Do synovial leptin levels correlate with pain in end stage arthritis?

Leptin levels are increased and its negative regulators, SOCS-3 and sOb-R are decreased in obese patients with osteoarthritis: a link between obesity and osteoarthritis: Figure 1

(2012) Katriina Vuolteenaho et al.   ANNALS OF THE RHEUMATIC DISEASES

Leptin and the hypothalamo-pituitary–adrenal stress axis

(2012) Eric W. Roubos et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Osteoarthritis synovial fluid activates pro-inflammatory cytokines in primary human chondrocytes

(2012) Paula Hoff et al.   INTERNATIONAL ORTHOPAEDICS

Serum adipokines in osteoarthritis; comparison with controls and relationship with local parameters of synovial inflammation and cartilage damage

(2012) T.N. de Boer et al.   OSTEOARTHRITIS AND CARTILAGE

Adipokine Hormones and Hand Osteoarthritis: Radiographic Severity and Pain

(2012) Mei Massengale et al.   PLoS One

Neuropathic pain symptoms in a community knee OA cohort

(2011) J.R. Hochman et al.   OSTEOARTHRITIS AND CARTILAGE

Leptin enhances NMDA-induced spinal excitation in rats: A functional link between adipocytokine and neuropathic pain

(2011) Yinghong Tian et al.   PAIN

Persistent pain after joint replacement: Prevalence, sensory qualities, and postoperative determinants

(2011) Vikki Wylde et al.   PAIN

Women with knee osteoarthritis have more pain and poorer function than men, but similar physical activity prior to total knee replacement

(2011) Shalome M Tonelli et al.   Biology of Sex Differences

Alteration of sensory neurons and spinal response to an experimental osteoarthritis pain model

(2010) Hee-Jeong Im et al.   ARTHRITIS AND RHEUMATISM

Gender Differences in the Correlation between Symptom and Radiographic Severity in Patients with Knee Osteoarthritis

(2010) Hyung Joon Cho et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

The synovial fluid adiponectin-leptin ratio predicts pain with knee osteoarthritis

(2010) Rajiv Gandhi et al.   CLINICAL RHEUMATOLOGY

A longitudinal study to explain the pain-depression link in older adults with osteoarthritis

(2010) Gillian A. Hawker et al.   ARTHRITIS CARE & RESEARCH

The nerve of osteoarthritis pain

(2010) Jacqueline R. Hochman et al.   ARTHRITIS CARE & RESEARCH

Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis

(2009) Timothy M. Griffin et al.   ARTHRITIS AND RHEUMATISM

The link between structural damage and pain in a genetic model of osteoarthritis and intervertebral disc degeneration: A joint misadventure

(2009) Mary B. Goldring   ARTHRITIS AND RHEUMATISM

Leptin Enhances Synthesis of Proinflammatory Mediators in Human Osteoarthritic Cartilage—Mediator Role of NO in Leptin-InducedPGE2, IL-6, and IL-8 Production

(2009) Katriina Vuolteenaho et al.   MEDIATORS OF INFLAMMATION

Imaging the painful osteoarthritic knee joint: what have we learned?

(2009) Claire YJ Wenham et al.   Nature Reviews Rheumatology

Leptin derived from adipocytes in injured peripheral nerves facilitates development of neuropathic pain via macrophage stimulation

(2009) T. Maeda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights from Imaging on the Epidemiology and Pathophysiology of Osteoarthritis

(2009) David J. Hunter   RADIOLOGIC CLINICS OF NORTH AMERICA

Joint pain

(2009) Hans-Georg Schaible et al.   EXPERIMENTAL BRAIN RESEARCH

The discordance between clinical and radiographic knee osteoarthritis: A systematic search and summary of the literature

(2008) John Bedson et al.   BMC MUSCULOSKELETAL DISORDERS

Inflammatory Biomarkers and Physical Function in Older, Obese Adults with Knee Pain and Self-Reported Osteoarthritis After Intensive Weight-Loss Therapy

(2008) Gary D. Miller et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Effect of Weight Loss on Proinflammatory State of Mononuclear Cells in Obese Women

(2008) Wayne H.-H. Sheu et al.   Obesity

The Symptoms of Osteoarthritis and the Genesis of Pain

(2008) David J. Hunter et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA