Review
Pharmacology & Pharmacy
Sha-Sha Guo, Zhen-Guo Wang
Summary: Salvia miltiorrhiza, a perennial herb with high medicinal value in China, contains Salvianolic acid B (Sal-B) which has been shown to exhibit anticancer activity by targeting multiple cell signaling pathways to inhibit tumor growth and metastasis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Haolan Zou, Xiaorong Guo, Rao Yang, Shengsong Wang, Lin Li, Junfeng Niu, Donghao Wang, Xiaoyan Cao
Summary: This study demonstrated that Sm-miR408 regulates the accumulation of phenolic acids in Salvia miltiorrhiza by targeting SmLAC3 expression levels, which consequently affects the lignin content in the roots.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agricultural Engineering
Weihong Li, Kedi Liu, Xingru Tao, Shi Zhao, Fei Mu, Sha Chen, Wenya Wang, Jing Li, Xinming Lu, Yang Bai, Li 'an Hou, Jialin Duan, Peifeng Wei, Miaomiao Xi
Summary: A mixture of 80% Sal-A, 10% Sal-B, and 10% DSS was found to be the most effective in cardioprotection. The inhibition of CK-MB by this mixture was even better than the treatment drugs, while there was no significant difference in the inhibition of cTnI and Myo. This study provides a basis for further research on the active monomers of Salvia miltiorrhiza in the treatment of myocardial infarction.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Xuehai Zheng, Duo Chen, Binghua Chen, Limin Liang, Zhen Huang, Wenfang Fan, Jiannan Chen, Wenjin He, Huibin Chen, Luqiang Huang, Youqiang Chen, Jinmao Zhu, Ting Xue
Summary: Salvia bowleyana is a traditional Chinese medicinal plant with a high-quality chromosome-scale genome assembly, providing valuable genomic resources for understanding salvianolic acid B biosynthesis and regulation. Transcriptome analysis reveals important gene expression patterns related to salvianolic acid B accumulation, offering insights into potential biosynthetic pathways. Genome-wide analysis, including the laccase gene family, sheds light on the evolution of S. bowleyana and its unique genetic characteristics.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rao Yang, Shengsong Wang, Haolan Zou, Lin Li, Yonghui Li, Donghao Wang, Hongxing Xu, Xiaoyan Cao
Summary: The study showed that SmMYB52 significantly inhibited root growth and IAA accumulation in Salvia miltiorrhiza sterile seedlings, while activating phenolic acid biosynthesis and the JA signaling pathway. SmMYB52 also directly binds to and activates key enzyme genes for SalB biosynthesis, promoting its accumulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Integrative & Complementary Medicine
Qi Chen, QingYang Xu, Huilin Zhu, Junyi Wang, Ning Sun, Huimin Bian, Yu Li, Chao Lin
Summary: Sal B inhibits cardiomyocyte apoptosis and promotes angiogenesis by regulating autophagy, thereby improving myocardial ischemia.
Article
Plant Sciences
Lan Yao, Renjie Zhao, Shiyang He, Qi Feng, Yingjin Qiao, Pei Wang, Jun Li
Summary: This study investigated the nephroprotective effects of Sal A and Sal B in renal interstitial fibrosis (RIF) through in vivo and in vitro experiments. The results showed that Sal A, Sal B, and Sal A+B improved kidney dysfunction, reduced fibrotic markers, and reversed apoptosis and endoplasmic reticulum stress. It suggests that Sal A, Sal B, and Sal A+B may be potential therapeutic agents for the amelioration of RIF.
Article
Integrative & Complementary Medicine
Wang Qian-qian, Wang Meng, Li Yan, Liu Yong-hui, Sun Lian-qing
Summary: The study showed that Sal B can protect against diabetic peripheral neuropathy by attenuating apoptosis and pyroptosis. Results demonstrated that Sal B could inhibit high glucose-induced damage, including reduced cell proliferation and oxidative stress.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Jie Xiang, Chunling Zhang, Tietao Di, Lu Chen, Wei Zhao, Lianggang Wei, Shiyong Zhou, Xueli Wu, Gengxin Wang, Yun Zhang
Summary: This study found that Salvianolic acid B (Sal B) could improve diabetes-induced endothelial dysfunction and mitochondrial dysfunction by regulating apoptosis and mitophagy of endothelial cells.
Article
Agriculture, Dairy & Animal Science
Liping Cao, Guojun Yin, Jinliang Du, Rui Jia, Jiancao Gao, Nailin Shao, Quanjie Li, Haojun Zhu, Yao Zheng, Zhijuan Nie, Weidong Ding, Gangchun Xu
Summary: This study evaluated the protective effect of Sal B on oxidative hepatic injury in Nile tilapia and investigated the potential mechanisms involved. The results showed that Sal B can reduce reactive oxygen species (ROS) levels and resist oxidative injury in hepatocytes induced by CTX. The protective effect of Sal B on Nile tilapia is related to the regulation of Nrf2, AMPK/mTOR, and MAPK pathways.
Article
Engineering, Multidisciplinary
Jun Qian, Xiaoqian Xu, Jiajia Su, Weihuan Zeng, Bing Han, Xiaolong Hao, Guoyin Kai
Summary: This study reported a strategy for effective adsorption of Salvianolic acid A (SAA) from aqueous solution using surface molecularly imprinted magnetic nanoparticles (SIMNP). By selecting appropriate functional monomers, high-efficiency and highly selective adsorption of SAA was achieved in a short period of time, providing a new approach for the effective capture of SAA.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Plant Sciences
Li-fang Zou, Di-fa Liu, Hua Yang, Chun-hong Zhou, Shuang-bing Deng, Ni-shan Xu, Xue-mei He, Yao-qi Liu, Meng Shao, Lin-zhong Yu, Jun-shan Liu
Summary: Two new and four known compounds were isolated from Danshen. Among them, C1 exhibited anti-inflammatory activities by activating a7nAchR signaling and subsequently inhibiting STAT3 and NF-KB pathways. This study provided evidence for the clinical application of Danshen and contributed to the development of C1 as a novel drug for the treatment of cardiovascular disease.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Florence Hui Ping Tan, Andrew Chung Jie Ting, Ban Guan Leow, Nazalan Najimudin, Nobumoto Watanabe, Ghows Azzam
Summary: The study demonstrated that Danshen water extract (DWE) and its major components, SalA and SalB, have the potential to reduce fibrillation of Aβ42 and protect neuronal cells from cell death associated with Aβ42 exposure. Furthermore, treating Drosophila melanogaster with DWE, SalA and SalB showed benefits in partially reversing degenerated eye structures, extending lifespan, and improving mobility in an Alzheimer's disease model.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Zhiping He, Xingquan Liu, Fenghua Wu, Shaozhen Wu, Gary O'Neal Rankin, Ivan Martinez, Yon Rojanasakul, Yi Charlie Chen
Summary: The study demonstrated that gallic acid (GA) can inhibit ovarian cancer cell proliferation by promoting apoptosis and blocking cell cycle progression, indicating its potential preventive and therapeutic effects in ovarian cancer.
APPLIED SCIENCES-BASEL
(2021)
Article
Medicine, Research & Experimental
Jia-Peng Lin, Mao-Hua Huang, Zhi-Ting Sun, Lei Chen, Yu-He Lei, Yu-Qing Huang, Ming Qi, Shu-Ran Fan, Shou-Guo Chen, Chi-Wing Chung, Mei-Ching Chan, Jun-Shan Liu, Min Hu, Min-Feng Chen, Wen-Cai Ye, Yue-Yue Chen, Li-Juan Deng
Summary: The study aimed to evaluate the effect of periplocin on inhibiting hepatocellular carcinoma (HCC) and further determine its mechanisms. The findings revealed that periplocin inhibited HCC progression by G2/M arrest, apoptosis, and suppression of myeloid-derived suppressor cells (MDSCs) accumulation through the blockade of the AKT/NF-κB pathway. These results suggest that periplocin has the potential to be developed as an effective therapeutic agent for HCC.