Article
Psychology, Clinical
Kenneth S. Kendler, Henrik Ohlsson, Eve K. Moscicki, Jan Sundquist, Alexis C. Edwards, Kristina Sundquist
Summary: This study examines the impact of genetic liability to suicide attempt and suicide death, finding that family genetic risk scores play a significant role in predicting both outcomes. Univariate and multivariate models show that the highest genetic risk scores are for suicide attempt, alcohol use disorder, drug use disorder, and major depression. While some of the genetic risk factors for psychiatric disorders contribute to the risk for suicide attempt and suicide death through the development of these disorders, these risks also directly predispose to suicidal behaviors.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Developmental
Rafal Szmajda, Lukasz Mokros, Dagmara Szmajda-Krygier, Agnieszka Gmitrowicz
Summary: The study aimed to determine the association between psychiatric diagnosis and selected psychosocial factors and the risk of suicide attempts among adolescent psychiatric patients. The primary diagnoses of mood disorders and emotional and behavioral disorders were found to be associated with a higher risk of suicide attempts. Other psychosocial factors such as truancy, sexual abuse, heartbreak, and frequent conflicts were also related to an increased risk of suicide attempts.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Clinical Neurology
Tanner J. Bommersbach, Taeho Greg Rhee, Elina A. Stefanovics, Robert A. Rosenheck
Summary: The study found that the majority of individuals with a history of suicide attempts did not attempt suicide again in the past 5 years. Recovery involves not only psychiatric and substance use disorders, but also improvements in key socio-demographic factors and social connectedness over many years.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Emergency Medicine
Akira Suekane, Wataru Takayama, Rio Hashimoto, Koji Morishita, Yasuhiro Otomo
Summary: This study investigated the risk factors associated with the recurrence of suicide attempts via drug overdose. The findings showed that a history of schizophrenia was an independent risk factor for overdose recurrence, and the presence of a cohabitant was significantly associated with a lower risk of recurrence.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Carlos Blanco, Melanie M. Wall, Nicolas Hoertel, Robert F. Krueger, Shang-Min Liu, Bridget F. Grant, Mark Olfson
Summary: Most psychiatric disorders are associated with a broad range of adverse outcomes due to shared psychological dimensions, rather than individual disorders. Understanding these dimensions can help identify intervention targets to reduce the burden of common psychiatric disorders on individuals and society.
MOLECULAR PSYCHIATRY
(2021)
Article
Clinical Neurology
Amy Perry, Katherine Gordon-Smith, Arianna Di Florio, Nick Craddock, Lisa Jones, Ian Jones
Summary: Women with bipolar disorder are at high risk of recurrence during pregnancy and the postpartum period, and experiencing mania/psychosis during pregnancy further increases the risk of postpartum mania/psychosis in this high-risk group. These findings may have important implications for predicting and managing severe postpartum recurrence of bipolar disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Hyun-Bum Kim, Youn-Sun Park, Ju-Eun Lee, Kyung-Do Han, Young-Hak Park
Summary: Through questionnaires, it was found that self-recognition of voice disorder (SRVD) is closely related to mental health status, including psychological stress, depressive symptoms, and suicidal ideation. The study also revealed that long-term SRVD is associated with more pronounced psychological stress, depressive symptoms, and suicidal ideation. These findings highlight the significant connection between voice and emotions.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Helene Astrup, Martin O. Myhre, Anine T. Kildahl, Fredrik A. Walby
Summary: This study found gender differences in suicide rates and service utilization among young people in contact with Child and Adolescent Mental Health Services before suicide. Boys were more likely to terminate treatment contact at the time of death.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Casey Crump, Jan Sundquist, Kenneth S. Kendler, Alexis C. Edwards, Kristina Sundquist
Summary: This national cohort study in Sweden found that all substance use disorders (SUDs) were significantly associated with increased risk of suicide death, with opioid and sedative/hypnotic use disorders showing the strongest associations. These findings can help improve risk stratification and interventions for preventing suicide in individuals with SUDs.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Clinical Neurology
Yanni Wang, Xin Zhou, Bo Cao, Lijuan Chen, Ruoxi Wang, Ling Qi, Linlin Meng, Lingyun Zeng, Xia Liu, Wenjia Wang, Chuanxiao Li, Jiezhi Yang, Xueyan Gu, Zezhi Li, Yongjie Zhou
Summary: This study identified multiple correlates for SA in MD adolescents engaged in NSSI, including suicidal ideation, psychological distress, self-esteem, and deliberate time before self-injury, which may contribute to the development of suicidal behaviors in an interactive manner.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Clinical
Ikuo Otsuka, Hanga Galfalvy, Jia Guo, Masato Akiyama, Dan Rujescu, Gustavo Turecki, Akitoyo Hishimoto, J. John Mann
Summary: This study found that major psychiatric disorders and diathesis-related traits contribute to suicidal behavior, and there are shared polygenic effects between different psychiatric disorders/traits. Although the sample size is small and limits the analysis, these results are still significant.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Nike Zoe Welander, Jessica Mwinyi, Sana Asif, Helgi Birgir Schioth, Alkistis Skalkidou, Emma Fransson
Summary: The study found that migraine may be a risk factor for anxiety in mid-pregnancy and contribute to the development of mixed symptoms of peripartum depression and anxiety in late pregnancy.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Medicine, General & Internal
Samuel Martineau, Ioana-Alina Cristea, Astrid Chevance, Daniele Fanelli, Florian Naudet
Summary: This descriptive study aimed to identify large clinical trials on antidepressants for mental disorders. The study assessed the proportion of trials that could be considered as 'seeding trials' and described their methodological characteristics and outcomes. The researchers found that large trials are rare in antidepressant research, and some of them could be 'seeding trials'. The study also highlighted the limited exploration of suicidality in these trials. The delay between the research and publication of the results posed challenges in identifying seeding trials.
Article
Psychiatry
Elham Davtalab Esmaeili, Mostafa Farahbakhsh, Ehsan Sarbazi, Farzad Khodamoradi, Saber Gaffari Fam, Hosein Azizi
Summary: Recent studies have improved understanding of suicide trends, risk factors, and protective factors, but predictors of suicide re-attempt remain poorly understood in prospective designs, particularly in Iran. A 5-year prospective study of Suicide Attempters in Malekan County revealed that age <= 25, higher family income, psychiatric disorders, low education, stressful life events, alcohol abuse, and smoking were the most reliable predictors of suicide re-attempt. Healthcare systems should be aware of these predictors to develop appropriate suicide prevention strategies tailored to different at-risk groups.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Psychology, Clinical
Alexis C. Edwards, Henrik Ohlsson, Jan Sundquist, Casey Crump, Eve Moscicki, Kristina Sundquist, Kenneth S. Kendler
Summary: This study used Swedish registry data to examine the relationship between substance use disorders (SUDs) and suicide death. The findings suggest that individuals with SUDs, particularly those with AUD, opiates, sedatives, and multiple substance use, have a higher risk of suicide death. The impact of SUDs is further exacerbated by higher levels of genetic liability to suicide death and younger age at index suicide attempt.
PSYCHOLOGICAL MEDICINE
(2022)
Letter
Psychiatry
Marina Sanchez-Rico, Frederic Limosin, Nicolas Hoertel
AMERICAN JOURNAL OF PSYCHIATRY
(2022)
Article
Psychology, Clinical
Carlos Blanco, Melanie M. Wall, Nicolas Hoertel, Robert F. Krueger, Mark Olfson
Summary: Most risk factors for psychiatric disorders are mediated through broad psychopathological dimensions, supporting the need for a trans-diagnostic approach to etiological research and intervention.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Margaux Chene, Marina Sanchez-Rico, Carlos Blanco, Rachel Pascal De Raykeer, Cecile Hanon, Pierre Vandel, Frederic Limosin, Nicolas Hoertel
Summary: In older adults with major psychiatric disorders, all psychiatric symptoms are associated with increased mortality, mainly through a general psychopathology dimension. No BPRS item or lower order factor has a significant effect on mortality beyond the general psychopathology factor. Greater number of medical conditions, older age, male sex, and being hospitalized or institutionalized at baseline are significantly associated with this increased risk, independently from the general psychopathology factor.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Immunology
Sarah Lim, Christopher J. Tignanelli, Nicolas Hoertel, David R. Boulware, Michael G. Usher
Summary: This analysis examines the prevalence of contraindications to nirmatrelvir/ritonavir among 66,007 COVID-19 patients. Possible contraindications were found in 14.8% of patients, and the prevalence increased with higher severity of illness.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Oncology
Jacques Medioni, Daniel Scimeca, Yecenia Lopez Marquez, Emmanuelle Leray, Marie Dalichampt, Nicolas Hoertel, Mohammed Bennani, Pascal Trempat, Naoual Boujedaini
Summary: This study evaluated the benefits of homeopathy on the quality of life of patients with nonmetastatic breast cancer. The use of homeopathy in patients with breast cancer after diagnosis has increased, leading to a decrease in medications for palliating cancer treatment side effects. This indicates an improvement in quality of life for patients who use homeopathy.
CLINICAL BREAST CANCER
(2023)
Article
Psychiatry
Charles Ouazana-Vedrines, Thomas Lesuffleur, Pierre Denis, Nicolas Hoertel, Frederic Limosin, Antoine Rachas, Philippe Tuppin, Cedric Lemogne
Summary: Ranking antidepressants based on efficacy and tolerability in the general population helps in selecting the best first-line medication. This study aimed to replicate a proof-of-concept study by ranking antidepressants based on prescription sequences consistent with continuation or change. Using a nationwide cohort from the French national health data system, the study provides evidence that prescription sequences are a reliable and reproducible tool for ranking antidepressant treatments in real life settings. The results showed that escitalopram was the most acceptable option, followed by venlafaxine, citalopram, sertraline, fluoxetine, and paroxetine.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychiatry
Carlos Blanco, Leonie Kampe, Melanie M. Wall, Shang-Min Liu, Shuai Wang, Eve Caligor, Mark Olfson
Summary: Despite the lack of published studies on the prevalence and correlates of defense mechanisms in nationally representative samples, this study used approximations from personality traits assessments to estimate the prevalence and correlates of 12 defense mechanisms in a representative sample of US adults. The results showed that neurotic, immature, and pathological defense mechanisms are prevalent in the general population and associated with psychosocial impairment. Recognizing defense mechanisms may be important in clinical practice regardless of treatment modality.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Geriatrics & Gerontology
Emmanuel Leleu, Marina Sanchez-Rico, Miriam Abellan, Carlos Blanco, Sunthavy Yeim, Esther Chaugne, Frederic Limosin, Nicolas Hoertel
Summary: This study examines the association between lithium use and all-cause mortality and specific causes of death among older adults with psychiatric disorders. The results show that lithium use is not significantly associated with all-cause or disease-related mortality, and may be associated with a reduced risk of suicide.
AGING & MENTAL HEALTH
(2023)
Article
Psychiatry
Joane Matta, Emmanuel Wiernik, Olivier Robineau, Gianluca Severi, Mathilde Touvier, Clement Gouraud, Charles Ouazana-Vedrines, Victor Pitron, Brigitte Ranque, Nicolas Hoertel, Omer Van den Bergh, Michael Witthoeft, Sofiane Kab, Marcel Goldberg, Marie Zins, Cedric Lemogne
Summary: This study aimed to investigate the association between trust in different sources of information on COVID-19 at the beginning of the pandemic and the burden of incident persistent symptoms. Using data from the French CONSTANCES population-based cohort, the study found that participants with higher trust in government/journalists had fewer incident persistent symptoms at follow-up. Trust in government/journalists and medical doctors/scientists was also associated with a lower likelihood of having at least one symptom.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2023)
Article
Psychology, Developmental
Mark Olfson, Melanie M. Wall, Shuai Wang, Carlos Blanco
Summary: The objective of this study was to estimate the prevalence of current DSM-5 disorders in children aged 9 to 10 and their associations with sociodemographic and physical characteristics. The study found that the prevalence of any current mental disorder was 10.11%, with higher rates among boys and children from low-income families. Boys, children from families with incomes below $25,000 and $25,000 to $49,000, and obese children were at increased risk for any current child mental disorder. Children from low-income families were particularly at risk for attention-deficit/hyperactivity disorder and disruptive behavior disorders.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Bruce J. Kirenga, Levicatus Mugenyi, Marina Sanchez-Rico, Henry Kyobe, Winters Muttamba, Raymond Mugume, Eliya Mwesigwa, Ezra Kalimo, Vicky Nyombi, Ivan Segawa, Loryndah Olive Namakula, Rogers Sekibira, Wilberforce Kabweru, Rosemary Byanyima, Hellen Aanyu, Pauline Byakika-Kibwika, Henry G. Mwebesa, Nicolas Hoertel, William Bazeyo
Summary: Prior research suggests that fluvoxamine, an SSRI used for mental disorders, may be effective against COVID-19. This study found that fluvoxamine was associated with reduced mortality and increased symptom resolution in inpatients with COVID-19. However, further research is needed to confirm these findings and assess potential side effects.
MOLECULAR PSYCHIATRY
(2023)
Article
Psychiatry
Axel Baptista, Valerian Chambon, Nicolas Hoertel, Mark Olfson, Carlos Blanco, David Cohen, Pierre O. Jacquet
Summary: This study found that the emergence of borderline personality disorder (BPD) is associated with prioritizing short-term reproductive goals over long-term somatic maintenance goals, which can be seen as a developmental response to adverse early life experiences. Early life adversity is directly or indirectly associated with a diagnosis of BPD, and prioritizing short-term reproductive goals further increases the risk of BPD. These findings help explain the physiological and behavioral correlates of BPD.
Article
Chemistry, Medicinal
Nicolas Hoertel, Katayoun Rezaei, Marina Sanchez-Rico, Alfonso Delgado-Alvarez, Johannes Kornhuber, Erich Gulbins, Mark Olfson, Charles Ouazana-Vedrines, Alexander Carpinteiro, Celine Cougoule, Katrin Anne Becker, Jesus M. Alvarado, Frederic Limosin
Summary: The study suggests that the use of medications inhibiting acid sphingomyelinase (FIASMA) can reduce the risk of mortality in patients with SARS-CoV-2 infection. The multicenter retrospective observational study included 72,105 adult patients and found a significant association between FIASMA medication use and reduced 28-day mortality risk.
Article
Psychiatry
Marina Sanchez-Rico, Katayoun Rezaei, Alfonso Delgado-Alvarez, Frederic Limosin, Nicolas Hoertel, Jesus M. Alvarado
Summary: Psychiatric and non-psychiatric comorbidity may be associated with increased 28-day mortality among patients with psychiatric disorders and COVID-19, with the exception of a lower risk of death observed in patients with mood disorders.
BRAZILIAN JOURNAL OF PSYCHIATRY
(2023)