Article
Chemistry, Physical
Tomomi Ujihara, Nobuyuki Hayashi
Summary: The study elucidated the structure of the epigallocatechin-3-O-gallate (EGCg)/caffeine complex in aqueous solution, revealing a 1:1 complex formation and major intermolecular forces of aromatic/aromatic and CH/pi interactions. Water molecules were found to stabilize the EGCg/caffeine complex through hydration and intermolecular cross-linking.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Immunology
Yucheol Cheong, Minjin Kim, Jina Ahn, Hana Oh, Jongkwan Lim, Wonil Chae, Seung Won Yang, Min Seok Kim, Ji Eun Yu, Sanguine Byun, Yo Han Jang, Baik Lin Seong
Summary: The study investigated the potential use of catechins derived from green tea as adjuvants for subunit and inactivated vaccines, demonstrating their ability to enhance immune responses and provide protection against vaccines, including influenza virus.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Plant Sciences
Yan Wang, Yu-Fan Xiang, Ai-Lin Liu
Summary: This study compared the lipid-lowering activity of EGCG and caffeine, and investigated their joint action using C. elegans as a model organism. It was found that EGCG exhibited stronger lipid-lowering efficacy than caffeine, and the combination of EGCG and caffeine was more effective in reducing lipid levels than either substance alone. The study also suggested the use of EGCG and caffeine as a dietary intervention for preventing hyperlipidemia.
PLANT FOODS FOR HUMAN NUTRITION
(2022)
Article
Food Science & Technology
Baogui Liu, Zhiyin Chen, Yangling Zhang, Enshuo Liu, Shuming Han, Zhihua Gong, Wenjun Xiao
Summary: The study improved the bioavailability and efficacy of EGCG by preparing EGCG+LTA/βCD inclusion complexes, which significantly enhanced its lipid-lowering and weight loss effects by improving gut microflora and EGCG bioavailability.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Chemistry, Applied
Manzar Alam, Sabeeha Ali, Ghulam Md Ashraf, Anwar L. Bilgrami, Dharmendra Kumar Yadav, Md Imtaiyaz Hassan
Summary: Epigallocatechin 3-gallate (EGCG), a polyphenolic component derived from green tea extract, possesses various biological functions, including anti-cancer and anti-inflammatory properties. It modulates multiple signaling pathways to inhibit tumor growth and induce cell death. EGCG also exhibits antioxidant, anti-angiogenic, and apoptotic effects. Therefore, EGCG shows potential in cancer treatment.
Article
Food Science & Technology
Nadine Tritsch, Marc C. Steger, Valerie Segatz, Patrik Blumenthal, Marina Rigling, Steffen Schwarz, Yanyan Zhang, Heike Franke, Dirk W. Lachenmeier
Summary: This article reviews the safety of coffee leaf tea, highlighting caffeine and epigallocatechin gallate (EGCG) as potentially hazardous substances. The caffeine content is comparable to roasted coffee beans, while the EGCG content is typically low. The article suggests a maximum intake of 1-3 cups per day of coffee leaf tea. The conclusion is that coffee leaf tea is not assumed to be risky for consumers.
Article
Chemistry, Applied
Jianyong Zhang, Hongchun Cui, Jiahuan Qiu, Xiaoqing Wang, Yixin Zhong, Caiping Yao, Lanying Yao, Qunxiong Zheng, ChunHua Xiong
Summary: This study aimed to improve the stability and bioavailability of EGCG in aqueous solutions and in vivo by preparing EGCG glycosylated arachin nanoparticles and EGCG glycosylated casein nanoparticles. The results showed that the DPPH scavenging activity of the nanoparticles was stable within temperature range of 25-70 degrees Celsius. EGCG enhanced the crosslinking effect of molecular particles in the glycosylation complexes solution. The glycosylated protein nanoparticles were stable to acid-base and enzymolysis in simulated gastrointestinal fluid.
Article
Agriculture, Multidisciplinary
Lijie Jia, Fuming Wang, Ke Zhang, Dongxu Wang, Xiaoxiao Wang, Xiuli Li, Jinsong Zhang
Summary: The study found that L-theanine in tea can inhibit the oxidation of tea catechins by chelating copper, thereby protecting the liver from damage.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Green & Sustainable Science & Technology
Justyna Piechocka, Krystyna Szymandera-Buszka
Summary: The study aimed to determine the correlations between thiamine concentration and the antioxidant activity of EGCG and caffeine, as well as thiamine stability. Thiamine showed sensitivity to secondary oxidation products, with higher losses in thiamine pyrophosphate form. Adding tea components increased fat stability and reduced thiamine losses, with EGCG showing lower thiamine loss dynamics compared to caffeine.
Article
Cell Biology
Honghui Zhang, Wei Su, Rusong Zhao, Mei Li, Shigang Zhao, Zi-Jiang Chen, Han Zhao
Summary: This study delves into the precise impact and underlying mechanisms of EGCG on aged oocytes. Both in vitro and in vivo experiments demonstrate EGCG's capacity to enhance the quality of aged oocytes. In vitro application of EGCG yields remarkable improvements, including heightened rates of first polar body extrusion, refined spindle morphology, enhanced mitochondrial function, and reduced oxidative stress. Besides, EGCG may enhance Arf6 expression through direct interaction in aged oocytes, consequently promoting the assembly of spindle-associated F-actin and mitigating the aneuploidy induced by the disruption of spindle F-actin. In addition, these positive outcomes are corroborated by enhanced fertility observed in aged mice, providing a therapeutic intervention to address fertility challenges associated with advanced age.
CELL PROLIFERATION
(2023)
Article
Plant Sciences
Qianjin Xie, Xiaqiang Cai, Xu Dong, Ying Wang, Minghui Sun, Lingling Tai, Yan Xu
Summary: The combination of EGCG with Vc and glycerol could effectively increase its stability and uric acid-lowering activity, which sheds light on the development and application of EGCG in the fields of food and medicine.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Tomonori Unno, Yoshiharu Araki, Shun Inagaki, Makoto Kobayashi, Masaki Ichitani, Takanobu Takihara, Hitoshi Kinugasa
Summary: Dietary fructooligosaccharides (FOS) were found to increase the plasma concentration of EGCG in rats by preventing its auto-oxidation. Treatment with FOS resulted in a dose-dependent increase in cecal lactate levels and alterations in the abundance of Lactobacillus and Collinsella. Consequently, FOS contributed to the protection of EGCG from auto-oxidation and allowed it to be absorbed into the blood circulation.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Immunology
Yingjie Wang, Shanqiu Jian, Wen Li, Ling Zhao, Gang Ye, Fei Shi, Lixia Li, Yuanfeng Zou, Xu Song, Xinghong Zhao, Zhongqiong Yin, Yinglun Li, Huaqiao Tang
Summary: This study evaluated the protective effect of epigallocatechin gallate (EGCG) on liver damage secondary to P. aeruginosa infection. The results showed that EGCG reduced liver function markers, improved histopathological changes, reduced oxidative stress and inhibited inflammation response. EGCG exerted its liver protective effect through regulation of multiple signaling pathways, providing a new therapeutic strategy for P. aeruginosa infection-related liver damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Engineering, Environmental
Yuan Cheng, Xin Li, Ming-Ya Fang, Qing-Jing Ye, Zhi-Miao Li, Golam Jalal Ahammed
Summary: The application of EECCG alleviated the adverse effects of cadmium stress in tomato plants by reducing oxidative stress and promoting the expression of RBOH1 gene. These findings contribute to our understanding of the stress resistance properties of EGCG in plants.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Review
Oncology
Chunguang Wang, Meiling Bai, Zhiguang Sun, Nan Yao, Aiting Zhang, Shengyu Guo, Zatollah Asemi
Summary: MicroRNAs (miRNAs) are small non-coding RNAs that affect gene expression and are inappropriately expressed in various cancers. Recent research shows that phytochemicals like EGCG can modulate miRNAs and have potential anticancer effects. Targeting specific miRNAs with EGCG can regulate cancer-related processes and improve current cancer treatments.
CANCER CELL INTERNATIONAL
(2023)
Article
Otorhinolaryngology
Xiaojing Sharon Wu, Anna Miles, Andrea Braakhuis
Summary: Texture-modified diets (TMDs) are commonly prescribed to improve swallowing safety for older adults with swallowing difficulties. The International Dysphagia Diet Standardization Initiative (IDDSI) provides a framework for TMDs. This study used the consolidated framework for implementation research (CFIR) to identify the barriers and enablers to IDDSI adoption in aged-care facilities (ACFs). The findings showed that while ACF managers were aware of IDDSI and had access to online resources, staff awareness and training were lacking. Collaboration and improved communication were important for successful implementation of IDDSI.
Article
Nutrition & Dietetics
Xiaojing Sharon Wu, Lina Yousif, Anna Miles, Andrea Braakhuis
Summary: Residents consuming texture-modified diets with ONS had higher intake of energy, protein, carbohydrates, and fat compared to those without ONS. However, they still fell short of their energy and carbohydrate requirements. Both groups had inadequate fibre intake and high saturated fat intake, with a significant portion of residents at risk of malnutrition.
Article
Nutrition & Dietetics
S. C. Broome, R. D. Atiola, A. J. Braakhuis, C. J. Mitchell, T. L. Merry
Summary: This study examined the effect of mitochondria-targeted antioxidant supplementation on muscle recovery following exercise. The results showed that MitoQ did not alleviate muscle soreness and may delay the recovery of muscle function after eccentric exercise.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2022)
Review
Nutrition & Dietetics
Xingbo Li, Andrea Braakhuis, Zengning Li, Rajshri Roy
Summary: The university food environment has an impact on the dietary behaviors of students, with taste being the most important factor. Students sometimes perceive unhealthy foods as healthy options. The diet quality of students is influenced by various factors.
FRONTIERS IN NUTRITION
(2022)
Review
Health Care Sciences & Services
Jessica A. Malloy, Stephanie R. Partridge, Joya A. Kemper, Andrea Braakhuis, Rajshri Roy
Summary: The primary objective of this review is to assess the breadth of literature on digital health interventions that have been co-designed for and by young adults, including the types of available evidence, the identification of key characteristics relevant to young adult co-design, and the examination of research conduct in this space.
JMIR RESEARCH PROTOCOLS
(2022)
Article
Nutrition & Dietetics
Xiaojing S. Wu, Anna Miles, Andrea Braakhuis
Summary: The study aimed to design, deliver, and evaluate a tailored intervention to facilitate IDDSI implementation in aged care. The results showed that the tailored interventions significantly increased TMD compliance and improved staff knowledge, which remained at a high level even 6 months after the intervention.
CURRENT DEVELOPMENTS IN NUTRITION
(2022)
Article
Geriatrics & Gerontology
Xiaojing Wu, Lina Yousif, Anna Miles, Andrea Braakhuis
Summary: This study aimed to explore the provision of TMDs and mealtime challenges in aged care facilities. The study found that TMD menus failed to meet nutritional requirements and standards, and there were issues with inconsistent meal quality and lack of standardization in serving procedures. The dining environment also needed to be individualized.
Article
Education, Scientific Disciplines
Anna Worthington, Nicola Gillies, Rajshri Roy, Andrea Braakhuis
Summary: Implementing behavior strategies into nutrition research requires consideration. The use of the Nine Principles framework and theory-based design in an eHealth behavior change support (BCS) program showed promising results in enhancing adherence to healthy eating and dietary tracking in young adults participating in a randomized control trial. This suggests that incorporating theory and user-centered design in such interventions may be effective in improving adherence in research studies.
JOURNAL OF NUTRITION EDUCATION AND BEHAVIOR
(2023)
Article
Nutrition & Dietetics
Emma Clarke, Gemma Pugh, Eveline van den Heuvel, Erin Kavanagh, Pamela Cheung, Andrew Wood, Mark Winstanley, Andrea Braakhuis, Amy L. Lovell
Summary: In this study, the nutrition interventions/education needs of childhood cancer survivors in New Zealand were explored. The study found that the current survivorship care pathway is inadequate in providing interventions/education, and survivors face common challenges related to weight and dietary changes. The study also identified the varied requirements for interventions/education in survivorship.
NUTRITION & DIETETICS
(2023)
Article
Nutrition & Dietetics
Amy L. Lovell, Rajshri Roy, Alana Klein, Alana Cavadino, Meika Foster, Jeremy D. Krebs, Andrea Braakhuis, Troy L. Merry
Summary: There is growing evidence that following a Mediterranean diet can reduce the incidence of diet-related diseases. However, little is known about the dietary patterns of New Zealand adults in relation to the Mediterranean diet. This study aimed to assess the habitual dietary patterns, nutrient intakes, and adherence to the Mediterranean diet in a sample of 1012 New Zealand adults. The results showed low adherence to the Mediterranean diet, indicating the need for significant changes in food choices among the New Zealand population.
Article
Nutrition & Dietetics
Nicola A. Gillies, Anna Worthington, Larissa Li, Tamlin S. Conner, Emma N. Bermingham, Scott O. Knowles, David Cameron-Smith, Rina Hannaford, Andrea Braakhuis
Summary: This study compared the health, wellbeing, and behavioral implications of consuming a flexitarian diet (including low-to-moderate amounts of red meat) and a vegetarian diet (including plant-based meat alternatives) among young adults. The results showed that participants in the flexitarian group had higher adherence to the intervention and higher satisfaction with red meat compared to those in the vegetarian group. Both intervention groups had increased vegetable intake and reported more positive eating experiences and satisfaction at the end of the intervention.
FRONTIERS IN NUTRITION
(2023)
Article
Physiology
Lillian C. Morton, Carl D. Paton, Troy Merry, Andrea J. Braakhuis
Summary: The study examined the effect of polyphenol supplementation on lung function and exercise performance in an ozone-polluted environment. The results suggest that polyphenol supplementation may provide small benefits to performance and reduce cough symptoms during high-intensity exercise in such environments.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Sport Sciences
Brendan J. O'Brien, Leo R. Bell, Declan Hennessy, Joshua Denham, Carl D. Paton
Summary: This study found that drinking coconut water had no significant impact on cycling performance and physiology compared to a sports drink.
Meeting Abstract
Oncology
Amy Lovell, Emma Clarke, Eveline Van Den Heuvel, Erin Kavanagh, Pamela Cheung, Andrea Braakhuis, Gemma Pugh
PEDIATRIC BLOOD & CANCER
(2022)
Article
Nutrition & Dietetics
Toan Pham, Scott Knowles, Emma Bermingham, Julie Brown, Rina Hannaford, David Cameron-Smith, Andrea Braakhuis
Summary: This study compared the digestive response of a meal containing red meat with a plant-based meat analog. It found that red meat had a higher bioavailability of amino acids compared to the plant-based alternative. The farming method of the beef had minimal impact on participants' responses.
CURRENT DEVELOPMENTS IN NUTRITION
(2022)