Article
Infectious Diseases
Anthony J. Garcia-Prats, Elin M. Svensson, Jana Winckler, Heather R. Draper, Lee Fairlie, Louvina E. van der Laan, Masebole Masenya, H. Simon Schaaf, Lubbe Wiesner, Jennifer Norman, Rob E. Aarnoutse, Mats O. Karlsson, Paolo Denti, Anneke C. Hesseling
Summary: The study evaluated the pharmacokinetics and safety of high rifampicin doses in 20 children aged 0-12 years, finding that a dose of 65-70 mg/kg of rifampicin was needed to achieve the target exposure in children.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Pooja V. Hegde, Wassihun W. Aragaw, Malcolm S. Cole, Gorakhnath Jachak, Priya Ragunathan, Sachin Sharma, Amaravadhi Harikishore, Gerhard Gruber, Thomas Dick, Courtney C. Aldrich
Summary: Tuberculosis (TB) is a major cause of infectious disease-related mortality and morbidity. Pyrazinamide (PZA) is a crucial component of TB treatment, but its mechanism of action is still unclear. Recent research has shown that the active metabolite pyrazinoic acid (POA) induces targeted protein degradation of the enzyme PanD in Mycobacterium tuberculosis (Mtb). By designing POA analogs, researchers have made progress in improving potency and overcoming PZA resistance.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Infectious Diseases
Qi Nie, Lixuan Tao, Yingying Li, Nanshan Chen, Hua Chen, Yong Zhou, Yanqiu Wang, Huidong Chen, Qiuping Tang, Xianguang Wang, Chaolin Huang, Chengfeng Yang
Summary: The high-dose gatifloxacin-based shortened treatment regimen has shown successful outcomes in treating multidrug- or rifampicin-resistant tuberculosis in many countries. However, it is associated with significant adverse drug reactions, particularly hepatotoxicity and prolongation of the QT interval, which should not be disregarded.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Camilla Hiul Suppli, Anders Norman, Dorte Bek Folkvardsen, Tina Norregaard Gissel, Ulla Moller Weinreich, Anders Koch, Christian Wejse, Troels Lillebaek
Summary: This study describes the first outbreak of multidrug-resistant tuberculosis (MDR-TB) in Denmark, which was identified through genotyping and epidemiological analysis. The findings highlight the importance of collaboration in controlling TB, especially in low-incidence countries like Denmark.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Pharmacology & Pharmacy
Samuel J. Modlin, Mikael Mansjo, Jim Werngren, Chidera M. Ejike, Sven E. Hoffner, Faramarz Valafar
Summary: In this case, a clinical case of pyrazinamide-resistant (PZA-R) tuberculosis (TB) was misdiagnosed as PZA-susceptible (PZA-S) by common molecular diagnostics. Whole Genome Sequencing (WGS) methods detected a large deletion in the pncA gene, indicating PZA-R TB. It was found that a small susceptible subpopulation obscured the majority resistant population, leading to the false susceptibility call. This highlights the importance of developing reliable molecular diagnostics and conducting frequent WGS surveillance to prevent erroneous diagnoses and the spread of resistant strains.
DRUG RESISTANCE UPDATES
(2023)
Article
Public, Environmental & Occupational Health
Y. Liu, Y. Sun, X. Zhang, Z. Zhang, Q. Xing, W. Ren, C. Yao, J. Yu, B. Ding, S. Wang, C. Li
Summary: This study investigated the frequency and distribution of gene mutations related to INH and RIF resistance in MDR-TB strains of Mycobacterium tuberculosis in Beijing, China. The majority of MDR strains belonged to the Beijing genotype, but the mutations were not significantly higher in this genotype. The high prevalence of specific mutations poses a major challenge to TB control in the region, and molecular diagnostics based on gene mutations proved to be an effective method for rapid detection of MDR-TB in Beijing, China.
EPIDEMIOLOGY AND INFECTION
(2021)
Article
Infectious Diseases
Simon Tiberi, Michael J. Vjecha, Adam Zumla, Jessica Galvin, Giovanni Battista Migliori, Alimuddin Zumla
Summary: The global report estimates a high number of MDR-TB cases, emphasizing the need for improving screening, diagnostic, treatment, and follow-up services; New TB drugs are showing promising results in improving cure rates, with a more tolerable six-month oral treatment regimen; The COVID-19 pandemic is negatively impacting TB services, requiring increased investment and expansion of TB treatment services.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Stella Zawedde-Muyanja, Joseph Musaazi, Barbara Castelnuovo, Adithya Cattamanchi, Achilles Katamba, Yukari C. Manabe
Summary: In Uganda, a multifaceted intervention using Xpert(R) MTB/RIF testing was conducted to improve TB treatment initiation among patients diagnosed with TB. The intervention included medical education sessions, modified laboratory request forms, and redesigned workflow processes. The results showed a significant improvement in the turnaround time for sputum test results and an increase in the proportion of patients starting treatment within two weeks of diagnosis.
Review
Infectious Diseases
Mohammad Bagheri, Ali Pormohammad, Fatemeh Fardsanei, Ali Yadegari, Maniya Arshadi, Behnaz Deihim, Bahareh Hajikhani, Ray J. Turner, Farima Khalili, Seyyed Mohammad Javad Mousavi, Masoud Dadashi, Mehdi Goudarzi, Hossein Dabiri, Hossein Goudarzi, Mehdi Mirsaeidi, Mohammad Javad Nasiri
Summary: This systematic review and meta-analysis evaluated the diagnostic accuracy of sequencing PZA susceptibility tests, showing a sensitivity of 87% and specificity of 94.7%. The results suggest that PZA sequencing may be used in conjunction with conventional tests, especially in situations where culture tests are not feasible.
MICROBIAL DRUG RESISTANCE
(2022)
Review
Biochemistry & Molecular Biology
Amit Kumar, Bidhu Bhusan Karkara, Gautam Panda
Summary: This article summarizes the importance of developing new drugs for tuberculosis, current research directions and efforts, and aims to provide assistance in designing new chemical entities (NCEs) for Mtb.
CHEMICAL BIOLOGY & DRUG DESIGN
(2021)
Article
Multidisciplinary Sciences
Zirwatul Adilah Aziz, Noorliza Mohamad Noordin, Wan Mazlina Wan Mohd, Mohd Amin Kasim
Summary: Diagnosis and treatment of tuberculosis infection (TBI) are crucial for tuberculosis elimination. A new digital lateral flow assay, QIAreach QuantiFERON-TB (QIAreach QFT), showed high agreement with QuantiFERON-TB Gold Plus (QFT-Plus) assay in terms of sensitivity, specificity, and overall agreement. QIAreach QFT could serve as an accurate and reliable point-of-need test for TB infection diagnosis, especially in decentralized settings with limited laboratory expertise and infrastructure.
Article
Multidisciplinary Sciences
Mary Ann D. Lansang, Marissa M. Alejandria, Irwin Law, Noel R. Juban, Maria Lourdes E. Amarillo, Olivia T. Sison, Jose Rene B. Cruz, Concepcion F. Ang, Joseph Adrian L. Buensalido, Johanna Patricia A. Canal, Nina T. Castillo-Carandang, Cynthia P. Cordero, Donna Mae G. Gaviola, Mary Ann J. Ladia, Jacinto Blas V. Mantaring, Myrna T. Mendoza, Maria Sonia S. Salamat, Hilton Y. Lam, Marina Tadolini, Anna Marie Celina G. Garfin
Summary: The 3rd national tuberculosis survey in the Philippines in 2007 showed a significant decline in TB prevalence, leading to increased investments for TB control. However, a survey conducted in 2016 found that the TB burden in the Philippines was higher than estimated from routine surveillance data, with no evidence of a decline in smear and culture positive TB cases despite significant investments in TB control. New strategies for case-finding and patient-centered care need to be intensified and expanded.
Article
Infectious Diseases
Vannesa Yue May Teng, Yan Ting Chua, Eunice En Ni Lai, Shilpa Mukherjee, Jessica Michaels, Chen Seong Wong, Liang Shen, Yee Sin Leo, Barnaby Young, Sophia Archuleta, Catherine W. M. Ong
Summary: The study found that screening for latent TB infection is low among HIV-TB co-infected patients in Singapore, and initiation of ART treatment may be delayed for some patients. It was also noted that pulmonary TB patients with HIV can still be infectious despite showing a normal chest x-ray.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Microbiology
Kone Kaniga, Rumina Hasan, Ruwen Jou, Edita Vasiliauskiene, Charoen Chuchottaworn, Nazir Ismail, Beverly Metchock, Skaidrius Miliauskas, Nguyen Viet Nhung, Camilla Rodrigues, Soyoun Shin, Hulya Simsek, Saijai Smithtikarn, Anh Le Thi Ngoc, Jirakan Boonyasopun, Mubin Kazi, Seungmo Kim, Phalin Kamolwat, Greta Musteikiene, Catherine Ann Sacopon, Sabira Tahseen, Laima Vasiliauskaite, Mei-Hua Wu, Shaheed Vally Omar
Summary: Bedaquiline Drug Resistance Emergence Assessment in Multidrug-resistant tuberculosis (MDR-TB) (DREAM) conducted a 5-year surveillance study across 11 countries, finding low resistance rates to Bedaquiline and no treatment-limiting patterns of cross-resistance or coresistance with key TB drugs.
JOURNAL OF CLINICAL MICROBIOLOGY
(2022)
Review
Chemistry, Medicinal
Pobitra Borah, Pran Kishore Deb, Katharigatta N. Venugopala, Nizar A. Al-Shar'i, Vinayak Singh, Satyendra Deka, Amavya Srivastava, Vinod Tiwari, Raghu Prasad Mailavaram
Summary: Human tuberculosis is primarily caused by Mycobacterium tuberculosis and presents a complex disease with factors like reactivation of latent form, disease progression in immunocompromised patients, emergence of drug-resistant strains, and drug interactions. New anti-TB drugs are needed to overcome these obstacles, and scientific advancements have revolutionized diagnosis, prevention, and treatment, but there are still knowledge gaps and challenges to address in future TB control programs.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2021)
Article
Respiratory System
Tavs Qvist, Marita Gilljam, Bodil Jonsson, David Taylor-Robinson, Soren Jensen-Fangel, Mikala Wang, Anita Svahn, Karsten Kotz, Lennart Hansson, Annika Hollsing, Christine R. Hansen, Pal L. Finstad, Tania Pressler, Niels Hoiby, Terese L. Katzenstein
JOURNAL OF CYSTIC FIBROSIS
(2015)
Article
Infectious Diseases
Bodil Jonsson, Elisabet Lonnermark, Malin Ridell
INFECTIOUS DISEASES
(2015)
Article
Multidisciplinary Sciences
Josephine M. Bryant, Dorothy M. Grogono, Daniela Rodriguez-Rincon, Isobel Everall, Karen P. Brown, Pablo Moreno, Deepshikha Verma, Emily Hill, Judith Drijkoningen, Peter Gilligan, Charles R. Esther, Peadar G. Noone, Olivia Giddings, Scott C. Bell, Rachel Thomson, Claire E. Wainwright, Chris Coulter, Sushil Pandey, Michelle E. Wood, Rebecca E. Stockwell, Kay A. Ramsay, Laura J. Sherrard, Timothy J. Kidd, Nassib Jabbour, Graham R. Johnson, Luke D. Knibbs, Lidia Morawska, Peter D. Sly, Andrew Jones, Diana Bilton, Ian Laurenson, Michael Ruddy, Stephen Bourke, Ian C. J. W. Bowler, Stephen J. Chapman, Andrew Clayton, Mairi Cullen, Owen Dempsey, Miles Denton, Maya Desai, Richard J. Drew, Frank Edenborough, Jason Evans, Jonathan Folb, Thomas Daniels, Helen Humphrey, Barbara Isalska, Soren Jensen-Fangel, Bodil Jonsson, Andrew M. Jones, Terese L. Katzenstein, Troels Lillebaek, Gordon MacGregor, Sarah Mayell, Michael Millar, Deborah Modha, Edward F. Nash, Christopher O'Brien, Deirdre O'Brien, Chandra Ohri, Caroline S. Pao, Daniel Peckham, Felicity Perrin, Audrey Perry, Tania Pressler, Laura Prtak, Tavs Qvist, Ali Robb, Helen Rodgers, Kirsten Schaffer, Nadia Shafi, Jakko van Ingen, Martin Walshaw, Danie Watson, Noreen West, Joanna Whitehouse, Charles S. Haworth, Simon R. Harris, Diane Ordway, Julian Parkhill, R. Andres Floto
Article
Infectious Diseases
Daniel Bengtsson, Martin Westerberg, Susanne Nielsen, Malin Ridell, Bodil Jonsson
INFECTIOUS DISEASES
(2018)
Article
Pediatrics
Birger Trollfors, Ruth Stangebye-Nielsen, Elisabeth Karlsson, Bodil Jonsson, Leif Dotevall
Article
Microbiology
Malene Winther, Michael Gabl, Tudor I. Oprea, Bodil Jonsson, Francois Boulay, Johan Bylund, Claes Dahlgren, Huamei Forsman
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2014)
Article
Immunology
Bodil Jonsson, Malin Ridell, Agnes E. Wold
Article
Computer Science, Cybernetics
Hector A. Caltenco, Bjorn Breidegard, Bodil Jonsson, Lotte N. S. Andreasen Struijk
INTERNATIONAL JOURNAL OF HUMAN-COMPUTER INTERACTION
(2012)
Article
Microbiology
Nahid Kondori, Marita Gilljam, Anders Lindblad, Bodil Jonsson, Edward R. B. Moore, Christine Wenneras
JOURNAL OF CLINICAL MICROBIOLOGY
(2011)
Article
Immunology
Bodil Jonsson, Malin Ridell, Agnes E. Wold
MICROBES AND INFECTION
(2012)
Article
Immunology
Bodil Jonsson, Malin Ridell, Agnes E. Wold
MICROBES AND INFECTION
(2012)
Article
Multidisciplinary Sciences
Johanna Thegerstrom, Bodil Jonsson, Lars Brudin, Bjorn Olsen, Agnes E. Wold, Jan Ernerudh, Vanda Friman
Article
Immunology
Bodil E. Jonsson, Johan Bylund, Bengt R. Johansson, Esbjorn Telemo, Agnes E. Wold
PATHOGENS AND DISEASE
(2013)
Article
Multidisciplinary Sciences
Nader Alaridah, Erika Tang Hallback, Jeanette Tangrot, Niclas Winqvistz, Erik Sturegard, Kerstin Floren-Johanssons, Bodil Jonsson, Erik Tenland, Christina Welinder-Olssons, Patrik Medstrand, Bertil Kaijser, Gabriela Godaly
SCIENTIFIC REPORTS
(2019)