Article
Engineering, Mechanical
Yudong Luo, Na Zhao, Yantao Shen, Peng Li
Summary: Inspired by the locomotion mechanism of earthworms, this paper proposes a method to mimic the earthworm's muscle using rigid elements-based morphing structures. The proposed earthworm-like robot achieves programable bidirectional 3D deformation, making it precisely controllable and efficient in peristaltic locomotion. Extensive simulations and experiments validate the effectiveness of the morphing mechanism, the consistency between the proposed locomotion model and practical tests, and the competitive speed of the developed prototype.
JOURNAL OF MECHANISMS AND ROBOTICS-TRANSACTIONS OF THE ASME
(2023)
Article
Nutrition & Dietetics
Kristen D. Turner, Ana Kronemberger, Dam Bae, Joshua M. Bock, William E. Hughes, Kenichi Ueda, Andrew J. Feider, Satoshi Hanada, Luis G. O. de Sousa, Matthew P. Harris, Ethan J. Anderson, Sue C. Bodine, M. Bridget Zimmerman, Darren P. Casey, Vitor A. Lira
Summary: In individuals with type 2 diabetes mellitus, supplementation with nitrate/nitrite can increase VO(2)max, with improvements in skeletal muscle oxidative capacity seen in those with more pronounced increases in VO(2)max.
Article
Biochemistry & Molecular Biology
Marioli Carrasco-Quiroz, Maria del Alamo-Sanza, Ana Maria Martinez-Gil, Rosario Sanchez-Gomez, Victor Martinez-Martinez, Ignacio Nevares
Summary: This study investigates the effect of different levels of oxygen saturation on the final characteristics of wines made from Tempranillo and Garnacha grape extracts. Controlled oxygen saturation levels were used to simulate possible oxidation before bottling. The results demonstrate the relationship between the oxidation state of wine and changes in its chemical composition, and provide insight into the impact of oxygen consumption before bottling on wines subjected to high and single doses of oxygen.
Article
Chemistry, Multidisciplinary
Natividad Isabel Navarro Pacheco, Radka Roubalova, Jaroslav Semerad, Alena Grasserova, Oldrich Benada, Olga Kofronova, Tomas Cajthaml, Jiri Dvorak, Martin Bilej, Petra Prochazkova
Summary: The research found that exposure to sublethal concentrations of TiO2 NPs had minimal effects on the cellular and molecular levels of Eisenia andrei earthworm immune cells, with no impact on cell viability, reactive oxygen species production, or DNA damage. Upregulation of certain genes was observed, but overall, there were no significant toxic effects of TiO2 NPs at the cellular and molecular levels.
Article
Biochemistry & Molecular Biology
Linlin Shi, Axin Zhang, Hong Liu, Huanling Wang
Summary: Oxygen homeostasis is crucial for understanding various aspects of biology. FoxO4 is a transcriptional regulator involved in cellular functions, but its role in hypoxia adaptation is not well understood. This study found that foxO4 expression was up-regulated under hypoxia and was regulated by Hif1a. Knockout of foxO4 increased tolerance to hypoxia in zebrafish. Further analysis revealed lower oxygen consumption and activity levels in foxO4(-/-) zebrafish, along with changes in mitochondrial function. These findings lay the groundwork for studying the role of foxO4 in hypoxia response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Jennifer S. Bigman, Leithen K. M'Gonigle, Nicholas C. Wegner, Nicholas K. Dulvy
Summary: Research suggests that respiratory surface area plays a bigger role in explaining metabolic rate variation across vertebrates, compared to temperature. Understanding the combination of oxygen acquisition and transport helps in understanding the evolutionary history of metabolic rate.
Article
Materials Science, Multidisciplinary
Daniel A. Domingo-Lopez, Ruth E. Levey, Benjamin Brennan, Oliver Carroll, Sarah E. Gale, Jeffrey R. Millman, Liam McDonough, Helena M. Kelly, William Ronan, Garry P. Duffy
Summary: Cell transplantation aims to cure currently incurable diseases. However, post-transplantation cell survival is limited by the lack of suitable support matrix and oxygen supply. This study develops a novel biomaterial, Oxygel, with high oxygen durability and validates a model to predict its application in cell encapsulation.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Engineering, Marine
Elina Apine, Madhu K. Mani, Praveen Rai, Indrani Karunasagar, Lucy M. Turner
Summary: Research on the effects of future climate change on the marine environment has mainly focused on temperate regions and organisms, with limited understanding of tropical regions and early life stages of marine species. This study found that simulated climate change conditions, especially freshening, significantly increased the metabolic responses of mud crab juveniles, and the presence of pathogenic bacteria further intensified these effects. These findings suggest that future climate change could have significant implications for the conservation and commercial farming of this species in South Asia.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2022)
Article
Cell Biology
Mitsusuke Tarama, Kenji Mori, Ryoichi Yamamoto
Summary: Constructing physical models of living cells and tissues is challenging due to the complexities of intra- and intercellular processes. This study develops a basic mechanochemical model to understand how a crawling cell coordinates processes for autonomous migration. The model focuses on the dependence of protrusion, contraction, adhesion, and de-adhesion on intracellular biochemical signals. The study sheds light on how intracellular chemical reactions contribute to directional cell migration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Health Care Sciences & Services
Dorota Siwicka-Gieroba, Chiara Robba, Jakub Golacki, Rafael Badenes, Wojciech Dabrowski
Summary: Organism survival relies on the balance of oxygen delivery and utilization, especially crucial for the brain after acute injuries. Clinical protocols play an important role in improving oxygen delivery and reducing mortality in brain-injured patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Multidisciplinary Sciences
Alexander Kogel, Pierre Hepp, Tina Stegmann, Adrienn Tuennemann-Tarr, Roberto Falz, Patrick Fischer, Felix Mahfoud, Ulrich Laufs, Sven Fikenzer
Summary: Wearing surgical and FFP2 masks reduces exercise capacity in heart failure patients, with FFP2 masks also affecting oxygen uptake and peak ventilation. This should be taken into consideration for daily activities of heart failure patients, which are often as challenging as exercise for healthy adults.
Review
Pharmacology & Pharmacy
Andie J. Robinson, Akhil Jain, Harry G. Sherman, Richard J. M. Hague, Ruman Rahman, Paola Sanjuan-Alberte, Frankie J. Rawson
Summary: Bioelectronic medicine is a treatment modality that alters the body's electrical communication systems using electricity. Cancer is identified by malfunctions in cells' bioelectrical circuitry, presenting opportunities for novel treatments utilizing bioelectric properties. By manipulating bioelectricity, such as controlling ionic and faradaic current processes, and understanding key links to cancer phenotypes, improvements in cancer therapy can be achieved.
ADVANCED THERAPEUTICS
(2021)
Article
Agriculture, Multidisciplinary
Tao Li, Jie-Qun Fan, Hua-Wei Qian, Ji-Hui Wei, Zhen-Guan Qian, Shui-Liang Guo, Wei-Guang Lv
Summary: In this study, a four-year investigation on taro-earthworm coculture farming showed that using a unique crop-earthworm model can increase taro yield, economic value and net income. The activities of earthworms reduced the weed seed bank, mitigated weed infestation, and decreased the need for weeding. This research demonstrates the ecosystem services provided by earthworms in agricultural systems, and how the coculture of taro and earthworms enhances crop production by reducing weed infestation and improving environmental quality.
AGRICULTURE ECOSYSTEMS & ENVIRONMENT
(2023)
Article
Agronomy
Lieven Van de Vondel, Annelies Christiaens, An Vermeulen, Marie-Christine Van Labeke, Frank Devlieghere, Peter Ragaert
Summary: A model structure was established to estimate the respiration rate of Phalaenopsis and Chrysanthemum as a function of oxygen concentration and temperature, facilitating the management of quality loss during storage and transport of plantlets and cuttings. The models can be used to estimate a dynamic oxygen consumption rate profile during storage and transport.
Article
Chemistry, Multidisciplinary
Zhaoxiang Yang, Yao An, Yonglin He, Xiaodong Lian, Yapei Wang
Summary: To mimic the burrowing activities of earthworms and improve soil porosity, researchers have developed a degradable actuator that can dig, grab, and lift soil when it receives rainfall. This scarifying actuator is made of degradable cellulose acetate and uncrosslinked polyacrylamide, which can bend rapidly and remarkably when absorbing water. Patterning polyacrylamide within cellulose acetate using reversible surface protection technique enables the actuator to generate complex deformations. This water-induced deformation is well-preserved in soil, making it suitable for rain diffusion and root breath.
ADVANCED MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Shu-Chun Chuang, Chung-Hwan Chen, Yin-Chin Fu, I-Chun Tai, Ching-Ju Li, Li-Fu Chang, Mei-Ling Ho, Je-Ken Chang
BIOCHEMICAL PHARMACOLOGY
(2015)
Article
Nanoscience & Nanotechnology
I-Chun Tai, Yao-Hsien Wang, Chung-Hwan Chen, Shu-Chun Chuang, Je-Ken Chang, Mei-Ling Ho
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2015)
Article
Fisheries
Jing-Chun Ko, Shu-Chun Chuang, Chung-Da Yang
Article
Immunology
Wan-Ling Huang, Shu-Chun Chuang, Chung-Da Yang
Article
Immunology
Shang-Pin Liu, Shu-Chun Chuang, Chung-Da Yang
Article
Biochemistry & Molecular Biology
Sung-Yen Lin, Jung Yu Kan, Cheng-Chang Lu, Han Hsiang Huang, Tsung-Lin Cheng, Hsuan-Ti Huang, Cheng-Jung Ho, Tien-Ching Lee, Shu-Chun Chuang, Yi-Shan Lin, Lin Kang, Chung-Hwan Chen
Article
Biochemistry & Molecular Biology
Shu-Chun Chuang, Chung-Hwan Chen, Ya-Shuan Chou, Mei-Ling Ho, Je-Ken Chang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Hsin-Chaio Chou, Chung-Hwan Chen, Liang-Yin Chou, Tsung-Lin Cheng, Lin Kang, Shu-Chun Chuang, Yi-Shan Lin, Mei-Ling Ho, Yan-Hsiung Wang, Sung-Yen Lin, Chau-Zen Wang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Liang-Yin Chou, Chung-Hwan Chen, Shu-Chun Chuang, Tsung-Lin Cheng, Yi-Hsiung Lin, Hsin-Chiao Chou, Yin-Chih Fu, Yan-Hsiung Wang, Chau-Zen Wang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Hsuan-Ti Huang, Tsung-Lin Cheng, Chung-Da Yang, Chi-Fen Chang, Cheng-Jung Ho, Shu-Chun Chuang, Jhong-You Li, Shih-Hao Huang, Yi-Shan Lin, Hsin-Yi Shen, Tsung-Han Yu, Lin Kang, Sung-Yen Lin, Chung-Hwan Chen
Summary: The study suggests that EGCG may serve as a potential disease-modifying drug for primary OA treatment, showing inhibitory effects on cartilage degradation and joint inflammation both in vitro and in vivo.
Article
Biochemistry & Molecular Biology
Hsuan-Ti Huang, Tsung-Lin Cheng, Cheng-Jung Ho, Han Hsiang Huang, Cheng-Chang Lu, Shu-Chun Chuang, Jhong-You Li, Tien-Ching Lee, Shih-Tse Chen, Yi-Shan Lin, Chih-Yao Lee, Lin Kang, Sung-Yen Lin, Chung-Hwan Chen
Summary: The study showed that EGCG can improve joint function by inhibiting joint inflammation and cartilage degradation, as well as reducing chondrocyte apoptosis, possibly through activation of autophagy.
Article
Biochemistry & Molecular Biology
Chung-Da Yang, Shu-Chun Chuang, Tsung-Lin Cheng, Mon-Juan Lee, Hui-Ting Chen, Sung-Yen Lin, Hsuan-Ti Huang, Cheng-Jung Ho, Yi-Shan Lin, Lin Kang, Mei-Ling Ho, Je-Ken Chang, Chung-Hwan Chen
Summary: The study introduces a new culture formula for human bone marrow stem cells, which allows for maintaining and expanding the cells with high proliferation rate and multiple lineage differentiation ability. The new formula also retains stable chromosome, DNA, telomere length, and telomerase activity of the cells even after long-term culture, minimizing senescence and preventing carcinogenesis. These modifications enhance the survival rate, growth rate, and basal characteristics of isolated HBMSCs, providing valuable insights for stem cell research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemical Research Methods
Chung-Hwan Chen, Anupama Venugopalan Nair, Shu-Chun Chuang, Yi-Shan Lin, Mei-Hsin Cheng, Chun-Yu Lin, Chia-Ying Chang, Shean-Jen Chen, Chi-Hsiang Lien
Summary: This study explores a new non-invasive method to study the molecular-level properties of collagen, which can help improve the ability to quantify the characteristics of both types of collagen, including estimating their pitch angles and other features.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Parasitology
Shu-Chun Chuang, Yao-Chi Chung, Chung-Da Yang
Article
Immunology
Shu-Chun Chuang, Wan-Ling Huang, Sau-Wei Kau, Yun-Pei Yang, Chung-Da Yang