Cluvenone induces apoptosis via a direct target in mitochondria: a possible mechanism to circumvent chemo-resistance?

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Chemistry and Biology of the CagedGarciniaXanthones

(2010) Oraphin Chantarasriwong et al.   CHEMISTRY-A EUROPEAN JOURNAL

The causes of cancer revisited: “Mitochondrial malignancy” and ROS-induced oncogenic transformation – Why mitochondria are targets for cancer therapy

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The Synthetic Caged Garcinia Xanthone Cluvenone Induces Cell Stress and Apoptosis and Has Immune Modulatory Activity

(2010) A. Batova et al.   MOLECULAR CANCER THERAPEUTICS

Targeting mitochondrial apoptosis by betulinic acid in human cancers

(2009) Simone Fulda et al.   DRUG DISCOVERY TODAY

Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger

(2009) Stephen J. Ralph et al.   MOLECULAR ASPECTS OF MEDICINE

Mitochondria as targets for cancer therapy

(2009) Stephen J. Ralph et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Evaluation of the pharmacophoric motif of the caged Garcinia xanthones

(2009) Oraphin Chantarasriwong et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Reactive oxygen species accumulation contributes to gambogic acid-induced apoptosis in human hepatoma SMMC-7721 cells

(2009) Feifei Nie et al.   TOXICOLOGY

Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins

(2008) Dayong Zhai et al.   MOLECULAR CANCER THERAPEUTICS

Elesclomol induces cancer cell apoptosis through oxidative stress

(2008) J. R. Kirshner et al.   MOLECULAR CANCER THERAPEUTICS