Article
Health Care Sciences & Services
Young-Joo Jeon, Sung-Hwan Cho, Eo-Jin Kim, Chang-Soo Ryu, Han-Sung Park, Jong-Woo Kim, Jeong-Yong Lee, Hui-Jeong An, Nam-Keun Kim
Summary: This study found an association between 3'-UTR variants in TS genes and colorectal cancer, suggesting they could potentially serve as biomarkers for CRC prognosis and prevention.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jaroslaw Goracy, Anna Bogacz, Izabela Uzar, Marlena Wolek, Malgorzata Lochynska, Pawel Zietek, Boguslaw Czerny, Aneta Cymbaluk-Ploska, Piotr Modliborski, Adam Kaminski
Summary: This study aimed to evaluate the association between NQO1 gene 609C > T polymorphism and colorectal cancer risk in the Polish population, finding that carriers of the TT genotype have an elevated risk for colorectal cancer. The analysis also revealed a significant increase in colorectal cancer risk in carriers of the TT genotype, particularly related to tumor stage and location.
Article
Oncology
Jielin Chen, Qijia Yan, Jingyue Sun, Qingyi Wang, Yongguang Tao, Desheng Xiao, Bin Xie
Summary: Precision medical treatment for colorectal cancer relies on accurate assessment of microsatellite status, which can be detected using a combination of polymerase chain reaction (PCR) and immunohistochemistry (IHC). MSI-H is a predictive biomarker for immune checkpoint inhibitors (ICIs). Misdiagnosis of microsatellite status can lead to resistance to ICIs. Therefore, it is important to rapidly and accurately assess microsatellite status for precision medicine in colorectal cancer.
Article
Biochemistry & Molecular Biology
Changwon Yang, Jisoo Song, Sunjae Hwang, Jungil Choi, Gwonhwa Song, Whasun Lim
Summary: The study found that apigenin enhances the inhibitory effect of 5-FU on colorectal cancer cells by suppressing TS expression, promoting apoptosis, and disrupting the cell cycle. Additionally, apigenin increases reactive oxygen species production and intracellular calcium levels, indicating its potential to improve therapeutic efficacy.
Article
Biochemical Research Methods
Weidu Song, Chuanhao Zhang, Huichao Lin, Taiyi Zhang, Haixia Liu, Xiaowen Huang
Summary: The proposed real-time rotary PCR reaction system (RRP) meets the requirements of low cost, low-power consumption, potential for miniaturization, and portability. Experimental and theoretical results demonstrate its feasibility in the rapid quantitative detection of Pseudomonas aeruginosa and have broad application prospects in bacteria detection and food safety.
Article
Biochemical Research Methods
Shaolei Huang, Yiquan An, Bangchao Xi, Xianglian Gong, Zhongfu Chen, Shan Shao, Shengxiang Ge, Jun Zhang, Dongxu Zhang, Ningshao Xia
Summary: Nucleic acid detection is a method that directly identifies the presence of pathogenic microorganisms and has advantages of high sensitivity, commendable specificity, and a short window period. A real-time PCR system based on multiple temperature zones was proposed to solve the time-consuming problem, enabling fast detection speed and high sensitivity under extreme conditions.
Article
Oncology
Zongren Ding, Yijun Wu, Guoxu Fang, Zhaowang Lin, Kongying Lin, Jun Fu, Qizhen Huang, Yanyan Tang, Wuyi You, Jingfeng Liu, Yongyi Zeng
Summary: This study developed and validated a radiomics nomogram for predicting TYMS status in hepatocellular carcinoma using Gd-DTPA contrast enhanced MRI. The radiomics nomogram showed favorable predictive efficacy and may be helpful for personalized treatment of hepatocellular carcinoma.
Article
Gastroenterology & Hepatology
Ishrat Parveiz Bhat, Tahseen Bilal Rather, Irfan Maqbool, Gowhar Rashid, Kulsum Akhtar, Gulzar A. Bhat, Fazl Q. Parray, Besina Syed, Ishrat Younas Khan, Mohsin Kazi, Muhammad D. Hussain, Mudassar Syed
Summary: CTGF expression is increased in colorectal cancer and is associated with patient prognosis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Oncology
Jordana Williams, Morris Kostiuk, Vincent L. Biron
Summary: HPV is responsible for most cervical cancers and some head and neck cancers. Specific detection methods are used to diagnose HPV infections in cervical and head and neck cancers.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Jian Li, Huan Li, Zeng-Ci Run, Zhen-Lei Wang, Tao Jiang, Yang An, Zhi Li
Summary: This study evaluated the diagnostic value of RASSF1A methylation in plasma for colorectal cancer (CRC) and hepatocellular carcinoma (HCC). The findings suggest that RASSF1A methylation in plasma may serve as a potential biomarker for CRC and HCC.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Zhaokang Bao, Jiale Cheng, Jiahao Zhu, Shengjun Ji, Ke Gu, Yutian Zhao, Shiyou Yu, You Meng
Summary: Bioinformatics analysis was used to identify potential biomarker genes and their relationship with breast cancer (BC). The study revealed that MND1 may serve as a potential biomarker and therapeutic target for BC, and its expression levels are positively correlated with immune cell infiltration.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Changwon Yang, Jisoo Song, Sunwoo Park, Jiyeon Ham, Wonhyoung Park, Hahyun Park, Garam An, Taeyeon Hong, Hee Seung Kim, Gwonhwa Song, Whasun Lim
Summary: This study investigated the effects of quercetin on colorectal cancer cells and found that quercetin can suppress thymidylate synthase levels and induce oxidative stress and calcium dysregulation. It also regulates the expression of specific tiRNAs and enhances apoptosis in CRC cells. Quercetin treatment in colitis-associated CRC mice showed enhanced sensitivity to 5-FU and reduced tumor growth. These findings suggest that quercetin has the potential to be used as an adjuvant with 5-FU for the treatment of CRC.
Article
Virology
Imene Ben Dhifallah, Kaouther Ayouni, Haifa Jmel, Wafa Kammoun, Kamel Hamzaoui, Amel Sadraoui, Henda Triki
Summary: The study revealed that the IL-12B gene polymorphism is significantly associated with an increased risk of chronic hepatitis B (CHB) in patients, particularly in males under the age of 50.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Clarissa Pessoa Fernandes Forte, Francisco Artur Forte Oliveira, Camile de Barros Lopes, Ana Paula Negreiros Nunes Alves, Mario Rogerio Lima Mota, Paulo Goberlanio de Barros Silva, Raquel Carvalho Montenegro, Andrea Kely Campos Ribeiro dos Santos, Jose Glauco Lobo Filho, Fabricio Bitu Sousa
Summary: The study found the presence of Streptococcus mutans in atherosclerotic plaque, suggesting a possible association between the bacteria and atherosclerosis. Control samples showed the presence of harmless bacteria not associated with tissue alteration. Further studies are needed for more information.
Article
Health Care Sciences & Services
Jung Oh Kim, Han Sung Park, Eun Ju Ko, Jung Hoon Sung, Jinkwon Kim, Seung Hun Oh, Ok Joon Kim, Nam Keun Kim
Summary: TS 1100T>C and 1170A>G polymorphisms are strongly associated with the risk of ischemic stroke and SBI in Koreans, with 1100T>C polymorphism also showing synergistic effects with low folic acid levels. These findings suggest that TS 1100T>C and 1170A>G polymorphisms may serve as potential biomarkers for ischemic stroke and SBI.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Letter
Hematology
Angelo B. C. Brito, Marcia Torresan Delamain, Cristiane de Oliveira, Marcello Ferreti Fanelli, Fernando Augusto Soares, Carmino A. de Souza, Jose Vassallo, Carmen Silvia Passos Lima
BRITISH JOURNAL OF HAEMATOLOGY
(2017)
Review
Oncology
Monica Bellei, Elena Sabattini, Emanuela Anna Pesce, Young-Hyeh Ko, Won Seog Kim, Maria Elena Cabrera, Virginia Martinez, Ivan Dlouhy, Roberto Pinto Paes, Tomas Barrese, Jose Vassallo, Vittoria Tarantino, Julie Vose, Dennis Weisenburger, Thomas Ruediger, Massimo Federico, Stefano Pileri
HEMATOLOGICAL ONCOLOGY
(2017)
Article
Physics, Atomic, Molecular & Chemical
Andre Lisboa Renno, Marcos Alves-Junior, Nicolas Vilczaki Schwab, Marcos Nogueira Eberlin, Andre Almeida Schenka, Alessandra Sussulini
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
(2017)
Article
Anatomy & Morphology
Rodrigo V. Oliveira, Valeria B. Souza, Philipi C. Souza, Fernando A. Soares, Jose Vassallo, Rafael M. Rocha, Andre A. Schenka
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
(2018)
Letter
Respiratory System
Helen Naemi Honma, Mauricio Wesley Perroud, Andre Moreno Morcillo, Jose Vassallo, Lair Zambon
JORNAL BRASILEIRO DE PNEUMOLOGIA
(2018)
Article
Multidisciplinary Sciences
Rafael Campos, Alberto Fernando Oliveira Justo, Fabiola Z. Monica, Jose Carlos Cogo, Ronilson Agnaldo Moreno, Valeria Barbosa de Souza, Andre Almeida Schenka, Gilberto De Nucci
Article
Cell Biology
Marcelo Vilas Boas Mota, Bruna Cunha Zaidan, Amanda Morato do Canto, Enrico Ghizoni, Helder Tedeschi, Luciano de Souza Queiroz, Marina K. M. Alvim, Fernando Cendes, Iscia Lopes-Cendes, Andre Almeida Schenka, Andre Schwambach Vieira, Fabio Rogerio
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2019)
Article
Pathology
Catherine Thirion-Delalande, Frederic Gervais, Bernard Palate, Roy Forster, Andre Almeida Schenka
TOXICOLOGIC PATHOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Rafael Campos, Felipe Fernandes Jacintho, Jose Britto-Junior, Fabiola Z. Monica, Alberto Fernando Oliveira Justo, Andre Sampaio Pupo, Ronilson Agnaldo Moreno, Valeria Barbosa de Souza, Andre Almeida Schenka, Edson Antunes, Gilberto De Nucci
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Jose Britto-Junior, David H. A. Pinheiro, Alberto F. O. Justo, Guilherme M. Figueiredo Murari, Rafael Campos, Fernanda Mariano, Valeria B. de Souza, Andre A. Schenka, Fabiola Z. Monica, Edson Antunes, Gilberto De Nucci
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2020)
Article
Pharmacology & Pharmacy
Livia L. Camargo, Alexandre Denadai-Souza, Lidia M. Yshii, Carla Lima, Simone A. Teixeira, Anderson R. A. Cerqueira, Mayara C. F. Gewehr, Elizabeth S. Fernandes, Andre A. Schenka, Marcelo N. Muscara, Emer S. Ferro, Soraia K. P. Costa
Summary: Hemopressin has shown analgesic effects in experimental arthritis and may be a novel therapeutic strategy for treating RA by reducing joint swelling and pain.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Oncology
Anita Cassoli Cortez, Marcia Torresan Delamain, Leandro Luiz Lopes de Freitas, Andre Almeida Schenka, Fabiano Reis
HEMATOLOGY TRANSFUSION AND CELL THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Antonio Tiago Lima, Eric Xavier dos Santos, Jose Britto-Junior, Valeria B. de Souza, Andre A. Schenka, Rafael Campos, Manoel Odorico Moraes, Maria Elisabete A. Moraes, Edson Antunes, Gilberto De Nucci
Summary: 6-Nitrodopamine (6-ND) is a newly released catecholamine that can cause powerful vasorelaxation by acting as a potent and selective dopamine D2-like receptor antagonist. Its synthesis/release can be inhibited by nitric oxide (NO) synthase inhibitor or by removal of the endothelium.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Jose Marcos Vieira Rocha, Valeria Barbosa de Souza, Patricia Costa Panunto, Jacqueline Spacagna Nicolosi, Emanueli do Nascimento da Silva, Solange Cadore, Oscar Moscoso Londono, Diego Muraca, Pablo Tancredi, Marina de Brot, Wilson Nadruz, Ana Lucia Tasca Gois Ruiz, Marcelo Knobel, Andre Almeida Schenka
Summary: This study synthesized citrate-coated iron oxide nanoparticles and evaluated their potential toxic effects using in vitro and in vivo models. The results showed that these nanoparticles had no adverse effects on cell viability and vital organ morphology. Therefore, this study provides a simple, fast, and reproducible method for the development of a safe drug nanodelivery system.
Retraction
Endocrinology & Metabolism
P. O. Prada, S. M. Hirabara, C. T. de Souza, A. A. Schenka, H. G. Zecchin, J. Vassallo, L. A. Velloso, E. Carneiro, J. B. C. Carvalheira, R. Curi, M. J. Saad