Journal
INTERNATIONAL REVIEWS OF IMMUNOLOGY
Volume 30, Issue 5-6, Pages 294-311Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/08830185.2011.595855
Keywords
Chimeric Antigen Receptors; Cancer; Gene Therapy; Immunotherapy
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Funding
- Brazilian Ministry of Health
- CAPES
- Conselho Nacional Desenvolvimento Cientifico e Tecnologico (CNPq)
- Instituto do Milenio de Terapia Genica - CNPq
- Instituto Nacional de Cancer
- Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ)
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The concept of chimeric antigen receptors (CARs) as molecules able to redirect T lymphocytes toward tumor cells is currently being exploited in the field of cancer immunotherapy. Despite promising preliminary results, some clinical trials evidenced limitations for this technology that must be overcome for more extensive application of CARs in tumor immunotherapy. We describe here the fundaments of these molecules in terms of structure, function, possible targets and preclinical and clinical applications. We also discuss strategies that can potentially overcome the limitations seen so far, paving the road to a wider application of this exciting new technology.
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