Safety, tolerability and anti-tumour activity of the androgen biosynthesis inhibitor ASP9521 in patients with metastatic castration-resistant prostate cancer: multi-centre phase I/II study

Prostate cancer: ESMO Consensus Conference Guidelines 2012

(2013) A. Horwich et al.   ANNALS OF ONCOLOGY

Discovery of 2-methyl-1-{1-[(5-methyl-1H-indol-2-yl)carbonyl]piperidin-4-yl}propan-2-ol: A novel, potent and selective type 5 17β-hydroxysteroid dehydrogenase inhibitor

(2013) Kazushi Watanabe et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Steroidogenic Enzyme AKR1C3 Is a Novel Androgen Receptor-Selective Coactivator that Promotes Prostate Cancer Growth

(2013) M. Yepuru et al.   CLINICAL CANCER RESEARCH

AKR1C3 as a target in castrate resistant prostate cancer

(2013) Adegoke O. Adeniji et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Molecular Markers in Sex Hormone Pathway Genes Associated with the Efficacy of Androgen-Deprivation Therapy for Prostate Cancer

(2013) Chia-Cheng Yu et al.   PLoS One

Activation of the Androgen Receptor by Intratumoral Bioconversion of Androstanediol to Dihydrotestosterone in Prostate Cancer

(2011) James L. Mohler et al.   CANCER RESEARCH

Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

(2011) C. Cai et al.   CANCER RESEARCH

Targeting Continued Androgen Receptor Signaling in Prostate Cancer

(2011) C. Massard et al.   CLINICAL CANCER RESEARCH

Resistance to CYP17A1 Inhibition with Abiraterone in Castration-Resistant Prostate Cancer: Induction of Steroidogenesis and Androgen Receptor Splice Variants

(2011) Elahe A. Mostaghel et al.   CLINICAL CANCER RESEARCH

Unknown

(2011) Minja Pfeiffer et al.   MOLECULAR MEDICINE

Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer

(2011) K.-H. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Androgen deprivation therapy: progress in understanding mechanisms of resistance and optimizing androgen depletion

(2009) William P Harris et al.   Nature clinical practice. Urology