis et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Proteins with weakly funneled energy landscapes challenge the classical structure-function paradigm

(2008) G. A. Papoian   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thermodynamics and kinetics of protein folding under confinement

(2008) J. Mittal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Measuring internal friction of an ultrafast-folding protein

(2008) T. Cellmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fuzzy complexes: polymorphism and structural disorder in protein–protein interactions

(2007) Peter Tompa et al.   TRENDS IN BIOCHEMICAL SCIENCES