Transcriptional Regulation of Brain-Derived Neurotrophic Factor (BDNF) by Methyl CpG Binding Protein 2 (MeCP2): a Novel Mechanism for Re-Myelination and/or Myelin Repair Involved in the Treatment of Multiple Sclerosis (MS)
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Title
Transcriptional Regulation of Brain-Derived Neurotrophic Factor (BDNF) by Methyl CpG Binding Protein 2 (MeCP2): a Novel Mechanism for Re-Myelination and/or Myelin Repair Involved in the Treatment of Multiple Sclerosis (MS)
Authors
Keywords
Multiple sclerosis (MS), Epigenetics, Histone deacetylase (HDAC) inhibitors, Experimental autoimmune encephalomyelitis (EAE), Methyl CpG binding protein 2 (MeCP2), Brain-derived neurotrophic factor (BDNF), Autoimmune disease
Journal
MOLECULAR NEUROBIOLOGY
Volume 53, Issue 2, Pages 1092-1107
Publisher
Springer Nature
Online
2015-01-12
DOI
10.1007/s12035-014-9074-1
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Note: Only part of the references are listed.- Epigenetic Silencing of the Proapoptotic Gene BIM in Anaplastic Large Cell Lymphoma through an MeCP2/SIN3a Deacetylating Complex
- (2015) Rocco Piazza et al. NEOPLASIA
- Exploring the Role of Nerve Growth Factor in Multiple Sclerosis: Implications in Myelin Repair
- (2014) C.M.R. Acosta et al. CNS & Neurological Disorders-Drug Targets
- A BDNF loop-domain mimetic acutely reverses spontaneous apneas and respiratory abnormalities during behavioral arousal in a mouse model of Rett syndrome
- (2014) M. Kron et al. Disease Models & Mechanisms
- SIRT1 is decreased during relapses in patients with multiple sclerosis
- (2014) Cosmin A. Tegla et al. EXPERIMENTAL AND MOLECULAR PATHOLOGY
- Curcumin induced up-regulation of Myelin basic protein (MBP) ameliorates sodium arsenite induced neurotoxicity in developing rat cerebellum
- (2014) Parul Kaushal et al. Journal of the Anatomical Society of India
- Multiple Sclerosis: Current and Emerging Disease-Modifying Therapies and Treatment Strategies
- (2014) Dean M. Wingerchuk et al. MAYO CLINIC PROCEEDINGS
- Brain Region-Specific Expression of MeCP2 Isoforms Correlates with DNA Methylation within Mecp2 Regulatory Elements
- (2014) Carl O. Olson et al. PLoS One
- Human endogenous retrovirus type W envelope protein inhibits oligodendroglial precursor cell differentiation
- (2013) David Kremer et al. ANNALS OF NEUROLOGY
- The Benefits and Detriments of Macrophages/Microglia in Models of Multiple Sclerosis
- (2013) Khalil S. Rawji et al. Clinical & Developmental Immunology
- Epstein–Barr virus and multiple sclerosis: association or causation?
- (2013) Julia Pakpoor et al. Expert Review of Neurotherapeutics
- Histone Deacetylase Sirtuin 1 Deacetylates IRF1 Protein and Programs Dendritic Cells to Control Th17 Protein Differentiation during Autoimmune Inflammation
- (2013) Heeyoung Yang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Multiple Roles of the p75 Neurotrophin Receptor in the Nervous System
- (2013) Y Chen et al. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
- Elevation of Tumor Necrosis Factor Alpha in Dorsal Root Ganglia and Spinal Cord is Associated with Neuroimmune Modulation of Pain in an Animal Model of Multiple Sclerosis
- (2013) F. Begum et al. Journal of Neuroimmune Pharmacology
- Oligodendroglial Expression of TrkB Independently Regulates Myelination and Progenitor Cell Proliferation
- (2013) A. W. Wong et al. JOURNAL OF NEUROSCIENCE
- Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain
- (2013) Junjie U Guo et al. NATURE NEUROSCIENCE
- A synonymous change, p.Gly16Gly in MECP2 Exon 1, causes a cryptic splice event in a Rett Syndrome patient
- (2013) Taimoor I Sheikh et al. Orphanet Journal of Rare Diseases
- Decitabine alters the expression of Mecp2 isoforms via dynamic DNA methylation at the Mecp2 regulatory elements in neural stem cells
- (2013) Vichithra R B Liyanage et al. Molecular Autism
- Curcumin derivatives promote Schwann cell differentiation and improve neuropathy in R98C CMT1B mice
- (2012) Ágnes Patzkó et al. BRAIN
- Astrocytes regulate myelin clearance through recruitment of microglia during cuprizone-induced demyelination
- (2012) Thomas Skripuletz et al. BRAIN
- MeCP2 Binds to 5hmC Enriched within Active Genes and Accessible Chromatin in the Nervous System
- (2012) Marian Mellén et al. CELL
- Vitamin D has wide regulatory effects on histone demethylase genes
- (2012) Fábio Pereira et al. CELL CYCLE
- MeCP2 modulates the canonical Wnt pathway activation by targeting SFRP4 in rheumatoid arthritis fibroblast-like synoviocytes in rats
- (2012) Cheng-gui Miao et al. CELLULAR SIGNALLING
- Vorinostat, a histone deacetylase inhibitor, suppresses dendritic cell function and ameliorates experimental autoimmune encephalomyelitis
- (2012) Zhenzhen Ge et al. EXPERIMENTAL NEUROLOGY
- Extracellular signal-regulated kinase 1/2 signaling promotes oligodendrocyte myelination in vitro
- (2012) Junhua Xiao et al. JOURNAL OF NEUROCHEMISTRY
- Increased promoter methylation of the immune regulatory gene SHP-1 in leukocytes of multiple sclerosis subjects
- (2012) Chiharu Kumagai et al. JOURNAL OF NEUROIMMUNOLOGY
- Pain in experimental autoimmune encephalitis: a comparative study between different mouse models
- (2012) Jianning Lu et al. Journal of Neuroinflammation
- Regulation of Postnatal Forebrain Amoeboid Microglial Cell Proliferation and Development by the Transcription Factor Runx1
- (2012) M. Zusso et al. JOURNAL OF NEUROSCIENCE
- Isoform-Specific Toxicity of Mecp2 in Postmitotic Neurons: Suppression of Neurotoxicity by FoxG1
- (2012) S. G. Dastidar et al. JOURNAL OF NEUROSCIENCE
- A TrkB Small Molecule Partial Agonist Rescues TrkB Phosphorylation Deficits and Improves Respiratory Function in a Mouse Model of Rett Syndrome
- (2012) D. A. Schmid et al. JOURNAL OF NEUROSCIENCE
- Differential regulation of CD4+ T helper cell responses by curcumin in experimental autoimmune encephalomyelitis
- (2012) Saravanan Kanakasabai et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Epigenetic changes in patients with multiple sclerosis
- (2012) Marcus W. Koch et al. Nature Reviews Neurology
- Valproic acid ameliorates inflammation in experimental autoimmune encephalomyelitis rats
- (2012) Z. Zhang et al. NEUROSCIENCE
- Remyelination Therapy for Multiple Sclerosis
- (2012) Michael B. Keough et al. Neurotherapeutics
- Novel MeCP2 Isoform-Specific Antibody Reveals the Endogenous MeCP2E1 Expression in Murine Brain, Primary Neurons and Astrocytes
- (2012) Robby M. Zachariah et al. PLoS One
- Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome
- (2012) R. Deogracias et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Linking Epigenetics to Human Disease and Rett Syndrome: The Emerging Novel and Challenging Concepts in MeCP2 Research
- (2012) Robby Mathew Zachariah et al. NEURAL PLASTICITY
- Epigenetic CpG Demethylation of the Promoter and Reactivation of the Expression of Neurog1 by Curcumin in Prostate LNCaP Cells
- (2011) Limin Shu et al. AAPS Journal
- Central nervous system rather than immune cell-derived BDNF mediates axonal protective effects early in autoimmune demyelination
- (2011) De-Hyung Lee et al. ACTA NEUROPATHOLOGICA
- Modulation of Autoimmune Demyelination by Laquinimod via Induction of Brain-Derived Neurotrophic Factor
- (2011) Jan Thöne et al. AMERICAN JOURNAL OF PATHOLOGY
- Functional role of brain-derived neurotrophic factor in neuroprotective autoimmunity: therapeutic implications in a model of multiple sclerosis
- (2011) R. A. Linker et al. BRAIN
- Regulation of chromatin by histone modifications
- (2011) Andrew J Bannister et al. CELL RESEARCH
- White Matter Network Abnormalities Are Associated with Cognitive Decline in Chronic Epilepsy
- (2011) Maarten J. Vaessen et al. CEREBRAL CORTEX
- Glatiramer Acetate in the Treatment of Multiple Sclerosis
- (2011) Patrice H. Lalive et al. CNS DRUGS
- Transgenic complementation of MeCP2 deficiency: phenotypic rescue of Mecp2-null mice by isoform-specific transgenes
- (2011) Bredford Kerr et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Ameliorative effects of curcumin against renal injuries mediated by inducible nitric oxide synthase and nuclear factor kappa B during gentamicin-induced toxicity in Wistar rats
- (2011) Ramar Manikandan et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- The role of dorsal root ganglia activation and brain-derived neurotrophic factor in multiple sclerosis
- (2011) Wenjun Zhu et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- CD44 Reciprocally Regulates the Differentiation of Encephalitogenic Th1/Th17 and Th2/Regulatory T Cells through Epigenetic Modulation Involving DNA Methylation of Cytokine Gene Promoters, Thereby Controlling the Development of Experimental Autoimmune Encephalomyelitis
- (2011) H. Guan et al. JOURNAL OF IMMUNOLOGY
- The effect of intrathecal administration of glial activation inhibitors on dorsal horn BDNF overexpression and hind paw mechanical allodynia in spinal nerve ligated rats
- (2011) Xin Zhang et al. JOURNAL OF NEURAL TRANSMISSION
- Recent insights into the mechanism of action of glatiramer acetate
- (2011) Mrinalini Kala et al. JOURNAL OF NEUROIMMUNOLOGY
- Changed Histone Acetylation Patterns in Normal-Appearing White Matter and Early Multiple Sclerosis Lesions
- (2011) X. Pedre et al. JOURNAL OF NEUROSCIENCE
- Levels of BDNF Impact Oligodendrocyte Lineage Cells following a Cuprizone Lesion
- (2011) M. W. VonDran et al. JOURNAL OF NEUROSCIENCE
- Insight into the mechanism of laquinimod action
- (2011) W. Brück et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Multiple sclerosis: more pieces of the immunological puzzle
- (2011) Ralf Gold et al. LANCET NEUROLOGY
- Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain
- (2011) Xiaoying Zhuang et al. MOLECULAR THERAPY
- Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
- (2011) Stephen Sawcer et al. NATURE
- White matter lesions in Parkinson disease
- (2011) Nicolaas I. Bohnen et al. Nature Reviews Neurology
- Brain-Derived Neurotrophic Factor Promotes Central Nervous System Myelination via a Direct Effect upon Oligodendrocytes
- (2011) Junhua Xiao et al. NEUROSIGNALS
- Role of HDAC3 on p53 Expression and Apoptosis in T Cells of Patients with Multiple Sclerosis
- (2011) Fanglin Zhang et al. PLoS One
- Critical Role of TCF-1 in Repression of the IL-17 Gene
- (2011) Jian Ma et al. PLoS One
- Excess Circulating Alternatively Activated Myeloid (M2) Cells Accelerate ALS Progression While Inhibiting Experimental Autoimmune Encephalomyelitis
- (2011) Ilan Vaknin et al. PLoS One
- Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine
- (2011) S. Ito et al. SCIENCE
- Emerging concepts in autoimmune encephalomyelitis beyond the CD4/TH1 paradigm
- (2010) Helena Batoulis et al. ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
- Epigenetic control of Hox genes during neurogenesis, development, and disease
- (2010) Benjamin A. Barber et al. ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
- HDAC inhibition promotes neuronal outgrowth and counteracts growth cone collapse through CBP/p300 and P/CAF-dependent p53 acetylation
- (2010) P Gaub et al. CELL DEATH AND DIFFERENTIATION
- Cytokine networks in multiple sclerosis: lost in translation
- (2010) Laura Codarri et al. CURRENT OPINION IN NEUROLOGY
- The role of MeCP2 in CNS development and function
- (2010) Elisa S. Na et al. HORMONES AND BEHAVIOR
- Current and future disease-modifying therapies in multiple sclerosis
- (2010) S. Y. Lim et al. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
- Fatigue and Cognition in Patients with Relapsing Multiple Sclerosis Treated with Interferon Beta
- (2010) Maria Melanson et al. INTERNATIONAL JOURNAL OF NEUROSCIENCE
- Exogenous Brain-Derived Neurotrophic Factor Rescues Synaptic Dysfunction in Mecp2-Null Mice
- (2010) D. D. Kline et al. JOURNAL OF NEUROSCIENCE
- Multiple sclerosis: risk factors, prodromes, and potential causal pathways
- (2010) Sreeram V Ramagopalan et al. LANCET NEUROLOGY
- Glatiramer acetate (GA, Copolymer-1) an hypothetical treatment option for Rett syndrome
- (2010) B. Ben-Zeev et al. MEDICAL HYPOTHESES
- A novel transcriptional regulator of myelin gene expression: implications for neurodevelopmental disorders
- (2010) Parvez Vora et al. NEUROREPORT
- Targeted Retrograde Gene Delivery of Brain-Derived Neurotrophic Factor Suppresses Apoptosis of Neurons and Oligodendroglia After Spinal Cord Injury in Rats
- (2010) Hideaki Nakajima et al. SPINE
- The Human Endogenous Retrovirus Link between Genes and Environment in Multiple Sclerosis and in Multifactorial Diseases Associating Neuroinflammation
- (2009) Hervé Perron et al. CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
- Amelioration of experimental autoimmune encephalomyelitis by curcumin treatment through inhibition of IL-17 production
- (2009) Lin Xie et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Epigenetic control
- (2009) Geneviève P. Delcuve et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Neuroprotection and neurogeneration in MS and its animal model EAE effected by glatiramer acetate
- (2009) Ruth Arnon et al. JOURNAL OF NEURAL TRANSMISSION
- Brain-derived neurotrophic factor gene delivery in an animal model of multiple sclerosis using bone marrow stem cells as a vehicle
- (2009) Tapas K. Makar et al. JOURNAL OF NEUROIMMUNOLOGY
- BDNF Exerts Contrasting Effects on Peripheral Myelination of NGF-Dependent and BDNF-Dependent DRG Neurons
- (2009) J. Xiao et al. JOURNAL OF NEUROSCIENCE
- Brain-derived neurotrophic factor and TrkB receptor in experimental autoimmune encephalomyelitis and multiple sclerosis
- (2009) Lorenzo De Santi et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Experimental autoimmune encephalomyelitis-induced upregulation of tumor necrosis factor-alpha in the dorsal root ganglia
- (2009) M. Melanson et al. Multiple Sclerosis Journal
- MECP2 Isoform-Specific Vectors with Regulated Expression for Rett Syndrome Gene Therapy
- (2009) Mojgan Rastegar et al. PLoS One
- Promoting oligodendrogenesis and myelin repair using the multiple sclerosis medication glatiramer acetate
- (2009) V. Skihar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The interaction of neurotrophins with the p75NTR common neurotrophin receptor: A comprehensive molecular modeling study
- (2009) Igor L. Shamovsky et al. PROTEIN SCIENCE
- Epigenetic mechanisms in mammals
- (2008) J. K. Kim et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Therapeutic Potential of Vitamin D for Multiple Sclerosis
- (2008) Masaaki Niino et al. CURRENT MEDICINAL CHEMISTRY
- Myelin repair strategies: a cellular view
- (2008) Vittorio Gallo et al. CURRENT OPINION IN NEUROLOGY
- MeCP2 knockdown reveals DNA methylation-independent gene repression of target genes in living cells and a bias in the cellular location of target gene products
- (2008) Shinya Yakabe et al. GENES & GENETIC SYSTEMS
- White Matter Lesions in Patients With Localization-Related Epilepsy
- (2008) Jacobus F. A. Jansen et al. INVESTIGATIVE RADIOLOGY
- Oligodendroglial Cells and Neurotrophins: A Polyphonic Cantata in Major and Minor
- (2008) Hans H. Althaus et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Low and dysregulated BDNF secretion from immune cells of MS patients is related to reduced neuroprotection
- (2008) David Azoulay et al. JOURNAL OF NEUROIMMUNOLOGY
- Brain-derived neurotrophic factor effects on oligodendrocyte progenitors of the basal forebrain are mediated through trkB and the MAP kinase pathway
- (2008) Ashlee Van't Veer et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Characterizing White Matter Damage in Rat Spinal Cord with Quantitative MRI and Histology
- (2008) Piotr Kozlowski et al. JOURNAL OF NEUROTRAUMA
- Higher expression of BDNF receptor gp145trkB is associated with lower apoptosis intensity in T cell lines in multiple sclerosis
- (2008) Lorenzo De Santi et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Effect of laquinimod on MRI-monitored disease activity in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study
- (2008) G Comi et al. LANCET
- Novel therapeutic strategies for multiple sclerosis — a multifaceted adversary
- (2008) Rocio S. Lopez-Diego et al. NATURE REVIEWS DRUG DISCOVERY
- Deletion of Mecp2 in Sim1-Expressing Neurons Reveals a Critical Role for MeCP2 in Feeding Behavior, Aggression, and the Response to Stress
- (2008) Sharyl L. Fyffe et al. NEURON
- Glial reactions and degeneration of myelinated processes in spinal cord gray matter in chronic experimental autoimmune encephalomyelitis
- (2008) J. Wu et al. NEUROSCIENCE
- Peripherally-Derived BDNF Promotes Regeneration of Ascending Sensory Neurons after Spinal Cord Injury
- (2008) Xing-Yun Song et al. PLoS One
- MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription
- (2008) M. Chahrour et al. SCIENCE
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