Sorafenib exposure decreases over time in patients with hepatocellular carcinoma

Proposal of a new population pharmacokinetics (PK) model of sorafenib and rationale for a three-daily schedule.

(2017) P. Boudou-Rouquette et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase II randomized trial on dose-escalated sorafenib (S) versus best supportive care (BSC) in patients with advanced hepatocellular carcinoma (HCC) with disease progression on prior S treatment.

(2017) T. Pressiani et al.   JOURNAL OF CLINICAL ONCOLOGY

Clinical effectiveness and cost-effectiveness of imatinib dose escalation for the treatment of unresectable and/or metastatic gastrointestinal stromal tumours that have progressed on treatment at a dose of 400 mg/day: a systematic review and economic evaluation

(2014) J Hislop et al.   HEALTH TECHNOLOGY ASSESSMENT

Functional and Clinical Evidence of the Influence of Sorafenib Binding to Albumin on Sorafenib Disposition in Adult Cancer Patients

(2011) Michel Tod et al.   PHARMACEUTICAL RESEARCH

Enhancing the clinical activity of sorafenib through dose escalation: rationale and current experience

(2011) Thomas J. Semrad et al.   Therapeutic Advances in Medical Oncology

Imatinib plasma levels: correlation with clinical benefit in GIST patients

(2010) N Widmer et al.   BRITISH JOURNAL OF CANCER

The role of imatinib plasma level testing in gastrointestinal stromal tumor

(2010) Suzanne George et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Long-term safety of sorafenib in advanced renal cell carcinoma: Follow-up of patients from phase III TARGET

(2010) Thomas E. Hutson et al.   EUROPEAN JOURNAL OF CANCER

Breast Cancer Resistance Protein and P-glycoprotein Limit Sorafenib Brain Accumulation

(2010) J. S. Lagas et al.   MOLECULAR CANCER THERAPEUTICS

Validation of an HPLC-UV method for sorafenib determination in human plasma and application to cancer patients in routine clinical practice

(2009) B. Blanchet et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE