Article
Dentistry, Oral Surgery & Medicine
Simone E. S. Faustino, Kellen C. Tjioe, Agnes Assao, Michele C. Pereira, Andre L. Carvalho, Luiz P. Kowalski, Denise T. Oliveira
Summary: ILVD and PLVD showed no significant association with occult lymph node metastasis or clinical follow-up, but ILVD was significantly associated with regional recurrence. PLVD was related to perineural invasion and had significant associations with disease-specific and disease-free survivals.
Article
Oncology
Zhenyu Yang, Xingliang Tan, Yanjun Wang, Yuantao Zou, Dong Chen, Zhiming Wu, Zhuowei Liu, Yonghong Li, Zike Qin, Hui Han, Fangjian Zhou, Kai Yao
Summary: The study evaluated the relationship between deep inguinal lymph node metastasis and pelvic lymph node metastasis in PSCC, finding that deep ILNM is the most accurate factor for predicting PLNM. Patients with deep ILNM should be referred for pelvic lymph node dissection, as it indicates poor prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Xia Zhong, Xue-Hua Tu, Gu-Ha A-Lai, Ze-Guo Zhuo, Peng Yao, Ying Zhang, Zhi-Jie Xu, Yi-Dan Lin
Summary: This study found that the distance between the lower tumor margin and esophagogastric junction is associated with the risk of abdominal lymph node metastasis in patients with esophageal cancer, providing guidance for surgeons in preoperative risk assessment and lymph node dissection.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xingguo Zhao, Wenming Li, Jiulou Zhang, Shui Tian, Yang Zhou, Xiaoquan Xu, Hao Hu, Dapeng Lei, Feiyun Wu
Summary: This study aimed to investigate the role of CT radiomics in preoperative prediction of lymph node metastasis (LNM) in laryngeal squamous cell carcinoma (LSCC). A radiomics model incorporating radiomic signature and independent clinical factors was established and showed better discrimination and clinical usefulness compared to clinical model and traditional CT report. The CT-based radiomics nomogram can improve preoperative identification of nodal status and assist in clinical decision-making in LSCC.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Hao-Ji Yan, Wen-Jun Mao, Rui-Xuan Yu, Kai-Yuan Jiang, Heng Huang, Zheng-Dong Zong, Qin-Chun Qian, Xiao-Guang Guo, Hong-Ying Wen, Dong Tian
Summary: A nomogram developed using preoperative clinical characteristics showed good performance in predicting recurrent laryngeal nerve lymph node metastasis and prognosis in patients with esophageal squamous cell carcinoma.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Zhenghao Chen, Chuan Qin, Gang Wang, Donghao Shang, Ye Tian, Lushun Yuan, Rui Cao
Summary: This study developed a nomogram that included an StrLNM signature to predict the lymph node metastasis status in bladder cancer patients. The nomogram showed good performance in prediction and was validated in multiple independent cohorts.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Shanhong Lu, Hang Ling, Juan Chen, Lei Tan, Yan Gao, Huayu Li, Pingqing Tan, Donghai Huang, Xin Zhang, Yong Liu, Yitao Mao, Yuanzheng Qiu
Summary: This study investigated the role of pre-treatment MRI radiomics in predicting lymph node metastasis in patients with HPSCC. The results showed that the radiomics nomogram based on MRI images had promising predictive value and clinical usefulness for LN metastasis in HPSCC patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yansong Xu, Yi Chen, Chenyan Long, Huage Zhong, Fangfang Liang, Ling-xu Huang, Chuanyi Wei, Shaolong Lu, Weizhong Tang
Summary: Preoperative CEA level, grading, and PNI were identified as independent risk factors for LNM in colon cancer. The nomogram constructed in this study demonstrated good consistency and calibration capabilities for predicting LNM risk in both the training and validation sets.
FRONTIERS IN ONCOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Wan Duan, Zhangxia Wu, Xueying Mei, Jingyuan Li, Huanzi Lu, Yujie Liang, Xiaomei Lao, Guiqing Liao
Summary: This study examined the role of platelets in the tumor microenvironment of oral squamous cell carcinoma (OSCC) and found that intratumoral platelet microthrombi (PLT-MT) were associated with clinicopathological characteristics and predictive value. PLT-MT was also correlated with lymph node metastasis and prognosis prediction.
Article
Endocrinology & Metabolism
Jinxiao Sun, Qi Jiang, Xian Wang, Wenhua Liu, Xin Wang
Summary: A nomogram combining clinical and US risk factors was developed for predicting preoperative CLNM in PTMC, showing promising results with high accuracy and consistency between the nomogram and clinical findings for predicting CLNM.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Leilei Shen, Juntang Guo, Weidong Zhang, Chaoyang Liang, Han Chen, Yang Liu
Summary: The necessity of performing 4L lymph node dissection (LND) remains uncertain and controversial. This study aimed to analyze the clinicopathological and survival outcomes of 4L LND from the perspective of histology.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Xi Yang, Lu Fang, Chenping Zhang
Summary: The study revealed that the differential expression of TNFRSF10C in the immune-related pathway is associated with lymph node metastasis and disease-free survival in tongue cancer patients. This suggests TNFRSF10C CNV log2 ratio may serve as an indicator of good prognosis for patients with non-LNM after neck dissection.
Article
Oncology
Shaoyuan Zhang, Linyi Sun, Danjie Cai, Guobing Liu, Dongxian Jiang, Jun Yin, Yong Fang, Hao Wang, Yaxing Shen, Yingyong Hou, Hongcheng Shi, Lijie Tan
Summary: This study aimed to predict the lymph node status and survival of esophageal squamous cell carcinoma before treatment using PET-CT-related parameters. A total of 311 patients were included and a predictive model was constructed based on the training and test sets. The model accurately predicts the risk of lymph node metastasis and the patient's 5-year overall survival in esophageal squamous cell carcinoma.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
Yi Zeng, Fenglin Cai, Pengliang Wang, Xinyu Wang, Yong Liu, Li Zhang, Rupeng Zhang, Luchuan Chen, Han Liang, Zaisheng Ye, Jingyu Deng
Summary: This study aims to establish a prognostic model based on extragastric lymph node metastasis (ELNM) and lymph node ratio (LNR) in node-positive gastric cancer (GC). The results show that this model has good prognostic prediction in patients with node-positive GC.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Oncology
Xi'E Hu, Jingyi Xue, Shujia Peng, Ping Yang, Zhenyu Yang, Lin Yang, Yanming Dong, Lijuan Yuan, Ting Wang, Guoqiang Bao
Summary: This study developed a nomogram to preoperatively predict the risk of SLN metastasis in breast cancer patients, demonstrating high predictive performance and clinical usefulness.
FRONTIERS IN ONCOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Andrea Gabusi, Davide B. Gissi, Sara Grillini, Martina Stefanini, Achille Tarsitano, Claudio Marchetti, Maria Pia Foschini, Lucio Montebugnoli, Luca Morandi
Summary: Preliminary data showed shared epigenetic alterations between PD and OSCC patients in two inflammatory genes (GP1BB and MIR193), indicating potential links between the two diseases. This study may provide insights for future research focused on the pathogenesis of PD and OSCC.
Article
Gastroenterology & Hepatology
Benedetto Mangiavillano, Stefano Francesco Crino, Antonio Facciorusso, Francesco Di Matteo, Carmelo Barbera, Alberto Larghi, Gianenrico Rizzatti, Silvia Carrara, Marco Spadaccini, Francesco Auriemma, Carlo Fabbri, Cecilia Binda, Chiara Coluccio, Gianmarco Marocchi, Teresa Staiano, Maria Cristina Conti Bellocchi, Laura Bernardoni, Leonardo Henri Eusebi, Giovanna Grazia Cirota, Germana De Nucci, Serena Stigliano, Gianpiero Manes, Giacomo Bonanno, Andrew Ofosu, Laura Lamonaca, Danilo Paduano, Federica Spatola, Alessandro Repici
Summary: In endoscopic ultrasound-guided fine-needle biopsy, using the macroscopic on-site evaluation (MOSE) technique with 22G Franseen needles is comparable to the conventional method in terms of diagnostic accuracy, specimen adequacy, and safety. MOSE can reduce the number of needle passes required for diagnosis.
Article
Dentistry, Oral Surgery & Medicine
A. Tarsitano, F. Ceccariglia, M. Bevini, L. Breschi, P. Felice, C. Marchetti
Summary: The study presents a new design for a patient-specific three-dimensionally printed reconstructive plate (3DBO-PSI) to restore the mandibular height and profile in mandibular reconstruction using the fibula free flap. Twenty patients underwent mandibular resection and reconstruction with the 3DBO-PSI, with a mean follow-up period of 20 months. Microvascular failure occurred in two patients, but no complications related to the 3DBO-PSI were recorded. The proposed reconstructive method was reliable and reproducible, with successful dental rehabilitation in seven patients.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2023)
Review
Cell Biology
Maria P. P. Foschini, Rieko Nishimura, Viscardo Paolo Fabbri, Zsuzsanna Varga, Handan Kaya, Gabor Cserni
Summary: Myoepithelial cells (MECs) form a continuous layer surrounding the breast glands, acting as a barrier during neoplastic transformation. They can undergo various changes and give rise to a wide spectrum of morphological pictures seen in benign and malignant breast tumors. This study aims to provide a review of MECs lesions and their correlation to prognosis, as these tumors are relatively rare.
Review
Oncology
Johan M. Kros, Elisabeth Rushing, Aime L. Uwimana, Aurelio Hernandez-Lain, Alex Michotte, Maysa Al-Hussaini, Franck Bielle, Christian Mawrin, Gianluca Marucci, C. Mircea S. Tesileanu, Roger Stupp, Brigitta Baumert, Martin van den Bent, Pim J. French, Thierry Gorlia
Summary: The histologic parameters, especially the mitotic count, provide additional prognostic value in IDH mutant astrocytomas. The mitotic count significantly affects the PFS and marginally the OS. Furthermore, the mitotic count also affects the PFS of tumors with CDKN2A/B homozygous deletion.
Article
Clinical Neurology
Valentina Opancina, Silvia Esposito, Francesco Di Meco, Eleonora Bruno, Marco Moscatelli, Ignazio G. Vetrano, Luisa Chiapparini, Miljan Opancina, Mariangela Farinotti, Nebojsa Zdravkovic, Bianca Pollo, Gianluca Marucci, Fabio M. Doniselli
Summary: The purpose of this study is to summarize the typical and atypical MRI findings of pediatric isolated-not NF1-related pilocytic astrocytomas (pPAs) and correlate specific MRI patterns with clinical variables. The results showed that typical MRI findings of pediatric pPAs include well-defined contours, hypo- and hyperintense signals on T1-wi and T2-wi, hyperintense signals on FLAIR, and heterogeneous signals on T1-wi and T2-wi sequences. Additionally, a positive correlation was found between pPA location and age, while the degree of connection between pPA location and gender was small.
NEUROLOGICAL SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Claudio Ricci, Francesco Serbassi, Laura Alberici, Carlo Ingaldi, Leonardo H. Eusebi, Emilio De Raffele, Loris Pironi, Anna S. Sasdelli, Cristina Mosconi, Valentina Vicennati, Riccardo Casadei
Summary: Immunonutrition can reduce infectious complications and length of stay in patients undergoing pancreatic surgery. However, the small differences in mortality, morbidity, and postoperative pancreatic fistula rates make it impossible to exclude type II error due to large sample sizes.
Review
Oncology
Andrea Ambrosini-Spaltro, Francesco Di Donato, Luca Saragoni, Gabor Cserni, Emad Rakha, Maria Pia Foschini
Summary: This study aimed to examine the prognostic factors of microinvasive breast carcinoma through a systematic review and meta-analysis. The results showed that lymph node status has a significant association with prognosis, while other factors such as estrogen receptor, progesterone receptor, HER2 status, multifocality or grade of microinvasion, and patient's age do not significantly affect prognosis. Therefore, lymph node status is the main prognostic factor of microinvasive breast carcinoma.
Article
Oncology
Balint Cserni, Darren Kilmartin, Mark O'Loughlin, Xavier Andreu, Zsuzsanna Bago-Horvath, Simonetta Bianchi, Ewa Chmielik, Paulo Figueiredo, Giuseppe Floris, Maria Pia Foschini, Aniko Kovacs, Paivi Heikkila, Janina Kulka, Anne-Vibeke Laenkholm, Inta Liepniece-Karele, Caterina Marchio, Elena Provenzano, Peter Regitnig, Angelika Reiner, Ales Ryska, Anna Sapino, Elisabeth Specht Stovgaard, Cecily Quinn, Vasiliki Zolota, Mark Webber, Sharon A. Glynn, Rita Bori, Erika Csorgo, Orsolya Olah-Nemeth, Tamas Pancsa, Anita Sejben, Istvan Sejben, Andras Voros, Tamas Zombori, Tibor Nyari, Grace Callagy, Gabor Cserni
Summary: Tumour-infiltrating lymphocytes (TILs) reflect the host's response against tumours, especially in triple-negative breast cancers. ONEST helps in estimating the number of observers required for a more reliable estimation of inter-observer agreement in TIL assessments, which has not been explored previously. This analysis suggests that between six and nine pathologists can provide a good approximation of inter-observer agreement in TIL assessments.
Editorial Material
Medicine, General & Internal
Dario de Biase, Enrico Franceschi, Gianluca Marucci
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Matilde Taddei, Silvia Esposito, Gianluca Marucci, Alessandra Erbetta, Paolo Ferroli, Laura Grazia Valentini, Chiara Pantaleoni, Stefano D'Arrigo, Veronica Saletti, Bianca Pollo, Rosina Paterra, Daria Riva, Sara Bulgheroni
Summary: In this study, the cognitive and behavioral outcomes of children with low-grade CNS tumors treated with surgical intervention were analyzed retrospectively. The results showed that the sample had normal cognitive abilities and behavioral functioning, but weaknesses were observed in verbal working memory and processing speed. Factors such as younger age at symptoms' onset, glioneuronal histological type, cortical location with preoperative seizures, timing of surgery, and seizure control after surgery were found to be associated with cognitive and behavioral functioning. Timely treatment and regular assessment are important for the global outcome and daily functioning of these patients.
Article
Clinical Neurology
Roberta Di Giacomo, Alessandra Burini, Elisa Visani, Fabio Martino Doniselli, Valeria Cuccarini, Rita Garbelli, Gianluca Marucci, Dalia De Santis, Giuseppe Didato, Francesco Deleo, Chiara Pastori, Andrea Stabile, Flavio Villani, Michele Rizzi, Luca Girardi, Marco de Curtis
Summary: This study describes the clinical, diagnostic, and neuropathological findings of 12 patients with temporal encephaloceles and epilepsy, compared with a control group of 26 patients with temporal lobe epilepsy. The study found that encephaloceles have distinct characteristics including later epilepsy onset, higher prevalence of psychiatric comorbidities, no history of febrile convulsions, and differences in seizure semiology. Neuropathological examination revealed four different patterns of encephaloceles.
NEUROLOGICAL SCIENCES
(2023)
Article
Health Care Sciences & Services
Elisabetta Lucchi, Laura Cercenelli, Vincenzo Maiolo, Barbara Bortolani, Emanuela Marcelli, Achille Tarsitano
Summary: The prognostic impact of tumor volume and tumor sphericity in oral cancer patients was analyzed. The study found that larger tumor volumes were associated with higher recurrence and tumor-related death rates. On the other hand, higher tumor sphericity was associated with better disease-free survival. This study suggests that tumor volume and sphericity can provide useful information for predicting prognosis in oral cancer.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Oncology
Esther Diana Rossi, Zubair Baloch, Guliz Barkan, Maria Pia Foschini, Daniel Kurtycz, Marc Pusztaszeri, Philippe Vielh, William C. Faquin
Summary: The use of standardized reporting systems for non-gynecologic cytopathology, including the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC), has gained popularity in the past decade. The MSRSGC defines diagnostic categories and provides risk assessment and management algorithms for salivary gland lesions. The second edition of MSRSGC, published in 2023, includes refined risks of malignancy, updates in ancillary testing, and a guide to the practical application of the latest ancillary markers.
CANCER CYTOPATHOLOGY
(2023)
Review
Cell Biology
Esther Diana Rossi, Zubair Baloch, Guliz Barkan, Maria Pia Foschini, Daniel Kurtycz, Marc Pusztaszeri, Philippe Vielh, William C. Faquin
Summary: The use of standardised reporting systems for non-gynaecologic cytopathology has gained popularity in various areas, including thyroid fine-needle aspiration and urine cytology. The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) provides a defined risk assessment and clinical management algorithm for diagnosing salivary gland lesions. The MSRSGC has been widely accepted and its second edition includes updated risk assessments and advancements in imaging and ancillary testing.
