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Biochemistry & Molecular Biology
Rohan Reddy Nagavally, Siddharth Sunilkumar, Mumtaz Akhtar, Louis D. Trombetta, Sue M. Ford
Summary: Chrysin demonstrates nephroprotective effects against CsA-induced renal dysfunction and fibrosis by inhibiting TGF-beta(1)-dependent EMT in proximal tubule cells through modulation of Smad-dependent and independent signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
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Biochemistry & Molecular Biology
Fengbao Luo, Renfang Xu, Guanglai Song, Dong Xue, Xiaozhou He, Ying Xia
Summary: The study demonstrates that DOR activation efficiently blocks the fibrosis process induced by TGF-beta 1 in renal proximal tubule cells, by inhibiting multiple signaling pathways.
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Cell Biology
Shu Yang, Guangyan Yang, Xinyu Wang, Jiaqing Xiang, Lin Kang, Zhen Liang
Summary: This study demonstrates the anti-fibrotic role of SIRT2 in renal tubules and hepatocytes. SIRT2 inhibits fibrotic gene expression by reducing the activation of the TGF-beta signaling pathway. It interacts with and deacetylates SMAD2 and SMAD3 to promote their degradation and decrease the activation of SMAD3.
CELL DEATH & DISEASE
(2023)
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Medicine, Research & Experimental
Ning Zhao, Minwei He, Wei Chen, Peng Jin, Lulu Cao, Jinhai Deng, Xu Cheng, Lu Wang
Summary: Our study identified FAM96A as a crucial regulator of tumor metastasis and epithelial-mesenchymal transition (EMT) by inhibiting the TGF-beta signaling pathway.
Article
Integrative & Complementary Medicine
Congying Wei, Yansong Zhang, Xiaobin Zhong, Sisi Lu, Xiaoqin Zou, Yufang Yang, Songqing Huang, Zhenguang Huang
Summary: This study aimed to investigate the effects and potential molecular mechanisms of Ginkgo biloba leaf extract (EGb) on chronic renal interstitial fibrosis induced by cisplatin. The results demonstrated that EGb could attenuate renal damage and fibrosis, decrease fibrosis-associated protein levels, inhibit the Smad3/TGF-beta 1 and Smad3/p38 MAPK pathways, and improve renal function.
Article
Biochemistry & Molecular Biology
Hua Fu, Yong-Hong Gu, Juan Tan, Ye-Ning Yang, Guo-Hui Wang
Summary: The crosstalk between macrophages and tubular epithelial cells is important in the progression of renal fibrosis. In this study, the significance of circular RNA ACTR2 (circACTR2) in regulating macrophage inflammation, epithelial-mesenchymal transition (EMT) of tubular epithelial cells, and the development of renal fibrosis was revealed. circACTR2 promoted the activation of NLRP3 inflammasome, inflammation in macrophages, and stimulated EMT and fibrosis of tubular epithelial cells by sponging miR-561. Knocking down circACTR2 and overexpressing miR-561 may benefit the treatment of renal fibrosis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Cell Biology
Yan Lin, Fangfang Cai, Xiaoyang Wang, Yunwen Yang, Yongzhe Ren, Chun Yao, Xiaoxing Yin, Hongqin Zhuang, Zichun Hua
Summary: This study suggests that FADD may play a critical role in the development of renal fibrosis. Through various staining and immunofluorescence analysis, neutrophil infiltration, glomerular mesangial cell proliferation, and base-membrane thickening were observed in FADD-D mice. Macrophage infiltration was significantly enhanced, and the levels of renal fibrosis-related markers were elevated. Mechanism study indicates that FADD phosphorylation may activate the TLR4/myD88/NF-kappa B signaling pathway as well as the mTOR and TGF-beta/Smad pathway, accelerating the process of epithelial mesenchymal transition and eventually resulting in IgA nephritis and renal fibrosis.
Review
Pharmacology & Pharmacy
Sara Lovisa
Summary: EMT, a process crucial in wound healing, fibrosis, and cancer, has gained significant attention from researchers since its discovery in the seventies. Despite advances in understanding its functional role, targeting EMT in fibrotic diseases remains a challenge at an early stage of development.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Mary Flokis, Frank J. Lovicu
Summary: FGF-2 and TGF-beta can regulate LEC behavior, with FGF-2 promoting fiber differentiation and TGF-beta inducing EMT. When used together, central LECs undergo EMT while peripheral LECs favor fiber differentiation. This differential regulation is important in the development of lens pathology.
Article
Cell Biology
Ha Young Jang, Soo-Jin Kim, Kyu-Sang Park, Jeong Hun Kim
Summary: Degenerative changes of RPE triggered by TGF-beta 2 and oxidative stress play a critical role in AMD progression. The expression of antiaging protein alpha-klotho declines with age, increasing the risk of age-related diseases. Alpha-klotho protects against TGF-beta 2-induced RPE degeneration and EMT both in vitro and in vivo. It inhibits TGF-beta 2 signaling, EMT, oxidative stress, and senescence-associated signaling.
CELL DEATH & DISEASE
(2023)
Article
Medicine, Research & Experimental
Qinglan Wang, Yanyan Tao, Hongdong Xie, Chenghai Liu, Ping Liu
Summary: miR-101 inhibits tubular EMT induced by TGF-beta 1 by targeting TβR-I, suggesting it may be an important regulator of RIF.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Immunology
Lei Wu, Chao Rong, Qing Zhou, Xin Zhao, Xue-Mei Zhuansun, Shan Wan, Mao-Min Sun, Shou-Li Wang
Summary: This study showed that BM-MSCs attenuated cisplatin-induced renal fibrosis by regulating the miR-146a-5p/Tfdp2 axis in mRTECs. This provides a new direction for the treatment of chronic kidney diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuqin Tan, Tong Zheng, Rui Zhang, Suxiang Chen, Qingdi Cheng, Jinhua Zhang, Ruojiao Wang, Min Chen, Ning Na
Summary: This study elucidates the role of the APA writer CSTF2 in the process of renal fibrosis, demonstrating that CSTF2 is upregulated by TGF-beta and facilitates FGF2 overexpression to form a pro-fibrotic axis. These findings suggest that CSTF2 is a potentially promising target for renal fibrosis that does not directly disrupt TGF-beta signaling.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Pharmacology & Pharmacy
Xiaohong Sun, Haiming Xiao, Shanshan Li, Rui Chen, Zeyuan Lin, Yan Yang, Zhiquan Chen, Li Deng, Heqing Huang
Summary: This study reveals that Cx32 plays a protective role in diabetic renal tubulointerstitial fibrosis by suppressing EMT and ECM production, as well as inhibiting ROS generation in renal tubules. Mechanistically, Cx32 down-regulates PKCα expression to inhibit the formation of p22phox-NOX4 complex, leading to reduced NOX4 protein levels.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yilu Zhou, Charlotte Hill, Liudi Yao, Juanjuan Li, David Hancock, Julian Downward, Mark G. Jones, Donna E. Davies, Rob M. Ewing, Paul Skipp, Yihua Wang
Summary: Alveolar type II (ATII) epithelial cells function as stem cells and are crucial for alveolar renewal, repair, and cancer. Research has shown that RAS activation induces epithelial-mesenchymal transition (EMT), while activation of the TGF-beta signaling pathway alone only induces partial EMT.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)