Article
Biochemistry & Molecular Biology
Weilin Zhang, Zhongcheng Huang, Zhigang Xiao, Hui Wang, Qianchao Liao, Zhengru Deng, Deqing Wu, Junjiang Wang, Yong Li
Summary: This study discovered that miR-1262 acts as an anti-tumor miRNA in colon cancer by targeting FGFR1. The NF-Kappa B/miR-1262/FGFR1 axis regulates the malignant characteristics of colon cancer cells, including proliferation, invasion, and migration.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Chemistry, Multidisciplinary
Esra Dirimtekin, Maria Mortoglou, Ceren Alavanda, Asmaa Benomar Yemlahi, Esra Arslan Ates, Ilter Guney, Pinar Uysal-Onganer
Summary: miR-34a is downregulated and associated with inhibition of tumor growth and invasion in ovarian cancer, while FOXP1 is reported as either an oncogene or tumor suppressor. It is found that miR-34a and FOXP1 are reversely correlated, and inhibition of miR-34a leads to upregulation of FOXP1 expression and increased cellular invasion. miR-34a could be a potential biomarker for improving the diagnostic efficiency of ovarian cancer, and its overexpression may reduce pathogenesis by targeting FOXP1.
Article
Oncology
Sangmin Kim, Daeun You, Yisun Jeong, Sun Young Yoon, Sung A. Kim, Jeong Eon Lee
Summary: The study investigated the expression of the PDGF family in ER-α(+) breast cancer patients and the effects of PDGFR inhibitors on cell cycle, growth, and metastasis-related gene expression. The results suggest that PDGFR inhibitors can be used for the treatment of ER-α(+) breast cancer.
Article
Cardiac & Cardiovascular Systems
Julien Solinc, Jessica Raimbault-Machado, France Dierick, Lamiaa El Bernoussi, Ly Tu, Raphael Thuillet, Nathalie Mougenot, Benedicte Hoareau-Coudert, Virginie Monceau, Catherine Pavoine, Fabrice Atassi, David Sassoon, Giovanna Marazzi, Richard P. Harvey, Peter Schofield, Daniel Christ, Marc Humbert, Christophe Guignabert, Florent Soubrier, Sophie Nadaud
Summary: This study demonstrates the significant role of the platelet-derived growth factor receptor alpha (PDGFR alpha) pathway in progenitor cell-dependent vascular remodeling and neomuscularization associated with pulmonary arterial hypertension (PAH). Inhibition of PDGFR alpha activity reduces pulmonary vessel neomuscularization, while constitutive activation of PDGFR alpha leads to neomuscularization and PH development. These findings suggest that PDGFR alpha blockers may be a promising therapeutic strategy for reducing vascular remodeling in PAH patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Gastroenterology & Hepatology
Kristen M. Smith-Edwards, Brian S. Edwards, Christina M. Wright, Sabine Schneider, Kimberly A. Meerschaert, Lindsay L. Ejoh, Sarah A. Najjar, Marthe J. Howard, Kathryn M. Albers, Robert O. Heuckeroth, Brian M. Davis
Summary: The study demonstrates that sympathetic neurons differentially regulate the activity of neurons and non-neuronal cells in the proximal and distal colon, promoting distinct changes in motility patterns. This highlights the important role of neural innervation in different regions of the colon and its significant impact on digestive health.
Article
Hematology
Julian Leberzammer, Stijn M. Agten, Xavier Blanchet, Rundan Duan, Hans Ippel, Remco T. A. Megens, Christian Schulz, Maria Aslani, Johan Duchene, Yvonne Doring, Natalie J. Jooss, Pengyu Zhang, Richard Brandl, Konstantin Stark, Wolfgang Siess, Kerstin Jurk, Johan W. M. Heemskerk, Tilman M. Hackeng, Kevin H. Mayo, Christian Weber, Philipp von Hundelshausen
Summary: The study explored the molecular mechanisms of CXCL12 in arterial thrombosis, revealing that inhibition of CXCR4 can attenuate platelet aggregation and limit arterial thrombosis. Mechanistically, CXCL12 activates Btk leading to platelet aggregation, while the interaction between CXCL12 and CCL5 can inhibit this process. A novel peptide was found to inhibit CXCL12-induced platelet aggregation without prolonging bleeding time.
Article
Neurosciences
Jelena Medved, William M. Wood, Michael D. van Heyst, Amin Sherafat, Ju-Young Song, Sagune Sakya, Dennis L. Wright, Akiko Nishiyama
Summary: Oligodendrocyte precursor cells play a crucial role in brain development and have the potential to be targeted for the treatment of brain tumors.
Article
Cell Biology
Bo Wang, Dongping Li, Yaroslav Ilnytskyy, Igor Kovalchuk, Olga Kovalchuk
Summary: The tRiMetF31 fragment suppresses angiogenesis by silencing PFKFB3, presenting a potential therapeutic target for breast cancer.
CELL DEATH DISCOVERY
(2022)
Article
Chemistry, Multidisciplinary
Ana L. Graca, Manuel Gomez-Florit, Hugo Osorio, Marcia T. Rodrigues, Rui M. A. Domingues, Rui L. Reis, Manuela E. Gomes
Summary: This study produced and characterized platelet-derived EVs and investigated their effects on different cell types. The EVs were found to regulate stem cell differentiation, promote angiogenesis, and modulate macrophage polarization, suggesting their potential as therapeutic tools in tissue engineering and regenerative medicine.
Article
Biochemistry & Molecular Biology
Susan Y. S. Li, Rebecca Johnson, Leon C. D. Smyth, Mike Dragunow
Summary: This review provides an updated overview of the actions of platelet-derived growth factors on neurovascular function, their role in regulating perivascular cell types, and their clinical relevance and therapeutic potential for neurological diseases.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Microbiology
Minmin Zhou, Shaobo Wang, Jiao Guo, Yang Liu, Junyuan Cao, Xiaohao Lan, Xiaoying Jia, Bo Zhang, Gengfu Xiao, Wei Wang
Summary: PDGFR beta was identified as a potential therapeutic target against JEV infection, with the inhibitor imatinib showing protection against JEV-induced lethality by reducing viral load in the brain and preventing histopathological changes.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Wanting Niu, Teck Chuan Lim, Abdulmonem Alshihri, Ravikumar Rajappa, Lishan Wang, Motoichi Kurisawa, Myron Spector
Summary: This study demonstrated the high viability of bone marrow mesenchymal stem cells (bMSCs) in Gelatin-hydroxyphenyl propionic acid (Gtn-HPA) covalent cross-linking gelation. The incorporation of platelet-derived growth factor (PDGF)-BB directly into the gel or released from polyelectrolyte complex nanoparticles (PCNs) stimulated bMSC migration and proliferation effectively. Stromal cell-derived factor (SDF)-1 alpha enhanced migration and proliferation when released from PCNs, highlighting the potential of using Gtn-HPA/PDGF-BB as an injectable therapeutic agent for musculoskeletal tissue defects.
Article
Cell & Tissue Engineering
Lucile Bansard, Oceane Bouvet, Elisa Moutin, Gaetan Le Gall, Alessandro Giammona, Elodie Pothin, Marion Bacou, Cedric Hassen-Khodja, Benoit Bordignon, Jean Francois Bourgaux, Michel Prudhomme, Frederic Hollande, Julie Pannequin, Jean Marc Pascussi, Chris Planque
Summary: This study identifies miR-148a as a targetable element upstream of PXR signaling in CSCs, which can decrease PXR expression and impair tumor relapse after chemotherapy. The anti-helminthic drug niclosamide is identified as an inducer of miR-148a expression, which decreases PXR expression and CSC numbers, and synergizes with chemotherapeutic agents to prevent tumor relapse.
Article
Biochemistry & Molecular Biology
Rimma Sergeevna Kamentseva, Marianna Viktorovna Kharchenko, Gulnara Vladikovna Gabdrahmanova, Michael Alexandrovich Kotov, Vera Vladislavovna Kosheverova, Elena Sergeevna Kornilova
Summary: This study compared the effects of EGF, TGF-α, and AREG on physiological responses in endometrial MSCs and HeLa cells, and investigated the internalization and degradation of EGFR stimulated by these ligands. The study found that while EGF and TGF-α stimulated cell proliferation and prevented differentiation in enMSCs in an EGFR-dependent manner, AREG had no effect. Additionally, differences were observed in the degradation and recovery of EGFR in different cell lines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Roman Moravcik, Sona Olejarova, Jana Zlacka, Iveta Herichova
Summary: miR-34a strongly influences the expression of components of the circadian oscillator independently of p53 status and exerts its tumour suppressor effects by inhibiting the expression of sirt1 and cyclin D1 mRNA. 17-beta-estradiol (E2) administration also inhibits the migration and proliferation of colorectal cancer cells, but this effect is not dependent on the action of miR-34a. The possible ambiguous oncogenic characteristics of miR-34a should be considered in future clinical studies.
