Article
Oncology
Uros Bumbasirevic, Marko Zivkovic, Milos Petrovic, Vesna Coric, Nikola Lisicic, Nebojsa Bojanic
Summary: In the treatment of seminoma, routine radiotherapy is no longer recommended for clinical stage I patients. Instead, a risk-adapted approach is preferred, with adjuvant carboplatin chemotherapy as the main treatment option. Active surveillance can prevent overtreatment but requires strict follow-up and increased radiation exposure.
Article
Oncology
J. Aparicio, X. Garcia del Muro, P. Maroto, J. Terrasa, D. Castellano, R. Bastus, J. Guma, N. Sagastibeltza, I Duran, S. Ochenduszko, J. A. Meana, J. Garcia-Sanchez, J. A. Arranz, R. Girones, J. R. Germa
Summary: In the context of risk-adapted treatment for stage I seminoma, administering two courses of AC to patients with tumor size > 4 cm and/or rete testis invasion is associated with a higher incidence of second recurrences but does not significantly modify the pattern of relapses or their outcome.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2021)
Article
Oncology
Bela Mrinakova, Karol Kajo, Viera Lehotska, Martina Ondrusova, Sona Balogova, Zuzana Pinakova, Vera Novotna, Vanda Usakova, Lucia Fedorkova, Iveta Waczulikova, Juraj Kausitz, Dalibor Ondrus
Summary: This study compared the impact of active surveillance (S) and adjuvant chemotherapy (ACT) on the survival of patients with clinical stage I testicular seminoma. The results suggest that for high-risk patients, ACT may be a suitable treatment, while S is a viable option for low-risk patients.
Article
Oncology
Angelika Terbuch, Florian Posch, Thomas Bauernhofer, Philipp J. Jost, Richard Partl, Heidi Stranzl-Lawatsch, Giulia Baciarello, Karim Fizazi, Patrizia Giannatempo, Elena Verzoni, Christopher Sweeney, Praful Ravi, Ben Tran, Umberto Basso, Jeff White, Bruno Vincenzi, Christoph Oing, Hernan Javier Cutuli, Klaus Peter Dieckmann, Marija Gamulin, Michal Chovanec, Christian Daniel Fankhauser, Axel Heidenreich, Osama Mohamad, Constance Thibault, Stefanie Fischer, Silke Gillessen
Summary: This study retrospectively analyzed data from 61 patients with testicular seminoma who experienced relapse after radiation therapy. The results showed that cisplatin-based chemotherapy led to excellent outcomes for these patients. The median time to relapse after radiation therapy was 15.6 months, and some patients relapsed more than 2 years or even 5 years later.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Urology & Nephrology
Muhannad Alsyouf, Siamak Daneshmand
Summary: The management of clinical stage II seminoma has shifted towards minimizing long-term morbidities while still achieving oncologic cure, with surgery emerging as an important treatment option for these patients. Studies such as SEMS and PRIMETEST have shown promising results for primary retroperitoneal lymph node dissection in clinical stage II seminoma.
WORLD JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Manar Mahmoud Sayed, Azza Mohamad Nasr, Ibtesam Mohamad Saad Eldin, Yasser Anwar Abdelazim
Summary: We retrospectively analyzed the impact of post-orchiectomy treatment modalities on the prognosis of clinical stage I seminoma patients who presented to our institute from 2005 to 2019. The results showed that regardless of the post-operative approach, the 5-year overall survival rate for all patients was 100%. The 5-year disease-free survival rate was 100% for patients who received adjuvant chemotherapy or radiotherapy, and 93% for patients who were kept under active surveillance.
ARCHIVIO ITALIANO DI UROLOGIA E ANDROLOGIA
(2023)
Editorial Material
Hematology
Izidore S. Lossos
Summary: In a retrospective analysis by Bobillo et al, it was found that using R-CHOP or R-CHOP-like regimens to treat stage I DLBCL patients led to excellent overall outcomes. However, patients with extranodal presentation had worse prognosis compared to those with nodal disease. Consolidation with radiation therapy improved progression-free survival and overall survival in extranodal patients, particularly in PET-positive patients at the end of immunochemotherapy.
Article
Oncology
Isamu Tachibana, Andre Alabd, Yan Tong, Alex Piroozi, Mohammad Mahmoud, Sean Q. Kern, Timothy A. Masterson, Nabil Adra, Richard S. Foster, Nasser H. Hanna, Lawrence H. Einhorn, Clint Cary
Summary: This study confirmed the efficacy of surgery for CS II seminoma, avoiding the side effects of chemotherapy or radiotherapy. Patients with delayed development of CS II disease had the best surgical outcomes, and careful surveillance may prevent overtreatment in patients with borderline CS II disease.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Urology & Nephrology
Vasco Quaresma, Diogo Henriques, Lorenzo Marconi, Joao Lorigo, Ana-Marta Ferreira, Roberto Jarimba, Pedro Nunes, Arnaldo Figueiredo, Belmiro Parada
Summary: This study evaluated the clinical outcomes of 55 patients with stage I seminoma and analyzed the factors influencing treatment choice and oncological outcomes. The results showed that active surveillance is a safe modality, and adjuvant radiotherapy and adjuvant chemotherapy with carboplatin have similar results with fewer adverse effects in the chemotherapy group.
ARCHIVIO ITALIANO DI UROLOGIA E ANDROLOGIA
(2023)
Article
Urology & Nephrology
Goncagul Akdag, Ozkan Alan, Akif Dogan, Zeynep Yuksel, Sedat Yildirim, Oguzcan Kinikoglu, Emre Kudu, Heves Surmeli, Hatice Odabas, Mahmut Emre Yildirim, Nedim Turan
Summary: This study aimed to investigate the effects of treatment options on the prognosis of stage-I testicular seminoma patients. The results showed that adjuvant therapy did not significantly improve disease-free survival compared to active surveillance. Furthermore, lymphovascular invasion was identified as an important prognostic indicator for determining the treatment strategy and prognosis.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Urology & Nephrology
Maximilian Peter Brandt, C. Ruf, K. P. Dieckmann, I Syring, C. Ruckes, T. Nestler, H. U. Schmelz, R. Dotzauer, A. Hiester, P. Albers, D. Nettersheim, C. Bolenz, S. H. Loosen, A. Heidenreich, D. Pfister, A. Haferkamp, F. Zengerling, P. Paffenholz
Summary: In this study, the clinical characteristics and oncological outcomes of patients with CSIS were assessed. Data from five tertiary referring centers in Germany were analyzed, identifying 43 out of 2616 TGCT patients as CSIS. The correct classification of cCSIS was crucial in guiding treatment and achieving a 5-year relapse-free survival rate of 88.9%.
WORLD JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Mitchell M. Huang, Zhuo T. Su, Joseph G. Cheaib, Michael J. Biles, Mohamad E. Allaf, Hiten D. Patel, Phillip M. Pierorazio
Summary: The study shows that non-risk-adapted active surveillance (NRAS) is the most cost-effective management strategy for patients with clinical stage I (CSI) seminoma, offering the lowest per-patient healthcare cost and highest Quality-Adjusted Life Years (QALYs) gained over a 10-year period. NRAS also allows a high percentage of patients to avoid unnecessary treatment compared to current practice and risk-adapted active surveillance.
EUROPEAN UROLOGY FOCUS
(2021)
Article
Oncology
Alexandros Papachristofilou, Jens Bedke, Stefanie Hayoz, Ulrich Schratzenstaller, Miklos Pless, Marcus Hentrich, Susanne Krege, Anja Lorch, Daniel -M Aebersold, Paul Martin Putora, Dominik-R Berthold, Deborah Zihler, Friedemann Zengerling, Annette Dieing, Arndt -Christian Mueller, Corinne Schaer, Christine Biaggi, Silke Gillessen, Richard Cathomas
Summary: A novel approach combining de-escalated chemotherapy with de-escalated involved node radiotherapy resulted in a 3-year progression-free survival rate of 93.7% with minimal toxic effects. The primary endpoint was not met, but the findings suggest that this regimen could be an alternative to standard-of-care treatment. Further research is needed to confirm these results.
Article
Medicine, General & Internal
Aihong Bi, Sifu Yang, Yang Ding, Yong Yu, Wenming Zhan, Tao Song
Summary: This study investigates the prognostic value of radiotherapy (RT) and chemotherapy (CT) in the management of Merkel cell carcinoma (MCC) patients. The results show that RT is associated with significantly improved overall survival (OS), while CT negatively impacts OS. However, in stage III patients, RT is still a positive factor, and CT is not significantly associated with OS.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Mariano Provencio, Ernest Nadal, Jose L. Gonzalez-Larriba, Alex Martinez-Marti, Reyes Bernabe, Joaquim Bosch-Barrera, Joaquin Casal-Rubio, Virginia Calvo, Amelia Insa, Santiago Ponce, Noemi Reguart, Javier de Castro, Joaquin Mosquera, Manuel Cobo, Andres Aguilar, Guillermo Lopez Vivanco, Carlos Camps, Rafael Lopez-Castro, Teresa Moran, Isidoro Barneto, Delvys Rodriguez-Abreu, Roberto Serna-Blasco, Raquel Benitez, Carlos Aguado de la Rosa, Ramon Palmero, Florentino Hernando-Trancho, Javier Martin-Lopez, Alberto Cruz-Bermudez, Bartomeu Massuti, Atocha Romero
Summary: This study evaluated the efficacy of the neoadjuvant nivolumab plus chemotherapy regimen on operable stage III non-small-cell lung cancer (NSCLC) patients. The results showed that patients receiving the combination therapy had a higher rate of pathological complete response and longer survival, indicating the effectiveness of this treatment approach in this patient population.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Takanori Ikeda, Takeshi Yamashita, Masaharu Akao, Hirotsugu Atarashi, Yukihiro Koretsune, Ken Okumura, Wataru Shimizu, Hiroyuki Tsutsui, Kazunori Toyoda, Atsushi Hirayama, Masahiro Yasaka, Takenori Yamaguchi, Satoshi Teramukai, Tetsuya Kimura, Jumpei Kaburagi, Atsushi Takita, Hiroshi Inoue
Summary: Active cancer does not affect the incidence of stroke/systemic embolic events in elderly patients with non-valvular atrial fibrillation (NVAF), but patients with cancer have a higher incidence of major bleeding events and all-cause death compared to those without cancer.
CIRCULATION JOURNAL
(2022)
Article
Oncology
Motohiro Tamiya, Kei Fujikawa, Hidekazu Suzuki, Toshihide Yokoyama, Takeshi Uenami, Akihiro Tamiya, Yuki Sato, Go Saito, Junji Uchida, Mitsunori Morita, Tomonori Hirashima, Yasushi Fukuda, Masaki Kanazu, Kazutaka Hosoya, Takuji Suzuki, Kiyonobu Ueno, Daichi Fujimoto, Toru Kumagai, Satoshi Teramukai
Summary: The study found that predicting the acquisition of T790M mutation is crucial for treatment selection in NSCLC patients with EGFR mutations. CART can identify different patient subgroups based on certain background variables, aiding in the selection of the most appropriate first-line EGFR-TKI treatment.
INVESTIGATIONAL NEW DRUGS
(2022)
Article
Oncology
Ayako Muramatsu, Tsutomu Kobayashi, Yuka Kawaji-Kanayama, Hitoji Uchiyama, Nana Sasaki, Nobuhiko Uoshima, Mitsushige Nakao, Ryoichi Takahashi, Kazuho Shimura, Hiroto Kaneko, Miki Kiyota, Katsuya Wada, Yoshiaki Chinen, Koichi Hirakawa, Shin-ichi Fuchida, Chihiro Shimazaki, Shinsuke Mizutani, Taku Tsukamoto, Yuji Shimura, Masafumi Taniwaki, Satoshi Teramukai, Junya Kuroda
Summary: Carfilzomib (CFZ) is a powerful therapy for relapsed/refractory multiple myeloma (RRMM), but it often leads to cardiovascular adverse events (CVAEs). This study found that hypertension is the most common CFZ-related CVAE and suggested that baseline serum interleukin-6 level can predict CFZ-induced hypertension.
LEUKEMIA & LYMPHOMA
(2022)
Editorial Material
Pharmacology & Pharmacy
Akihiro Hirakawa, Hiroyuki Sato, Masataka Igeta, Kei Fujikawa, Takashi Daimon, Satoshi Teramukai
Summary: This article discusses the principles and potential issues of applying Bayesian methods in registration trials in Japan, and introduces examples of clinical trials in which Bayesian approaches are expected to be used. It provides a foundation for discussions between industry and regulatory agencies on the use of Bayesian methods for early drug approval.
PHARMACEUTICAL STATISTICS
(2022)
Article
Health Care Sciences & Services
Keitaro Senoo, Tomonori Miki, Takashi Ohkura, Hibiki Iwakoshi, Tetsuro Nishimura, Hirokazu Shiraishi, Satoshi Teramukai, Satoaki Matoba
Summary: This study aimed to investigate whether a newly developed smartphone app could improve medication adherence in elderly patients with atrial fibrillation. The results showed that the app, named Smart AF, significantly improved medication adherence in this patient population.
JMIR MHEALTH AND UHEALTH
(2022)
Article
Cardiac & Cardiovascular Systems
Sachiko Yamazaki, Satoshi Numata, Hidetake Kawajiri, Kaichiro Manabe, Koki Ikemoto, Satoshi Teramukai, Hitoshi Yaku
SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Ophthalmology
Morio Ueno, Munetoyo Toda, Kohsaku Numa, Hiroshi Tanaka, Kojiro Imai, John Bush, Satoshi Teramukai, Naoki Okumura, Noriko Koizumi, Akihisa Yamamoto, Motomu Tanaka, Chie Sotozono, Junji Hamuro, Shigeru Kinoshita
Summary: This study investigated the safety and efficacy of cultured human corneal endothelial cell (hCEC) injection therapy with mature differentiated cell subpopulations for corneal endothelial failure. Results showed that using a higher proportion of mature cell subpopulations provided rapid recovery of central corneal thickness, better corneal endothelial cell density, and lower decline in cell density over 3 years post-surgery.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Takeshi Yamashita, Masaharu Akao, Hirotsugu Atarashi, Takanori Ikeda, Yukihiro Koretsune, Ken Okumura, Wataru Shimizu, Shinya Suzuki, Hiroyuki Tsutsui, Kazunori Toyoda, Atsushi Hirayama, Masahiro Yasaka, Takenori Yamaguchi, Satoshi Teramukai, Tetsuya Kimura, Yoshiyuki Morishima, Atsushi Takita, Hiroshi Inoue
Summary: This study evaluated the impact of polypharmacy on 2-year outcomes in elderly patients with non-valvular atrial fibrillation. The results showed that patients receiving more medications were older, had poorer renal function, and had more comorbidities. Moreover, with increasing medications, the incidence rates of stroke, bleeding, and other adverse events significantly increased.
CIRCULATION JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Yoshiaki Matsuura, Motohiro Nishimura, Kinya Furuichi, Rina Hirohashi, Satoshi Teramukai, Junichi Shimada, Masayoshi Inoue
Summary: This study investigated the clinical significance and influence of lipiodol spreading during CT-guided marking on VATS surgery. The results showed that lipiodol spreading did not directly affect surgery and complications, but it served as a sign of intrathoracic pleural adhesion, which could lead to prolonged surgical duration and increased bleeding.
GENERAL THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Letter
Geriatrics & Gerontology
Masahiro Akishita, Shinya Suzuki, Hiroshi Inoue, Masaharu Akao, Hirotsugu Atarashi, Takanori Ikeda, Yukihiro Koretsune, Ken Okumura, Wataru Shimizu, Hiroyuki Tsutsui, Kazunori Toyoda, Atsushi Hirayama, Masahiro Yasaka, Takenori Yamaguchi, Satoshi Teramukai, Tetsuya Kimura, Yoshiyuki Morishima, Atsushi Takita, Takeshi Yamashita
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2022)
Correction
Cardiac & Cardiovascular Systems
Hiroshi Inoue, Takeshi Yamashita, Masaharu Akao, Hirotsugu Atarashi, Takanori Ikeda, Ken Okumura, Yukihiro Koretsune, Wataru Shimizu, Hiroyuki Tsutsui, Kazunori Toyoda, Atsushi Hirayama, Masahiro Yasaka, Takenori Yamaguchi, Masahiro Akishita, Naoyuki Hasebe, Kazuomi Kario, Yuji Mizokami, Ken Nagata, Masato Nakamura, Yasuo Terauchi, Takatsugu Yamamoto, Satoshi Teramukai, Tetsuya Kimura, Jumpei Kaburagi, Atsushi Takita
JOURNAL OF CARDIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Hisashi Noma, Kengo Nagashima, Shogo Kato, Satoshi Teramukai, Toshi A. Furukawa
Summary: This article presents flexible random-effects distribution models for meta-analysis, as an alternative to the commonly adopted restrictive normal distribution assumption. Two real-world examples are provided to demonstrate the unsuitability of the normal distribution assumption and the potential for misleading conclusions. The authors also developed a statistical package for easy implementation of these new methods.
JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Urology & Nephrology
Mikio Sugimoto, Takuma Kato, Yoichiro Tohi, Yosuke Shimizu, Ryuji Matsumoto, Takahiro Inoue, Yutaka Takezawa, Kimihiko Masui, Hiroshi Sasaki, Hiromi Hirama, Shiro Saito, Shin Egawa, Toshiyuki Kamoto, Satoshi Teramukai, Shinsuke Kojima, Takashi Kikuchi, Yoshiyuki Kakehi
Summary: This study aimed to investigate the efficacy and safety of enzalutamide after combined androgen blockade for recurrence. The results showed that enzalutamide effectively managed non-metastatic castration-resistant prostate cancer and had high survival rates.
Article
Gastroenterology & Hepatology
Takuji Kawamura, Masau Sekiguchi, Hiroyuki Takamaru, Yasuhiko Mizuguchi, Go Horiguchi, Masayuki Kato, Kiyonori Kobayashi, Miwa Sada, Yasushi Oda, Akira Yokoyama, Takahiro Utsumi, Yosuke Tsuji, Daisuke Ohki, Yoji Takeuchi, Satoki Shichijo, Hiroaki Ikematsu, Koji Matsuda, Satoshi Teramukai, Nozomu Kobayashi, Takahisa Matsuda, Yutaka Saito, Kiyohito Tanaka
Summary: This study aims to explore whether the reasonable detection rate of endoscopically diagnosed lesions as adenomas can be calculated and used as a surrogate colonoscopy quality indicator. By analyzing a database generated from colonoscopy reports, it was found that the number of endoscopic adenomas was higher than pathological adenomas primarily due to non-resection during the examination. The overall polyp detection rate, endoscopic ADR, and pathological ADR were 56.4%, 48.0%, and 32.7% respectively.
DIGESTIVE ENDOSCOPY
(2023)
Article
Cardiac & Cardiovascular Systems
Takanori Ikeda, Takeshi Yamashita, Masaharu Akao, Hirotsugu Atarashi, Yukihiro Koretsune, Ken Okumura, Wataru Shimizu, Shinya Suzuki, Hiroyuki Tsutsui, Kazunori Toyoda, Atsushi Hirayama, Masahiro Yasaka, Takenori Yamaguchi, Satoshi Teramukai, Tetsuya Kimura, Yoshiyuki Morishima, Atsushi Takita, Hiroshi Inoue
Summary: This exploratory study used the ANAFIE dataset to assess the relationship between resting heart rate during AF and clinical outcomes in Japanese elderly NVAF patients. The results showed that a heart rate >= 110 bpm was associated with a significantly higher incidence of cardiac events, and the risk was higher in patients with non-paroxysmal AF.
JOURNAL OF CARDIOLOGY
(2023)