The Role of Tec Family Kinases in the Regulation of T-helper-cell Differentiation

Selective Expression Rather than Specific Function of Txk and Itk Regulate Th1 and Th2 Responses

(2014) N. Sahu et al.   JOURNAL OF IMMUNOLOGY

Differential Sensitivity to Itk Kinase Signals for T Helper 2 Cytokine Production and Chemokine-Mediated Migration

(2014) N. Sahu et al.   JOURNAL OF IMMUNOLOGY

Essential Roles for the Tec Family Kinases Tec and Btk in M-CSF Receptor Signaling Pathways That Regulate Macrophage Survival

(2014) M. Melcher et al.   JOURNAL OF IMMUNOLOGY

Naive and Innate Memory Phenotype CD4+ T Cells Have Different Requirements for Active Itk for Their Development

(2014) J. Hu et al.   JOURNAL OF IMMUNOLOGY

The Tec Kinases Itk and Rlk Regulate NKT Cell Maturation, Cytokine Production, and Survival

(2014) M. Felices et al.   JOURNAL OF IMMUNOLOGY

From interleukin-9 to T helper 9 cells

(2012) Michael Stassen et al.   Annals of the New York Academy of Sciences

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

CD4 T cells and their antigens in the pathogenesis of autoimmune diabetes

(2011) Kathryn Haskins et al.   CURRENT OPINION IN IMMUNOLOGY

T helper cell populations: As flexible as the skin?

(2011) Ari Waisman   EUROPEAN JOURNAL OF IMMUNOLOGY

Type 1 regulatory T cells (Tr1) in autoimmunity

(2011) Caroline Pot et al.   SEMINARS IN IMMUNOLOGY

The ITK-SYK Fusion Oncogene Induces a T-Cell Lymphoproliferative Disease in Mice Mimicking Human Disease

(2010) C. Dierks et al.   CANCER RESEARCH

Genetic proof for the transient nature of the Th17 phenotype

(2010) Florian C. Kurschus et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

SAP Protein-Dependent Natural Killer T-like Cells Regulate the Development of CD8+ T Cells with Innate Lymphocyte Characteristics

(2010) Mihalis Verykokakis et al.   IMMUNITY

Epigenetic Instability of Cytokine and Transcription Factor Gene Loci Underlies Plasticity of the T Helper 17 Cell Lineage

(2010) Ryuta Mukasa et al.   IMMUNITY

Interleukin-2-inducible T Cell Kinase (Itk) Network Edge Dependence for the Maturation ofiNKT Cell

(2010) Qian Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma

(2010) Konstanze Pechloff et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Protein Tyrosine Kinase Tec Regulates a CD44highCD62L- Th17 Subset

(2010) N. Boucheron et al.   JOURNAL OF IMMUNOLOGY

Importance of Cytokines in Murine Allergic Airway Disease and Human Asthma

(2010) Fred D. Finkelman et al.   JOURNAL OF IMMUNOLOGY

Quantitative Phosphoproteomic Analysis of T Cell Receptor Signaling in Diabetes Prone and Resistant Mice

(2010) Leo K. Iwai et al.   JOURNAL OF PROTEOME RESEARCH

In Vivo Significance of ITK-SLP-76 Interaction in Cytokine Production

(2010) J. A. Grasis et al.   MOLECULAR AND CELLULAR BIOLOGY

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

Effector T cell plasticity: flexibility in the face of changing circumstances

(2010) Kenneth M Murphy et al.   NATURE IMMUNOLOGY

T cells expressing the transcription factor PLZF regulate the development of memory-like CD8+ T cells

(2010) Michael A Weinreich et al.   NATURE IMMUNOLOGY

Raising the NKT cell family

(2010) Dale I Godfrey et al.   NATURE IMMUNOLOGY

Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4+ T Cells

(2010) J. J. O'Shea et al.   SCIENCE

T-Cell Signaling Regulated by the Tec Family Kinase, Itk

(2010) A. H. Andreotti et al.   Cold Spring Harbor Perspectives in Biology

ZAP-70: An Essential Kinase in T-cell Signaling

(2010) H. Wang et al.   Cold Spring Harbor Perspectives in Biology

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

5-Aminomethylbenzimidazoles as potent ITK antagonists

(2009) Doris Riether et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Enhanced development of CD4+    T cells in the absence of Itk results in elevated IgE production

(2009) Q. Qi et al.   BLOOD

Transcriptional signatures of Itk-deficient CD3+, CD4+ and CD8+ T-cells

(2009) K Blomberg et al.   BMC GENOMICS

Heterogeneity and plasticity of T helper cells

(2009) Jinfang Zhu et al.   CELL RESEARCH

How are TH1 and TH2 effector cells made?

(2009) Derk Amsen et al.   CURRENT OPINION IN IMMUNOLOGY

ITK Inhibitors in Inflammation and Immune-Mediated Disorders

(2009) Nisebita Sahu et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

IL-17/Th17 in anti-fungal immunity: What's new?

(2009) Teresa Zelante et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Characterization of a novel interaction between transcription factor TFII-I and the inducible tyrosine kinase in T cells

(2009) Catarina Sacristán et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Follicular Helper T Cells: Lineage and Location

(2009) Nicolas Fazilleau et al.   IMMUNITY

Plasticity of CD4+ T Cell Lineage Differentiation

(2009) Liang Zhou et al.   IMMUNITY

Differential Expression of Interleukin-17A and -17F Is Coupled to T Cell Receptor Signaling via Inducible T Cell Kinase

(2009) Julio Gomez-Rodriguez et al.   IMMUNITY

Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression

(2009) Ethan M. Shevach   IMMUNITY

Control of Regulatory T Cell Lineage Commitment and Maintenance

(2009) Steven Z. Josefowicz et al.   IMMUNITY

Regulation and pro-inflammatory function of interleukin-17 family cytokines

(2009) Chen Dong   IMMUNOLOGICAL REVIEWS

The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development

(2009) Amanda L. Prince et al.   IMMUNOLOGICAL REVIEWS

T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance

(2009) Robert J. Salmond et al.   IMMUNOLOGICAL REVIEWS

Bruton’s tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain

(2009) Abdalla J. Mohamed et al.   IMMUNOLOGICAL REVIEWS

Tec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/Txk

(2009) Julie A. Readinger et al.   IMMUNOLOGICAL REVIEWS

PKCθ and Itk functionally interact during primary mouse CD3+ T cell activation

(2009) Nikolaus Thuille et al.   IMMUNOLOGY LETTERS

IL-22–producing “T22” T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17–producing TH17 T cells

(2009) Kristine E. Nograles et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Girls homozygous for an IL-2–inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation

(2009) Kirsten Huck et al.   JOURNAL OF CLINICAL INVESTIGATION

Th1, Th17, and Th9 Effector Cells Induce Experimental Autoimmune Encephalomyelitis with Different Pathological Phenotypes

(2009) A. Jager et al.   JOURNAL OF IMMUNOLOGY

c-Maf Regulates IL-10 Expression during Th17 Polarization

(2009) Jiangnan Xu et al.   JOURNAL OF IMMUNOLOGY

Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells

(2009) Sara Trifari et al.   NATURE IMMUNOLOGY

Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells

(2009) Thomas Duhen et al.   NATURE IMMUNOLOGY

Tec kinase Itk in   T cells is pivotal for controlling IgE production in vivo

(2009) M. Felices et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of potent inhibitors of interleukin-2 inducible T-cell kinase (ITK) through structure-based drug design

(2008) Brian N. Cook et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cytokines that regulate autoimmunity

(2008) Caroline Diveu et al.   CURRENT OPINION IN IMMUNOLOGY

Impaired T-cell development in the absence of Vav1 and Itk

(2008) Julia Raberger et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation

(2008) Wenjun Ouyang et al.   IMMUNITY

The Transcription Factor PLZF Directs the Effector Program of the NKT Cell Lineage

(2008) Adam K. Savage et al.   IMMUNITY

Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens

(2008) Meredith M. Curtis et al.   IMMUNOLOGY

Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset

(2008) Marc Veldhoen et al.   NATURE IMMUNOLOGY

The BTB–zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions

(2008) Damian Kovalovsky et al.   NATURE IMMUNOLOGY

The transcriptional regulator PLZF induces the development of CD44 high memory phenotype T cells

(2008) J. Raberger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA