Journal
INTERNATIONAL ORTHOPAEDICS
Volume 33, Issue 2, Pages 413-418Publisher
SPRINGER
DOI: 10.1007/s00264-008-0649-1
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- National Health Insurance
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The possibility of controlling the harmful intra-articular influence of elevated interleukin (IL)-1 beta synovial fluid concentration after anterior cruciate ligament (ACL) surgery could be useful. We investigated the correlation between serum and synovial fluid IL-1 beta levels following ACL reconstruction. We measured IL-1 beta concentration periodically in three synovial fluid and four serum samples in each of 20 patients receiving either autologous conditioned serum (ACS) containing endogenous anti-inflammatory cytokines including IL-1Ra and several growth factors (group A) or placebo (group B). A decrease in IL-1 beta synovial fluid concentration appeared to be more pronounced in absolute terms in group A. In eight patients serum IL-1 beta was detected on the 6th postoperative day. In four of them whose synovial fluid levels were over 10 pg/ml on the 6th postoperative day, serum IL-1 beta was detected on the 10th postoperative day. The results were different in group B. Correlation between serum and synovial fluid IL-1 beta appearance persists in patients after ACL surgery and ACS application. This study is an example of ACS influence on the ACL healing process controlling the IL-1 beta levels on the basis of the serum IL-1 beta detection.
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