Anti-androgen enzalutamide enhances prostate cancer neuroendocrine (NE) differentiation via altering the infiltrated mast cells → androgen receptor (AR) → miRNA32 signals

Neuroendocrine differentiation of prostate cancer

(2013) Zhen Li et al.   ASIAN JOURNAL OF ANDROLOGY

Cancer statistics, 2013

(2013) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Interleukin-1  Promotes Skeletal Colonization and Progression of Metastatic Prostate Cancer Cells with Neuroendocrine Features

(2013) Q. Liu et al.   CANCER RESEARCH

Mast Cells as a Potential Prognostic Marker in Prostate Cancer

(2013) Gianluigi Taverna et al.   DISEASE MARKERS

Differential Androgen Deprivation Therapies with Anti-androgens Casodex/Bicalutamide or MDV3100/EnzalutamideversusAnti-androgen Receptor ASC-J9® Lead to PromotionversusSuppression of Prostate Cancer Metastasis

(2013) Tzu-Hua Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-663 Induces Castration-Resistant Prostate Cancer Transformation and Predicts Clinical Recurrence

(2013) Li Jiao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Androgen receptor (AR) differential roles in hormone-related tumors including prostate, bladder, kidney, lung, breast and liver

(2013) C Chang et al.   ONCOGENE

Anti-androgen receptor ASC-J9 versus anti-androgens MDV3100 (Enzalutamide) or Casodex (Bicalutamide) leads to opposite effects on prostate cancer metastasis via differential modulation of macrophage infiltration and STAT3-CCL2 signaling

(2013) T-H Lin et al.   Cell Death & Disease

EGF promotes neuroendocrine-like differentiation of prostate cancer cells in the presence of LY294002 through increased ErbB2 expression independent of the phosphatidylinositol 3-kinase-AKT pathway

(2012) M.Alicia Cortés et al.   CARCINOGENESIS

Human intestinal mast cells are a potent source of multiple chemokines

(2012) Katrin Feuser et al.   CYTOKINE

Release of macrophage migration inhibitory factor by neuroendocrine-differentiated LNCaP cells sustains the proliferation and survival of prostate cancer cells

(2012) Thomas Tawadros et al.   ENDOCRINE-RELATED CANCER

The neuropeptide 26RFa is expressed in human prostate cancer and stimulates the neuroendocrine differentiation and the migration of androgeno-independent prostate cancer cells

(2012) Jessy Alonzeau et al.   EUROPEAN JOURNAL OF CANCER

p21-Activated kinase 4 promotes prostate cancer progression through CREB

(2012) M-H Park et al.   ONCOGENE

Altered expression of microRNA miR-21, miR-155, and let-7a and their roles in pulmonary neuroendocrine tumors

(2012) Hyoun Wook Lee et al.   PATHOLOGY INTERNATIONAL

Neuroendocrine-derived peptides promote prostate cancer cell survival through activation of IGF-1R signaling

(2012) John O. DaSilva et al.   PROSTATE

Mast Cell Chemotaxis – Chemoattractants and Signaling Pathways

(2012) Ivana Halova et al.   Frontiers in Immunology

PolyA RT-PCR-based quantification of microRNA by using universal TaqMan probe

(2011) Xin Luo et al.   BIOTECHNOLOGY LETTERS

MiR-221 expression affects invasion potential of human prostate carcinoma cell lines by targeting DVL2

(2011) Chang Zheng et al.   MEDICAL ONCOLOGY

Mast Cells Are Novel Independent Prognostic Markers in Prostate Cancer and Represent a Target for Therapy

(2010) Anna Johansson et al.   AMERICAN JOURNAL OF PATHOLOGY

Differential androgen receptor signals in different cells explain why androgen-deprivation therapy of prostate cancer fails

(2010) Y Niu et al.   ONCOGENE

Immunological microenvironment in prostate cancer: High mast cell densities are associated with favorable tumor characteristics and good prognosis

(2009) Achim Fleischmann et al.   PROSTATE

Interleukin-8 signaling promotes androgen-independent proliferation of prostate cancer cells via induction of androgen receptor expression and activation

(2008) A. Seaton et al.   CARCINOGENESIS

The Interleukin-8 Pathway in Cancer

(2008) D. J.J. Waugh et al.   CLINICAL CANCER RESEARCH

Targeting the stromal androgen receptor in primary prostate tumors at earlier stages

(2008) Y. Niu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA