Article
Engineering, Environmental
Yuqing Zhu, Xiaohe Zheng, Rui Zhu, Hongrui Zhao, Hongli Zhai, Feiyang Qian, Tenghua Zhang, Zihui Xie, Silan Liu, Bowen Jiang, Yan Sheng, Jiaming Hu
Summary: The researchers developed a versatile diagnostic biosensor called SMARTLOCK, which combines DNA tetrahedron, nonlinear HCR and CRISPR-Cas12a system for simultaneous detection of multiple biomarkers. The SMARTLOCK sensor demonstrated high selectivity and sensitivity in detecting miR-141, miR-375, miR21, ATP, cortisol, insulin, and their combinations. This study shows the potential of SMARTLOCK as a highly accurate and cost-effective tool for the screening, diagnosis, and prognosis of various diseases.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biophysics
Ioana Cozma, Erin M. McConnell, John D. Brennan, Yingfu Li
Summary: DNAzymes, synthetic functional nucleic acids, are widely used in biosensing applications for molecular recognition and signal generation. RCDs and PMDs have proven to be particularly effective for use in proof-of-concept biosensing systems, catalyzing RNA cleavage and peroxidation reactions of chromophores, respectively. This emerging field of DNAzyme-based biosensors shows great promise for development in the coming decades.
BIOSENSORS & BIOELECTRONICS
(2021)
Review
Environmental Sciences
Neelam Yadav, Vinod Kumar Garg, Anil Kumar Chhillar, Jogender Singh Rana
Summary: Environmental deterioration caused by human activities poses a threat to sustainable, clean, and green environment. Environmental nanotechnology provides an innovative solution by reducing unnecessary use of raw materials, electricity, excessive use of agrochemicals, and release of industrial effluents.
Review
Chemistry, Multidisciplinary
Ting Yu, Yunlei Xianyu
Summary: Array-based biosensors are effective tools for distinguishing minute differences in biomolecules like bacteria. Recognition of bacteria, signal readout, and mathematical analysis are crucial for discrimination ability. Various strategies for bacteria recognition include biomolecule-receptor interaction, material-bacteria interaction, and targeting bacterial metabolites.
Review
Biochemical Research Methods
Kaylin Cleo Januarie, Onyinyechi V. Uhuo, Emmanuel Iwuoha, Usisipho Feleni
Summary: Tuberculosis is a major infectious disease worldwide caused by Mycobacterium tuberculosis, with early diagnosis and treatment being crucial for control. However, current TB sensing techniques like ELISA and IGRAs have limitations in sensitivity and stage differentiation. Novel biosensor and microfluidic approaches show promise in improving interferon-gamma detection for TB diagnosis.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Analytical
Hye Kyu Choi, Jinho Yoon
Summary: The accurate and rapid diagnosis of viral diseases using biosensors has gained attention in recent years. Nanotechnology offers a promising strategy to overcome the limitations of conventional viral nucleic acid-based biosensors. By implementing nanotechnologies, such as functional nanomaterials and surface nanoengineering, the performance and range of sensing targets of biosensors can be improved. This review provides interdisciplinary information on nanotechnology-assisted biosensors, giving a valuable basis for the development of novel viral nucleic acid biosensors.
Review
Chemistry, Multidisciplinary
Jing Hu, Yunlei Xianyu
Summary: The interaction between nanoparticles and plants significantly advances research fields such as nanotechnology, agriculture, food science, electrical engineering, and biomedicine. Nanoparticles can serve as growth regulators, pesticides, fertilizers, antimicrobial agents, biosensors, and plant mimics in plant studies. Plants, on the other hand, contribute to the development of nanotechnology by inspiring the preparation of nanoparticles and plant-inspired nanobionics.
Review
Chemistry, Multidisciplinary
Kazbek Dyussembayev, Prabhakaran Sambasivam, Ido Bar, Jeremy C. Brownlie, Muhammad J. A. Shiddiky, Rebecca Ford
Summary: Plant pathogens are major contributors to reduced crop productivity, with chemical control methods potentially leading to loss of fungal susceptibility. The development of early and accurate pathogen detection biosensing systems holds great promise, while traditional methods often lack accuracy, specificity, and rapidity.
FRONTIERS IN CHEMISTRY
(2021)
Article
Engineering, Biomedical
James Joseph, Kevin N. Baumann, Alejandro Postigo, Laura Bollepalli, Sarah E. Bohndiek, Silvia Hernandez-Ainsa
Summary: Optoacoustic tomography allows non-invasive deep tissue imaging of optical contrast, with applications in cancer imaging utilizing molecular imaging contrast agents based on NIR dyes. Biodegradable DNA-based nanocarriers enable precise incorporation of NIR dyes for enhanced optoacoustic signal generation and prolonged blood circulation, leading to improved tumor accumulation through the EPR effect. In vivo imaging of tumor xenografts in mice using DNA-NCs shows enhanced OT signals compared to free fluorophores, indicating potential for improved tumor imaging efficacy with clinically relevant NIR dyes.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Biophysics
Samet Kocabey, Guillermo P. Acuna, Curzio Ruegg
Summary: miRNA has the potential to be biomarkers for early disease detection, and the sensitive and accurate detection of miRNA can improve diagnosis and treatment of diseases, especially cancer. This study introduces a DNA origami nanoarray system that uses super-resolution microscopy technique DNA-PAINT to detect miRNAs based on their distance to boundary markers. The sensor can detect up to 4 miRNAs separately or in combination, with high sensitivity and large dynamic range, without the need for amplification. The detection system can also discriminate single base mismatches with low false positive rates. This ultrasensitive and amplification-free miRNA detection method has been successfully applied to detect breast-cancer associated miRNAs in cell extracts and plasma.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Multidisciplinary Sciences
Liwen Jiang, Ke Zhang, Yixin Yao, Shuai Li, Jiao Li, Zhen Tian, Weili Zhang
Summary: This article introduces a new method for analyzing aqueous salt solutions using terahertz optoacoustics. The method manipulates terahertz optoacoustic signals through temperature control to reduce water background and provide more solute information. The results demonstrate the significant potential of this method for distinguishing different salt solutions and quantitatively analyzing salt concentrations.
Review
Engineering, Environmental
George Luka, Ehsan Samiei, Nishat Tasnim, Arash Dalili, Homayoun Najjaran, Mina Hoorfar
Summary: Cryptosporidium, a critical waterborne protozoan pathogen, has been a major cause of death and serious illnesses worldwide, with high costs for detection and treatment. Current detection methods have limitations and there is a need for improving and developing low-cost, portable, and rapid detection tools for applications in the water quality industry. Recent advances in nanotechnology, biosensing, and microfluidics have facilitated the development of sophisticated tools for detecting Cryptosporidium.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Chemistry, Analytical
Hussamaldeen Jaradat, Ammar Al-Hamry, Mohammed Ibbini, Najla Fourati, Olfa Kanoun
Summary: This study developed an H. pylori immunosensor based on detecting the biomarker HopQ in saliva. The sensor was created by modifying screen-printed carbon electrodes with MWCNT-COOH decorated with gold nanoparticles and grafting HopQ capture antibody on the surface. The sensor showed excellent sensitivity and linearity in the 10 pg/mL-100 ng/mL range, with a limit of detection of 2.0 pg/mL and a limit of quantification of 8.6 pg/mL. It demonstrated high selectivity, stability, reproducibility, and cost-effectiveness for early detection of H. pylori.
Review
Chemistry, Multidisciplinary
Goeun Park, Hanbin Park, Sang-Chan Park, Moonbong Jang, Jinho Yoon, Jae-Hyuk Ahn, Taek Lee
Summary: Zika virus (ZIKV) and dengue virus (DENV) infections are becoming more common due to global warming. Accurate diagnosis is essential for controlling these viral infections. Recent research has focused on developing biosensors for the accurate diagnosis of ZIKV and DENV using DNA nanotechnology. These biosensors offer advantages over traditional diagnostic methods, such as PCR and ELISA. DNA can serve as a bioreceptor and be easily modified with functional groups, making it a valuable tool for the development of specific bioreceptors that bind to viral proteins or nucleic acids. This review discusses advances in DNA-nanotechnology-based biosensors for the detection of ZIKV and DENV.
Review
Chemistry, Analytical
Omid Heydari Shayesteh, Reza Mahjub, Akram Ranjbar, Katayoun Derakhshandeh, Mahdi Jamshidi
Summary: Accurate determination of narrow therapeutic index drugs is crucial for clinicians to make clear judgments regarding drug therapy for patients. Traditional analytical techniques have limitations, leading to high interest in nano/(bio)sensing technology.
Article
Physics, Multidisciplinary
S. Egerev
ACTA PHYSICA POLONICA A
(2015)
Article
Acoustics
S. A. Ermilov, R. Su, A. Conjusteau, F. Anis, V. Nadvoretskiy, M. A. Anastasio, A. A. Oraevsky
ULTRASONIC IMAGING
(2016)
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Biochemical Research Methods
Anton Liopo, Richard Su, Dmitri A. Tsyboulski, Alexander A. Oraevsky
JOURNAL OF BIOMEDICAL OPTICS
(2016)
Article
Optics
Yang Lou, Kun Wang, Alexander A. Oraevsky, Mark A. Anastasio
JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION
(2016)
Review
Biochemistry & Molecular Biology
Dario Livio Longo, Rachele Stefania, Silvio Aime, Alexander Oraevsky
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Editorial Material
Optics
Pai-Chi Li, Martin Frenz, Alexander Oraevsky
Article
Acoustics
A. A. Oraevsky, B. Clingman, J. Zalev, A. T. Stavros, W. T. Yang, J. R. Parikh
Article
Engineering, Biomedical
E. V. Petrova, H. P. Brecht, M. Motamedi, A. A. Oraevsky, S. A. Ermilov
PHYSICS IN MEDICINE AND BIOLOGY
(2018)
Article
Acoustics
Elena Petrova, Anton Liopo, Alexander A. Oraevsky, Sergey A. Ermilov
Article
Acoustics
Saher M. Maswadi, Bennett L. Ibey, Caleb C. Roth, Dmitri A. Tsyboulski, Hope T. Beier, Randolph D. Glickman, Alexander A. Oraevsky
Proceedings Paper
Optics
Richard Su, Anton Liopo, Sergey A. Ermilov, Alexander A. Oraevsky
PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2016
(2016)
Proceedings Paper
Optics
Yang Lou, Kenji Mitsuhashi, Catherine M. Appleton, Alexander Oraevsky, Mark A. Anastasio
PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2016
(2016)
Proceedings Paper
Optics
Yang Lou, Alexander Oraevsky, Mark A. Anastasio
PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2016
(2016)
Proceedings Paper
Optics
Saher M. Maswadi, Dmitri Tsyboulski, Caleb C. Roth, Randolph D. Glickman, Hope T. Beier, Alexander A. Oraevsky, Bennett L. Ibey
PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2016
(2016)
Proceedings Paper
Optics
Fatima Anis, Kun Wang, Richard Su, Sergey A. Ermilov, Alexander A. Oraevsky, Mark A. Anastasio
PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2015
(2015)
