The Brave New World of clinical cancer research: Adaptive biomarker-driven trials integrating clinical practice with clinical research

Multicompany trials adapt to disciplines beyond cancer

(2014) Asher Mullard   NATURE MEDICINE

Lung cancer trial aims to bolster personalized medicine

(2014) Charlotte Harrison   NATURE REVIEWS DRUG DISCOVERY

The Innovative Medicines Initiative: an engine for regulatory science

(2014) Michel Goldman et al.   NATURE REVIEWS DRUG DISCOVERY

Large personalised medicine trial in lung cancer heralds new research partnership

(2014) I. Torjesen   BMJ-British Medical Journal

Bayesian hierarchical modeling of patient subpopulations: Efficient designs of Phase II oncology clinical trials

(2013) Scott M Berry et al.   Clinical Trials

Reports from the 2010 Clinical and Translational Cancer Research Think Tank Meeting: Design Strategies for Personalized Therapy Trials

(2012) D. A. Berry et al.   CLINICAL CANCER RESEARCH

Personalized Medicine in a Phase I Clinical Trials Program: The MD Anderson Cancer Center Initiative

(2012) A.-M. Tsimberidou et al.   CLINICAL CANCER RESEARCH

Pathologic Complete Response Predicts Recurrence-Free Survival More Effectively by Cancer Subset: Results From the I-SPY 1 TRIAL—CALGB 150007/150012, ACRIN 6657

(2012) Laura J. Esserman et al.   JOURNAL OF CLINICAL ONCOLOGY

Adaptive clinical trials in oncology

(2011) Donald A. Berry   Nature Reviews Clinical Oncology

The BATTLE Trial: A Bold Step toward Improving the Efficiency of Biomarker-Based Drug Development

(2011) Eric H. Rubin et al.   Cancer Discovery

The BATTLE Trial: Personalizing Therapy for Lung Cancer

(2011) Edward S. Kim et al.   Cancer Discovery

I-SPY 2: An Adaptive Breast Cancer Trial Design in the Setting of Neoadjuvant Chemotherapy

(2009) AD Barker et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Detecting an Overall Survival Benefit that Is Derived From Progression-Free Survival

(2009) Kristine R. Broglio et al.   JNCI-Journal of the National Cancer Institute