Article
Cardiac & Cardiovascular Systems
Pierangela Presta, Davide Bolignano, Giuseppe Coppolino, Filiberto Serraino, Pasquale Mastroroberto, Michele Andreucci, Giorgio Fuiano
Summary: Chronic, long-term ACE-I treatment may influence the inflammatory response following CPB, but this drug class apparently has neutral impact on perioperative renal outcomes.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Priyanka Priyanka, Alexander Zarbock, Junichi Izawa, Thomas G. Gleason, Ronny W. Renfurm, John A. Kellum
Summary: This study investigated the relationship of acute kidney injury severity with the risk for major adverse kidney events at 180 days after cardiac surgery, showing that even milder forms of acute kidney injury, such as isolated stage 1 oliguria, are associated with adverse long-term consequences.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Surgery
Hsun-Yi Fu, Nai-Kuan Chou, Yih-Sharng Chen, Hsi-Yu Yu
Summary: This study found a high incidence of postoperative AKI in patients with pre-existing impaired renal function, which was associated with high preoperative serum creatinine levels and decreased CPB target temperature. AKI patients had higher hospital mortality and a worse two-year renal function evolution compared to non-AKI patients.
ASIAN JOURNAL OF SURGERY
(2021)
Article
Pediatrics
Peiyao Zhang, Yuanyuan Tong, Jinping Liu, Shengwen Guo, Yu Jin, Liting Bai, Yixuan Li, Zhengyi Feng, Ju Zhao
Summary: The study found that the hypothermic DO(2)i is negatively associated with postoperative AKI in neonates undergoing hypothermic CPB, with a cut-off value of DO(2)i > 269 mL min(-1) m(-2) potentially protecting neonates from the risk of AKI. This research adds new evidence regarding the critical DO(2)i value for neonates undergoing hypothermic CPB, helping to improve postoperative outcomes for newborns based on a 6-year experience.
PEDIATRIC RESEARCH
(2022)
Review
Medicine, General & Internal
Christina Massoth, Alexander Zarbock
Summary: Acute kidney injury after cardiac surgery presents specific patterns of damage and recovery, which are crucial for management and outcomes. The KDIGO classification only partially covers the conceptual framework and is insufficient for a comprehensive diagnosis. This review discusses the strengths and limitations of recent criteria for CSA-AKI and provides an overview of biomarkers. The evolving understanding of CSA-AKI as a time-sensitive condition has led to an increased demand for enhancing diagnostic criteria and implementing biomarkers in clinical practice.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Urology & Nephrology
Sidharth Kumar Sethi, Rajesh Sharma, Aditi Gupta, Abhishek Tibrewal, Romel Akole, Rohan Dhir, Kritika Soni, Shyam Bihari Bansal, Pranaw Kumar Jha, Anil Bhan, Vijay Kher, Rupesh Raina
Summary: This study aimed to establish long-term renal outcomes for pediatric patients after cardiac surgery, focusing on urinary biomarker abnormalities that persist years after surgery and may contribute to a low glomerular filtration rate during follow-up. The presence of AKI, AKI stage, and younger age were not associated with low GFR at follow-up, while children with a higher surgical complexity score tended to have lower GFR.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Anesthesiology
Lihai Chen, Liang Hong, Aixia Ma, Yanfei Chen, Yue Xiao, Feng Jiang, Ruijian Huang, Cui Zhang, Xinyi Bu, Yali Ge, Jifang Zhou
Summary: This study found that venous congestion is associated with acute kidney injury and disease in patients undergoing cardiac surgery, while intraoperative hypotension is not associated with the development of acute kidney disease.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Cardiac & Cardiovascular Systems
Won Ho Kim, Jinyoung Bae, Sang-Hwan Ji, Kyung Won Shin, Jin-Tae Kim, Young-Jin Lim, Jae-Hyon Bahk
Summary: The study identified two subgroups within KDIGO stage 1 acute kidney injury for patients undergoing cardiac or thoracic aortic surgery, with different clinical outcomes. Patients in stage 1b had worse length of hospital stay and 5-year all-cause mortality compared to those in stage 1a.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Mahmoud Diab, Thomas Lehmann, Wolfgang Bothe, Payam Akhyari, Stephanie Platzer, Daniel Wendt, Antje-Christin Deppe, Justus Strauch, Stefan Hagel, Albrecht Guenther, Gloria Faerber, Christoph Sponholz, Marcus Franz, Andre Scherag, Ilia Velichkov, Miriam Silaschi, Jens Fassl, Britt Hofmann, Sven Lehmann, Rene Schramm, Georg Fritz, Gabor Szabo, Thorsten Wahlers, Klaus Matschke, Artur Lichtenberg, Mathias W. Pletz, Jan F. Gummert, Friedhelm Beyersdorf, Christian Hagl, Michael A. Borger, Michael Bauer, Frank M. Brunkhorst, Torsten Doenst
Summary: This study investigated the effect of hemoadsorption during cardiac surgery for infective endocarditis (IE) on postoperative organ dysfunction and found that hemoadsorption did not reduce the occurrence of organ dysfunction. Although hemoadsorption reduced cytokine levels during surgery, it did not have an impact on clinically relevant outcome measures.
Article
Cardiac & Cardiovascular Systems
Chi Chi Do-Nguyen, David L. Sturmer, Guangyu Yang, Robert B. Hawkins, Milo Engoren, Jeremy Wolverton, Michael Heung, Min Zhang, Donald S. Likosky
Summary: Postoperative acute kidney injury (AKI) in cardiac surgery patients is associated with low oxygen delivery (DO2) during cardiopulmonary bypass. Analyses of the data showed that decreasing nadir DO2 was associated with an increased risk of AKI, and suggested that managing and treating nadir DO2 during cardiopulmonary bypass may decrease postoperative AKI risk.
ANNALS OF THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Shouqiang Zhu, Peng Lu, Zhenran Liu, Shaoyang Li, Peitong Li, Bingdi Wei, Jiayi Li, Yupei Wang
Summary: This study aimed to describe the longitudinal dynamic hemoglobin trajectories in patients undergoing cardiac surgery and explore their predictive value for AKI compared to traditional threshold values. The interaction of red blood cell transfusion was also investigated. The results showed three distinct hemoglobin trajectories, and patients in the highest and medium trajectory groups had significantly lower AKI risk.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Nikolay O. Kamenshchikov, Yana J. Anfinogenova, Boris N. Kozlov, Yulia S. Svirko, Stanislav E. Pekarskiy, Vladimir V. Evtushenko, Vladimir A. Lugovsky, Vladimir M. Shipulin, Vladimir V. Lomivorotov, Yuriy K. Podoksenov
Summary: This study evaluated the effects of nitric oxide (NO) supplementation on the development of acute kidney injury (AKI) after cardiac surgery. The results showed that NO treatment during cardiopulmonary bypass (CPB) was associated with a lower incidence of AKI and higher urine output. There was also a decrease in urinary neutrophil gelatinase-associated lipocalin levels in the NO treatment group. Concentrations of NO metabolites were significantly increased in this group.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Betty Pat, Joo-Yeun Oh, Juan Xavier Masjoan Juncos, Pamela C. Powell, James F. Collawn, Rakesh P. Patel, Louis J. Dell'Italia
Summary: This study reveals the potential of red blood cell-derived exosomes released during cardiopulmonary bypass to induce hemolysis and mediate acute kidney injury (AKI).
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Anesthesiology
Yi Shun Wang, Dong Xu Chen, Min Yan, Zhong Wu, Ying Qiang Guo, Qian Li, Lei Du
Summary: This study developed and validated a model to predict the severity of acute kidney injury (AKI) after on-pump cardiac surgery using 10 predictors. The model showed good accuracy in predicting AKI severity and may be useful in clinical practice.
JOURNAL OF CLINICAL ANESTHESIA
(2022)
Article
Medicine, General & Internal
Elena Carrasco-Serrano, Pablo Jorge-Monjas, Maria Fe Munoz-Moreno, Esther Gomez-Sanchez, Juan Manuel Priede-Vimbela, Miguel Bardaji-Carrillo, Hector Cubero-Gallego, Eduardo Tamayo, Christian Ortega-Loubon
Summary: The level of DO(2)i during cardiopulmonary bypass has an impact on the development of CSA-AKI, with 303 mL/min/m(2) being identified as a good predictor threshold. Low DO(2)i is a risk factor for CSA-AKI.
JOURNAL OF CLINICAL MEDICINE
(2022)
Letter
Cardiac & Cardiovascular Systems
Giuseppe Santarpino, Ignazio Condello, Giuseppe Filiberto Serraino
ANNALS OF THORACIC SURGERY
(2022)
Article
Surgery
Raffaele Serra, Umberto Marcello Bracale, Caterina Chila, Maria Renne, Chiara Mignogna, Nicola Ielapi, Salvatore Ciranni, Giuseppina Torcia, Egidio Bevacqua, Maria Donata Di Taranto, Pasquale Mastroroberto, Giuseppe Filiberto Serraino, Michele Provenzano, Michele Andreucci
Summary: This study investigates the correlation between histopathological abnormalities and clinical issues in chronic venous disease (CVD). The results show an increasing trend of positive structures for VEGF, FN, and MMP-9 with disease staging. VEGF and FN are associated with progressive increase from C2 to C4, while MMP-9 has significant positivity even in early stages of the disease, particularly in CEAP C4 patients. PGP 9.5 decreases in CEAP C4 patients, consistent with decreased vein wall innervation.
ANNALS OF VASCULAR SURGERY
(2022)
Review
Medicine, General & Internal
Nunzio Montelione, Vincenzo Catanese, Antonio Nenna, Mohamad Jawabra, Emanuele Verghi, Francesco Loreni, Francesco Nappi, Mario Lusini, Ciro Mastroianni, Federica Jiritano, Giuseppe Filiberto Serraino, Pasquale Mastroroberto, Francesco Alberto Codispoti, Massimo Chello, Francesco Spinelli, Francesco Stilo
Summary: This narrative review summarizes the current knowledge on the value of circulating biomarkers as predictors of internal stent restenosis (ISR) in peripheral arterial disease (PAD) and explores the advantages of drug-coated balloons angioplasty (DCB) in treating ISR in the femoropopliteal (FP) district. The review highlights the need for further studies and long-term follow-up to confirm the efficacy of DCB and emphasizes the correlation between PAD and inflammation biomarkers.
Review
Biochemistry & Molecular Biology
Davide Costa, Michele Andreucci, Nicola Ielapi, Giuseppe Filiberto Serraino, Pasquale Mastroroberto, Umberto Marcello Bracale, Raffaele Serra
Summary: Chronic Venous Disease (CVD) is a complex and multifactorial condition involving genetic, proteomic, and cellular mechanisms that result in structural and functional changes to the veins of lower limbs. The expression of certain genes and alterations in the extracellular matrix play a role in the susceptibility to CVD. This article provides an up-to-date overview of the molecular determinants of CVD, including genetic and hormonal influences, ECM imbalance, histopathology, and the role of endothelial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Mariarita Caroleo, Elvira Anna Carbone, Biagio Arcidiacono, Marta Greco, Amedeo Primerano, Maria Mirabelli, Gilda Fazia, Marianna Rania, Marta Letizia Hribal, Luca Gallelli, Daniela Patrizia Foti, Pasquale De Fazio, Cristina Segura-Garcia, Antonio Brunetti
Summary: Nesfatin-1 is a new neuropeptide that regulates hunger/satiety, eating, and affective disorders. The secretion of nesfatin-1 in adipocytes and its relationship with NUCB2 and FTO gene polymorphisms, BMI, Eating Disorders (EDs), and pathological behaviors were investigated. Higher levels of nesfatin-1 were found in hypoxic adipocytes and omental visceral adipose tissue (VAT) of obese individuals. Nesfatin-1 levels were associated with grazing, emotional, sweet, and binge eating, hyperphagia, social eating, and childhood obesity. Obese individuals with certain NUCB2 and FTO gene polymorphisms had higher levels of nesfatin-1.
Article
Genetics & Heredity
Selena Mimmi, Nicola Lombardo, Domenico Maisano, Giovanna Piazzetta, Corrado Pelaia, Girolamo Pelaia, Marta Greco, Daniela Foti, Vincenzo Dattilo, Enrico Iaccino
Summary: Dupilumab has been proven effective in treating diseases such as asthma and atopic dermatitis, and now its use as add-on therapy for patients with CRSwNP could lead to reduced remission time and improved quality of life. The study also showed that miRNAs may serve as potential biomarkers for immune modulation. Preliminary data indicated that dupilumab treatment led to a reduction in inflammation and modulation of specific miRNAs related to proliferation, inflammation, and drug-resistance.
Review
Biochemistry & Molecular Biology
Giuseppe Filiberto Serraino, Federica Jiritano, Davide Costa, Nicola Ielapi, Domenica Battaglia, Umberto Marcello Bracale, Pasquale Mastroroberto, Michele Andreucci, Raffaele Serra
Summary: This systematic review aims to explore the role of matrix metalloproteinases (MMPs) in routine cardiac operations, especially cardiopulmonary bypass (CPB). The results show that MMP levels are significantly correlated with CPB and the gelatinases MMP-2 and MMP-9 are highly released during cardiac surgery with CPB. Increased MMP levels are associated with adverse post-operative outcomes. Future large-scale prospective multicenter randomized clinical trials are needed to investigate the impact of mechanical and pharmacological strategies on the inflammatory response and postoperative outcomes in cardiac surgery and CPB.
Article
Medicine, General & Internal
Davide Bolignano, Marta Greco, Pierangela Presta, Alfredo Caglioti, Nazareno Carullo, Mariateresa Zicarelli, Daniela Patrizia Foti, Francesco Dragone, Michele Andreucci, Giuseppe Coppolino
Summary: MBG levels in chronic kidney transplant recipients are influenced by sodium balance, renal impairment, and the severity of left ventricular hypertrophy (LVH). Therefore, MBG may represent an important missing link between reduced graft function and pathological cardiac remodeling, and hold important prognostic value for improving cardio-renal risk assessment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Maria Mirabelli, Vera Tocci, Alessandra Donnici, Stefania Giuliano, Paola Sarnelli, Alessandro Salatino, Marta Greco, Luigi Puccio, Eusebio Chiefari, Daniela Patrizia Foti, Antonio Brunetti
Summary: The study aimed to determine the impact of modifiable and non-modifiable risk factors in the development of gestational diabetes mellitus (GDM), with a focus on preconception BMI and age. Understanding these factors could inform prevention and intervention strategies in areas with high prevalence of GDM. Importance rating: 8/10.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Giuseppe Filiberto Serraino, Federica Jiritano, Davide Costa, Nicola Ielapi, Desiree Napolitano, Pasquale Mastroroberto, Umberto Marcello Bracale, Michele Andreucci, Raffaele Serra
Summary: Hypertrophic cardiomyopathy (HCM) is a genetic condition characterized by altered collagen turnover of the extracellular matrix. Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) are abnormally released in patients with HCM. This systematic review found that MMP levels, particularly MMP2, were higher in HCM patients compared to healthy subjects. MMPs can be used as biomarkers for HCM and for monitoring treatment outcomes.
Article
Cardiac & Cardiovascular Systems
Antonino Salvatore Rubino, Luca Salvatore De Santo, Antonio Pio Montella, Caterina Golini Petrarcone, Lucrezia Palmieri, Denise Galbiati, Nicola Galdieri, Marisa De Feo
Summary: Preoperative anemia is significantly associated with postoperative renal dysfunction, stroke, and the need for high-dosage inotropes in patients referred for redo procedures.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Medicine, General & Internal
Marta Greco, Maria Mirabelli, Alessandro Salatino, Francesca Accattato, Vincenzo Aiello, Francesco S. Brunetti, Eusebio Chiefari, Salvatore A. Pullano, Antonino S. Fiorillo, Daniela P. Foti, Antonio Brunetti
Summary: This cross-sectional study aims to identify potential novel biomarkers for the early diagnosis of type 2 diabetes (T2D) by investigating the differential expression patterns of circulating microRNAs (miRNAs) in patients with impaired fasting glucose (IFG) and new-onset T2D. Out of the 372 analyzed miRNAs, 33 showed significantly different expression patterns in IFG and new-onset T2D patients compared to healthy controls. Nine miRNAs exhibited specific upregulation in new-onset T2D patients, suggesting their role as early biomarkers for progression from prediabetes to T2D.
Review
Chemistry, Medicinal
Vera Tocci, Maria Mirabelli, Alessandro Salatino, Luciana Sicilia, Stefania Giuliano, Francesco S. Brunetti, Eusebio Chiefari, Giovambattista De Sarro, Daniela P. Foti, Antonio Brunetti
Summary: In recent years, the number of pregnancies complicated by gestational diabetes mellitus (GDM) has increased dramatically. GDM occurs when there is maternal insulin resistance during gestation and is not compensated by increased insulin secretion. Insufficient management of GDM can lead to serious problems for both mother and child. Lifestyle changes are the first treatment option, but if ineffective, insulin injections are recommended. The use of metformin as an alternative pharmacological option for GDM treatment has been proposed but lacks unanimous consensus due to concerns about its long-term effects on the child.
Article
Medicine, General & Internal
Davide Bolignano, Marta Greco, Mario D'Agostino, Paola Cianfrone, Loredana Tripodi, Roberta Misiti, Mariateresa Zicarelli, Ludovica Ganino, Daniela Patrizia Foti, Michele Andreucci, Giuseppe Coppolino
Summary: In this study, the clinical significance of measuring urinary marinobufagenin (mu MBG) in patients with non-advanced chronic kidney disease (CKD) was explored. It was found that uMBG levels were lower in CKD patients compared to controls and were significantly correlated with eGFR levels. Furthermore, the use of statins, presence of diabetes, and urine sodium were identified as independent predictors of uMBG levels in this population.
MEDICINA-LITHUANIA
(2023)
Article
Biochemistry & Molecular Biology
Roberta Macri, Irene Bava, Federica Scarano, Rocco Mollace, Vincenzo Musolino, Micaela Gliozzi, Marta Greco, Daniela Foti, Luigi Tucci, Jessica Maiuolo, Cristina Carresi, Annamaria Tavernese, Ernesto Palma, Carolina Muscoli, Vincenzo Mollace
Summary: This study aimed to test the effects of Ferutinin rich-Ferula communis L. root extract (FcFE) at different concentrations on H9C2 cells and evaluate its antioxidant properties in cardiomyocytes to explore new potential therapeutic activities. The results showed that FcFE could protect against Doxorubicin-induced cardiotoxicity. Further molecular characterization of this natural compound may open the way for testing FcFE at low concentrations in vivo and in clinical studies as an adjuvant in cancer therapy to prevent side effects on heart cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)