☆ 4.2 Article

Late-onset progressive visual loss in a man with unusual MRI findings: MS, Harding's, Leber's or Leber's Plus ?

IRISH JOURNAL OF MEDICAL SCIENCE (2010)

Journal

IRISH JOURNAL OF MEDICAL SCIENCE

Volume 179, Issue 4, Pages 599-601

Publisher

SPRINGER LONDON LTD

DOI: 10.1007/s11845-010-0586-z

Keywords

Multiple sclerosis; Leber's optic neuropathy; Harding's disease; Mitochondrial

Categories

Medicine, General & Internal

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Abstract

Leber's hereditary optic neuropathy (LHON) is a maternally inherited disorder, typically presenting in the second and third decade. We report the case of an elderly gentleman with significant vascular risk factors, presenting with slowly progressive, bilateral, visual loss with high signal lesions in the pericallosal and periventricular deep white matter on MRI brain studies. Possible diagnoses included late-onset MS, ischaemic optic neuropathies, a mitochondrial disorder or an overlap syndrome such as Harding's disease.

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