Journal
ACTA BIOCHIMICA POLONICA
Volume 62, Issue 3, Pages 547-552Publisher
ACTA BIOCHIMICA POLONICA
DOI: 10.18388/abp.2015_1015
Keywords
kaempferide; flavonoids; Mannich base derivatives; synthesis; antiproliferative activity
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Funding
- National Natural Science Foundation of China [J1210040]
- Hunan Provincial Natural Science Foundation of China [14JJ2048]
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Kaempferide (3,5,7-trihydroxy-4'-methoxyflavone, 1), a naturally occurring flavonoid with potent anticancer activity in a number of human tumour cell lines, was first semisynthesized from naringin. Based on Mannich reaction of kaempferide with various secondary amines and formaldehyde, nine novel kaempferide Mannich base derivatives 2-10 were synthesized. The aminomethylation occurred preferentially in the position at C-6 and C-8 of the A-ring of kaempferide. All the synthetic compounds were tested for antiproliferative activity against three human cancer cell lines (Hela, HCC1954, SK-OV-3) by the standard MTT method. The results showed that compounds 1, 2 and 5-10 were more potent against Hela cells with IC50 values of 12.47-28.24 mu M than the positive control cis-platin (IC50 41.25 mu M), compounds 5, 6, 8 and 10 were more potent against HCC1954 cells with IC50 values of 8.82-14.97 mu M than the positive control cis-platin (IC50 29.68 mu M), and compounds 2, 3, 5, 6 and 10 were more potent against SK-OV-3 cells with IC50 values of 7.67-18.50 mu M than the positive control cis-platin (IC50 21.27 mu M).
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