Article
Chemistry, Multidisciplinary
Rodrigo Ken Kawassaki, Mariana Romano, Mayara Klimuk Uchiyama, Roberta Mansini Cardoso, Mauriicio S. Baptista, Sandra H. P. Farsky, Khallil Taverna Chaim, Robson Raphael Guimaraes, Koiti Araki
Summary: A novel ultrasmall paramagnetic nanoparticle (UPN), decorated with iron oxide on 3 nm titanium dioxide nanoparticles, has been developed as a potential alternative blood-pool contrast agent to gadoteric acid (GA) for MR angiography. It exhibits comparable relaxometric parameters to GA and has strong and prolonged contrast enhancement before renal excretion.
Article
Materials Science, Biomaterials
Bo Song, Jiao Jiang, Huinan Yan, Shengjun Huang, Jingli Yuan
Summary: The combination of MRI and TGLI allows for the visualization of lesion tissues and target biomolecules with high spatial resolution and penetration depth. This study used stable lanthanide complexes as signal reporters for TGLI and MRI, and successfully constructed a tumor-targetable probe for bimodal imaging in tumor-bearing mice. The bimodal imaging provided accurate anatomical and molecular information, and demonstrated the potential for monitoring cancer cells in vivo.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Applied
Hamed Nosrati, Marziyeh Salehiabar, Faezeh Mozafari, Jalil Charmi, Nuri Erdogan, Mohammadreza Ghaffarlou, Fatemeh Abhari, Hossein Danafar, Ali Ramazani, Yavuz Nuri Ertas
Summary: Early diagnosis and treatment of cancer is crucial, and theranostic systems play a significant role in this aspect. In this study, bi-functional nanoparticles were developed as dual MRI/CT contrast agent and carrier of natural anticancer drug. These nanoparticles showed good performance in both MRI and CT imaging contrast, while also demonstrating high biocompatibility and anticancer activity.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Jie Zeng, Linlin Huo, Zhenyu Wang, Xin Sun, Yu Guo, Muyao Li, Mingya Tan, Shiqi Zhu, Jingqin Fang, Zhenghuan Zhao
Summary: In recent years, great progress has been made in precisely controlling the structures of magnetic nanoparticles to investigate structure-relaxivity relationships. However, the influence of hollow structures with unique interior structures on the relaxation rate of magnetic nanoparticles has been rarely studied. In this work, we obtained a series of hollow manganese-doped iron oxide nanoparticles (MnIONs) with different void and dopant ratios and investigated the influence of hollow structures on the T-1/T-2 relaxation rate. The results showed that hollow MnIO nanoparticles exhibit increased T-1 relaxivity due to the increased surface-to-volume ratio, while they also show increased T-2 relaxivity attributed to the increased number of magnetic cores per unit volume and magnetic field inhomogeneity induced by hollow structures.
CHEMISTRY OF MATERIALS
(2023)
Letter
Clinical Neurology
Vasilios C. Constantinides, Christina Deligianni, Antonios Dimitrakopoulos, George P. Paraskevas, Elisabeth Kapaki
Summary: The lentiform fork sign is a rare MRI finding typically associated with metabolic acidosis, but can also occur in autoimmune disorders. This case report describes a 73-year-old female patient with systemic lupus erythematosus presenting with the lentiform fork sign, which resolved with treatment. Further research is needed to explore the association between the lentiform fork sign and autoimmune disorders in the absence of metabolic acidosis.
NEUROLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Juanye Zhang, Yingying Ning, Hua Zhu, Nicholas J. Rotile, He Wei, Himashinie Diyabalanage, Eric C. Hansen, Iris Y. Zhou, Stephen C. Barrett, Mozhdeh Sojoodi, Kenneth K. Tanabe, Valerie Humblet, Alan Jasanoff, Peter Caravan, Moungi G. Bawendi
Summary: SNIO-CBP, a single-nanometer iron oxide (SNIO) nanoparticle functionalized with a type I collagen-binding peptide (CBP), is a promising T1-weighted MRI contrast agent for noninvasive detection of liver fibrosis. It exhibits high relaxivity and fast elimination from bloodstream, making it suitable for rapid imaging. The results suggest SNIO-CBP as a potential gadolinium-free molecular MRI probe for characterizing chronic liver disease.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Chemistry, Multidisciplinary
Ruth Antwi-Baah, Yajing Wang, Xiaoqin Chen, Kui Yu
Summary: Metal-based nanoparticles, especially gadolinium, manganese, and iron, have shown potential as MRI contrast agents due to their desirable properties. However, most nanoparticles have not been translated into clinical applications yet.
ADVANCED MATERIALS INTERFACES
(2022)
Review
Chemistry, Multidisciplinary
Mike Jeon, Mackenzie Halbert, Zachary R. Stephen, Miqin Zhang
Summary: Gadolinium-based chelates are commonly used contrast agents for MRI, but their toxicity and potential retention in patients' bodies have raised safety concerns. Iron oxide nanoparticles have emerged as a promising alternative due to their non-toxic and biodegradable nature, but their development as T-1 contrast agents is complex and challenging. Progress is being made in exploring IONPs as safe and improved alternatives, but there are still many hurdles to overcome before they can be used clinically.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Physical
Hao Zhang, Zhijia Lv, Dongzhi Xue, Tianqi Zhang, Longhai Jin, Yue Cao, Shuai Zhang, Yinghui Wang, Hongjie Zhang
Summary: A TME-responsive theranostic nanoagent was fabricated using a layer-by-layer synthesis method, which can achieve enhanced chemotherapy within tumor cells without collateral damage to normal tissues. The nanoagent efficiently kills tumor cells in both in vitro and in vivo experiments.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Elizabeth A. Kras, Samira M. Abozeid, Waldine Eduardo, Joseph A. Spernyak, Janet R. Morrow
Summary: The Fe(III) macrocyclic complexes containing different donor groups exhibit varied solution chemistry and water proton relaxivity. They show large kinetic inertness under acidic conditions and an increase in relaxivity at very acidic pH values (<3), indicating an acid-catalyzed process. Additionally, Fe(NOTP) displays contrast enhancement in MRI studies and clears through a renal pathway.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Bo Song, Xinyue Zhang, Xinyi Wen, Qi Liu, Hua Ma, Weihua Guo, Mingqian Tan, Lei Jia, Jingli Yuan
Summary: The study developed a novel bioconjugate, Tf-Eu-Gd, with intense long-lived luminescence, high MR relaxivity, and good biocompatibility. As a probe, Tf-Eu-Gd can specifically accumulate in cancer cells overexpressing Tf receptors for TGL and MR imaging of tumors.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Biochemical Research Methods
Junwei Liu, Lulu Liu, Saisi Qu, Tongtong Zhang, Danyang Wang, Qinghua Ji, Tian Wang, Hongyu Shi, Kaichen Song, Weijia Fang, Wei Chen, Weiwei Yin
Summary: This study identified the impact of Gd contamination on CyTOF data quality, and developed a computational method named GdClean to effectively remove Gd contamination signals while preserving the real signals.
Article
Chemistry, Multidisciplinary
Celia Martinez de la Torre, Kasey A. Freshwater, Mara A. Looney-Sanders, Qiang Wang, Margaret F. Bennewitz
Summary: This study compared the potential of nano-encapsulated manganese oxide (NEMO) particles from US Nano and Nanoshel as contrast agents for MRI. It was found that the commercialized formulations did not meet the expected standards, while certain particles from US Nano and Nanoshel showed better characteristics for T-1 MRI imaging.
Article
Chemistry, Multidisciplinary
Yekkuni L. Balachandran, Wei Wang, Hongyi Yang, Haiyang Tong, Lulu Wang, Feng Liu, Hongsong Chen, Kai Zhong, Ye Liu, Xingyu Jiang
Summary: In this study, small heterogeneous iron oxide/dysprosium oxide nanoparticles were synthesized as a contrast agent for magnetic resonance imaging. These nanoparticles can target the liver and improve image resolution and signal-to-noise ratio at ultrahigh magnetic fields, allowing for precise diagnosis of liver fibrosis stages.
Article
Chemistry, Multidisciplinary
Yulia Kargina, Alexey Sobolev, Ekaterina S. Kozlyakova, Alexander N. Vasiliev, Alexander Yu Kharin, Nina Sharonova, Alexander M. Perepukhov, Anna Stavitskaya, Anatoly A. Ischenko, Victor Yu Timoshenko
Summary: Composite nanoparticles based on nanocrystalline silicon with varying iron content were synthesized and characterized. Iron-enriched agglomerates were detected in the nanoparticles with iron content above 2.5%. Magnetic relaxation measurements showed shortened proton relaxation times in aqueous suspensions of the nanoparticles. In vitro experiments showed low cytotoxicity of the prepared nanoparticles.
JOURNAL OF NANOPARTICLE RESEARCH
(2022)
Article
Oncology
Maija Rossi, Eeva Boman, Mika Kapanen
Article
Engineering, Biomedical
J. Latikka, H. Eskola
ANNALS OF BIOMEDICAL ENGINEERING
(2019)
Article
Oncology
Maija Rossi, Eeva Boman, Mika Kapanen
Article
Cardiac & Cardiovascular Systems
Florentino Luciano Caetano dos Santos, Marcin Kolasa, Mitsugu Terada, Juha Salenius, Hannu Eskola, Michelangelo Paci
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marko Laaksomaa, Sebastian Sarudis, Maija Rossi, Turkka Lehtonen, Jani Pehkonen, Jenny Remes, Helmi Luukkanen, Tanja Skytta, Mika Kapanen
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2019)
Article
Oncology
Maija Rossi, Tuomas Viren, Janne Heikkila, Jan Seppala, Eeva Boman
Summary: This study investigated the effects of soft tissue deformations on target coverage and doses in modulated arc radiotherapy of the breast or chest wall. The use of optimization bolus and automatic skin flash tool improved target coverage in the presence of tissue swelling.
Article
Oncology
Miia Nadhum, Eeva Boman, Maija Rossi
Summary: This study compared four different prostate radiotherapy techniques for patients with hip prosthesis. The results indicated that VMAT_ASTR and VMAT_F were the most robust techniques, maintaining good treatment plan quality even in cases of prosthesis misalignment.
Article
Oncology
Maija Rossi, Marko Laaksomaa, Antti Aula
Summary: This study investigated the accuracy of patient setup in breast cancer patients using deep inspiration breath-hold (DIBH) with surface-guided radiotherapy (SGRT) and image-guided radiotherapy (IGRT). The results showed that residual position errors were small after both SGRT and IGRT, but re-evaluation of the planning target volume (PTV) margins is necessary to ensure accuracy.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ullamari Hakulinen, Antti Brander, Tero Ilvesmaki, Mika Helminen, Juha Ohman, Teemu M. Luoto, Hannu Eskola
Summary: DTI analysis is influenced by various factors, and the ROI method is widely used for post-processing. The study found the freehand ROI method to be highly reliable with excellent ICC values. Age-related differences in DTI parameters were observed, with younger adults showing higher FA and AD values in certain brain regions.
BMC MEDICAL IMAGING
(2021)
Article
Acoustics
Anna Vuorenmaa, Eetu Siitama, Ullamari Hakulinen, Hannu Eskola
Summary: The purpose of this study was to investigate and evaluate the technical performance of ultrasound imaging device displays. The results indicate that the majority of displays fail to meet the recommended luminance levels for diagnostic and secondary displays. The testing and criteria for monitor performance need to be updated to reflect the advancements in display technology.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2023)
Article
Oncology
Marko Laaksomaa, Torsten Moser, Julia Kritz, Kiira Pynnonen, Maija Rossi
Summary: This study compared the setup accuracy of different shaped ROIs in adjuvant radiotherapy for breast cancer patients in free breathing. The AlignRT system showed improved reproducibility compared to conventional laser setup, with only minor differences found in patient posture and isocenter position between different ROI shapes.
REPORTS OF PRACTICAL ONCOLOGY AND RADIOTHERAPY
(2021)
Proceedings Paper
Engineering, Biomedical
Ruhunur Ozdemir, Kai Lehtimaki, Jukka Peltola, Hannu Eskola
Summary: This study uses diffusion MRI techniques and models such as constrained spherical deconvolution to investigate the structural connectivity of the anterior nuclei of the thalamus (ANT). Different subdivisions of ANT show distinct connectivity patterns throughout the hippocampus, mammillary bodies, and neocortex, aiding in accurate fiber tracking.
MEDICAL IMAGING 2020: BIOMEDICAL APPLICATIONS IN MOLECULAR, STRUCTURAL, AND FUNCTIONAL IMAGING
(2021)
Proceedings Paper
Engineering, Biomedical
Juha Latikka, Hannu Eskola
WORLD CONGRESS ON MEDICAL PHYSICS AND BIOMEDICAL ENGINEERING 2018, VOL 1
(2019)
Proceedings Paper
Engineering, Biomedical
V. Tunninen, T. Kauppinen, H. Eskola
Proceedings Paper
Engineering, Biomedical
T. Ilvesmaki, U. Hakulinen, H. Eskola