Koumine Enhances Spinal Cord 3α-Hydroxysteroid Oxidoreductase Expression and Activity in a Rat Model of Neuropathic Pain

Pharmacologic Treatment of Neuropathic Pain Following Spinal Cord Injury

(2015) Sean DeFrates et al.   ORTHOPEDICS

Anti-allodynic and Neuroprotective Effects of Koumine, a Benth Alkaloid, in a Rat Model of Diabetic Neuropathy

(2014) Qian Ling et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Medicinal plants of the genus Gelsemium (Gelsemiaceae, Gentianales)—A review of their phytochemistry, pharmacology, toxicology and traditional use

(2014) Gui-Lin Jin et al.   JOURNAL OF ETHNOPHARMACOLOGY

Microglia and Neuropathic Pain

(2013) Håkan Aldskogius et al.   CNS & Neurological Disorders-Drug Targets

Neurosteroid allopregnanolone attenuates high glucose-induced apoptosis and prevents experimental diabetic neuropathic pain: In vitro and in vivo studies

(2013) Samira Afrazi et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Gelsemine, a principal alkaloid from Gelsemium sempervirens Ait., exhibits potent and specific antinociception in chronic pain by acting at spinal α3 glycine receptors

(2013) Jing-Yang Zhang et al.   PAIN

Contribution of Microglia and Astrocytes to the Central Sensitization, Inflammatory and Neuropathic Pain in the Juvenile Rat

(2012) Hiroshi Ikeda et al.   Molecular Pain

Response to commentary: A new definition of neuropathic pain

(2012) Steven H. Horowitz   PAIN

Effects of koumine, an alkaloid of Gelsemium elegans Benth., on inflammatory and neuropathic pain models and possible mechanism with allopregnanolone

(2012) Ying Xu et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

The active alkaloids of Gelsemium elegans Benth. are potent anxiolytics

(2012) Ming Liu et al.   PSYCHOPHARMACOLOGY

Gelsenicine from Gelsemium elegans Attenuates Neuropathic and Inflammatory Pain in Mice

(2011) Ming Liu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Allopregnanolone prevents memory impairment: Effect on mRNA expression and enzymatic activity of hippocampal 3-α hydroxysteroid oxide-reductase

(2011) Carla Escudero et al.   BRAIN RESEARCH BULLETIN

Role of the neurosteroid allopregnanolone in the hyperalgesic behavior induced by painful nerve injury in rats

(2011) Takashi Kawano et al.   Journal of Anesthesia

Preparative separation of alkaloids from Gelsemium elegans Benth. using pH-zone-refining counter-current chromatography

(2011) Yan-Ping Su et al.   JOURNAL OF CHROMATOGRAPHY A

The involvement of the neurosteroid allopregnanolone in the antihyperalgesic effect of paroxetine in a rat model of neuropathic pain

(2011) Takashi Kawano et al.   NEUROREPORT

Implication of allopregnanolone in the antinociceptive effect of N-palmitoylethanolamide in acute or persistent pain

(2011) Oscar Sasso et al.   PAIN

Cellular and functional evidence for a protective action of neurosteroids against vincristine chemotherapy-induced painful neuropathy

(2010) Laurence Meyer et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Selective regulation of 3α-hydroxysteroid oxido-reductase expression in dorsal root ganglion neurons: A possible mechanism to cope with peripheral nerve injury-induced chronic pain

(2010) Christine Patte-Mensah et al.   PAIN

Allopregnanolone prevents and suppresses oxaliplatin-evoked painful neuropathy: Multi-parametric assessment and direct evidence

(2010) Laurence Meyer et al.   PAIN

Antianxiety activity ofGelsemium sempervirens

(2010) Vandana Dutt et al.   PHARMACEUTICAL BIOLOGY

Dose-effect study of Gelsemium sempervirens in high dilutions on anxiety-related responses in mice

(2010) Paolo Magnani et al.   PSYCHOPHARMACOLOGY

Allopregnanolone treatment delays cholesterol accumulation and reduces autophagic/lysosomal dysfunction and inflammation in Npc1−/− mouse brain

(2009) Guanghong Liao et al.   BRAIN RESEARCH

Comparative Analysis of Gelsemine andGelsemium sempervirensActivity on Neurosteroid Allopregnanolone Formation in the Spinal Cord and Limbic System

(2009) Christine Venard et al.   Evidence-based Complementary and Alternative Medicine

Are neuroactive steroids promising therapeutic agents in the management of acute and chronic pain?

(2009) Vesna Jevtovic-Todorovic et al.   PSYCHONEUROENDOCRINOLOGY

Endogenous steroid production in the spinal cord and potential involvement in neuropathic pain modulation

(2008) A.G. Mensah-Nyagan et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Selective Activation of Microglia in Spinal Cord but Not Higher Cortical Regions Following Nerve Injury in Adult Mouse

(2008) Fuxing Zhang et al.   Molecular Pain