Article
Biochemistry & Molecular Biology
Xiaozhuo Liu, Houtan Moshiri, Qian He, Ansuman Sahoo, Sarah E. Walker
Summary: The yeast eukaryotic initiation factor 4B plays an important role in translation preinitiation complexes. Recent studies have found that yeast mRNAs have differential dependence on eIF4B under different growth conditions. It is suggested that the activity of eIF4B in translation may alter yeast phenotypes by selecting different mRNAs. By comparing the effects of disrupting yeast eIF4B RNA- and 40S-binding motifs, it is found that the 40S-binding N-terminal Domain (NTD) is associated with stress responses and promotes yeast growth. Deletion of the NTD significantly reduces translation activity and alters the composition of ribosome-associated mRNAs. Gene ontology analysis reveals that transcripts dependent on the NTD encode proteins associated with the cellular membrane system and the cell wall.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Oncology
Jingpeng Liu, Xiao Jiang, Ailing Zou, Zhaoyi Mai, Zhijie Huang, Liying Sun, Jianjiang Zhao
Summary: The study identified a unique circRNA, circIGHG, which is significantly upregulated in oral squamous cell carcinoma (OSCC) and associated with poor prognosis. It promotes OSCC invasion and metastasis by interacting with miR-142-5p and IGF2BP3, with epithelial-mesenchymal transition being the main mechanism. These findings suggest that circIGHG could serve as a biomarker and therapeutic target for early diagnosis and treatment of OSCC.
Review
Pathology
Vahid Hosseini, Soheila Montazersaheb, Narges Hejazi, Sina Aslanabadi, Mina Mohammadinasr, Mohammad Saeid Hejazi
Summary: This review focuses on the role of miRNAs in oral squamous cell carcinoma (OSCC) and their regulatory mechanisms, suggesting the potential of miRNAs as therapeutic targets. The study is of great significance for understanding and treating OSCC.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Biochemistry & Molecular Biology
Patrick Senechal, Francis Robert, Regina Cencic, Akiko Yanagiya, Jennifer Chu, Nahum Sonenberg, Marilene Paquet, Jerry Pelletier
Summary: The translation initiation factor eIF4F is crucial for cap-dependent protein synthesis initiation. Different subunits of eIF4F have varying roles in development and tumorigenesis, with some being essential for viability and tumor onset, while others have non-essential functions. This study highlights the complex roles of different eIF4F subunits in gene expression regulation during embryogenesis and tumor development.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Xiangpu Wang, Haoyue Xu, Zuo Zhou, Siyuan Guo, Renji Chen
Summary: The aim of this study was to investigate the role of IGF2BP2 in oral squamous cell carcinoma (OSCC) and provide new biomarkers or potential therapeutic targets. High expression of IGF2BP2 was found in OSCC and was significantly correlated with poor overall survival. The findings suggest that IGF2BP2 may serve as a potential prognostic biomarker and be associated with tumor-infiltrating immune cells in OSCC.
BIOSCIENCE REPORTS
(2022)
Article
Oncology
Ching-Mei Chen, Tian-Huei Chu, Chih-Chi Chou, Chih-Yen Chien, Jian-Shiang Wang, Chao-Cheng Huang
Summary: The study indicates that exosomal miR-155 and miR-21 are upregulated in OSCC patients, while miR-126 is downregulated. MiR-155 and miR-21 promote cell proliferation and invasion by suppressing PTEN and Bcl-6 tumor suppressors, while miR-126 inhibits oncogenic behaviors and EGFL7 expression. Exosomal miRNAs in blood may serve as biomarkers for the diagnosis and prognosis of OSCC.
Review
Oncology
Ran Huang, Qiong Dai, Ruixue Yang, Yi Duan, Qi Zhao, Johannes Haybaeck, Zhihui Yang
Summary: Esophageal squamous cell carcinoma (ESCC) is a malignant tumor with a high prevalence in China and worldwide. Current treatments have limited effectiveness, highlighting the importance of finding new therapeutic targets. The PI3K/AKT/mTOR pathway shows potential as a research hotspot and may provide new insights for ESCC treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Chengdong Wu, Dekai Liu, Lufei Zhang, Jingjie Wang, Yuan Ding, Zhongquan Sun, Weilin Wang
Summary: A novel tsRNA, tRNA(Gln-TTG) derived 5 '-tiRNA-Gln, is found to be significantly downregulated in hepatocellular carcinoma (HCC) and its expression is correlated with disease progression. This tsRNA inhibits translation by binding to EIF4A1, leading to the impairment of HCC progression.
FRONTIERS OF MEDICINE
(2023)
Review
Genetics & Heredity
Prakash Amruth Raj Chukka, Stacey D. Wetmore, Nehal Thakor
Summary: Translational control plays a crucial role in dictating gene expression and altering physiological processes in eukaryotic cells. eIF5B plays a significant role in this process, especially in the survival and drug resistance of cancer cells.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Paul Powell, Usha Bhardwaj, Dixie Goss
Summary: This study identifies secondary structures that selectively interact with eIF3 and explores its role in translation initiation of BYDV. The findings propose a new model for BYDV translation initiation and expand the known functionality of eIF3.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Oncology
Ying Zhou, Shuhong Zhang, Zhonghan Min, Zhongwei Yu, Huaiwei Zhang, Jiao Jiao
Summary: This research aimed to investigate the role and mechanism of circ_0011946 in oral squamous cell carcinoma (OSCC) cells. Findings showed that circ_0011946 silence inhibited OSCC cell proliferation, migration, and invasion, while promoting apoptosis through the regulation of the miR-216a-5p/BCL2L2 axis. The study suggests that circ_0011946 may serve as a potential therapeutic target for OSCC.
Article
Oncology
Songtao Zhang, Runfang Zhang, Chao Wang, Wenbo Gong, Miaomiao Xue, Lina Liu, Yuanyuan Zhang
Summary: In previously untreated oral SCC patients, Level VI metastasis is rare but associated with poor prognosis, presenting with adverse pathologic features, metastatic foci size ranging from 2.6 to 4.5 cm, high recurrence and mortality rates.
Review
Immunology
Suchitra Singh, Ajay Kumar Singh
Summary: Oral cancer is a significant contributor to the global cancer burden, and oral bacteria, particularly Porphyromonas gingivalis, are believed to play a crucial role in its spread. Understanding the pathogenesis of P. gingivalis in oral squamous cell carcinoma is of great importance.
MICROBES AND INFECTION
(2022)
Article
Cell Biology
Weiwen Zhu, Jie Wang, Xiang Liu, Yanbin Xu, Rundong Zhai, Jiayi Zhang, Mengqi Wang, Mengyao Wang, Laikui Liu
Summary: Oral squamous cell carcinoma (OSCC), the most common malignancy of the oral and maxillofacial region, severely affects human health. In this study, researchers identified a long non-coding RNA called CYTOR, which is highly expressed in oral cancer patients. They found that CYTOR promotes cell migration and invasion, and affects mitochondrial metabolism and RNA splicing in oral cancer cells.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Guodong Xu, Hang Chen, Shibo Wu, Jiabin Chen, Shufen Zhang, Guofeng Shao, Lebo Sun, Yinyu Mu, Kaitai Liu, Qiaoling Pan, Ni Li, Xiaoxia An, Shuang Lin, Wei Chen
Summary: This study found that eukaryotic initiation factor 5A2 (eIF5A2) is upregulated under hypoxic conditions and is associated with autophagy and cisplatin resistance. eIF5A2 acts downstream of HIF-1 alpha, a hypoxia-inducible factor. Targeted downregulation of eIF5A2 can reduce hypoxia-induced autophagy and cisplatin resistance in NSCLC cells. The role of eIF5A2 in cisplatin resistance was further validated in an in vivo mouse model. A combination of eIF5A2-targeted therapy and cisplatin chemotherapy is suggested as an effective strategy to reverse hypoxia-induced cisplatin resistance and inhibit NSCLC development.
CELL DEATH & DISEASE
(2022)
