Bruton Tyrosine Kinase (BTK) and Its Role in B-cell Malignancy

Modeling Pharmacological Inhibition of Mast Cell Degranulation as a Therapy for Insulinoma

(2015) Laura Soucek et al.   NEOPLASIA

Dual Functions of Bruton's Tyrosine Kinase and Tec Kinase during Fc  Receptor-Induced Signaling and Phagocytosis

(2014) J. Jongstra-Bilen et al.   JOURNAL OF IMMUNOLOGY

B-cell receptors and heavy chain diseases: guilty by association?

(2011) D. Corcos et al.   BLOOD

Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765

(2011) S. E. M. Herman et al.   BLOOD

Inhibition of IgE-mediated secretion from human basophils with a highly selective Bruton's tyrosine kinase, Btk, inhibitor

(2011) Donald MacGlashan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk

(2011) Xingguang Liu et al.   NATURE IMMUNOLOGY

The Bruton tyrosine kinase inhibitor PCI-32765 ameliorates autoimmune arthritis by inhibition of multiple effector cells

(2011) Betty Y Chang et al.   ARTHRITIS RESEARCH & THERAPY

Mast Cells Are Novel Independent Prognostic Markers in Prostate Cancer and Represent a Target for Therapy

(2010) Anna Johansson et al.   AMERICAN JOURNAL OF PATHOLOGY

Cellular origin(s) of chronic lymphocytic leukemia: cautionary notes and additional considerations and possibilities

(2010) N. Chiorazzi et al.   BLOOD

Neutrophil development and function critically depend on Bruton tyrosine kinase in a mouse model of X-linked agammaglobulinemia

(2010) K. Fiedler et al.   BLOOD

Tyrosine kinase Btk regulates E-selectin-mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC)  2 and PI3K  pathways

(2010) H. Mueller et al.   BLOOD

CXCL12 (SDF-1)/CXCR4 Pathway in Cancer

(2010) B. A. Teicher et al.   CLINICAL CANCER RESEARCH

Elevated cytokine production restores bone resorption by human Btk-deficient osteoclasts

(2010) Lynett Danks et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

(2010) R. Eric Davis et al.   NATURE

The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy

(2010) L. A. Honigberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures

(2010) Andreas Kuglstatter et al.   PROTEIN SCIENCE

Primary B Cell Immunodeficiencies: Comparisons and Contrasts

(2009) Mary Ellen Conley et al.   Annual Review of Immunology

B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406

(2009) M. P. Quiroga et al.   BLOOD

Mantle cell lymphoma cells express high levels of CXCR4, CXCR5, and VLA-4 (CD49d): importance for interactions with the stromal microenvironment and specific targeting

(2009) Antonina V. Kurtova et al.   BLOOD

PI3 Kinase Signals BCR-Dependent Mature B Cell Survival

(2009) Lakshmi Srinivasan et al.   CELL

Phosphatidylinositol 3'-Kinase Catalytic Subunit   Gene Amplification Contributes to the Pathogenesis of Mantle Cell Lymphoma

(2009) A. Psyrri et al.   CLINICAL CANCER RESEARCH

Bruton’s tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain

(2009) Abdalla J. Mohamed et al.   IMMUNOLOGICAL REVIEWS

Bruton's Tyrosine Kinase Revealed as a Negative Regulator of Wnt- -Catenin Signaling

(2009) R. G. James et al.   Science Signaling

High-level expression of the T-cell chemokines CCL3 and CCL4 by chronic lymphocytic leukemia B cells in nurselike cell cocultures and after BCR stimulation

(2008) J. A. Burger et al.   BLOOD

Proteasome-dependent autoregulation of Bruton tyrosine kinase (Btk) promoter via NF- B

(2008) L. Yu et al.   BLOOD

Tyrosine Kinases Btk and Tec Regulate Osteoclast Differentiation by Linking RANK and ITAM Signals

(2008) Masahiro Shinohara et al.   CELL

IgE receptor and signal transduction in mast cells and basophils

(2008) Donald MacGlashan   CURRENT OPINION IN IMMUNOLOGY

The Tec Family Tyrosine Kinase Btk Regulates RANKL-induced Osteoclast Maturation

(2008) Seoung Hoon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bruton's Tyrosine Kinase Separately Regulates NFκB p65RelA Activation and Cytokine Interleukin (IL)-10/IL-12 Production in TLR9-stimulated B Cells

(2008) Koon-Guan Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stromal Gene Signatures in Large-B-Cell Lymphomas

(2008) G. Lenz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multiple Colorectal Neoplasms in X-Linked Agammaglobulinemia

(2007) Lodewijk A.A. Brosens et al.   Clinical Gastroenterology and Hepatology