Article
Engineering, Biomedical
Pablo Blazquez-Carmona, Juan Mora-Macias, Jose Antonio Sanz-Herrera, Juan Morgaz, Rocio Navarrete-Calvo, Jaime Dominguez, Esther Reina-Romo
Summary: Bone lengthening is a bone regeneration technique with common complications of inadequate adaptation of surrounding soft tissues. However, the effects of these tissues are limited, including tissue relaxation, application of a viscoelastic model, and anatomical changes in surrounding soft tissues.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Review
Chemistry, Multidisciplinary
Fotis Vogiatzis, Petros Roussos, Ioannis Doulis, Georgia Palikaraki, Panagiotis Christopoulos, Iosif Sifakakis
Summary: This systematic review examines the effects of surgically assisted rapid palatal expansion (SARPE) on facial soft tissues. The included studies suggest a post-surgical increase in alar width and alar base width. However, due to methodological limitations and high risk of bias, quantitative synthesis was not feasible.
APPLIED SCIENCES-BASEL
(2022)
Article
Endocrinology & Metabolism
Feiyu Cai, Aihemaitijiang Yusufu, Kai Liu, Wenjiao Chen, Ruomei Zhao, Yanshi Liu, Yi Liu
Summary: The study evaluated the difference in bone regeneration between rats under high-fat diets (HFD) and low-fat diets (LFD) by monitoring the process of bone regeneration in distraction osteogenesis (DO) model animals. The results showed that HFD resulted in elevated blood lipids, increased adipose differentiation at the bone marrow level, and delayed bone regeneration.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Engineering, Biomedical
A. T. Bachmeier, E. Euler, R. Bader, W. Boecker, P. H. Thaller
Summary: The purpose of this study was to numerically determine the callus distraction force (CDF) and total distraction force (TDF) during distraction osteogenesis (DO) in adult tibia, in order to improve the understanding of callus tissue behavior and optimize DO procedures. The results showed that our model predictions were plausible and in line with in vivo data, indicating the feasibility of our approach.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Engineering, Biomedical
Hanjiang Zhao, Xiangyu Wang, Anting Jin, Minjiao Wang, Zeying Wang, Xingtai Huang, Jiewen Dai, Xudong Wang, Dan Lin, Steve G. F. Shen
Summary: Rapid maxillary expansion (RME) is a common treatment for craniomaxillofacial deformity, but it often has high relapse rates and unsatisfactory therapeutic effects. In this study, a standardized rat RME model was established and a mesoporous bioactive glass/fibrin glue (MBG/FG) composite hydrogel was developed to enhance osteogenesis in the expanded palate. The results showed that the injection of 1% MBG/FG composite hydrogel significantly promoted bone formation and inhibited osteoclastogenesis in the expanded mid-palatal suture.
BIOACTIVE MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Ruisen Fu, Yili Feng, David Bertrand, Tianming Du, Youjun Liu, Bettina M. Willie, Haisheng Yang
Summary: The study proposed a distraction strategy with varying distraction rates to shorten distraction time and improve efficiency. It was found that rate-varying distraction led to faster and better healing outcomes compared to constant-rate distraction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Engineering, Biomedical
Jie Hu, Jiahui Shao, Gan Huang, Jieyuan Zhang, Shuting Pan
Summary: Bone is a highly vascularized tissue, and the ability of magnesium (Mg) to promote osteogenesis and angiogenesis has been widely studied. Various Mg-enriched materials have been made and can promote angiogenesis and osteogenesis. Recent advances in the study of metal materials releasing Mg ions are reviewed, and most studies suggest that Mg can enhance vascularized osteogenesis. Additionally, mechanisms related to vascularized osteogenesis are summarized, and future research strategies for Mg-enriched materials are proposed, with clarifying the specific mechanism of promoting angiogenesis being the key.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Anatomy & Morphology
A. T. Bachmeier, E. Euler, R. Bader, W. Boecker, P. H. Thaller
Summary: A novel method was developed to determine distraction areas (DA) in distraction osteogenesis of long bones, providing valuable information for anatomical knowledge and biomechanical modeling. This method improves understanding of bone formation and callus tissue during the lengthening process.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2021)
Article
Nanoscience & Nanotechnology
Haoyu Zhao, Yachao Jia, Feng Wang, Yimin Chai, Chunfu Zhang, Jia Xu, Qinglin Kang
Summary: In this study, mesoporous silica-coated magnetic nanoparticles doped with cobalt ions were synthesized to accelerate bone repair. The results showed that local injection of these nanoparticles significantly accelerated bone healing in a mouse model. This study’s findings are important for expediting the treatment process of bone fractures.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Orthopedics
Pablo S. Corona, Carla Carbonell-Rosell, Matias Vicente, Jordi Serracanta, Kevin Tetsworth, Vaida Glatt
Summary: A three-stage surgical approach for the treatment of chronically infected tibial injuries with combined bone and soft-tissue defects yields high rates of infection eradication and successful limb salvage, with favorable functional outcomes and high patient satisfaction.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Seyit Ahmet Ozturk, Siddik Malkoc, Umit Yolcu, Zehra Ileri, Ozge Celik Guler
Summary: The study found that MMDO and RME procedures provide an effective non-extraction treatment alternative for transverse maxillomandibular deficiency, improving facial soft tissue profiles.
ANGLE ORTHODONTIST
(2021)
Article
Orthopedics
Mootaz F. Thakeb, Michael A. Kozman, Mohamed A. ElGebeily, Mostafa M. Baraka, Mohamed A. Al Kersh
Summary: This study aims to compare bone transport through induced membrane (BTM) and conventional bone transport (BT) in the management of infected long-bone defects. The results show that BTM had significantly faster docking site union, lower incidence of postoperative complications including docking site nonunion and infection recurrence rates compared to BT. The study concludes that BTM technique offers advantages in terms of faster docking site union, lower complication rates, and fewer additional procedures required, albeit with the need for a two-stage operation.
JOURNAL OF ORTHOPAEDIC TRAUMA
(2023)
Article
Computer Science, Interdisciplinary Applications
Ruisen Fu, Yili Feng, Yang Liu, Xing Gao, David T. Bertrand, Tianming Du, Youjun Liu, Bettina M. Willie, Haisheng Yang
Summary: This study investigated the effects of different AT modes on DO outcomes using computer simulation. The results showed that applying AT during the early consolidation phase significantly enhanced bone formation and reduced the overall healing time. However, the effects of AT depended on its duration and rate. Moderate durations and rates of AT promoted blood perfusion recovery and bone regeneration, while high rates and longer durations of AT adversely affected bone regeneration and delayed bone bridging.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Review
Cell Biology
Ze Liu, Qi Liu, Hongbin Guo, Jieyu Liang, Yi Zhang
Summary: Distraction osteogenesis (DO) is a bone regeneration technology that promotes new bone formation through continuous and stable traction force. However, the long consolidation course of DO can lead to complications. Current treatment strategies include gene, growth factor, stem-cell, physical, and pharmacological therapies, with physical and pharmacological therapies being considered safe and effective. Recent research provides evidence for the effectiveness of physical and pharmacological therapies in promoting bone healing during DO.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell & Tissue Engineering
Y. Li, Y. Yang, M. Wang, X. Zhang, S. Bai, X. Lu, Y. Li, E. I. Waldorff, N. Zhang, W. Y. W. Lee, G. Li
Summary: The study compared a new, high slew rate (HSR) PEMF signal with different treatment durations with the standard FDA-approved signal, finding that HSR signal significantly enhances bone formation and could shorten daily treatment duration.
BONE & JOINT RESEARCH
(2021)
