Article
Chemistry, Medicinal
Afsaneh Alizadeh, Sakineh Mohammah-Alizadeh-Charandabi, Laleh Khodaie, Mojgan Mirghafourvand
Summary: This study investigated the effects of Nigella sativa L. seed oil on urinary incontinence, quality of life, and sexual function in menopausal women. The results showed a positive effect on mixed urinary incontinence and incontinence-QoL, but no significant impact on stress incontinence, urge incontinence, sexual function, and menopause-specific QoL.
PHYTOTHERAPY RESEARCH
(2023)
Article
Urology & Nephrology
Haiyu Pang, Tao Xu, Zhaoai Li, Jian Gong, Qing Liu, Yuling Wang, Juntao Wang, Zhijun Xia, Lan Zhu
Summary: This study estimated the remission and transition rate of urinary incontinence (UI) subtypes in women and evaluated the impact of body mass index (BMI) on this process. The results showed that the annual remission rate of UI among adult women was 12.7%, and women with a higher BMI had lower remission and a higher predicted probability of developing mixed urinary incontinence (MUI) after 4 years.
JOURNAL OF UROLOGY
(2022)
Article
Obstetrics & Gynecology
James W. Alexander, Paivi Karjalainen, Lin Li Ow, Mugdha Kulkarni, Joseph K. Lee, Teemu Karjalainen, Alison Leitch, Germana Ryan, Anna Rosamilia
Summary: This study compared the effects of CO2 vaginal laser therapy with sham therapy for treating stress urinary incontinence. At the completion of treatment, there was no significant difference between CO2 vaginal laser therapy and sham therapy in subjective and objective stress urinary incontinence outcomes.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Health Care Sciences & Services
Towe Wadensten, Emma Nystrom, Karin Franzen, Anna Lindam, Elisabet Wasteson, Eva Samuelsson
Summary: The study aimed to investigate the efficacy of the mobile app Tat II for self-management of urgency incontinence (UUI) and mixed incontinence (MUI) in women. Results showed that the treatment app significantly improved incontinence symptoms in the treatment group, indicating that the app is effective in improving incontinence.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Urology & Nephrology
Alexandra Rogers, Stephanie Bragg, Kimberly Ferrante, Chuladatta Thenuwara, David K. L. Peterson
Summary: The novel leadless tibial nerve stimulator, eCoin (R), was evaluated in a pivotal trial for treating refractory urgency urinary incontinence. Results showed that 68% of subjects experienced at least a 50% reduction in urgency urinary incontinence episodes after 48 weeks, with 16% experiencing device-related events.
JOURNAL OF UROLOGY
(2021)
Article
Medicine, General & Internal
Christoph Paasch, Sonja Soeder, Eric Lorenz, Sophie Heisler, Matthias Goetze, Hendrik Borgmann, Julia Olthoff, Michael Huenerbein, Richard Hunger, Rene Mantke
Summary: The present study aimed to evaluate the effectiveness of pelvic floor training with the ACTICORE1 biofeedback device. The results showed that biofeedback training with ACTICODE1 significantly reduces symptoms of urinary incontinence.
ANNALS OF MEDICINE AND SURGERY
(2023)
Article
Psychology, Multidisciplinary
Eman A. Elhosary, Hamada Ahmed Hamada, Fatimah Ali AlMubali, Guillermo Lopez F. Sanchez, Sara M. Ahmed
Summary: The study evaluates the effectiveness of 448 kHz monopolar capacitive resistive radiofrequency (MCRR) in the treatment of stress urinary incontinence (SUI) in females. The results show that the combination of MCRR therapy and pelvic floor exercises significantly reduces symptom frequency, improves pelvic floor muscle strength, and has better effects compared to placebo treatment.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Obstetrics & Gynecology
Alix Komar, Carol E. Bretschneider, Margaret G. Mueller, Christina Lewicky-Gaupp, Sarah Collins, Julia Geynisman-Tan, Meera Tavathia, Kimberly Kenton
Summary: The study aimed to compare the effectiveness of retropubic midurethral sling combined with onabotulinumtoxinA to the sling alone in improving mixed urinary incontinence symptoms. However, results showed that the addition of onabotulinumtoxinA did not significantly improve overall incontinence symptoms at 3 months postoperatively. Women undergoing midurethral sling for mixed urinary incontinence reported significant improvement regardless of onabotulinumtoxinA injections, with the onabotulinumtoxinA group showing less urgency severity and greater improvement in urgency symptoms after 3 months.
OBSTETRICS AND GYNECOLOGY
(2021)
Article
Urology & Nephrology
Rufus Cartwright, Larissa Franklin, Kari A. O. Tikkinen, Ilkka Kalliala, Pawel Miotla, Tomasz Rechberger, Ifeoma Offiah, Steve McMahon, Barry O'Reilly, Sabrina Lince, Kirsten Kluivers, Wilke M. Post, Geert Poelmans, Melody R. Palmer, Hunter Wessells, Andrew Wong, Diana Kuh, Mika Kivimaki, Meena Kumari, Massimo Mangino, Tim Spector, Jeremy A. Guggenheim, Benjamin Lehne, N. Maneka G. De Silva, David M. Evans, Debbie Lawlor, Ville Karhunen, Minna Mannikko, Malgorzata Marczak, Phillip R. Bennett, Vik Khullar, Marjo-Riitta Jarvelin, Andrew Walley
Summary: Genome-wide association studies in European women identified new risk loci for stress and urgency urinary incontinence, with differential gene expression between the two types of incontinence observed at the cellular level.
JOURNAL OF UROLOGY
(2021)
Article
Obstetrics & Gynecology
Janis M. Miller, Megan O. Schimpf, Kieran Hawthorne, Sarah B. Hortsch, Caroline Garcia, Abigail R. Smith
Summary: This study aimed to test the effect of reducing the intake of irritating beverages on void frequency in women. Through guidance, women were instructed to replace listed beverages with non-irritants in one group, while the other group received healthy eating guidance. The results showed that reducing the intake of potentially irritating beverages while maintaining total fluid intake did not predict void frequency.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2022)
Article
Urology & Nephrology
Chihiro Okada, Joseph I. Kim, Nicole Roselli, Priyanka Kadam Halani, Michal L. Melamed, Nitya Abraham
Summary: This study investigated the association between urge urinary incontinence and food insecurity. The results showed that adults reporting food insecurity in the past year were more likely to experience urge urinary incontinence, and food-insecure participants consumed significantly less bladder irritants including caffeine and alcohol compared to food-secure participants. These findings suggest that the association between urge urinary incontinence and food insecurity is not solely driven by diet, but may be a proxy for social inequity.
JOURNAL OF UROLOGY
(2023)
Review
Urology & Nephrology
Mohammad Hout, Aaron Gurayah, Maria Camila Suarez Arbelaez, Ruben Blachman-Braun, Khushi Shah, Thomas R. W. Herrmann, Hemendra N. Shah
Summary: This study evaluated the risk of urinary incontinence after various prostate enucleation procedures. The results showed that there was no significant difference in the incidence of urinary incontinence among different surgical methods, but age, prostate size, surgery time, and laser time were linearly associated with urinary incontinence.
WORLD JOURNAL OF UROLOGY
(2022)
Review
Urology & Nephrology
Mauro Gacci, Vasileios Sakalis, Markos Karavitakis, Jean-Nicolas Cornu, Christian Gratzke, Thomas R. W. Herrmann, Iason Kyriazis, Sachin Malde, Charalampos Mamoulakis, Malte Rieken, Natasha Schouten, Emma J. Smith, Mark J. Speakman, Kari A. O. Tikkinen, Stavros Gravas
Summary: This 2022 European Association of Urology guideline summary provides updated information on the definition, pathophysiology, diagnosis, and treatment of male UI, and introduces treatment methods for different types of UI.
Article
Chemistry, Medicinal
Mahbubeh Karbalaiee, Azar Daneshpajooh, Narges Khanjani, Samira Sohbati, Mehrnaz Mehrabani, Mehrzad Mehrbani, Mitra Mehrabani
Summary: This study evaluated the efficacy of a frankincense-based herbal product (FHP) in the treatment of urinary incontinence. The results showed that the FHP group and the solifenacin group had significantly reduced frequency and amount of leakage compared to the placebo group. Two weeks after treatment completion, the effects of the FHP were still significant.
PHYTOTHERAPY RESEARCH
(2023)
Article
Medicine, Research & Experimental
Alison J. Huang, Louise C. Walter, Kristine Yaffe, Eric Vittinghoff, Erica Kornblith, Michael Schembri, Ann Chang, Leslee L. Subak
Summary: The TRIUMPH study is a randomized, double-blinded, 3-arm, parallel-group trial that aims to evaluate the effects of anticholinergic and beta-3 adrenergic agonist bladder therapy on cognition and other multisystem functional domains in older women with urgency incontinence. The results of this study will provide evidence to guide counseling and decision-making for older women when considering pharmacologic treatments for urgency incontinence.
Article
Obstetrics & Gynecology
Milena M. Weinstein, Sarah Collins, Lieschen Quiroz, Jennifer T. Anger, Marie Fidela R. Paraiso, Jessica DeLong, Holly E. Richter
Summary: This prematurely terminated trial compared the use of an intravaginal motion-based digital therapeutic device for pelvic floor muscle training (PFMT) with PFMT alone in women with stress-predominant urinary incontinence (SUI). The primary outcomes did not show statistically significant differences between the intervention and control group. However, the PFMT with the digital therapeutic device resulted in significantly fewer SUI episodes and greater improvement in symptom-specific quality of life outcomes. A larger powered trial is underway.
FEMALE PELVIC MEDICINE AND RECONSTRUCTIVE SURGERY
(2022)
Article
Obstetrics & Gynecology
Holly E. Richter, Megan U. Carnes, Yuko M. Komesu, Emily S. Lukacz, Lily Arya, Megan Bradley, Rebecca G. Rogers, Vivian W. Sung, Nazema Y. Siddiqui, Benjamin Carper, Donna Mazloomdoost, Darryl Dinwiddie, Marie G. Gantz
Summary: This study aimed to investigate the association between preoperative urinary and vaginal microbiomes and surgical treatment responses in women with mixed urinary incontinence. The results showed that women with greater vaginal Lactobacillus abundance had better surgical treatment responses, while those with greater vaginal Prevotella abundance had worse responses.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
W. Thomas Gregory, Alison G. Cahill, Candice Woolfolk, Jerry L. Lowder, Aaron B. Caughey, Sindhu K. Srinivas, Alan T. N. Tita, Methodius G. Tuuli, Holly E. Richter
Summary: This study found that immediate pushing and delayed pushing did not result in different rates of occult levator ani muscle injury among nulliparous women with neuraxial analgesia. Further research is needed to understand the development and prevention of subsequent pelvic floor disorders.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Linda Brubaker, Erica Marsh, Marcelle Cedars, Dee Fenner, Amy Murtha, Barbara Goff, Dineo Khabele
Summary: The advancement of women leaders in obstetrics and gynecology does not match the changes in the physician workforce. Gender equity should be a core value in the culture of obstetrics and gynecology, and actions should be taken to prioritize and demonstrate commitment to gender equity. This commentary proposes principles and leadership practices to promote gender equity in academic leadership roles within obstetrics and gynecology.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Holly E. Richter, Amaanti Sridhar, Charles W. Nager, Yuko M. Komesu, Heidi S. Harvie, Halina M. Zyczynski, Charles Rardin, Anthony Visco, Donna Mazloomdoost, Sonia Thomas
Summary: Among women with symptomatic uterovaginal prolapse, sacrospinous hysteropexy with graft resulted in a lower surgical failure rate compared to vaginal hysterectomy with uterosacral suspension. Obesity and duration of prolapse symptoms were identified as risk factors associated with surgical failure, and should be considered when determining treatment plans.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Medical Ethics
Linda Brubaker, Jesse Nodora, Tamara Bavendam, John Connett, Amy M. Claussen, Cora E. Lewis, Kyle Rudser, Siobhan Sutcliffe, Jean F. Wyman, Janis M. Miller
Summary: Authorship and dissemination policies vary among research consortia, and the creation of a repository and toolkit could improve efficiency and integrity in team science work.
ACCOUNTABILITY IN RESEARCH-POLICIES AND QUALITY ASSURANCE
(2022)
Article
Urology & Nephrology
Ariana L. Smith, Kyle Rudser, Bernard L. Harlow, Gerald McGwin, Julia Barthold, Sonya S. Brady, Linda Brubaker, Shayna D. Cunningham, James W. Griffith, Kim Kenton, Heather Klusaritz, Cora E. Lewis, Emily S. Lukacz, Julia Maki, Alayne D. Markland, Elizabeth R. Mueller, Diane K. Newman, Jesse Nodora, Leslie M. Rickey, Todd Rockwood, Melissa Simon, Jean F. Wyman, Siobhan Sutcliffe
Summary: This study aims to understand the distribution of bladder health and the factors that promote bladder health and prevent LUTS in women. It is a population-based longitudinal cohort study conducted in the United States, involving community-dwelling women. Data collection includes self-administered surveys and objective measures. The findings will contribute to the development of interventions for bladder health promotion and LUTS prevention in women.
NEUROUROLOGY AND URODYNAMICS
(2023)
Article
Urology & Nephrology
Linda Brubaker, Julia Barthold, Colleen M. Fitzgerald, Kimberly Kenton, Cora E. Lewis, Jerry Lowder, Emily S. Lukacz, Alayne Markland, Melanie Meister, Janis Miller, Elizabeth R. Mueller, Kyle Rudser, Ariana L. Smith, Diane K. Newman
Summary: This study describes the methods used for the in-person assessment of the RISE FOR HEALTH (RISE) study, a population-based prospective cohort study. Participants undergo various physical assessments, including pelvic floor muscle assessments, musculoskeletal tests, and the Short Physical Performance Battery. They also provide samples for urogenital microbiome analysis. The data collected from this assessment will be used to prioritize future research and prevention strategies.
NEUROUROLOGY AND URODYNAMICS
(2023)
Article
Obstetrics & Gynecology
Methodius G. Tuuli, W. Thomas Gregory, Lily A. Arya, Jerry L. Lowder, Candice Woolfolk, Aaron B. Caughey, Sindhu K. Srinivas, Alan T. N. Tita, George A. Macones, Alison G. Cahill, Holly E. Richter
Summary: This study aimed to assess whether immediate or delayed pushing in the second stage of labor results in higher risk of pelvic floor morbidity. The results showed that among nulliparous patients in the second stage with neuraxial analgesia, immediate pushing did not increase perineal lacerations, pelvic organ prolapse, or patient-reported pelvic floor symptoms at 6 weeks and 6 months postpartum.
OBSTETRICS AND GYNECOLOGY
(2023)
Article
Microbiology
Tanya Kumar, MacKenzie Bryant, Kalen Cantrell, Se Jin Song, Daniel McDonald, Helena M. M. Tubb, Sawyer Farmer, Emily S. S. Lukacz, Linda Brubaker, Rob Knight
Summary: The urogenital microbiome is an important yet understudied human microbiome niche, and urine has been found to contain microorganisms that can affect health. It is crucial to study urine sample storage conditions for scientific rigor and reproducibility.
Article
Education, Scientific Disciplines
Diana Ha, Selam Ghebrendrias, Audra Meadows, Daphne Yvette LaCoursiere, Amanda Lewis, Mark Lawson, Michael Morales, Cynthia Gyamfi-Bannerman, Linda Brubaker
Summary: Structural racism is deeply rooted in academic medical institutions. To address this issue, the Department of Obstetrics, Gynecology and Reproductive Sciences at the University of California, San Diego established a Culture and Justice Quorum. Through various initiatives, the Quorum aims to promote justice and eliminate racism, and has received institutional recognition for its inclusive efforts.
Editorial Material
Medicine, General & Internal
Sarah Averbach, Diana Ha, Audra Meadows, Linda Brubaker, Cynthia Gyamfi-Bannerman
Article
Obstetrics & Gynecology
Linda Brubaker, Harry Horsley, Rajvinder Khasriya, Alan J. Wolfe
Summary: This article presents the case of a 30-year-old woman who seeks specialty consultation for frequent episodes of urinary urgency, frequency, and dysuria. Although her home dipsticks suggest a urinary tract infection (UTI) and her urinalysis shows a moderate number of white blood cells, her urine cultures are always negative. The challenges of this clinical presentation are discussed along with evidence-based evaluation and treatment options.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2023)
Article
Obstetrics & Gynecology
Kelsey Lipking, Isuzu Meyer, David T. Redden, Holly E. Richter
Summary: This study aimed to identify characteristics associated with discharge home with a urinary catheter in women undergoing colpocleisis. Higher preoperative postvoid residual volume and levator myorrhaphy were associated with postoperative catheterization in women undergoing colpocleisis.
Article
Urology & Nephrology
Christopher J. Chermansky, Holly E. Richter, Karny Jacoby, Wilson Titanji, Brenda Jenkins, Till Geib, Benjamin M. Brucker
Summary: The intravesical instillation of an onabotulinumtoxinA + D hydrogel admixture for refractory overactive bladder was well tolerated but did not show improvement over placebo in reducing urinary incontinence episodes. Treatment-emergent adverse events were similar among all groups, with asymptomatic bacteriuria being the most common reported.
JOURNAL OF UROLOGY
(2022)