Review
Medicine, General & Internal
Matthew Wells, Sughra Alawi, Kyaing Yi Mon Thin, Harsha Gunawardena, Adrian R. Brown, Anthony Edey, John D. Pauling, Shaney L. Barratt, Huzaifa I. Adamali
Summary: Antisynthetase syndrome is a subtype of idiopathic inflammatory myopathy that is strongly associated with interstitial lung disease. Diagnosis is made by detecting specific antibodies and relevant clinical and radiologic features. A multidisciplinary team, including rheumatologists, respiratory physicians, and radiologists, is needed for accurate diagnosis.
FRONTIERS IN MEDICINE
(2022)
Article
Biology
Marco Angelo Monte, Massimiliano Veroux, Margherita Stefania Rodolico, Valentina Losi, Luigi Di Pino, Rita Bella, Giuseppe Lanza, Ines Paola Monte
Summary: Fabry's disease patients exhibit wide phenotypic variability, even at single-organ level, likely due to individual genetic mutation, while a multidisciplinary approach can achieve early clinical detection and management compared to conventional methods.
Review
Oncology
Magda Zanelli, Marco Pizzi, Francesca Sanguedolce, Maurizio Zizzo, Andrea Palicelli, Alessandra Soriano, Alessandra Bisagni, Giovanni Martino, Cecilia Caprera, Marina Moretti, Francesco Masia, Loredana De Marco, Elisabetta Froio, Moira Foroni, Giuditta Bernardelli, Maria Isabel Alvarez de Celis, Alessandro Giunta, Francesco Merli, Stefano Ascani
Summary: Mastocytosis represents a heterogeneous group of neoplastic mast cell disorders, with gastrointestinal symptoms being a major cause of morbidity in patients. Diagnosing the disease can be challenging and requires a close multidisciplinary team approach for diagnosis and treatment.
Review
Microbiology
Dallas J. Smith, Jeremy A. W. Gold, Kaitlin Benedict, Karen Wu, Meghan Lyman, Alexander Jordan, Narda Medina, Shawn R. Lockhart, D. Joseph Sexton, Nancy A. Chow, Brendan R. Jackson, Anastasia P. Litvintseva, Mitsuru Toda, Tom Chiller
Summary: Fungal infections can lead to severe disease and death, and have a significant economic impact on healthcare systems. Multidisciplinary public health research is crucial for saving lives and preventing disability from fungal diseases. The main research priorities include assessing the burden and distribution of fungal diseases, improving diagnostics, therapeutics, and vaccines, and understanding the impact on public health and individual patients.
Article
Management
Sheetal Prakash Silal
Summary: Infectious diseases, whether established or emerging, are a significant burden globally. Operational research plays a vital role in strengthening health systems and supporting disease control efforts.
EUROPEAN JOURNAL OF OPERATIONAL RESEARCH
(2021)
Article
Fisheries
Ludmila L. C. Menezes, Janaina G. A. Santos, Igo G. Guimaraes, Delma M. C. Padua, Vania M. V. Machado, Cristielle N. Souto
Summary: This study evaluated the available phosphorus requirement for tambaqui using different response parameters, and found that varying levels of dietary phosphorus significantly affected fish growth performance and bone density.
AQUACULTURE NUTRITION
(2021)
Article
Immunology
Santiago Quirce, Borja G. Cosio, Agustin Espana, Ricardo Blanco, Joaquim Mullol, Cecilio Santander, Victoria del Pozo
Summary: Elevated eosinophil counts in blood and tissue are indicative of various pathological processes, including inflammatory diseases. Normalization of eosinophilia can serve as a biomarker for treatment response and prognosis. Biological therapies targeting eosinophils have shown effectiveness in managing eosinophilic diseases and offer a potential common strategy for the treatment of patients with multiple comorbidities and type 2 inflammation. A multidisciplinary approach involving healthcare professionals from different specialties is essential for the optimal management of eosinophil-associated diseases, covering diagnosis, treatment, and follow-up care.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Gorm Thorlacius-Ussing, Marie Bruun, Le Gjerum, Kristian S. Frederiksen, Hanneke F. M. Rhodius-Meester, Wiesje M. van der Flier, Gunhild Waldemar, Steen G. Hasselbalch
Summary: The study found that a multidisciplinary consensus conference had higher diagnostic accuracy of disease etiology and increased clinicians' confidence when evaluating patients with cognitive decline. This highlights the importance of utilizing a multidisciplinary diagnostic evaluation approach for dementia diagnostics.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Oncology
Miguel Esperanca-Martins, Diogo Roque, Tiago Barroso, Andre Abrunhosa-Branquinho, Diogo Belo, Nuno Simas, Luis Costa
Summary: The prevalence of metastatic spine disease is increasing and requires a multidisciplinary approach for optimal clinical outcomes. We reviewed recent data and proposed an updated algorithmic approach to personalized management. A flowchart-based approach provides evidence-based decision-making in a context of uncertainty and urgency.
Review
Medicine, General & Internal
C. R. H. Hedin, E. Sonkoly, M. Eberhardson, M. Stahle
Summary: Psoriasis and inflammatory bowel disease (IBD) are immune-mediated diseases with higher prevalence in northern Europe. Changes in gut microbiota play a key role in IBD pathogenesis, while genetic susceptibility has a greater impact on psoriasis.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Pediatrics
Kristen A. Marten, David B. Allen, Jennifer Rehm, Cassandra Vanderwall, Amy L. Peterson, Aaron L. Carrel
Summary: The study aimed to determine the post-treatment outcomes of children seen in a multidisciplinary pediatric obesity clinic (MPOC). Research findings showed that outpatient, multidisciplinary intervention for pediatric obesity was effective in reducing or stabilizing BMI Z-score during and beyond the intervention, particularly when patients were referred at an early age. Age at the time of referral was found to be the only significant predictor of change in BMI Z-score.
ACADEMIC PEDIATRICS
(2023)
Review
Gastroenterology & Hepatology
Jelena Jadzic, Danijela Djonic
Summary: Given that the liver is involved in many metabolic mechanisms, chronic liver disease (CLD) can lead to complications such as secondary osteoporosis and increased bone fragility, which are often overlooked. Studies have shown that up to one-third of CLD patients meet diagnostic criteria for osteopenia or osteoporosis. Recent publications indicate that the risk of bone fragility in CLD patients depends on the etiology, duration, and stage of liver disease. This poses a significant socioeconomic burden and calls for more effective prevention, diagnosis, and treatment measures.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Endocrinology & Metabolism
Winnie Liu, Brendan Lee, Sandesh C. S. Nagamani, Lindsey Nicol, Frank Rauch, Eric T. Rush, V. Reid Sutton, Eric Orwoll
Summary: Osteogenesis imperfecta (OI) is a genetic disorder that causes increased bone fragility. Medications used for fracture reduction in adults with OI, such as bisphosphonates and teriparatide, have shown potential in improving bone mineral density (BMD) but lack conclusive data on fracture protection. Other drugs and treatments have not been systematically studied in adults with OI. Further research is needed to develop medications that can effectively reduce fracture rates in adults with OI.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Oncology
Alexander J. Schupper, Shrey Patel, Jeremy M. Steinberger, Isabelle M. Germano
Summary: Metastatic spine disease (MSD) is common in cancer patients and can cause pain, spinal instability, neurological compromise, and decreased quality of life. Minimally invasive spinal surgery (MISS) techniques are desirable for these medically complex and frail patients. This study reviewed published literature and ongoing clinical trials to provide the current state of the art.
Review
Chemistry, Physical
Sara G. Pedrero, Pilar Llamas-Sillero, Juana Serrano-Lopez
Summary: Millions of patients suffer from bone fractures and disorders every year, necessitating alternative therapies due to drawbacks of traditional treatments. Bone tissue engineering offers promising strategies to promote bone tissue regeneration through scaffolds, growth factors, and osteogenic cells.