Review
Pharmacology & Pharmacy
Yicheng Wei, Jialuo Cai, Ruiqiu Zhu, Ke Xu, Hongchang Li, Jianxin Li
Summary: This review focuses on the role of TRPA1 channel in fibroblasts, exploring its interactions with inflammatory factors and its different functions in the fibrosis process in different organs. The aim of this review is to describe the function of TRP channels in controlling fibrosis through fibroblasts in various inflammatory and immune-mediated diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ines B. Correia-Sa, Claudia M. Carvalho, Paula V. Serrao, Vera A. Machado, Sofia O. Carvalho, Marisa Marques, Maria A. Vieira-Coelho
Summary: The study revealed that inactivation of CB1 in human skin fibroblasts can prevent differentiation into myofibroblasts and collagen deposition, potentially playing a significant role in wound healing disorders. Further in vivo and pre-clinical studies should be conducted to validate these findings.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Liyuan Mao, Fang Xin, Jie Ren, Shuai Xu, Haixia Huang, Xu Zha, Xinxin Wen, Guoqing Gu, Guang Yang, Yuan Cheng, Chen Zhang, Wei Wang, Xicheng Liu
Summary: This study demonstrates the dual functions of 5-HT/5-HT2B/TGF-beta signaling in the initiation and progression of colitis-associated cancer (CAC), with a critical role in tumor suppression but a promotion of cancer progression in the late-stage of CAC.
Review
Oncology
Dale M. Watt, Jennifer P. Morton
Summary: Pancreatic ductal adenocarcinoma is an aggressive disease with limited available therapies, notable for its high tumour complexity and recent findings on the intricacy of signalling within the stroma, particularly the molecular and functional heterogeneity of cancer associated fibroblasts. While some progress has been made, there are still considerable gaps in our knowledge that require further research efforts.
Article
Biochemistry & Molecular Biology
Qin Li, Hang Yuan, Gang Zhao, Jie Zhang, Siqi Li, Di Gong, Tianyu Feng, Qiming Kou, Qijing Wang, Guanru Wang, Shan Li, Kai Li, Ping Lin
Summary: Breast cancer is the leading cause of cancer-related deaths in women worldwide, and cancer-associated fibroblasts (CAFs) play a critical role in its progression. However, the detailed molecular mechanisms of CAF activation are still unclear. This study found that loss of ZNF32 promotes the activation of CAFs, leading to increased growth and metastasis of breast cancer cells. Mechanistically, ZNF32 inhibits TGFB1 transcription, preventing fibroblast activation. This study implicates ZNF32 as a potential therapeutic target against breast cancer.
Article
Oncology
Shasha Liu, Chaoqi Zhang, Boqiao Wang, Huanyu Zhang, Guohui Qin, Congcong Li, Ling Cao, Qun Gao, Yu Ping, Kai Zhang, Jingyao Lian, Qitai Zhao, Dan Wang, Zhen Zhang, Xuan Zhao, Li Yang, Lan Huang, Bo Yang, Yi Zhang
Summary: The intense infiltration of regulatory T cells (Tregs) facilitates the qualities of glioma stem cells (GSCs) through TGF-beta secretion and NF-κB-IL6-STAT3 signaling pathway, leading to increased cancer stemness and tumorigenic potential. Blocking the IL6 receptor can mitigate the promotion effect of Tregs on glioma growth, and the expression levels of CD133, IL6, and TGF-beta could serve as prognosis markers for glioma patients.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Jiangcheng Shu, Lizhi Hu, Yichen Wu, Long Chen, Kai Huang, Zhaohui Wang, Minglu Liang
Summary: This study reveals that daidzein has an anti-fibrotic effect in myocardial fibrosis by reducing the activation of cardiac fibroblasts induced by TGF-beta 1, partially through regulating the TGF-beta 1/SMAD2/3 signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Oncology
Marta Gabasa, Evette S. Radisky, Rafael Ikemori, Giulia Bertolini, Marselina Arshakyan, Alexandra Hockla, Paula Duch, Ornella Rondinone, Alejandro Llorente, Maria Maqueda, Albert Davalos, Elena Gavilan, Alexandre Perera, Josep Ramirez, Pere Gascon, Noemi Reguart, Luca Roz, Derek C. Radisky, Jordi Alcaraz
Summary: Large cell carcinoma (LCC) is a rare and aggressive subtype of lung cancer with poor prognosis and no targeted therapies. In this study, MMP1 has been identified as overexpressed in LCC cell lines and is shown to be necessary for induction of fibroblast senescence and consequent tumor promotion. The combination of MMP1 and TGF-beta 1 is sufficient to induce fibroblast senescence and LCC promotion, implicating PAR-1 and oxidative stress in this process. These results suggest a novel therapeutic strategy for LCC based on targeting senescent TAFs.
Article
Biochemistry & Molecular Biology
Xiaohe Li, Yunqian Zhai, Buri Xi, Wei Ma, Jianwei Zhang, Xiaoyang Ma, Yang Miao, Yongjian Zhao, Wen Ning, Honggang Zhou, Cheng Yang
Summary: Pinocembrin has been shown to effectively suppress skin fibrosis by inhibiting the proliferation and migration of keloid fibroblasts and dermal fibroblasts. In vivo experiments have also confirmed the therapeutic potential of pinocembrin for skin fibrosis.
Article
Pharmacology & Pharmacy
Xiaokang Luo, Shiyang Song, Lei Qi, Chih-Liang Tien, Hui Li, Weiyi Xu, Theodore Lemuel Mathuram, Thomas Burris, Yuanbiao Zhao, Zheng Sun, Lilei Zhang
Summary: This study characterized the functional difference of REV-ERB in mouse embryonic fibroblasts and cardiac fibroblasts. The results demonstrated the essential cell-autonomous role of REV-ERB alpha/beta in maintaining cardiac fibroblasts in a healthy, quiescent state.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Birte Ohm, Isabelle Moneke, Wolfgang Jungraithmayr
Summary: CD26/DPP4 plays a significant role in fibroproliferative disorders, and inhibiting CD26/DPP4 can reduce fibrotic changes. CD26/DPP4 inhibitors have the potential to be an effective treatment for fibrosis and have been proven to be safe in clinical use.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Anatomy & Morphology
Nicholas K. Bodmer, Russell H. Knutsen, Robyn A. Roth, Ryan M. Castile, Michael D. Brodt, Carrie M. Gierasch, Thomas J. Broekelmann, Mark A. Gibson, Jeffrey A. Haspel, Spencer P. Lake, Jeffrey R. Koenitzer, Steven L. Brody, Matthew J. Silva, Robert P. Mecham, David M. Ornitz
Summary: The study reveals that Latent TGF beta binding protein-2 (LTBP2) has complex effects on bone and skin development, while not affecting the development or homeostasis of tissues that express high levels of LTBP2, such as the aorta and lung.
DEVELOPMENTAL DYNAMICS
(2023)
Article
Cell Biology
Xiaolan You, Jian Wu, Xiaojun Zhao, Xingyu Jiang, Wenxuan Tao, Zhiyi Chen, Chuanjiang Huang, Tingrui Zheng, Xianhe Shen
Summary: The study found that GAL-1 from cancer-associated fibroblasts induced the epithelial-mesenchymal transition of gastric cancer cells through the TGF-β1/Smad signaling pathway, leading to enhanced invasion and metastasis. High levels of GAL-1 in the gastric cancer microenvironment were associated with poor prognosis, suggesting potential new therapeutic targets for gastric cancer treatment.
Article
Immunology
Jingjing Zhang, Jinxin Qiu, Wenyong Zhou, Jianping Cao, Xuefei Hu, Wenli Mi, Bing Su, Bin He, Ju Qiu, Lei Shen
Summary: This study identifies neuropilin-1 (Nrp1) as a tissue-specific marker of lung-resident ILC2s, which enhances their function and type 2 immune response by upregulating IL-33 receptor ST2 expression. Inhibition of Nrp1 suppresses IL-5 and IL-13 production by ILC2s and protects mice from the development of pulmonary fibrosis.
Article
Nutrition & Dietetics
Youling Hao, Lili Jiang, Dandan Han, Dayong Si, Zhiyuan Sun, Zhenlong Wu, Zhaolai Dai
Summary: LM showed greater efficacy than LA in alleviating DSS-induced colonic inflammation. The coordinated regulation of transforming growth factor-beta subtypes and serotonin receptors in the colon may be one of the most important mechanisms underlying the probiotic effects of lactobacilli in gut inflammation.
JOURNAL OF NUTRITION
(2023)
Article
Immunology
Nefeli Giannopoulou, Latika Gupta, Laura Andreoli, Daniele Lini, Elena Nikiphorou, Rohit Aggarwal, Vikas Agarwal, Ioannis Parodis
Summary: The study found that COVID-19 vaccination in pregnant SLE patients was safe and did not exacerbate their autoimmune disease. Minor vaccine-related adverse events were reported but did not affect daily functioning and resolved within a few days. No adverse pregnancy outcomes were reported. Overall, the risk/benefit ratio of COVID-19 vaccination in SLE patients and high-risk pregnancies is favorable.
AUTOIMMUNITY REVIEWS
(2023)
Letter
Rheumatology
Laura Andreoli, Parikshit Sen, Daniele Lini, Melinda Nagy Vincze, Karen Schreiber, Vikas Agarwal, Rohit Aggarwal, Latika Gupta
Review
Psychology, Multidisciplinary
Prithvi Sanjeevkumar Gaur, Sreoshy Saha, Ashish Goel, Pavel Ovseiko, Shelley Aggarwal, Vikas Agarwal, Atiq Ul Haq, Debashish Danda, Andrew Hartle, Nimrat Kaur Sandhu, Latika Gupta
Summary: The COVID-19 pandemic has brought significant changes to healthcare delivery, revealing healthcare inequalities based on gender, ethnicity, and socioeconomic status. LGBTQ individuals have also faced inequities, which have been insufficiently explored in developing countries. Previous studies have briefly touched on the mental, physical, and emotional challenges faced by the LGBTQ community, such as fear of rejection, bullying, assault, and religious biases, hindering the collection of reliable data on their sexual orientation. Despite their need for medical and psychological support, they are reluctant to seek help and access appropriate healthcare and mental health services. This article examines the underlying causes of mental health issues faced by LGBTQ individuals in the Indian subcontinent, as well as the availability of healthcare services for sexual minorities in India, offering recommendations to promote their wellbeing.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Rheumatology
Mrudula Joshi, R. Naveen, Kshitij Jagtap, Ria Gupta, Vikas Agarwal, Rohit Aggarwal, Ashish Goel, Latika Gupta
Summary: YouTube is a popular platform for accessing health information, including information about myositis. This study evaluated the reliability and quality of myositis-related videos on YouTube and identified useful videos using standard metrics. The findings suggest that the majority of English YouTube videos on myositis provide useful information for patients, and physicians can guide patients to high-quality videos using criteria like GQS and professional medical societies.
CLINICAL RHEUMATOLOGY
(2023)
Article
Rheumatology
Manish Ora, Durga Prasanna Misra, Chengappa G. Kavadichanda, Kritika Singh, Upendra Rathore, Neeraj Jain, Vikas Agarwal, Sanjay Gambhir
Summary: This study evaluates the diagnostic accuracy of two novel F-18-fluorodeoxyglucose PET-CT parameters, the inflammatory volume (MIV) and total inflammatory glycolysis (TIG), for assessing active Takayasu arteritis (TAK). The results show that MIV and TIG perform similarly to existing PET-CT parameters and can be used to evaluate disease activity in TAK.
CLINICAL RHEUMATOLOGY
(2023)
Article
Rheumatology
Samuel Katsuyuki Shinjo, Minchul Kim, Leonardo Santos Hoff, Rafael Giovani Misse, Parikshit Sen, R. Naveen, Jessica Day, Rafael Alves Cordeiro, Jucier Goncalves Junior, Tulika B. Chatterjee, James B. Lilleker, Vishwesh Agarwal, Sinan Kardes, Marcin Milchert, Tamer Gheita, Babur Salim, Tsvetelina Velikova, Abraham Edgar Gracia-Ramos, Ioannis Parodis, Albert Selva O'Callaghan, Elena Nikiphorou, Ashima Makol, Ai Lyn Tan, Lorenzo A. Cavagna, Miguel A. Saavedra, Nelly Ziade, Johannes Knitza, Masataka Kuwana, Arvind Nune, Oliver Distler, Hector Chinoy, Vikas Agarwal, Rohit Aggarwal, Latika Gupta
Summary: The study compared pain intensity among individuals with idiopathic inflammatory myopathies (IIMs), other systemic autoimmune rheumatic diseases (AIRDs), and without rheumatic disease (wAIDs). It was found that patients with IIMs had higher pain levels than wAIDs patients, but lower than patients with other AIRDs. Pain was associated with poor functional status.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Chirag Rajkumar Kopp, Chandra Bhushan Prasad, Shankar Naidu, Vishal Sharma, Durga Prasanna Misra, Vikas Agarwal, Aman Sharma
Summary: Neurological involvement in SLE can be caused by co-existing NMOSD. Anti-AQP4 antibodies play a key role in the neuroinflammatory response and demyelinating lesions. This study reviewed the clinical course and outcomes of AQP4+ NMOSD/SLE overlap cases.
Review
Rheumatology
Mustafa Al-Maini, Mahesh Maindarkar, George D. Kitas, Narendra N. Khanna, Durga Prasanna Misra, Amer M. Johri, Laura Mantella, Vikas Agarwal, Aman Sharma, Inder M. Singh, George Tsoulfas, John R. Laird, Gavino Faa, Jagjit Teji, Monika Turk, Klaudija Viskovic, Zoltan Ruzsa, Sophie Mavrogeni, Vijay Rathore, Martin Miner, Manudeep K. Kalra, Esma R. Isenovic, Luca Saba, Mostafa M. Fouda, Jasjit S. Suri
Summary: The challenges in diagnosing and treating cardiovascular disease/stroke in rheumatoid arthritis (RA) arise from delayed symptoms and inadequate risk prediction. To improve accuracy, combining genomic-based and radiomic-based biomarkers with deep learning models can classify the risk effectively. This study demonstrates the potential of using these approaches to enhance CVD/stroke risk assessment in RA patients and provides recommendations for further research.
RHEUMATOLOGY INTERNATIONAL
(2023)
Letter
Rheumatology
Mrinalini Dey, R. Naveen, Elena Nikiphorou, Parikshit Sen, Sreoshy Saha, James B. Lilleker, Vishwesh Agarwal, Sinan Kardes, Jessica Day, Marcin Milchert, Mrudula Joshi, Tamer Gheita, Babur Salim, Tsvetelina Velikova, Abraham Edgar Gracia-Ramos, Ioannis Parodis, Albert Selva O'Callaghan, Minchul Kim, Tulika Chatterjee, Ai Lyn Tan, Ashima Makol, Arvind Nune, Lorenzo Cavagna, Miguel A. Saavedra, Samuel Katsuyuki Shinjo, Nelly Ziade, Johannes Knitza, Masataka Kuwana, Oliver Distler, Bhupen Barman, Yogesh Preet Singh, Rajiv Ranjan, Avinash Jain, Sapan C. Pandya, Rakesh Kumar Pilania, Aman Sharma, Manesh M. Manoj, Vikas Gupta, Chengappa G. Kavadichanda, Pradeepta Sekhar Patro, Sajal Ajmani, Sanat Phatak, Rudra Prosad Goswami, Abhra Chandra Chowdhury, Ashish Jacob Mathew, Padnamabha Shenoy, Ajay Asranna, Keerthi Talari Bommakanti, Anuj Shukla, Arunkumar R. Pande, Kunal Chandwar, John D. Pauling, Chris Wincup, Dondu Uskudar Cansu, Erick Adrian Zamora Tehozol, Jorge Rojas Serrano, Ignacio Garcia-De La Torre, Nicoletta Del Papa, Gianluca Sambataro, Atzeni Fabiola, Marcello Govoni, Simone Parisi, Elena Bartoloni Bocci, Gian Domenico Sebastiani, Enrico Fusaro, Marco Sebastiani, Luca Quartuccio, Franco Franceschini, Pier Paolo Sainaghi, Giovanni Orsolini, Rossella De Angelis, Maria Giovanna Danielli, Vincenzo Venerito, Lisa S. Traboco, Leonardo Santos Hoff, Suryo Anggoro Kusumo Wibowo, Stylianos Tomaras, Daman Langguth, Vidya Limaye, Merrilee Needham, Nilesh Srivastav, Akira Yoshida, Ran Nakashima, Shinji Sato, Naoki Kimura, Yuko Kaneko, Jesus Loarce-Martos, Sergio Prieto-Gonzalez, Albert Gil-Vila, Raquel Aranega Gonzalez, Hector Chinoy, Vikas Agarwal, Rohit Aggarwal, Latika Gupta
Meeting Abstract
Rheumatology
Pankti Mehta, Latika Gupta, Durga P. Misra, Vikas Agarwal, Able Lawrence, Ramnath Misra, Amita Aggarwal
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Meeting Abstract
Rheumatology
R. Naveen, Mantabya Singh, Anamika Anuja Kumari, Kritika Singh, Mohit Kumar Rai, Darpan R. Thakhare, Kishan Majithiya, Narayan Prasad, Vikas Agarwal, Latika Gupta
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Meeting Abstract
Rheumatology
Marc Aoude, Latika Gupta, Ihsane Hmamouchi, Vikas Agarwal, Rohit Aggarwal, Nelly Ziade
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Meeting Abstract
Rheumatology
Rudra P. Goswami, Vikas Agarwal, Rohit Agarwal, Latika Gupta
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Meeting Abstract
Rheumatology
Silvia Grignaschi, Lorenzo Cavagna, Minchul Kim, Vikas Agarwal, Rohit Aggarwal, Latika Gupta
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Meeting Abstract
Rheumatology
Latika Gupta, Leonardo Santos Hoff, R. Naveen, Parikshit Sen, Samuel Katsuyuki Shinjo, Vikas Agarwal, Rohit Aggarwal
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)