Strategy Evolution in the Total Synthesis of Spirastrellolide A Methyl Ester

Synthesis of the bis-spiroacetal C25–C40 moiety of the antimitotic agent spirastrellolide B using a bis-dithiane deprotection/spiroacetalisation sequence

(2010) Jack Li-Yang Chen et al.   CHEMICAL COMMUNICATIONS

Complex synthesis yields breast-cancer therapy

(2010) Heidi Ledford   NATURE

Spirastrellolide studies. Synthesis of the C(1)–C(25) southern hemispheres of spirastrellolides A and B, exploiting anion relay chemistry

(2010) Amos B. Smith et al.   TETRAHEDRON

Total Synthesis of Spirastrellolide F Methyl Ester—Part 1: Strategic Considerations and Revised Approach to the Southern Hemisphere

(2009) Gregory W. O'Neil et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of Spirastrellolide F Methyl Ester—Part 2: Macrocyclization and Completion of the Synthesis

(2009) Stefan Benson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent Advances in the Total Synthesis of Polyketide Natural Products as Promising Anticancer Agents

(2009) Ian Paterson et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Impact of Natural Products on Developing New Anti-Cancer Agents†

(2009) Gordon M. Cragg et al.   CHEMICAL REVIEWS

Synthesis and stereochemical determination of the spirastrellolides

(2009) Ian Paterson et al.   NATURAL PRODUCT REPORTS

Synthesis of the C1-C13 Subunit of Spirastrellolides A and B by Prins Cyclization

(2009) Gowravaram Sabitha et al.   SYNTHESIS-STUTTGART

Total Synthesis of Enzyme Inhibitor Spirastrellolide A—Stereochemical Confirmation

(2008) Michael V. Perkins   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of Spirastrellolide A Methyl Ester—Part 2: Subunit Union and Completion of the Synthesis

(2008) Ian Paterson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of Spirastrellolide A Methyl Ester—Part 1: Synthesis of an Advanced C17–C40 Bis-spiroacetal Subunit

(2008) Ian Paterson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

1,5-Anti Stereocontrol in the Boron-Mediated Aldol Reactions of β-Alkoxy Methyl Ketones:  The Role of the Formyl Hydrogen Bond

(2008) Robert S. Paton et al.   JOURNAL OF ORGANIC CHEMISTRY

Development of practical syntheses of the marine anticancer agents discodermolide and dictyostatin

(2008) Gordon J. Florence et al.   NATURAL PRODUCT REPORTS

Drug development from marine natural products

(2008) Tadeusz F. Molinski et al.   NATURE REVIEWS DRUG DISCOVERY

Synthesis of the C1−C23 Fragment of Spirastrellolide A

(2008) Jin-Haek Yang et al.   ORGANIC LETTERS

Toward the Synthesis of Spirastrellolide B:  A Synthesis of the C1−C23 Subunit

(2008) Katie A. Keaton et al.   ORGANIC LETTERS

Spirastrellolide B: The Synthesis of Southern (C9−C25) Region

(2008) Srivari Chandrasekhar et al.   ORGANIC LETTERS