Loss of Diacylglycerol Kinase-Ζ Inhibits Cell Proliferation and Survival in Human Gliomas

Phosphatidic acid (PA) increases EGF receptor (EGFR) expression by stabilizing mRNA, inhibiting RNAse-A, and by inhibiting lysosomal and proteasomal degradation of the internalized EGFR

(2015) Nathaniel Hatton et al.   MOLECULAR AND CELLULAR BIOLOGY

Increased diacylglycerol kinase ζ expression in human metastatic colon cancer cells augments Rho GTPase activity and contributes to enhanced invasion

(2014) Kun Cai et al.   BMC CANCER

Phospholipase D and the Maintenance of Phosphatidic Acid Levels for Regulation of Mammalian Target of Rapamycin (mTOR)

(2014) David A. Foster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Roles of Diacylglycerol Kinases in the Central Nervous System: Review of Genetic Studies in Mice

(2014) Mitsue Ishisaka et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

Glioblastoma and Other Malignant Gliomas

(2013) Antonio Omuro   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cytoplasmic localization of DGK  exerts a protective effect against p53-mediated cytotoxicity

(2013) T. Tanaka et al.   JOURNAL OF CELL SCIENCE

A miR-297/hypoxia/DGK-α axis regulating glioblastoma survival

(2013) Benjamin Kefas et al.   NEURO-ONCOLOGY

CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2006-2010

(2013) Q. T. Ostrom et al.   NEURO-ONCOLOGY

Evading apoptosis in cancer

(2013) Kaleigh Fernald et al.   TRENDS IN CELL BIOLOGY

Diacylglycerol Kinase   Is a Critical Signaling Node and Novel Therapeutic Target in Glioblastoma and Other Cancers

(2013) C. L. Dominguez et al.   Cancer Discovery

DGKζ is degraded through the cytoplasmic ubiquitin–proteasome system under excitotoxic conditions, which causes neuronal apoptosis because of aberrant cell cycle reentry

(2012) Masashi Okada et al.   CELLULAR SIGNALLING

Genetics of adult glioma

(2012) McKinsey L. Goodenberger et al.   Cancer Genetics

iASPP is over-expressed in human non-small cell lung cancer and regulates the proliferation of lung cancer cells through a p53 associated pathway

(2011) Jinfeng Chen et al.   BMC CANCER

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

HES6 gene is selectively overexpressed in glioma and represents an important transcriptional regulator of glioma proliferation

(2011) S Haapa-Paananen et al.   ONCOGENE

Cancer stem cells in solid tumors: Is ‘evading apoptosis’ a hallmark of cancer?

(2011) Heiko Enderling et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Diacylglycerol kinase ζ: At the crossroads of lipid signaling and protein complex organization

(2011) Esther Rincón et al.   PROGRESS IN LIPID RESEARCH

Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells

(2010) Kazuhito Sasaki et al.   BMC CANCER

Genetic Dissection of the Oncogenic mTOR Pathway Reveals Druggable Addiction to Translational Control via 4EBP-eIF4E

(2010) Andrew C. Hsieh et al.   CANCER CELL

Identification of a functional nuclear export sequence in diacyl glycerol kinase-ζ

(2010) Camilla Evangelisti et al.   CELL CYCLE

Survival of Patients with Newly Diagnosed Glioblastoma Treated with Radiation and Temozolomide in Research Studies in the United States

(2010) S. A. Grossman et al.   CLINICAL CANCER RESEARCH

A human functional protein interaction network and its application to cancer data analysis

(2010) Guanming Wu et al.   GENOME BIOLOGY

TIS21/BTG2/PC3 and cyclin D1 are key determinants of nuclear diacylglycerol kinase-ζ-dependent cell cycle arrest

(2009) Camilla Evangelisti et al.   CELLULAR SIGNALLING

Regulation of Angiogenic Factors by HDM2 in Renal Cell Carcinoma

(2008) V. A. Carroll et al.   CANCER RESEARCH

MDM2 Regulates Dihydrofolate Reductase Activity through Monoubiquitination

(2008) M. Maguire et al.   CANCER RESEARCH

Drug development of MET inhibitors: targeting oncogene addiction and expedience

(2008) Paolo M. Comoglio et al.   NATURE REVIEWS DRUG DISCOVERY

Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia

(2008) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA