Article
Dentistry, Oral Surgery & Medicine
Faez Saleh Al-Hamed, Lina Abu-Nada, Rania Rodan, Stylianos Sarrigiannidis, Jose Luis Ramirez-Garcialuna, Hanan Moussa, Osama Elkashty, Qiman Gao, Tayebeh Basiri, Laura Baca, Jesus Torres, Lisa Rancan, Simon D. Tran, Marie Lordkipanidze, Mari Kaartinen, Zahi Badran, Faleh Tamimi
Summary: The study found that double-spin L-PRP showed better efficacy in promoting bone healing by significantly reducing the size of bone defects and decreasing the number of inflammatory cells in the defect area compared to single-spin or filtered L-PRP.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Article
Orthopedics
Wen-Chung Tsai, Tung-Yang Yu, Gwo-Jyh Chang, Hsiang-Ning Chang, Li-Ping Lin, Miao-Sui Lin, Jong-Hwei S. Pang
Summary: The study demonstrated that simultaneous use of PRP and suramin promoted myoblast proliferation, reduced fibronectin expression, and decreased fibronectin expression at the site of muscle injury. In the animal study, the group treated with PRP plus suramin showed better muscle healing and contractile strength compared to the group treated with PRP alone.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Anatomy & Morphology
Haibo Dai, Haici Zhang, Zhilong Qiu, Qiang Shi
Summary: This study aimed to sort a subset of stem cells (FC-PSCs) from periosteum using flow cytometry and investigate their proliferative and osteogenic capacity in-vitro. The FC-PSCs were then delivered into bone defects using platelet-rich plasma (PRP) to facilitate bone repair. The results showed that FC-PSCs had superior proliferation and osteogenic potential compared to traditionally isolated stem cells (TP-PSCs), and PRP further enhanced their regenerative capabilities.
Article
Multidisciplinary Sciences
Jianying Zhang, Feng Li, Tyler Augi, Kelly M. Williamson, Kentaro Onishi, MaCalus Hogan, Matthew D. Neal, James H-C Wang
Summary: Platelet-rich plasma (PRP) containing PLT HMGB1 plays a crucial role in tendon wound healing by reducing inflammation, increasing local HMGB1 levels, and recruiting stem cells to the injured area. The efficacy of PRP treatment for tendon injuries in clinics may be dependent on the presence of PLT HMGB1 in PRP preparations.
Article
Multidisciplinary Sciences
Ondrej Hrdy, Kamil Vrbica, Marek Kovar, Tomas Korbicka, Radka Stepanova, Roman Gal
Summary: This study aimed to assess the incidence of significant muscle wasting in critically ill patients and identify predictors. Ultrasound measurements of the rectus femoris cross-sectional area (RFcsa) on the first and seventh day showed that 59.6% of patients had a decrease of at least 10% in RFcsa. Age was identified as a borderline predictor for muscle wasting.
SCIENTIFIC REPORTS
(2023)
Article
Veterinary Sciences
Anamika Changrani-Rastogi, Krutika Swadi, Mitali Barve, Niyati Bajekal
Summary: This study evaluated the effect of autologous platelet-rich fibrin (PRF) in the management of feline cutaneous wounds. The results showed that PRF could serve as a low-risk and convenient adjunctive therapy to promote wound healing in cats.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Biophysics
Ting Wang, Wanwan Yi, Yu Zhang, Hang Wu, Hengwei Fan, Jiulong Zhao, Shige Wang
Summary: In recent years, the healing of chronic wounds has become a challenging problem in clinical practice. This study aimed to address the challenges in wound care by designing a dual-network hydrogel composed of sodium alginate and platelet-rich plasma. The hydrogel showed a three-dimensional network structure and exhibited the potential for cell proliferation and vascular regeneration. When applied to wound skin in rats, the hydrogel effectively promoted wound closure. Overall, this strategy offers a simple and feasible approach for overcoming the shortcomings of conventional wound dressings.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Veterinary Sciences
Esraa Zalama, Gamal Karrouf, Awad Rizk, Basma Salama, Alaa Samy
Summary: This study investigated the regenerative efficacy of autologous Platelet Rich-Fibrin (PRF) and Zinc Oxide Nanoparticles (ZnONPs) in repairing large segmental bone ulnar defects. The results showed that the PRF/ZnONPs group had the highest bone quality and quantity, followed by the PRF group with high quantity but low bone quality, while the control group had minimal quantity but medium bone quality.
BMC VETERINARY RESEARCH
(2022)
Article
Multidisciplinary Sciences
Mohammed A. H. Abdelhakiem, Ayman Hussein, Samia Moustafa Seleim, Abdelbaset Eweda Abdelbaset, Mahmoud Abd-Elkareem
Summary: This study investigated the effect of silver nanoparticles (AgNPs) and platelet-rich fibrin (PRF) on the healing of severed superficial digital flexor tendon (SDFT) in donkeys. Three groups of adult donkeys were used, with the first group serving as the control group and the second and third groups treated with AgNPs and PRF, respectively. The healing progress was evaluated clinically and through gross and microscopic examinations. Results showed that both PRF and AgNPs improved SDFT healing, with significant reduction in lameness observed in the third month after surgery.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Siwen Wang, Zhonghan Li, Desiree Aispuro, Nathan Guevara, Juno Van Valkenburgh, Boxi Chen, Xiaoyun Zhou, Matthew N. McCarroll, Fei Ji, Xu Cong, Priyanka Sarkar, Rohit Chaudhuri, Zhili Guo, Nicole P. Perkins, Shiqun Shao, Jason K. Sello, Kai Chen, Min Xue
Summary: The study reports a hydrophilic endocytosis-promoting peptide (EPP6) that can transport a wide array of small-molecule cargos into animal cells. Mechanistic studies revealed that EPP6 enters cells through a caveolin-and dynamin-dependent endocytosis pathway and partitions among cytosol, lysosomes, and some long-lived compartments. It also demonstrates significant transcytosis abilities. The research provides a new category of well-defined delivery tags for biomedical applications.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Orthopedics
Yan-Chun Gao, Qi-Yang Wang, Chen-Chen Wang, Shichang Zhao, Hua Chen
Summary: PRP treatment combined with CTR improves the pain severity and functional status in patients with moderate symptoms of CTS, but it does not show any advantages in treating individuals with severe CTS.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Critical Care Medicine
Esther M. M. Van Lieshout, Dennis Den Hartog
Summary: Bone has the ability to completely regenerate under normal healing conditions, but about 10% of patients may still experience healing problems. Optimal healing potential involves the interplay of biomechanical and biological factors. PRP as a biological enhancement material has the potential to enhance fracture healing.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2021)
Article
Chemistry, Multidisciplinary
Shangzhi Li, Qi Dong, Xiaotong Peng, Yun Chen, Hongjun Yang, Weilin Xu, Yanteng Zhao, Pu Xiao, Yingshan Zhou
Summary: A self-healing nanocomposite hydrogel based on hyaluronic acid has been developed, which exhibits good strength, self-healing ability, and the potential to load platelet-rich plasma (PRP) for promoting skin wound healing.
Review
Cell Biology
Edward J. Calabrese, Rachna Kapoor, Gaurav Dhawan, Vittorio Calabrese
Summary: Platelet-rich plasma is widely accepted for wound healing, showing unique hormetic-like concentrations in its complex mixtures, making it a new area for biomedical research and applications.
WOUND REPAIR AND REGENERATION
(2022)
Article
Agriculture, Dairy & Animal Science
Vasileia Angelou, Dimitra Psalla, Chrysostomos Dovas, George M. Kazakos, Christina Marouda, Kyriakos Chatzimisios, Zacharenia Kyrana, Evangelia Moutou, Maria Karayannopoulou, Lysimachos G. Papazoglou
Summary: This study investigated the efficacy of autologous platelet-rich plasma (PRP) infiltration in open wounds in cats. The results showed that PRP infiltration promoted faster and better wound healing, as well as improved perfusion. This is the first study to focus on the topical application of PRP in treating open wounds in laboratory cats, and the results are encouraging, demonstrating faster healing in the PRP group.