Systemic Proteasome Inhibition Induces Sustained Post-stroke Neurological Recovery and Neuroprotection via Mechanisms Involving Reversal of Peripheral Immunosuppression and Preservation of Blood–Brain–Barrier Integrity

Paradigms of protein degradation by the proteasome

(2014) Tomonao Inobe et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Neurogenesis and Inflammation after Ischemic Stroke: What is Known and Where We Go from Here

(2014) Matthew K Tobin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Injury-Induced Neurogenesis

(2014) Tzong-Shiue Yu et al.   NEUROSCIENTIST

Biodistribution and Efficacy Studies of the Proteasome Inhibitor BSc2118 in a Mouse Melanoma Model

(2014) Izabela Mlynarczuk-Bialy et al.   Translational Oncology

Effects of neural progenitor cells on post-stroke neurological impairment—a detailed and comprehensive analysis of behavioral tests

(2014) Thorsten R. Doeppner et al.   Frontiers in Cellular Neuroscience

Effects of acute versus post-acute systemic delivery of neural progenitor cells on neurological recovery and brain remodeling after focal cerebral ischemia in mice

(2014) T R Doeppner et al.   Cell Death & Disease

The Immune Response to Acute Focal Cerebral Ischemia and Associated Post-stroke Immunodepression: A Focused Review

(2014)   Aging and Disease

Targeting the Ubiquitin Proteasome System: Beyond Proteasome Inhibition

(2013) Wendy Xolalpa et al.   CURRENT PHARMACEUTICAL DESIGN

From Bortezomib to other Inhibitors of the Proteasome and Beyond

(2013) Daniela Buac et al.   CURRENT PHARMACEUTICAL DESIGN

Exacerbation of ischemic brain injury in hypercholesterolemic mice is associated with pronounced changes in peripheral and cerebral immune responses

(2013) Josephine Herz et al.   NEUROBIOLOGY OF DISEASE

The unique functions of tissue-specific proteasomes

(2013) Andrea Kniepert et al.   TRENDS IN BIOCHEMICAL SCIENCES

The novel proteasome inhibitor BSc2118 protects against cerebral ischaemia through HIF1A accumulation and enhanced angioneurogenesis

(2012) Thorsten R. Doeppner et al.   BRAIN

Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation

(2012) Dirk M Hermann et al.   LANCET NEUROLOGY

Roles for HIF-1α in neural stem cell function and the regenerative response to stroke

(2011) Lee Anna Cunningham et al.   BEHAVIOURAL BRAIN RESEARCH

Novel Proteasome Inhibitors to Overcome Bortezomib Resistance

(2011) Amy M. Ruschak et al.   JNCI-Journal of the National Cancer Institute

Stroke and the immune system: from pathophysiology to new therapeutic strategies

(2011) Richard Macrez et al.   LANCET NEUROLOGY

Intermittent Hypoxia after Transient Focal Ischemia Induces Hippocampal Neurogenesis and c-Fos Expression and Reverses Spatial Memory Deficits in Rats

(2011) Yi-Wei Tsai et al.   PLoS One

BSc2118 is a novel proteasome inhibitor with activity against multiple myeloma

(2010) Jan Sterz et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Acute Hepatocyte Growth Factor Treatment Induces Long-Term Neuroprotection and Stroke Recovery via Mechanisms Involving Neural Precursor Cell Proliferation and Differentiation

(2010) Thorsten R Doeppner et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

O2 regulates stem cells through Wnt/β-catenin signalling

(2010) Jolly Mazumdar et al.   NATURE CELL BIOLOGY

Hypoxia Inducible Factor 1 as a Therapeutic Target in Ischemic Stroke

(2009) Honglian Shi   CURRENT MEDICINAL CHEMISTRY

Mutant Ubiquitin-Mediated β-Secretase Stability via Activation of Caspase-3 is Related to β-Amyloid Accumulation in Ischemic Striatum in Rats

(2009) Yong Zhang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke

(2009) Mathias Gelderblom et al.   STROKE

Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia

(2008) E. Candelario-Jalil et al.   NEUROSCIENCE