Article
Medicine, General & Internal
Seung Hyung Han, Kyung Duk Park, Soon Chul Kim
Summary: This case report describes a rare case of nodular regenerative hyperplasia of the liver in a child, accompanied by antiphospholipid syndrome (APS). The patient showed significant improvement with anticoagulation therapy. Therefore, in children with hepatic nodular regenerative hyperplasia or vascular thrombosis, it is recommended to conduct antiphospholipid antibody testing and implement appropriate management promptly.
Article
Pathology
Pooja Navale, Raul S. Gonzalez
Summary: Nodular regenerative hyperplasia (NRH) presents challenges in histological diagnosis, especially in cases of mild disease and limited biopsy samples. NRH is often associated with portal hypertension (PHTN) and should be suspected in biopsies. Sinusoidal dilation, while nonspecific, is commonly observed in NRH.
Article
Gastroenterology & Hepatology
Daniel D. Penrice, Nimish Thakral, Camille A. Kezer, Ryan Lennon, Roger K. Moreira, Rondell P. Graham, Patrick S. Kamath, Douglas A. Simonetto
Summary: Nodular regenerative hyperplasia (NRH) is a rare condition with low rates of liver-related complications and mortality. Most patients do not have an identified risk factor or etiology, and liver-related outcomes do not appear to differ based on associated conditions.
LIVER INTERNATIONAL
(2022)
Article
Surgery
Hai-Bo Zheng, Na Da, Qin-Xia Bo, Li Cao, Jian-Wei Li, Shu-Guo Zheng, Yong Cao, Xiao-Jun Wang
Summary: This study investigated the safety and feasibility of laparoscopic resection of focal nodular hyperplasia (FNH) in the hepatic caudate lobe. The results showed that laparoscopic surgery was successful in appropriate patients. Skilled techniques, preoperative evaluation, appropriate surgical approach choice, and intraoperative bleeding control were critical for the surgery.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Biotechnology & Applied Microbiology
Xuan Yu, Jiandong Chang, Dezhi Zhang, Qiang Lu, Songsong Wu, Kai Li
Summary: This study retrospectively analyzed the clinical data of patients who underwent ultrasound-guided percutaneous thermal ablation for FNH in China. The results showed that this treatment method is safe and effective, with a high technical success rate and a low incidence of complications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Pediatrics
Aviya Lanis, Rita Volochayev, David E. Kleiner, Anusha Vittal, Theo Heller, Lisa G. Rider, Susan Shenoi
Summary: This article presents two cases of Nodular Regenerative Hyperplasia (NRH) associated with Juvenile Dermatomyositis (JDM). Clinical symptoms and laboratory tests indicated liver disease, but there was no evidence of active liver disease or portal hypertension. Liver biopsy confirmed the diagnosis of NRH. Medications such as methotrexate, azathioprine, and cyclophosphamide used to treat JDM have been associated with NRH and should be discontinued if NRH develops.
PEDIATRIC RHEUMATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Marika Rudler, Virginia Hernandez-Gea, Bogdan Dumitru Procopet, Alvaro Giraldez, Lucio Amitrano, Candid Villanueva, Luis Ibanez, Gilberto Silva-Junior, Joan Genesca, Christophe Bureau, Jonel Trebicka, Rafael Banares, Aleksander Krag, Elba Llop, Wim Laleman, Jose Maria Palazon, Jose Castellote, Susana Rodrigues, Lise Lotte Gluud, Carlos Noronha Ferreira, Nouria Canete, Manuel Rodriguez, Arnulf Ferlitsch, Jose Luis Mundi, Henning Gronbaek, Manuel Hernandez-Guerra, Romano Sassatelli, Alessandra Dell'era, Marco Senzolo, Juan G. Abraldes, Manuel Romero-Gomez, Alexander Zipprich, Meritxell Casas, Helena Masnou, Helene Larrue, Massimo Primignani, Frederik Nevens, Jose Luis Calleja, Remy Schwarzer, Christian Jansen, Marie-Angele Robic, Irene Conejo, Javier Martinez Gonzalez, Maria Vega Catalina, Agustin Albillos, Edilmar Alvarado, Maria Anna Guardascione, Maxime Mallet, Simona Tripon, Georgina Casanovas, Jaume Bosch, Juan-Carlos Garcia-Pagan, Dominique Thabut
Summary: pTIPS is more effective in improving survival compared to endoscopic treatment for high-risk patients with cirrhosis and variceal bleeding. HE at admission does not affect the efficacy of pTIPS.
Article
Radiology, Nuclear Medicine & Medical Imaging
Leann M. Kania, Jaydev Dave, Flavius F. Guglielmo, Haresh V. Naringrekar, Abdullah Alturki, Jesse M. Civan, Mark A. Bundschuh, Donald G. Mitchell
Summary: This retrospective study aimed to distinguish between focal nodular hyperplasia (FNH) and hepatic adenoma (HA) by evaluating the early enhancement of a draining hepatic vein (EDHV) and absence of perilesional enhancement (PLE) on arterial phase MR images. The study involved 34 patients, and the results showed that EDHV was identified in 48.5% of FNH cases and only 8.8% of HA cases. PLE was observed more frequently in HA cases. Therefore, the presence of EDHV suggests FNH, while the presence of PLE indicates the absence of FNH.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jordan D. LeGout, Candice W. Bolan, Andrew W. Bowman, Melanie P. Caserta, Frank K. Chen, Kelly L. Cox, Rupan Sanyal, Beau B. Toskich, Jason T. Lewis, Lauren F. Alexander
Summary: Focal nodular hyperplasia (FNH) is a benign liver lesion that can be accurately diagnosed using imaging techniques. It is often difficult to differentiate FNH from hepatocellular adenoma, but they are managed differently. FNH-like lesions, occurring in abnormal liver backgrounds, need to be distinguished from malignancies. Familiarity with the imaging appearances of different conditions and their association with FNH-like lesions is crucial for accurate identification and avoiding unnecessary interventions.
Article
Biochemistry & Molecular Biology
Matthew Zhao, Sammy Saab, Chloe Craw, Edward Wolfgang Lee
Summary: This study investigated the impact of renal function on hepatic encephalopathy (HE) following transjugular intrahepatic portosystemic shunt (TIPS) placement for refractory ascites. The study found that patients with impaired renal function or chronic renal dysfunction were at an increased risk for HE within 60 days after TIPS placement.
Article
Cardiac & Cardiovascular Systems
Okan Ince, Hakan Onder, Mehmet Genctuerk, Jafar Golzarian, Shamar Young
Summary: The study aimed to develop and assess machine learning models for predicting post-procedural hepatic encephalopathy following TIPS placement. Various features were analyzed, and three ML models (SVM, LR, CatBoost) were developed and evaluated for their performance in predicting HE. The results showed that certain features were significantly associated with the development of post-procedural HE.
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Xin Li, Sasan Partovi, Wendy Melissa Coronado, Sameer Gadani, Charles Martin, Dustin Thompson, Abraham Levitin, Baljendra Kapoor
Summary: This manuscript discusses the current state of research on HE after TIPS placement, including information on risk stratification, complication prevention, and treatment options.
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2022)
Article
Medicine, General & Internal
Leon Louis Seifert, Philipp Schindler, Martin Schoster, Jan Frederic Weller, Christian Wilms, Hartmut H. Schmidt, Miriam Maschmeier, Max Masthoff, Michael Koehler, Hauke Heinzow, Moritz Wildgruber
Summary: Higher age and previous HE are risk factors for post-TIPS HE. Lactulose monoprophylaxis has no prophylactic effect, while the combination of lactulose and rifaximin can prevent HE recurrence but not in patients without a history of HE.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Aileen Liang, Sukhman Brar, Majed Almaghrabi, Mohammad Qasim Khan, Karim Qumosani, Anouar Teriaky
Summary: In the prophylactic medical therapy for preventing post-TIPS hepatic encephalopathy (HE), most medications were found to be ineffective when used alone. However, a combination therapy of rifaximin and lactulose may be beneficial.
Article
Gastroenterology & Hepatology
Menghao Li, Kai Li, Shihao Tang, Yong Lv, Qiuhe Wang, Zhengyu Wang, Bohan Luo, Jing Niu, Ying Zhu, Wengang Guo, Wei Bai, Enxin Wang, Dongdong Xia, Zhexuan Wang, Xiaomei Li, Jie Yuan, Zhanxin Yin, Jonel Trebicka, Guohong Han
Summary: This study found that alterations in gut dysbiosis were negatively associated with the occurrence and severity of post-TIPS HE, and improving the microbiota can help reduce the incidence of HE. Analysis of the gut microbiota can be used to screen suitable patients for TIPS and prevent the occurrence of HE.