Streptozotocin Intracerebroventricular-Induced Neurotoxicity and Brain Insulin Resistance: a Therapeutic Intervention for Treatment of Sporadic Alzheimer’s Disease (sAD)-Like Pathology

AβPP A713T Mutation in Late Onset Alzheimer's Disease with Cerebrovascular Lesions

(2017) Livia Bernardi et al.   JOURNAL OF ALZHEIMERS DISEASE

Insulin-Resistant Brain State after Intracerebroventricular Streptozotocin Injection Exacerbates Alzheimer-like Changes in Tg2576 AβPP-Overexpressing Mice

(2017) Konstanze Plaschke et al.   JOURNAL OF ALZHEIMERS DISEASE

A Multi-Center Randomized Proof-of-Concept Clinical Trial Applying [18F]FDG-PET for Evaluation of Metabolic Therapy with Rosiglitazone XR in Mild to Moderate Alzheimer's Disease

(2017) Sofia Tzimopoulou et al.   JOURNAL OF ALZHEIMERS DISEASE

Testosterone ameliorates streptozotocin-induced memory impairment in male rats

(2014) Alireza Mohajjel Nayebi et al.   ACTA PHARMACOLOGICA SINICA

Liver X receptor agonist T0901317 reduces neuropathological changes and improves memory in mouse models of experimental dementia

(2014) Rupinder K. Sodhi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effect of Licofelone—A Dual COX/5-LOX Inhibitor in Intracerebroventricular Streptozotocin-Induced Behavioral and Biochemical Abnormalities in Rats

(2014) Ashok Kumar et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Efficacy of some antioxidants supplementation in reducing oxidative stress post sodium tungstate exposure in male wistar rats

(2014) S. Sachdeva et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Bacopa monniera ameliorates cognitive impairment and neurodegeneration induced by intracerebroventricular-streptozotocin in rat: behavioral, biochemical, immunohistochemical and histopathological evidences

(2014) M. Badruzzaman Khan et al.   METABOLIC BRAIN DISEASE

Protection of streptozotocin induced insulin receptor dysfunction, neuroinflammation and amyloidogenesis in astrocytes by insulin

(2014) N. Rajasekar et al.   NEUROPHARMACOLOGY

Nesfatin-1 Stimulates Fatty-Acid Oxidation by Activating AMP-Activated Protein Kinase in STZ-Induced Type 2 Diabetic Mice

(2014) Jing Dong et al.   PLoS One

Agmatine Improves Cognitive Dysfunction and Prevents Cell Death in a Streptozotocin-Induced Alzheimer Rat Model

(2014) Juhyun Song et al.   YONSEI MEDICAL JOURNAL

Ameliorative effect of Noni fruit extract on streptozotocin-induced memory impairment in mice

(2013) Shakti D. Pachauri et al.   BEHAVIOURAL PHARMACOLOGY

Rosmarinic acid prevents lipid peroxidation and increase in acetylcholinesterase activity in brain of streptozotocin-induced diabetic rats

(2013) Nadia Mushtaq et al.   CELL BIOCHEMISTRY AND FUNCTION

Postsynaptic distribution of IRSp53 in spiny excitatory and inhibitory neurons

(2013) Alain C. Burette et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Neuroprotective effects of Pouteria ramiflora (Mart.) Radlk (Sapotaceae) extract on the brains of rats with streptozotocin-induced diabetes

(2013) Alice Vieira da Costa et al.   METABOLIC BRAIN DISEASE

Intracerebroventricular Streptozotocin Exacerbates Alzheimer-Like Changes of 3xTg-AD Mice

(2013) Yanxing Chen et al.   MOLECULAR NEUROBIOLOGY

Taurine ameliorates neurobehavioral, neurochemical and immunohistochemical changes in sporadic dementia of Alzheimer’s type (SDAT) caused by intracerebroventricular streptozotocin in rats

(2013) Hayate Javed et al.   NEUROLOGICAL SCIENCES

Xanthoceraside attenuates learning and memory deficits via improving insulin signaling in STZ-induced AD rats

(2013) Peng Liu et al.   NEUROSCIENCE LETTERS

Gallic acid prevents memory deficits and oxidative stress induced by intracerebroventricular injection of streptozotocin in rats

(2013) Mohammad Taghi Mansouri et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Glial activation and post-synaptic neurotoxicity: The key events in Streptozotocin (ICV) induced memory impairment in rats

(2013) Shivika Rai et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Protective effects of oral crocin against intracerebroventricular streptozotocin-induced spatial memory deficit and oxidative stress in rats

(2013) B. Naghizadeh et al.   PHYTOMEDICINE

Defensive Effect of Lansoprazole in Dementia of AD Type in Mice Exposed to Streptozotocin and Cholesterol Enriched Diet

(2013) Rupinder K. Sodhi et al.   PLoS One

Clitoria ternatea ameliorated the intracerebroventricularly injected streptozotocin induced cognitive impairment in rats: behavioral and biochemical evidence

(2013) Jogender Mehla et al.   PSYCHOPHARMACOLOGY

Neuroprotective effects of donepezil against cholinergic depletion

(2013) Debora Cutuli et al.   Alzheimers Research & Therapy

The Novel Multi-Target Iron Chelating-Radical Scavenging Compound M30 Possesses Beneficial Effects on Major Hallmarks of Alzheimer's Disease

(2012) Lana Kupershmidt et al.   ANTIOXIDANTS & REDOX SIGNALING

Antioxidants for Alzheimer Disease

(2012) Douglas R. Galasko et al.   ARCHIVES OF NEUROLOGY

Cognitive decline in STZ-3V rats is largely due to dysfunctional insulin signalling through the dentate gyrus

(2012) Akiko Sheala Shingo et al.   BEHAVIOURAL BRAIN RESEARCH

Inhibition of central angiotensin converting enzyme ameliorates scopolamine induced memory impairment in mice: Role of cholinergic neurotransmission, cerebral blood flow and brain energy metabolism

(2012) Santoshkumar Tota et al.   BEHAVIOURAL BRAIN RESEARCH

Green tea (−)epigallocatechin-3-gallate reverses oxidative stress and reduces acetylcholinesterase activity in a streptozotocin-induced model of dementia

(2012) Regina Biasibetti et al.   BEHAVIOURAL BRAIN RESEARCH

A study on neuroinflammation and NMDA receptor function in STZ (ICV) induced memory impaired rats

(2012) Shivika Rai et al.   JOURNAL OF NEUROIMMUNOLOGY

Anti-inflammatory/anti-amyloidogenic effects of plasmalogens in lipopolysaccharide-induced neuroinflammation in adult mice

(2012) Masataka Ifuku et al.   Journal of Neuroinflammation

Attenuating effect of lisinopril and telmisartan in intracerebroventricular streptozotocin induced experimental dementia of Alzheimer’s disease type: possible involvement of PPAR-γ agonistic property

(2012) Birdavinder Singh et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

A study on neuroinflammatory marker in brain areas of okadaic acid (ICV) induced memory impaired rats

(2012) Pradeep Kumar Kamat et al.   LIFE SCIENCES

Amyloid-β Protein Modulates Insulin Signaling in Presynaptic Terminals

(2012) David Heras-Sandoval et al.   NEUROCHEMICAL RESEARCH

Amelioration of intracerebroventricular streptozotocin induced cognitive impairment by Evolvulus alsinoides in rats: In vitro and in vivo evidence

(2012) Jogender Mehla et al.   NEUROCHEMISTRY INTERNATIONAL

Naringenin ameliorates Alzheimer’s disease (AD)-type neurodegeneration with cognitive impairment (AD-TNDCI) caused by the intracerebroventricular-streptozotocin in rat model

(2012) M. Badruzzaman Khan et al.   NEUROCHEMISTRY INTERNATIONAL

Rutin prevents cognitive impairments by ameliorating oxidative stress and neuroinflammation in rat model of sporadic dementia of Alzheimer type

(2012) H. Javed et al.   NEUROSCIENCE

Neuroprotective effect of RO-20-1724-a phosphodiesterase4 inhibitor against intracerebroventricular streptozotocin induced cognitive deficit and oxidative stress in rats

(2012) Vivek Sharma et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Improvement of brain energy metabolism and cholinergic functions contributes to the beneficial effects of silibinin against streptozotocin induced memory impairment

(2011) Santoshkumar Tota et al.   BEHAVIOURAL BRAIN RESEARCH

ICV STZ induced impairment in memory and neuronal mitochondrial function: A protective role of nicotinic receptor

(2011) Gunjan Saxena et al.   BEHAVIOURAL BRAIN RESEARCH

Lithium, phenserine, memantine and pioglitazone reverse memory deficit and restore phospho-GSK3β decreased in hippocampus in intracerebroventricular streptozotocin induced memory deficit model

(2011) Teresa Ponce-Lopez et al.   BRAIN RESEARCH

S-allyl cysteine attenuates oxidative stress associated cognitive impairment and neurodegeneration in mouse model of streptozotocin-induced experimental dementia of Alzheimer's type

(2011) Hayate Javed et al.   BRAIN RESEARCH

Rosiglitazone Does Not Improve Cognition or Global Function when Used as Adjunctive Therapy to AChE Inhibitors in Mild-to-Moderate Alzheimers Disease: Two Phase 3 Studies

(2011) C. Harrington et al.   Current Alzheimer Research

Modulation of nitrergic pathway by sesamol prevents cognitive deficits and associated biochemical alterations in intracerebroventricular streptozotocin administered rats

(2011) Shubham Misra et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Insulin receptor signaling in rat hippocampus: A study in STZ (ICV) induced memory deficit model

(2011) Rahul Agrawal et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Telmisartan attenuates oxidative stress and renal fibrosis in streptozotocin induced diabetic mice with the alteration of angiotensin-(1–7)masreceptor expression associated with its PPAR-γ agonist action

(2011) Arun Prasath Lakshmanan et al.   FREE RADICAL RESEARCH

Neuroprotective Effect of Cyclooxygenase Inhibitors in ICV-STZ Induced Sporadic Alzheimer’s Disease in Rats

(2011) Dinesh Kumar Dhull et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Cerebral amyloid angiopathy in streptozotocin rat model of sporadic Alzheimer’s disease: a long-term follow up study

(2011) Melita Salkovic-Petrisic et al.   JOURNAL OF NEURAL TRANSMISSION

Melatonin treatment restores mitochondrial function in Alzheimer’s mice: a mitochondrial protective role of melatonin membrane receptor signaling

(2011) Natasa Dragicevic et al.   JOURNAL OF PINEAL RESEARCH

Neuroprotective efficacy of Nardostachys jatamansi and crocetin in conjunction with selenium in cognitive impairment

(2011) M. Badruzzaman Khan et al.   NEUROLOGICAL SCIENCES

Mitochondrial dysfunction: A crucial event in okadaic acid (ICV) induced memory impairment and apoptotic cell death in rat brain

(2011) Pradeep K. Kamat et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Protective effect of quercetin against intracerebral streptozotocin induced reduction in cerebral blood flow and impairment of memory in mice

(2010) Santoshkumar Tota et al.   BEHAVIOURAL BRAIN RESEARCH

Current Challenges for the Early Detection of Alzheimer's Disease: Brain Imaging and CSF Studies

(2010) Rachel Mistur et al.   Journal of Clinical Neurology

Treadmill training restores spatial cognitive deficits and neurochemical alterations in the hippocampus of rats submitted to an intracerebroventricular administration of streptozotocin

(2010) Letícia Rodrigues et al.   JOURNAL OF NEURAL TRANSMISSION

Effects of Erythropoietin on Memory Deficits and Brain Oxidative Stress in the Mouse Models of Dementia

(2010) Rohit Kumar et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Involvement of PPAR-gamma in curcumin-mediated beneficial effects in experimental dementia

(2010) Puneet Rinwa et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Oxidative stress in Alzheimer disease: A possibility for prevention

(2010) David J. Bonda et al.   NEUROPHARMACOLOGY

Neuroinflammation and Cognitive Aging

(2010) Raymond L. Ownby   Current Psychiatry Reports

Selenium prevents cognitive decline and oxidative damage in rat model of streptozotocin-induced experimental dementia of Alzheimer's type

(2009) Tauheed Ishrat et al.   BRAIN RESEARCH

Amelioration of intracerebroventricular streptozotocin induced cognitive dysfunction and oxidative stress by vinpocetine — a PDE1 inhibitor

(2009) Rahul Deshmukh et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer's type (SDAT)☆

(2009) Tauheed Ishrat et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

 -Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin

(2009) Q.-L. Ma et al.   JOURNAL OF NEUROSCIENCE

Protective effect of curcumin against intracerebral streptozotocin induced impairment in memory and cerebral blood flow

(2009) Himani Awasthi et al.   LIFE SCIENCES

A study of brain insulin receptors, AChE activity and oxidative stress in rat model of ICV STZ induced dementia

(2009) Rahul Agrawal et al.   NEUROPHARMACOLOGY

Effect of curcumin on brain insulin receptors and memory functions in STZ (ICV) induced dementia model of rat

(2009) Rahul Agrawal et al.   PHARMACOLOGICAL RESEARCH

Chronic treatment with tocotrienol, an isoform of vitamin E, prevents intracerebroventricular streptozotocin-induced cognitive impairment and oxidative–nitrosative stress in rats

(2009) Vinod Tiwari et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Melatonin alleviates memory deficits and neuronal degeneration induced by intracerebroventricular administration of streptozotocin in rats

(2009) Gunjan Saxena et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Cytoskeletal pathologies of Alzheimer disease

(2009) James R. Bamburg et al.   CELL MOTILITY AND THE CYTOSKELETON

Insulin-like growth factor I and glucagon-like peptide-2 responses to fasting followed by controlled or ad libitum refeeding in rats

(2008) David W. Nelson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Candesartan improves memory decline in mice: Involvement of AT1 receptors in memory deficit induced by intracerebral streptozotocin

(2008) Santoshkumar Tota et al.   BEHAVIOURAL BRAIN RESEARCH

Therapeutic potential of resveratrol in Alzheimer's disease

(2008) Valérie Vingtdeux et al.   BMC NEUROSCIENCE

Inhibition of glycogen synthase kinase-3β downregulates total tau proteins in cultured neurons and its reversal by the blockade of protein phosphatase-2A

(2008) Ludovic Martin et al.   BRAIN RESEARCH

Modulation of celecoxib- and streptozotocin-induced experimental dementia of Alzheimer's disease by pitavastatin and donepezil

(2008) Bhupesh Sharma et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Expression of CD74 is increased in neurofibrillary tangles in Alzheimer's disease

(2008) Kathryn J Bryan et al.   Molecular Neurodegeneration

Influence of TRPV1 on Diabetes-Induced Alterations in Thermal Pain Sensitivity

(2008) Reddy M Pabbidi et al.   Molecular Pain

Declining brain glucose metabolism in normal individuals with a maternal history of Alzheimer disease

(2008) L. Mosconi et al.   NEUROLOGY

Effects of treadmill exercise on memory and c-Fos expression in the hippocampus of the rats with intracerebroventricular injection of streptozotocin

(2008) Yong-Seok Jee et al.   NEUROSCIENCE LETTERS

Exploitation of HIV protease inhibitor Indinavir as a memory restorative agent in experimental dementia

(2008) Bhupesh Sharma et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Clinical study of the risk factors of insulin resistance and metabolic syndrome after kidney transplantation

(2008) Weiguo Sui et al.   TRANSPLANT IMMUNOLOGY

Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system

(2007) Jing Chen et al.   BRAIN BEHAVIOR AND IMMUNITY

Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in mice

(2007) Gunjan Saxena et al.   EUROPEAN JOURNAL OF PHARMACOLOGY