Article
Medicine, Research & Experimental
Zihao Chang, Qiunan Zhang, Qian Hu, Yuqi Liu, Lanzhen Zhang, Runping Liu
Summary: The study shows that the total tannin fraction of Terminalia bellirica (TB-TF) can inhibit hepatocellular carcinoma growth, promote the polarization of tumor-associated macrophages towards an anti-tumor phenotype, increase T cell infiltration, and restore cytotoxic function of CD8+T cells.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Engineering, Biomedical
Yanni Ge, Jiaojiao Zhang, Kai Jin, Ziqiang Ye, Wei Wang, Zhuxian Zhou, Juan Ye
Summary: This study developed a photothermal agent, copper sulfide@ovalbumin (CuS@OVA), with an effective photothermal effect on tumors. CuS@OVA can optimize the tumor microenvironment and stimulate an adaptive immune response, enhancing the antitumor efficiency of immune checkpoint blockade (ICB) and suppressing tumor growth and metastasis.
ACTA BIOMATERIALIA
(2023)
Article
Nanoscience & Nanotechnology
Siyu Wu, Jiayi Ma, Jun Liu, Chun Liu, Su Ni, Ting Dai, Yan Wang, Yiping Weng, Hongbin Zhao, Dong Zhou, Xiubo Zhao
Summary: In this study, a nanostructured scaffold loaded with telmisartan was developed to modulate the immune response and promote bone healing. The results showed that telmisartan-loaded scaffolds exhibited anti-inflammatory activity and enhanced bone regeneration by regulating macrophage polarization.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Pharmacology & Pharmacy
Yongheng Gao, Xia Huang, Hongwei Lin, Mingxuan Zhao, Wei Liu, Wangping Li, Luyao Han, Qiong Ma, Chuan Dong, Yujuan Li, Ying Hu, Faguang Jin
Summary: PM2.5 exposure leads to elevated levels of ROS in the lungs, causing oxidative stress and inflammation. Treatment with Antioxi-EVs derived from ADSCs can suppress ROS levels and reduce oxidative stress, inflammation, and lung injury induced by PM2.5 through anti-oxidative stress and immunomodulation pathways.
Article
Fisheries
Marta Carvalho, Silvia Torrecillas, Daniel Montero, Antonio Sanmartin, Ramon Fontanillas, Ana Farias, Katerina Moutou, Jorge Hernandez Velasquez, Marisol Izquierdo
Summary: In recent years, aquaculture research and industry have been searching for novel alternatives to fish meal to make fish feeds more effective and sustainable. Insect meals and single-cell proteins from bacteria have shown promise, but their effects on gilthead sea bream have not been thoroughly studied. This study evaluated the effects of replacing fish meal with insect meal or single-cell protein in practical diets for gilthead sea bream juveniles.
Article
Chemistry, Multidisciplinary
Yi-Fang Tsai, Thiyagarajan Natarajan, Zhi-Han Lin, I-Kuen Tsai, Damodar Janmanchi, Sunney I. Chan, Steve S. -F. Yu
Summary: This study presents a strategy for the electrocatalysis of selective methane oxidation by immobilizing tricopper catalysts on the cathodic surface. The technology achieves significant enhancements in performance of the catalysts toward methane oxidation, leading to high product throughputs and turnover frequencies. It is of great importance for the on-site direct conversion of methane into methanol.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Agriculture, Dairy & Animal Science
Nathan Felix, Kalidoss Manikandan, Arumugam Uma, Sadasivam J. Kaushik
Summary: The study found that a single cell protein (SCP) produced from methane-oxidising bacteria Methylococcus capsulatus can replace fishmeal in the diets of Pacific white shrimp, Penaeus vannamei. Shrimp fed diets with increasing levels of SCP up to 200 g/kg showed improved growth and feed efficiency. Nitrogen and phosphorous retention in shrimp were also improved with SCP inclusion in the diets. The study demonstrated that SCP from M. capsulatus can be efficiently used in the diet of P. vannamei up to 200 g/kg with significant beneficial effects on growth, feed and nutrient utilization.
ANIMAL FEED SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
W-H Chang, H-H Lin, I-K Tsai, S-H Huang, S-C Chung, I-P Tu, S. S-F Yu, S. Chan
Summary: The particulate methane monooxygenase (pMMO) is a key enzyme in methanotrophic bacteria that converts methane into methanol. Structural studies have revealed the active site and catalytic mechanism of the enzyme, shedding light on the process of methane oxidation.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Engineering, Biomedical
Sandra Camarero-Espinosa, Maria Carlos-Oliveira, Hong Liu, Joao F. Mano, Nicole Bouvy, Lorenzo Moroni
Summary: The research investigates the immunomodulatory properties of dual-porosity scaffolds with varying mechanical and topographical features, demonstrating the significant impact of the interplay between scaffold stiffness and surface properties on immune response and healing processes.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Agriculture, Multidisciplinary
Yilin Liao, Qi Yan, Tiange Cheng, Hantao Yao, Yaoyu Zhao, Dongjie Fu, Yaoting Ji, Bin Shi
Summary: This study demonstrates that sulforaphene can inhibit the development of periodontitis by regulating macrophage polarization. The research also identifies dendritic cell immunoreceptor as a crucial player in the process of macrophage polarization.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Fisheries
Brett Glencross, Pedro Munoz-Lopez, Chessor Matthew, Simon MacKenzie, Adam Powell, Matt Longshaw, Allan LeBlanc
Summary: This study examined the impact of acclimation time and inclusion level of a bacterial protein (BP) meal on the digestibility of protein and amino acids to post-smolt Atlantic salmon (Salmo salar). The results showed that longer acclimation time and higher inclusion level resulted in higher digestibility. Minimum 14-day acclimation time and 200 g/kg or greater inclusion level are recommended for reliable data.
Article
Materials Science, Multidisciplinary
Qian-Qian Wan, Jin-Long Sun, Yu-Xuan Ma, Luke C. Noble, Yan Dong, Zhi-Hong Feng, Jun-Ting Gu, Yi-Rong Wang, Wan-Rong Wang, Brian E. Bergeron, Kai Jiao, Franklin R. Tay, Li-Na Niu
Summary: The study revealed that TSCs modulate bone regeneration by inducing macrophage polarization into the M2 phenotype, enhancing osteogenic potential of mesenchymal stromal cells, and promoting healing of bone defects.
APPLIED MATERIALS TODAY
(2021)
Article
Veterinary Sciences
Zrinka Oreskovic, Lenka Leva, Katarina Chlebova, Karolina Hlavova, Radek Tesarik, Jan Gebauer, Martin Faldyna
Summary: This study investigated the effects of different cytokine microenvironments on porcine dendritic cells and found that an IFNγ-rich microenvironment induced a higher inflammatory response and release of polarizing cytokines. Different cytokine microenvironments have the potential to modulate the activation ability of dendritic cells.
RESEARCH IN VETERINARY SCIENCE
(2022)
Review
Pharmacology & Pharmacy
Chizumi Abe, Maharshi Bhaswant, Teruo Miyazawa, Taiki Miyazawa
Summary: Cancer is characterized by the rapid growth and spread of aberrant cells, leading to metastasis. Widespread metastases are the main cause of death in cancer patients. Different types of cancer cells vary in their proliferation and response to treatment, and conventional drugs often have harmful side effects. Utilizing exosomes as drug carriers for targeted therapy and regulating macrophage polarization in the tumor microenvironment show promise as natural and harmless approaches to cancer treatment.
Article
Engineering, Biomedical
Yaping Wang, Jingrong Wang, Rui Gao, Xiang Liu, Zujian Feng, Chuangnian Zhang, Pingsheng Huang, Anjie Dong, Deling Kong, Weiwei Wang
Summary: A synthetic fibrous glycopeptide hydrogel was developed and composited with 3D-printed PCL/nHA scaffold for cranial bone regeneration, showing significant promotion of stem cell proliferation and osteogenic differentiation as well as enhanced interaction between macrophages and stem cells. The composite scaffold exhibited superior efficacy in bone regeneration and osseointegration, creating a reparative microenvironment similar to normal cranium with increased anti-inflammatory macrophages and osteoblasts.
Article
Toxicology
A. Solhaug, C. Wisbech, T. E. Christoffersen, L. O. Hult, T. Lea, G. S. Eriksen, J. A. Holme
TOXICOLOGY LETTERS
(2015)
Article
Biotechnology & Applied Microbiology
Charlotte R. Kleiveland, Lene T. Olsen Hult, Signe Spetalen, Magne Kaldhusdal, Trine Eker Christofferesen, Oskar Bengtsson, Odd Helge Romarheim, Morten Jacobsen, Tor Lea
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2013)
Article
Nutrition & Dietetics
Trine E. Christoffersen, Hanne Jensen, Charlotte R. Kleiveland, Guro Dorum, Morten Jacobsen, Tor Lea
BRITISH JOURNAL OF NUTRITION
(2012)
Article
Biochemistry & Molecular Biology
Vigdis Sorensen, Yan Zhen, Malgorzata Zakrzewska, Ellen Margrethe Haugsten, Sebastien Walchli, Trine Nilsen, Sjur Olsnes, Antoni Wiedlocha
MOLECULAR AND CELLULAR BIOLOGY
(2008)
Article
Biotechnology & Applied Microbiology
Trine Eker Christoffersen, Lene Therese Olsen Hult, Katarzyna Kuczkowska, Kim Marius Moe, Siv Skeie, Tor Lea, Charlotte Ramstad Kleiveland
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2014)
Article
Clinical Neurology
Karianne Larsen, Henriette S. Jaeger, Lars H. Tveit, Maren R. Hov, Kjetil Thorsen, Jo Roislien, Volker Solyga, Christian G. Lund, Kristi G. Bache
Summary: This study found that integrating thrombolysis of acute ischemic stroke in an anesthesiologist-based EMS can reduce time-to-treatment and is safe. Mobile stroke units enable prehospital assessment of acute strokes as well as other medical and traumatic emergencies.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Karianne Larsen, Henriette S. Jaeger, Maren R. Hov, Kjetil Thorsen, Volker Solyga, Christian G. Lund, Kristi G. Bache
Summary: The study indicates that paramedics can effectively use NIHSS as an accurate and time efficient prehospital stroke severity quantification tool, early assessment of strokes can be beneficial for stroke treatment.
Article
Emergency Medicine
Henriette S. Jaeger, Ditte Tranberg, Karianne Larsen, Jan B. Valentin, Rolf A. Blauenfeldt, Sebastian Luger, Kristi G. Bache, Martin F. Gude
Summary: This study found that the combination of GFAP and PreSS can accurately identify and differentiate acute stroke patients within 4.5 hours after symptom onset. Rapid identification and treatment of stroke is crucial for patient outcomes.
SCANDINAVIAN JOURNAL OF TRAUMA RESUSCITATION & EMERGENCY MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Trine Nilsen, Ken R. Rosendal, Vigdis Sorensen, Jorgen Wesche, Sjur Olsnes, Antoni Wiedlocha
JOURNAL OF BIOLOGICAL CHEMISTRY
(2007)
Review
Biochemistry & Molecular Biology
V Sorensen, T Nilsen, A Wiedlocha
Article
Biochemistry & Molecular Biology
J Wesche, J Malecki, AW Wiedlocha, M Ehsani, E Marcinkowska, T Nilsen, S Olsnes
Article
Cell Biology
A Wiedlocha, T Nilsen, J Wesche, V Sorensen, J Malecki, E Marcinkowska, S Olsnes
MOLECULAR BIOLOGY OF THE CELL
(2005)
Article
Biochemistry & Molecular Biology
T Nilsen, T Slagsvold, CS Skjerpen, A Brech, H Stenmark, S Olsnes
JOURNAL OF BIOLOGICAL CHEMISTRY
(2004)