Article
Infectious Diseases
Wesley D. Kufel, Katie A. Parsels, Bruce E. Blaine, Jeffrey M. Steele, Robert W. Seabury, Elizabeth A. Asiago-Reddy
Summary: This study aimed to evaluate the incidence of serotonin toxicity among hospitalized patients who received linezolid with or without concurrent serotonergic agents. The results showed that even among patients who received multiple and high-dose serotonergic agents along with linezolid, the incidence of serotonin toxicity was exceedingly rare.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Neurosciences
James J. A. Livermore, Clare L. Holmes, Gyorgy Moga, Kristian Adamatzky, Hugo D. Critchley, Sarah N. Garfinkel, Daniel Campbell-Meiklejohn
Summary: This study aimed to determine the causal effect of acute changes in serotonin levels on cardiac interoception. The results showed that citalopram can increase cardiac interoceptive insight, improving confidence in the accuracy of interoceptive judgments, independently of the cardiac and subjective effects of the drug.
PSYCHOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Hyuk-Kwon Kwon, Kristin E. Yu, Sean Cahill, Kareme D. Alder, Christopher M. Dussik, Sang-Hun Kim, Lokesh Sharma, Jungho Back, Irvin Oh, Francis Y. Lee
Summary: Intracellular infiltration of bacteria in bacterial joint infections complicates treatment and destroys cartilage. Glycolytic pathways play a crucial role in the proliferation of bacteria and the host inflammatory response. By targeting glycolysis, the drug DMF can inhibit bacterial growth and reduce inflammation, protecting the joint.
EMBO MOLECULAR MEDICINE
(2022)
Article
Immunology
Hyuk-Kwon Kwon, Christopher M. Dussik, Sang-Hun Kim, Themis R. Kyriakides, Irvin Oh, Francis Y. Lee
Summary: This study proposes a new therapeutic approach for treating bacterial infection within the synovial joint by combining antimicrobial therapy with inflammation mitigation. Through experiments in a murine model, the researchers found that the combination of antibiotics and anti-inflammatory drugs can protect articular cartilage and reduce inflammatory damage.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Fawzy Elbarbry, Nicholas Moshirian
Summary: This systematic review evaluates the evidence linking linezolid to serotonin toxicity when used alone or in combination with other serotonergic agents. The results show a low incidence of serotonin toxicity both in linezolid monotherapy and combination therapy, and symptom resolution is achieved in most cases after discontinuation of linezolid and serotonergic agents.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hannah P. Fricke, Chandler J. Krajco, Molly J. Perry, Lauren J. Brettingen, Lella A. Wake, Julia F. Charles, Laura L. Hernandez
Summary: Exposure to fluoxetine during lactation has short-term effects on the bone of mother mice, as well as alters gene expression and circulating markers of bone turnover, and affects mammary gland characteristics. Despite the minimal long-term damage to bone, the changes in serotonin-driven lactational bone remodeling raise concerns about the safety of fluoxetine as a treatment for postpartum depression.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Neurosciences
Karine Liu, Alfonso Garcia, Jenn J. Park, Alexis A. Toliver, Lizmaylin Ramos, Carlos D. Aizenman
Summary: The study demonstrates that exposure to SSRIs has significant effects on the developing nervous system of Xenopus laevis tadpoles, with different impacts depending on the specific drug. Fluoxetine and Citalopram showed distinct behavioral and electrophysiological effects on tadpoles. These findings underscore the importance of serotonergic signaling for the developing nervous system.
Article
Toxicology
Joyce Cooper, Stephen B. Duffull, Geoffrey K. Isbister
Summary: This study aimed to investigate the frequency of serotonin toxicity following overdose of antidepressants that inhibit serotonin reuptake and the factors that influence the probability of serotonin toxicity occurring. The results showed that overdose dose and co-ingestion of certain medications increased the probability of serotonin toxicity, while increasing age and co-ingestion of certain medications decreased the probability.
CLINICAL TOXICOLOGY
(2023)
Article
Neurosciences
Keaton A. Unroe, Matthew E. Glover, Elizabeth A. Shupe, Ningping Feng, Sarah M. Clinton
Summary: SSRI exposure during perinatal period affects neurodevelopment and increases risk for psychiatric illness in offspring. Changes in BAI3 signaling may contribute to adverse effects of perinatal SSRI exposure, as evidenced by altered expression in patients with depression and schizophrenia.
Article
Public, Environmental & Occupational Health
Muneeba Wali, Mir Sadiq Shah, Tayyab Ur Rehman, Hammad Wali, Masroor Hussain, Laiq Zaman, Fahim Ullah Khan, Autif Hussain Mangi
Summary: The present study aimed to detect the presence of the cfr gene in clinical MRSA isolates. The results showed that multi-drug resistance among resistant MRSA isolates is largely attributed to the presence of the cfr gene, and the horizontal dissemination of the cfr gene among MRSA strains is facilitated by cfr-carrying transposons and plasmids.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2022)
Article
Gastroenterology & Hepatology
Johana Eyzaguirre-Velasquez, Maria Paz Gonzalez-Toro, Camila Gonzalez-Arancibia, Jorge Escobar-Luna, Caroll J. Beltran, Javier A. Bravo, Marcela Julio-Pieper
Summary: The study showed that sertraline increased transepithelial electrical resistance in the rat colon, while citalopram prevented the increase in phospho-IRF3 protein, a marker of TLR-3 activation, in the LP-rat ileum. These findings suggest that sertraline could be a potential therapeutic strategy for protecting intestinal barrier function in life-threatening situations or chronic conditions associated with gut epithelial disruption.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Yuval Bin Kanner, Qiu-Xu Teng, Assaf Ganoth, Dan Peer, Jing-Quan Wang, Zhe-Sheng Chen, Yossi Tsfadia
Summary: This study aimed to investigate whether three antidepressant drugs from the SSRI family could be repurposed as inhibitors of MRP1 and MRP7 transporters and reverse multidrug resistance in cancer cells. The results show that these drugs exhibited inhibitory/reversal effects on both MRP1-overexpressed cells and MRP7-overexpressed cells in the presence of chemotherapies, suggesting their potential in targeting multidrug resistance in cancer cells.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Clinical Neurology
George M. Anderson, Christine M. Ramsey, Kevin G. Lynch, Joel Gelernter, David W. Oslin
Summary: This study investigated the distribution of baseline platelet serotonin (5-HT) levels in depression patients seeking treatment and defined subgroups based on drug exposure. The bioeffect of 5-HT reuptake inhibitors (SRIs) and the relationship between demographic variables and platelet 5-HT concentration were also assessed. Data from a cross-sectional study of 1433 Veterans Administration (VA) patients were analyzed, revealing a bimodal distribution of platelet 5-HT levels and significant differences in population, sex, and age.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Environmental Sciences
Melissa Doot Kennedy, Victoria P. Connaughton
Summary: This study documents the phototactic responses of different amphipod populations to fluoxetine exposure. The results show that all species exhibit significant photonegative responses, but short-term and long-term exposure to fluoxetine have different effects on photoneutrality. The effects vary among populations and sampling locations, highlighting the species-specific and geographically distinct responses to light.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Infectious Diseases
Tobias Lienen, Mirjam Grobbel, Bernd-Alois Tenhagen, Sven Maurischat
Summary: The resistance of MRSA from food and livestock to last resort antibiotics is concerning, however, the occurrence of these resistance strains in Germany is rare.
