Article
Ophthalmology
Mert Simsek, Onur Inam, Emine Sen, Ufuk Elgin
Summary: This study found that patients with XFS had decreased choroidal vascularity in the macular and peripapillary regions, while unaffected fellow eyes may show vascular changes in the peripapillary choroid.
Article
Chemistry, Analytical
Marsida Bekollari, Maria Dettoraki, Valentina Stavrou, Aikaterini Skouroliakou, Panagiotis Liaparinos
Summary: The study investigated the changes in the optic nerve of glaucoma patients undergoing treatment by comparing OCT measurements and RETeval parameters. A total of 140 eyes were examined, with 59 eyes from patients with early glaucoma under treatment and 63 healthy eyes as the control group. The results showed that OCT and RETeval parameters exhibited statistical differences between the control and case group, suggesting their potential as valuable tools for examining early glaucoma patients.
Article
Ophthalmology
T. Michael Nork, Charlene B. Y. Kim, Alexander W. Katz, Carol A. Rasmussen, Mark Banghart, James N. Ver Hoeve
Summary: Through the study of multifocal electroretinography (mfERG) in experimental glaucoma (EG), it was found that short-latency changes may be related to both retinal ganglion cell (RGC) loss and elevated intraocular pressure (IOP).
DOCUMENTA OPHTHALMOLOGICA
(2023)
Article
Ophthalmology
Hiroki Tanaka, Kyoko Ishida, Kenji Ozawa, Takuma Ishihara, Akira Sawada, Kiyofumi Mochizuki, Tetsuya Yamamoto
Summary: This study found a higher correlation between N/T parameters and ganglion cell complex (GCC) and visual fields (VF), while similar associations were not obtained between mfPhNR/B parameters and OCT or VF parameters. Further research modifying stimuli and amplitudes will be needed to evaluate the value of mfERG.
Review
Biochemistry & Molecular Biology
Anna-Sophie Mursch-Edlmayr, Matthias Bolz, Clemens Strohmaier
Summary: Glaucomatous optic neuropathies have long been considered diseases caused by high intraocular pressure, but recent research has shown that vascular factors also play an important role in glaucoma. Advances in the study of ocular vasculature, ciliary circulation, retinal circulation, etc., may bring new breakthroughs in the treatment of glaucoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ophthalmology
Naoki Kiyota, Yukihiro Shiga, Kazuko Omodaka, Toru Nakazawa
Summary: This study found that LSFG-derived choroidal MBR might be a useful biomarker for predicting visual field defect progression in patients with open-angle glaucoma.
JAPANESE JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Medicine, General & Internal
Christopher Patrick Long, Hossein Ameri
Summary: This study retrospectively analyzed the impact of smoothing and adaptive data filtering on raw patient data in mfERG testing. The results showed statistically significant differences in P1 latency and P1 amplitude values between raw data and data modified by smoothing and adaptive filters. The findings of this study should inform physicians' interpretation of mfERG results.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Eleonora Micheletti, Sasan Moghimi, Takashi Nishida, Nevin El-Nimri, Golnoush Mamoudinezhad, Alireza Kamalipour, Vahid Mohammadzadeh, Linda M. Zangwill, Robert N. Weinreb
Summary: Factors such as intraocular pressure fluctuation, glaucoma medications, and baseline visual field damage are associated with the enlargement of choroidal microvasculature drop-out (MvD) in glaucomatous eyes.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Oliver W. Gramlich, Cheyanne R. Godwin, David Wadkins, Benjamin W. Elwood, Markus H. Kuehn
Summary: The study suggests that early functional and molecular differences in the retina of glaucoma patients may manifest before significant RGC loss, possibly due to reduced GABA receptor signaling and neuroinflammation. These initial changes could offer new targets for early detection and intervention in glaucoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Joong Won Shin, Youn Hye Jo, Min Kyung Song, Hun Jae Won, Michael S. Kook
Summary: The study found that nighttime diastolic blood pressure dip, visual field mean deviation, and daytime peak intraocular pressure are closely associated with the presence of choroidal microvasculature dropout in normal-tension glaucoma patients.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Mahmoud Fathy, Alia Noureldine, Hala M. Elmofty, Doaa Ahmad Tolba
Summary: This study investigates the impact of menopause and subsequent estrogen drop on optic nerve head structure and peripapillary vasculature. The results showed that postmenopausal women had significantly lower retinal nerve fiber layer thickness (RNFLT) and peripapillary vessel density (VD), and these measures were negatively correlated with age, hormonal drop, and intraocular pressure (IOP). The correlation between IOP and VD was stronger than its correlation with RNFLT. These findings suggest a link between hormonal changes after menopause and glaucoma in women, and highlight the potential of optical coherence tomography angiography (OCTA) in detecting early optic nerve damage.
SCIENTIFIC REPORTS
(2022)
Review
Ophthalmology
Solmaz Abdolrahimzadeh, Mariachiara Di Pippo, Chiara Ciancimino, Federico Di Staso, Andrew John Lotery
Summary: This review examines the literature on choroidal thickness and choroidal vascularity index in patients with RP, and evaluates whether these markers reflect the progression of the disease from an anatomical and functional perspective.
Article
Ophthalmology
Federico Bernabei, Marco Pellegrini, Leonardo Taroni, Matilde Roda, Pier Giorgio Toschi, Costantino Schiavi, Giuseppe Giannaccare, Pierre-Raphael Rothschild
Summary: This study compared choroidal vascularity index (CVI) and subfoveal choroidal thickness (CT) between eyes that had undergone encircling scleral buckling (SB) procedure and unoperated fellow eyes (FE). The results showed that eyes treated with encircling SB had increased choroidal thickness, total choroidal area, luminal area, and stromal area compared to fellow eyes, but there was no significant difference in CVI.
Article
Multidisciplinary Sciences
Seung Hyen Lee, Eun Ji Lee, Tae-Woo Kim
Summary: This study compares the extent of microvasculature impairment in the peripapillary retina and choroid in eyes with primary open-angle glaucoma (POAG) and investigates the association between the discrepancy in microvasculature impairments and the rate of progressive retinal nerve fiber layer (RNFL) thinning. The findings suggest that a larger width of choroidal microvasculature dropout relative to retinal microvascular impairment may indicate an increased risk of faster RNFL thinning in POAG patients.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Keiko Azuma, Atsushi Okubo, Takafumi Suzuki, Nozomi Igarashi, Yoko Nomura, Hirotsugu Soga, Hiroshi Murata, Ryosuke Fujino, Asako Ogawa, Haruka Matsui, Takeshi Nagamatsu, Takayuki Iriyama, Ryo Asaoka, Tatsuya Inoue, Maiko Maruyama-Inoue, Kazuaki Kadonosono, Ryo Obata
Summary: Anatomical differences in choroidal structure between pregnant women in the first trimester and healthy nonpregnant women were investigated using EDI-OCT and choroidal binarization analysis. The study identified a significant correlation between a larger choroidal luminal area and higher systolic blood pressure, particularly in the first trimester of pregnancy.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Tomer Langberg, Ryan Dashek, Bernard Mulvey, Kimberly A. Miller, Susan Osting, Carl E. Stafstrom, Thomas P. Sutula
NEUROBIOLOGY OF DISEASE
(2016)
Article
Cell Biology
Paula J. Klutho, Ryan J. Dashek, Lihui Song, Christopher P. Baines
CELL DEATH DISCOVERY
(2020)
Article
Ophthalmology
Ryan J. Dashek, Charlene B. Y. Kim, Carol A. Rasmussen, Elizabeth A. Hennes-Beean, James N. Ver Hoeve, T. Michael Nork
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2013)