Article
Biochemistry & Molecular Biology
Hee Jung Kim, Dong Uk Im, Gia Cac Chau, Neeraj Kumar Mishra, In Su Kim, Sung Hee Um
Summary: In this study, a newly synthesized indole derivative, CF3-allylated indole, was found to effectively inhibit adipogenesis by regulating PKA/AMPK signaling in the early stage of adipocyte differentiation. These findings suggest the potential of CF3-allylated indole in controlling initial adipocyte differentiation in metabolic disorders such as obesity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Nutrition & Dietetics
Xianfeng Deng, Bi Chen, Qin Luo, Xingru Zao, Haizhe Liu, Yongqiang Li
Summary: Hulless barley polyphenol (HBP) extract has the potential to inhibit obesity-related enzymes, prevent adipocyte differentiation, and attenuate adipogenesis, making it beneficial in preventing obesity.
FRONTIERS IN NUTRITION
(2022)
Article
Pharmacology & Pharmacy
Chaiwat Monmai, Jin-Suk Kim, Hyun Bo Sim, Doh-Won Yun, Sung-Dug Oh, Eui-Shik Rha, Jong-Jin Kim, So-Hyeon Baek
Summary: This study evaluated the effects of extracts from transgenic rice on inhibiting adipogenesis and anti-inflammatory activity. The results showed that the extracts significantly reduced lipid accumulation in cells and inhibited the expression of adipogenesis-related mRNA and inflammation-related factors. Therefore, transgenic rice may have potential as an obesity-reducing and/or -preventing agent.
Article
Chemistry, Medicinal
Ivana Cacciatore, Sonia Spalletta, Annalisa Di Rienzo, Vincenzo Flati, Erika Fornasari, Laura Pierdomenico, Piero Del Boccio, Silvia Valentinuzzi, Erica Costantini, Elena Toniato, Stefano Martinotti, Carmela Conte, Antonio Di Stefano, Iole Robuffo
Summary: This study synthesized a series of carvacrol derivatives and found that one derivative, CD3, exhibited anti-obesity and anti-inflammatory effects.
Article
Biochemistry & Molecular Biology
Dahae Lee, Hee Jae Kwak, Byoung Ha Kim, Seung Hyun Kim, Dong-Wook Kim, Ki Sung Kang
Summary: The study investigated the anti-adipogenic effects of hispidulin and p-synephrine alone and in combination, with the combination showing greater inhibition of lipid droplet formation. It may be a potential alternative strategy for developing novel anti-obesity drugs.
Article
Chemistry, Medicinal
Fernanda Malanconi Thomaz, Jussara de Jesus Simao, Viviane Simoes da Silva, Meira Maria Forcelini Machado, Lila Missae Oyama, Eliane Beraldi Ribeiro, Maria Isabel Cardoso Alonso Vale, Monica Marques Telles
Summary: The study found that Ginkgo biloba extract (GbE) can modulate adipocyte differentiation, increasing lipid content and gene expression of major adipogenesis markers. GbE can modify key proteins involved in the differentiation process and accelerate the expression of mature adipocyte proteins.
Article
Chemistry, Multidisciplinary
Soo-Jeung Park, Minhee Lee, Ki-Young Kim, Su Shin, Min-Woo Choi, Eun-Jin Hong, Jeongmin Lee
Summary: This study investigated the anti-obesity effect of the Trapa japonica Flerov extract (TJ) in differentiated 3T3-L1 adipocytes. The results showed that TJ reduced lipid accumulation by promoting lipolysis and inhibiting adipogenesis and lipogenesis. The component ellagic acid in TJ might contribute to its effectiveness.
APPLIED SCIENCES-BASEL
(2022)
Article
Food Science & Technology
Wenrui Liu, Lihua Wang, Jie Zhang
Summary: Peanut shells, as agricultural waste, contain luteolin (LUT) which has anti-obesity properties. The study found that the extract from peanut shells can inhibit adipogenesis, accelerate lipolysis, and promote lipid browning, making it a potential dietary supplement for weight management.
Article
Biochemistry & Molecular Biology
Melania Iara Funk, Melisa Ailen Conde, Graciela Piwien-Pilipuk, Romina Maria Uranga
Summary: Inhibition of adipocyte differentiation by menadione, a synthetic form of vitamin K, is mediated, at least in part, by increased ROS and lipid peroxidation, leading to decreased intracellular lipid accumulation and triglyceride content by inhibiting the PI3K/Akt pathway.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Hee Jung Kim, Yoon Seo Jang, Ji Won Ha, Moon-Jin Ra, Sang-Mi Jung, Jeong-Nam Yu, Kyunga Kim, Ki Hyun Kim, Sung Hee Um
Summary: The compounds isolated from Salix pseudolasiogyne twigs, oregonin and 2'-O-acetylsalicortin, were found to exhibit anti-adipogenic effects, with the latter significantly suppressing lipid accumulation at a concentration of 50 μM. These compounds have the potential to be used as therapeutic agents to effectively control adipocyte differentiation, a critical stage in the progression of obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Jae Min Hwang, Mun-Hoe Lee, Jin-Hee Lee, Jong Hun Lee
Summary: Agastache rugosa, or Korean mint, and its main component, tilianin, have anti-obesity effects by reducing lipid accumulation in adipocytes, indicating their potential as candidates for obesity-related supplements.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Leo Man-Yuen Lee, Zhi-Qiang Lin, Lu-Xi Zheng, Yi-Fan Tu, Yik-Hing So, Xiu-Hua Zheng, Tie-Jun Feng, Xi-Yue Wang, Wai-Ting Wong, Yun-Chung Leung
Summary: Growing evidence shows that restricting amino acid intake can reverse obesity by reducing adipose tissue mass. Amino acids not only serve as building blocks for proteins but also play a role as signaling molecules in various biological processes. Understanding how adipocytes respond to changes in amino acid levels is crucial for studying obesity and developing potential treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Seyoung Jung, Eun Woo Jeong, Youjin Baek, Sang-Ik Han, Gwang-woong Go, Hyeon Gyu Lee
Summary: This study evaluated the phenolic content, antioxidant and anti-obesity effects of sorghum extract (SE) prepared using three solvent systems, and found that SE50 exhibited the highest total polyphenol and flavonoid content. SE50 also showed significantly higher antioxidant capacity, and inhibited lipid accumulation in 3T3-L1 adipocytes. Moreover, SE50 downregulated the mRNA expression levels of adipogenic and lipogenic genes. These results suggest that SE50 could be used as a nutraceutical for anti-obesity.
FOOD SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Xionggao Han, Sun-Il Choi, Xiao Men, Se-Jeong Lee, Heegu Jin, Hyun-Ji Oh, Eunjin Kim, Jongwook Kim, Boo-Yong Lee, Ok-Hwan Lee
Summary: The study evaluated the anti-obesity effect of ESETM extract and found that it can inhibit adipogenesis and lipid accumulation, reducing weight change. The results suggest that ESETM may regulate weight through adipogenesis, lipogenesis, lipolysis, and thermogenesis pathways.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Magdalena Czajka, Krzysztof Sawicki, Magdalena Matysiak-Kucharek, Marcin Kruszewski, Jacek Kurzepa, Paulina Wojtyla-Buciora, Lucyna Kapka-Skrzypczak
Summary: Chlorpyrifos, a representative of organophosphorus pesticides, has effects on the viability, proliferation, differentiation, and fatty acid uptake in 3T3-L1 cells. Exposure to chlorpyrifos decreases cell viability but increases it at low concentrations. It inhibits proliferation and differentiation of preadipocytes, reduces lipid accumulation, and down-regulates key transcription factors. In fully differentiated adipocytes, chlorpyrifos increases basal free fatty acid uptake. These findings suggest that chlorpyrifos may play a role in the development of obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Applied
Le Ba Vinh, Se Jin Jo, Phong Nguyen Viet, Dan Gao, Kyoung Won Cho, Eun-Jeong Koh, Sung Sun Park, Young Ho Kim, Seo Young Yang
Summary: S. hexaphylla is an important medicinal plant with analgesic, sedative, and diuretic effects. This study identified seven compounds with anti-inflammatory properties, indicating that they may be useful candidates for treating inflammatory and other diseases.
NATURAL PRODUCT RESEARCH
(2021)
Article
Chemistry, Applied
Viet Cuong Le Canh, Vinh Le Ba, Pham Thi Hai Yen, Lien Le Thi, Pham Thi Thuy Hoai, Ton That Huu Dat, Do Thi Thao, Long Giang Bach, Young Ho Kim, Hoang Le Tuan Anh
Summary: A phytochemical investigation of Physalis minima isolated six withanolides, with compounds 1 and 3 exhibiting the strongest cytotoxicity against HepG2, SK-LU-1, and MCF7 cancer cell lines.
NATURAL PRODUCT RESEARCH
(2021)
Article
Chemistry, Applied
Le Canh Viet Cuong, Le Tuan Anh, Ton That Huu Dat, Tran Thi Phuong Anh, Le Quynh Lien, Young Ho Kim, Hoang Le Tuan Anh
Summary: A new ursane-type triterpene and eight known compounds were isolated from the aerial parts of Ophiorrhiza baviensis, with some compounds being reported for the first time in this plant species. The structures of these compounds were elucidated through analysis of HR-ESI-MS and NMR spectra, and their biological activities were evaluated. This study represents the first report on the chemical constituents and biological activities of O. baviensis.
NATURAL PRODUCT RESEARCH
(2021)
Article
Cell & Tissue Engineering
Mira Park, Sarmila Nepali, Helen Lew
STEM CELLS AND DEVELOPMENT
(2020)
Article
Chemistry, Applied
Le Xuan Duy, Vinh Le Ba, Dan Gao, Vu Dinh Hoang, Tran Quoc Toan, Seo Young Yang, Dao Duy Quang, Young Ho Kim, Nguyen Manh Cuong
Summary: Nine bioactive compounds were isolated from the fruits of the Vietnamese medicinal plant Docynia indica, with one newly discovered compound. These compounds showed inhibitory effects on soluble epoxide hydrolase, suggesting their potential in preventing cardiovascular and other related diseases.
NATURAL PRODUCT RESEARCH
(2021)
Article
Plant Sciences
Hoang Le Tuan Anh, Vinh Le Ba, Thi Thao Do, Van Kiem Phan, Hai Yen Pham Thi, Long Giang Bach, Manh Hung Tran, Phuong Anh Tran Thi, Young Ho Kim
Summary: A new compound, physalucoside A, along with withanolides and flavonoids, were isolated from the medicinal plantPhysalis angulata. The withanolides were found to be primarily responsible for the anti-inflammatory activity of the plant. This study suggests that withanolides hold promise as candidates for the development of new anti-inflammatory drugs.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2021)
Article
Chemistry, Medicinal
Le Ba Vinh, Nguyen Viet Phong, Irshad Ali, Gao Dan, Young Sang Koh, Hoang Le Tuan Anh, Do Thi Van Anh, Seo Young Yang, Young Ho Kim
MEDICINAL CHEMISTRY RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
In Sook Cho, Jang Hoon Kim, Yunjia Lin, Xiang Dong Su, Jong Seong Kang, Seo Young Yang, Young Ho Kim
Article
Biochemistry & Molecular Biology
Gi Ho Lee, Ji Yeon Kim, Sun Woo Jin, Thi Hoa Pham, Jin Song Park, Chae Yeon Kim, Jae Ho Choi, Eun Hee Han, Young Ho Kim, Hye Gwang Jeong
Summary: Inflammatory diseases are caused by excessive inflammation triggered by pro-inflammatory mediators, while the Nrf2 signaling pathway plays a protective role through regulating antioxidant enzymes. Impressic acid (IPA) isolated from Acanthopanax koreanum showed anti-inflammatory effects by inhibiting LPS-induced cytokines and ROS production, and activating the Nrf2 pathway in macrophages. This suggests that IPA has potential for preventing inflammation-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jae Ho Choi, Gi Ho Lee, Sun Woo Jin, Ji Yeon Kim, Yong Pil Hwang, Eun Hee Han, Young Ho Kim, Hye Gwang Jeong
Summary: The lupane-type triterpenoid Impressic acid (IPA) showed suppressive effects on AD-like skin symptoms induced by DNCB in mice, reducing serum IgE and TSLP concentrations, as well as mRNA levels of related genes. IPA also inhibited certain signaling pathways in cells and reduced inflammatory responses in ear tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Yoo Kyong Han, Ji Sun Lee, Seo Young Yang, Ki Yong Lee, Young Ho Kim
Summary: Compounds isolated from Lycopus lucidus, such as methyl rosmarinate, martynoside, dimethyl lithospermate, and 9 '' methyl lithospermate, showed significant inhibitory activity against sEH, making them potential candidates for further development in cardiovascular disease prevention and treatment.
Article
Biochemical Research Methods
Dan Gao, Jin Hyeok Kim, Le Ba Vinh, Eun-Young Seo, Seo Young Yang, Chong Woon Cho, Young Ho Kim, Kyung Tae Kim, Jaehoon Sim, Jong Seong Kang
Summary: The utilization of heat treatment and citric acid treatment to process ginseng flowers can convert polar ginsenosides into rare ginsenosides, improving their biological activities. Combining these two methods can significantly increase the content of less-polar ginsenosides, highlighting the potential for functional food applications.
PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY
(2022)
Article
Chemistry, Analytical
Dan Gao, Chong Woon Cho, Le Ba Vinh, Jin Hyeok Kim, Young Ho Kim, Jong Seong Kang
Summary: The chemical compositions of trifoliate orange changed greatly during the fermentation process. The HPLC-DAD-ESI-MS/MS technique was successfully applied to screen and identify the unknown constituents, providing a reliable method for quality control of fermented products. Multivariate statistical analysis helped classify the trifoliate oranges and Partial Least Square Discriminate Analysis was more suitable for accurate discrimination based on different chemical patterns in test samples.
ACTA CHROMATOGRAPHICA
(2021)
Article
Plant Sciences
Yu Juan Chai, Younghoon Go, Hai Qi Zhou, Hong Xu Li, Sun Joo Lee, Yeo Jin Park, Wahyu Widowatib, Rizal Rizal, Young Ho Kim, Seo Young Yang, Wei Li
Summary: Three undescribed bicyclo[3.2.1]octanoid neolignan glucosides, along with a known neolignan, were isolated from Piper crocatum leaves. Their chemical structures were elucidated through spectroscopic analyses and compared with previous data. Two compounds showed strong inhibitory effects against pyruvate dehydrogenase E1 alpha S300 phosphorylation in comparison to the positive control.
Article
Biochemistry & Molecular Biology
Jang Hoon Kim, Ji Su Park, Yun Ji Lee, Sena Choi, Young Ho Kim, Seo Young Yang
Summary: A novel compound and nine known compounds were isolated from the root bark of Ulmus davidiana, and tested for inhibitory activity on soluble epoxide hydrolase (sEH). Compound 2 was identified as a potential sEH inhibitor both in vitro and in silico, and further molecular dynamics study revealed detailed interaction signals with the enzyme. Compound 2 shows promise for development as a new sEH inhibitor from natural plants.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2021)