Article
Biochemistry & Molecular Biology
Vandana Zaman, Kelsey P. Drasites, Ali Myatich, Ramsha Shams, Donald C. Shields, Denise Matzelle, Azizul Haque, Narendra L. Banik
Summary: In this study, the researchers found that the activation of calpain-1 and calpain-2 in a nigrostriatal pathway has different effects on glial activation and neuronal survival in the Parkinson's disease (PD) model. They also found that attenuating calpain-2 may be important in reducing the loss of substantia nigra (SN) neurons in PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Stephen Mullin, Morten Gersel Stokholm, Derralyn Hughes, Atul Mehta, Peter Parbo, Rainer Hinz, Nicola Pavese, David J. Brooks, Anthony H. Schapira
Summary: The study found that carriers of glucocerebrosidase gene mutations without Parkinson's disease also present neuroinflammation. Microglial activation was observed in brain regions susceptible to Lewy pathology. Importantly, the degree of hyposmia was positively correlated with nigral binding potential.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Tushar Kamath, Evan Z. Macosko
Summary: Parkinson's disease is characterized by the death of dopaminergic neurons in the substantia nigra. Recent advances in genomic profiling have identified specific pathways and genetic variants involved in the susceptibility of dopaminergic neurons in Parkinson's disease. This provides new opportunities for understanding and developing therapies for this complex disorder.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Marta Gonzalez-Sepulveda, Joan Compte, Thais Cuadros, Alba Nicolau, Camille Guillard-Sirieix, Nuria Penuelas, Marina Lorente-Picon, Annabelle Parent, Jordi Romero-Gimenez, Joana M. Cladera-Sastre, Ariadna Laguna, Miquel Vila
Summary: Neurons that accumulate the highest levels of neuromelanin with age are also the most susceptible to degeneration in Parkinson's disease. Using a neuromelanin-producing rat model, Gonzalez-Sepulveda, Compte et al. show that slowing down age-dependent neuromelanin production can help prevent Parkinson's disease-like features.
Review
Endocrinology & Metabolism
Vandana Zaman, Donald C. Shields, Ramsha Shams, Kelsey P. Drasites, Denise Matzelle, Azizul Haque, Narendra L. Banik
Summary: Parkinson's disease is a neurodegenerative disorder linked to the loss of dopaminergic neurons in the substantia nigra. The disease's etiology is still unclear, but interactions between external and internal factors may play a crucial role in its onset and progression. Research in animal models and post-mortem human tissue has identified cellular and molecular changes in the diseased brain, indicating complex interactions between different glial cell types and molecular pathways.
METABOLIC BRAIN DISEASE
(2021)
Article
Cell Biology
Xue Zhang, Jing Wang, Jin-Zhao Gao, Xiao-Na Zhang, Kai-Xin Dou, Wan-Da Shi, An-Mu Xie
Summary: Inhibition of P2X4 receptor activity in Parkinson's disease may reduce symptoms and increase the expression of specific proteins, potentially alleviating the impact of the disease on the nervous system.
NEURAL REGENERATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Xingxing Jian, Guihu Zhao, He Chen, Yanhui Wang, Jinchen Li, Lu Xie, Bin Li
Summary: This study utilized transcriptomics analysis to identify several hub DEGs between PD patients and normal controls, showing high correlations among these genes. A Cox model with an eight-gene signature was constructed to predict PD progression and survival successfully in an independent dataset, highlighting the clinical significance of these findings.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Clinical Neurology
Semra Smajic, Cesar A. Prada-Medina, Zied Landoulsi, Jenny Ghelfi, Sylvie Delcambre, Carola Dietrich, Javier Jarazo, Jana Henck, Saranya Balachandran, Sinthuja Pachchek, Christopher M. Morris, Paul Antony, Bernd Timmermann, Sascha Sauer, Sandro L. Pereira, Jens C. Schwamborn, Patrick May, Anne Gruenewald, Malte Spielmann
Summary: In this study, the contribution of different cell types to Parkinson's disease pathology was investigated using single-nuclei RNA sequencing. The results revealed a disease-specific neuronal cell cluster and changes in glial cells, as well as the enrichment of Parkinson's disease risk genes. These findings highlight the importance of inflammatory signaling and immunomodulatory treatments in Parkinson's disease.
Article
Neurosciences
I. Friedrich, K. Reimann, S. Jankuhn, E. Kirilina, J. Stieler, M. Sonntag, J. Meijer, N. Weiskopf, T. Reinert, T. Arendt, M. Morawski
Summary: Iron is essential for neurons and glial cells but high concentrations of free iron can be detrimental, especially in neurodegenerative diseases. Changes in iron concentrations in the substantia nigra may play a key role in degeneration of dopaminergic neurons in Parkinson's disease. Quantitative analysis of iron provides insights into cellular iron levels in PD.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Review
Clinical Neurology
Xishun Ma, Tongxia Li, Lizhen Du, Tongliang Han
Summary: Parkinson's disease is a common nervous system disease with motor retardation and resting tremor as its main manifestations. Early diagnosis of Parkinson's disease is difficult, but transcranial sonography has been widely used for its diagnosis and treatment. This article reviews the recent advances in the study of Parkinson's disease using transcranial sonography.
FRONTIERS IN NEUROLOGY
(2022)
Article
Health Care Sciences & Services
Niels Bergsland, Laura Pelizzari, Maria Marcella Lagana, Sonia Di Tella, Federica Rossetto, Raffaello Nemni, Mario Clerici, Francesca Baglio
Summary: This study demonstrates robust and clinically meaningful associations between substantia nigra microstructure and Parkinson's disease, particularly showing a significant correlation between axial diffusivity in SNpc and UPDRS III scores in PD patients.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Cell Biology
Samir Kumar Beura, Abhishek Ramachandra Panigrahi, Pooja Yadav, Sunil Kumar Singh
Summary: Parkinson's disease is a common neurodegenerative disease characterized by motor and non-motor dysfunctions. Platelets play an important role in Parkinson's disease and may be a target for treatment.
AGEING RESEARCH REVIEWS
(2022)
Article
Food Science & Technology
Lei Wang, Shengyu Li, Yu Jiang, Zijian Zhao, Yunjiao Shen, Junjie Zhang, Lei Zhao
Summary: Probiotic Lactobacillus plantarum DP189 has a significant protective effect on the dopaminergic neurons in the substantia nigra of Parkinson's disease mice, improving behavioral abilities and increasing neurotransmitter levels.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Sangeun Han, Min Hyung Seo, Sabina Lim, Sujung Yeo
Summary: This study suggests a potential association between reduced ITGA7 expression and increased alpha-syn expression and apoptosis of dopaminergic cells in an MPTP-induced PD mouse model. This is the first study to show a link between ITGA7 and PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Geriatrics & Gerontology
Edoardo Brandi, Laura Torres-Garcia, Alexander Svanbergsson, Caroline Haikal, Di Liu, Wen Li, Jia-Yi Li
Summary: This study evaluated the microglial response in different brain regions, finding a high level of heterogeneity among them. This heterogeneity may contribute to different neuroinflammatory responses and their involvement in neurodegenerative diseases. The study also examined the impact of acute and chronic inflammation on synaptic alterations, as well as the effect of CX3CR1 partial ablation on microglial response. The results highlight the importance of microglial and astrocytic heterogeneity in region-specific inflammatory responses.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Oncology
Xin-Hong Wang, Xin Xie, Xiao-Guang Luo, Hong Shang, Zhi-Yi He
MOLECULAR MEDICINE REPORTS
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Na Wang, HuaGuang Yang, ChengBo Li, GuoGuang Fan, XiaoGuang Luo
EUROPEAN RADIOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Xin Xie, Xiaoguang Luo, Na Liu, Xiaohong Li, Fan Lou, Yumin Zheng, Yan Ren
JOURNAL OF NEUROCHEMISTRY
(2017)
Article
Immunology
Yang Liu, Xin Xie, Li-Ping Xia, Hong Lv, Fan Lou, Yan Ren, Zhi-Yi He, Xiao-Guang Luo
JOURNAL OF NEUROINFLAMMATION
(2017)
Article
Geriatrics & Gerontology
Fan Lou, Xiaoguang Luo, Ming Li, Yan Ren, Zhiyi He
NEUROBIOLOGY OF AGING
(2017)
Article
Biochemistry & Molecular Biology
Liping Xia, Xin Xie, Yang Liu, Xiaoguang Luo
NEUROCHEMICAL RESEARCH
(2017)
Article
Clinical Neurology
Xin Xie, Xiaoguang Luo, Mingliang Xie
PARKINSONISM & RELATED DISORDERS
(2017)
Article
Clinical Neurology
Fan Lou, Ming Li, Xiaoguang Luo, Yan Ren
PARKINSONS DISEASE
(2018)
Article
Multidisciplinary Sciences
Zhixin Huo, Xiaoguang Luo, Xiaoni Zhan, Qiaohong Chu, Qin Xu, Jun Yao, Hao Pang
Article
Neurosciences
Weiyao Chen, Xuejing Yan, Hong Lv, Yang Liu, Zhiyi He, Xiaoguang Luo
NEUROSCIENCE LETTERS
(2020)
Article
Biochemistry & Molecular Biology
L. Dong, Yumin Zheng, Lianbo Gao, Xiaoguang Luo
Summary: The study found that NEAT1 levels were significantly correlated with MPTP-induced Parkinson's disease (PD) mice, dopamine neurons, and cells treated with MPP+, and that NEAT1 inhibition effectively promoted cell proliferation, inhibited apoptosis and autophagy. Silencing NEAT1 increased the TH+ rate of neurons and greatly suppressed autophagy. Additionally, NEAT1 may impact apoptosis and autophagy of SH-SY5Y cells through miR-374c-5p.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Geriatrics & Gerontology
Huaguang Yang, Weiyin Vivian Liu, Shanshan Wang, Wenbin Yang, Changsheng Liu, Zhi Wen, Lanhua Hu, Jinxia Guo, Guoguang Fan, Xiaoguang Luo, Yunfei Zha
Summary: This study evaluated the incidence of freezing of gait (FOG) in multiple system atrophy (MSA) patients and assessed its clinical correlations. The results showed that FOG is a common symptom in MSA patients and is associated with poor quality of life, disease progression and severity, levodopa-equivalent dose, and cerebellum impairment.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Li Dong, Yumin Zheng, Xiaoguang Luo
Summary: This study focused on exploring the role of NEAT1 in Parkinson's disease (PD) and its effects on PD and related molecular mechanisms. The results showed that NEAT1 was involved in the development of PD, regulating cellular proliferation, apoptosis, and autophagy. Interfering with NEAT1 had potential therapeutic effects on PD by increasing the level of miR-107-5p.
Article
Immunology
Li Dong, Yu-Min Zheng, Xiao-Guang Luo, Zhi-Yi He
Summary: Parkinson's disease patients with a high inflammatory tendency experience continuous peripheral and intracranial inflammation, leading to reduced tumor incidence and increased neurodegeneration. CD28 and CTLA-4/PD-1 can reduce inflammatory responses, protect against neurodegeneration, and increase tumor incidence.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Yumin Zheng, Li Dong, Na Liu, Xiaoguang Luo, Zhiyi He
BIOMED RESEARCH INTERNATIONAL
(2020)