Article
Genetics & Heredity
Prashant S. Giri, Rasheedunnisa Begum, Mitesh Dwivedi
Summary: The TNFA gene-308 G A polymorphism is associated with vitiligo susceptibility, with varied results among different populations. The study also indicates significant associations between gene genotypes and alleles in active vitiligo patients and those with localized vitiligo in different regions.
Article
Immunology
Woorim Kim, Soo Jin Oh, Nga Thi Trinh, Jin Yeon Gil, In Ah Choi, Ji Hyoun Kim, Joo Hee Kim, Ju-Yang Jung, Jinhyun Kim, Hyoun-Ah Kim, Kyung Eun Lee
Summary: This study aimed to investigate the effects of genetic polymorphisms in RETN on the remission of RA patients receiving TNF-alpha inhibitors, and use machine learning algorithms to predict remission. The results showed that the most significant features associated with the efficacy of TNF-alpha inhibitors included sex, age, hypertension, sulfasalazine, and several genetic polymorphisms. The elastic net algorithm was found to be the best method for predicting remission in RA patients treated with TNF-alpha inhibitors.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Genetics & Heredity
Maria Tziastoudi, Ioanna Chronopoulou, Georgios Pissas, Christos Cholevas, Theodoros Eleftheriadis, Ioannis Stefanidis
Summary: This meta-analysis found no significant association between the TNF-a G-308A polymorphism and the risk for development and/or progression of IgAN. In conclusion, TNF-a does not appear to be a key component in the genetic architecture of sporadic IgAN.
Article
Multidisciplinary Sciences
Daniel J. Lightwood, Rebecca J. Munro, John Porter, David McMillan, Bruce Carrington, Alison Turner, Anthony Scott-Tucker, Elizabeth S. Hickford, Antje Schmidt, David Fox, Alison Maloney, Tom Ceska, Tim Bourne, James O'Connell, Alastair D. G. Lawson
Summary: TNF can be inhibited by small molecules that stabilize the TNF trimer in an asymmetric conformation. The authors also developed a monoclonal antibody that selectively binds this inactive form of TNF, enabling both target engagement assessment and structural characterization of TNF binding to TNF receptor 1.
NATURE COMMUNICATIONS
(2021)
Review
Ophthalmology
Wenna Gao, Ruilin Zhu, Liu Yang
Summary: The meta-analysis showed that the -308 A and -238 A alleles in the TNF-alpha gene may increase the risk of DR and showed discrepancies in different ethnicities.
OPHTHALMIC RESEARCH
(2021)
Review
Dentistry, Oral Surgery & Medicine
Aleksandar Jakovljevic, Nadja Nikolic, Jelena Jacimovic, Maja Miletic, Miroslav Andric, Jelena Milasin, Anita Aminoshariae, Amir Azarpazhooh
Summary: This study found no significant association between TNF-alpha 2308 G/A SNP and the risk of development of apical periodontitis (AP). Genetic factors did not show significant correlation with the clinical manifestations of AP (acute vs chronic). Further well-designed multicentric studies are needed to explore the relationship between TNF-alpha SNP and the development of AP due to the very low certainty of evidence.
JOURNAL OF ENDODONTICS
(2021)
Article
Medicine, Research & Experimental
Dimitra Papadopoulou, Fani Roumelioti, Christos Tzaferis, Panagiotis Chouvardas, Anna-Kathrine Pedersen, Filippos Charalampous, Eleni Christodoulou-Vafeiadou, Lydia Ntari, Niki Karagianni, Maria C. Denis, Jesper V. V. Olsen, Alexios N. Matralis, George Kollias
Summary: The neuroleptic drug amisulpride was found to reduce inflammatory potential and clinical score in a rheumatoid arthritis (RA) animal model, offering potential as a therapeutic option for RA patients.
Article
Biochemistry & Molecular Biology
Barbara Pesce, Carolina H. Ribeiro, Milton Larrondo, Veronica Ramos, Lilian Soto, Diego Catalan, Juan Carlos Aguillon
Summary: Tumor necrosis factor (TNF)-alpha regulates cytokine production by CD4+ T helper cells, and targeting TNFR2 may be an alternative strategy to normalize key cytokine levels that contribute to the pathogenesis of rheumatoid arthritis (RA).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Ming-Han Chen, Shan-Fu Yu, Jia-Feng Chen, Wei-Sheng Chen, The-Ling Liou, Chung-Tei Chou, Chung-Yuan Hsu, Han-Ming Lai, Ying-Chou Chen, Chang-Youh Tsai, Tien-Tsai Cheng
Summary: The study compared the impact of different treatment regimens for rheumatoid arthritis on patients' bone mineral density, finding that abatacept may have a better effect in preserving bone density. Anti-osteoporosis therapy can prevent systemic bone loss in patients regardless of the type of rheumatoid arthritis treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Ahmed Saleh, Ahmed Sultan, Mohamed A. Elashry, Ahmed Farag, Metwaly Ibrahim Mortada, Mayada A. Ghannam, Ahmed M. Saed, Sayed Ghoneem
Summary: This study found an association between TNF-alpha G-308 A gene polymorphism and the course and outcome of COVID-19 patients. People carrying the A allele of TNF-alpha polymorphism are more prone to COVID-19 infection, and the AA genotype is associated with a more aggressive pattern of the disease.
IMMUNOLOGICAL INVESTIGATIONS
(2022)
Article
Rheumatology
Samantha Louise Smith, Sheree Alexander, Nisha Nair, Sebastien Viatte, Stephen Eyre, Kimme L. Hyrich, Ann W. Morgan, Anthony G. Wilson, John D. Isaacs, Darren Plant, Anne Barton
Summary: The study aimed to explore whether the inflammatory protein MRP8/14 can serve as a biomarker for treatment response in rheumatoid arthritis (RA) patients receiving tumor necrosis factor (TNF) inhibitors. The results showed that in the 3-component and 2-component models, patients with high pre-treatment levels of MRP8/14 were 1.92 and 2.03 times more likely to be classified as EULAR responders compared to those with low levels. However, no significant associations were observed in the 4-component model. Conclusion: Apart from its correlation with CRP, there is no evidence to suggest that MRP8/14 explains additional variability in response to TNFi in RA patients beyond CRP alone.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Daniel H. Solomon, Jon T. Giles, Katherine P. Liao, Paul M. Ridker, Pamela M. Rist, Robert J. Glynn, Rachel Broderick, Fengxin Lu, Meredith T. Murray, Kathleen Vanni, Leah M. Santacroce, Shady Abohashem, Philip M. Robson, Zahi Fayad, Venkatesh Mani, Ahmed Tawakol, Joan Bathon
Summary: This study found that adding either a TNFi or triple therapy led to clinically important improvements in vascular inflammation. However, adding a TNFi did not reduce arterial inflammation more than triple therapy.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Biochemistry & Molecular Biology
Andy Ruiz, Yadira Palacios, Irene Garcia, Leslie Chavez-Galan
Summary: Tumor necrosis factor (TNF) is a key cytokine regulating inflammatory responses and plays a crucial role in granuloma formation during mycobacterial infections. The interactions between soluble and transmembrane TNF with their receptors influence effector mechanisms, providing insights into potential therapeutic strategies against mycobacterial infections. Understanding the structural and activation pathways of TNF and its receptors can offer valuable knowledge for developing more efficient therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Masanao Kyuuma, Ayaka Kaku, Chiemi Mishima-Tsumagari, Bunichiro Ogawa, Mayumi Endo, Yunoshin Tamura, Kei-ichiro Ishikura, Masashi Mima, Yutaka Nakanishi, Yasuyuki Fujii
Summary: Biologics are widely used in the treatment of various diseases, but concerns have been raised regarding the immunogenicity and adverse events associated with large immune complexes and aggregates. This study investigated the mechanism underlying the reduced incidence of injection site reactions (ISRs) with ozoralizumab, a trivalent bispecific nanobody compound, compared to other TNF alpha inhibitors. The results showed that ozoralizumab-TNF alpha immune complexes are smaller and lack an Fc portion, mitigating immune responses on neutrophils mediated by Fc gamma receptors. Furthermore, ozoralizumab-TNF alpha immune complexes did not induce significant inflammation at injection sites. These findings suggest that ozoralizumab may be a promising candidate for the treatment of rheumatoid arthritis with a lower risk of unwanted immune responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yi-Wen Duan, Shao-Xia Chen, Qiao-Yun Li, Ying Zang
Summary: This review focuses on the neuroimmune mechanism of neuropathic pain. TNF-alpha plays a crucial role in inducing and modulating neuropathic pain by facilitating peripheral and central sensitization. It controls cell survival and death through an inflammatory response and programmed cell death mechanisms. Overproduction of TNF-alpha in certain brain structures has an important role in pain-associated emotional disorders and memory deficits. The review also highlights the research prospects of the TNF-alpha-necroptosis pathway in pain modulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Federico Aranda, Sebastian Udry, Silvia Peres Wingeyer, Lea Christina Amshoff, Nadja Bogdanova, Peter Wieacker, Jose Omar Latino, Arseni Markoff, Gabriela de Larranaga
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2018)
Article
Medicine, General & Internal
Silvia Peres Wingeyer, Federico Aranda, Sebastian Udry, Jose Latino, Gabriela de Larranaga
Article
Immunology
Jose Omar Latino, Sebastian Udry, Silvia Peres Wingeyer, Diego Fernandez Romero, Paula Micone, Gabriela de Larranaga
IMMUNOLOGIC RESEARCH
(2018)
Review
Immunology
Cristina Belizna, Francesca Pregnolato, Sebastien Abad, Jaume Alijotas-Reig, Howard Amital, Zahir Amoura, Laura Andreoli, Emmanuel Andres, Achile Aouba, Sule Apras Bilgen, Laurent Arnaud, Boris Bienvenu, Viktoria Bitsadze, Patrick Blanco, Miri Blank, Maria Orietta Borghi, Antonia Caligaro, Elisabeta Candrea, Valentina Canti, Laurent Chiche, Jean Marie Chretien, Jan Willem Cohen Tervaert, Laura Damian, Teresa Delross, Emmanuelle Dernis, Katrien Devreese, Aleksandra Djokovic, Enrique Esteve-Valverde, Maria Favaro, Celine Fassot, Raquel Ferrer-Oliveras, Alban Godon, Mohamed Hamidou, Milena Hasan, Daniel Henrion, Bernard Imbert, Pierre Yves Jeandel, Pascale Jeannin, Patrick Jego, Noemie Jourde-Chiche, Jamilya Khizroeva, Olivier Lambotte, Cedric Landron, Jose Omar Latino, Estibaliz Lazaro, Karina de Leeuw, Thomas Le Gallou, Levent Kilic, Maarten Limper, Laurent Loufrani, Romain Lubin, Nadine Magy-Bertrand, Guillaume Mahe, Alexander Makatsariya, Thierry Martin, Christian Muchardt, Gyorgy Nagy, Loukman Omarjee, Pieter Van Paasen, Gilles Pernod, Florence Perrinet, Gilberto Pires Rosa, Marc Antoine Pistorius, Amelia Ruffatti, Fatma Said, Patrick Saulnier, Damien Sene, Loic Sentilhes, Ova Shovman, Jean Sibilia, Crina Sinescu, Natasa Stanisavljevic, Ljudmila Stojanovich, Lai Shan Tam, Angela Tincani, Frederic Tollis, Sebastian Udry, Marie Noelle Ungeheuer, Mathilde Versini, Ricard Cervera, Pier Luigi Meroni
AUTOIMMUNITY REVIEWS
(2018)
Article
Rheumatology
Gustavo Citera, Fernando Dal Pra, Christian A. Waimann, Hernan Maldonado Ficco, Teresita Alvarellos, Luciana A. Mas, Osvaldo L. Cerda, Sergio Paira, Antonio Catalan Pellet, Anastasia Secco, Lucila Marino, Maria Martire, Josefina Marcos, Mercedes A. Garcia, Adrian Salas, Alberto Berman, Horacio Berman, Oscar L. Rillo, Liliana Vargas, Edson Velozo, Ricardo Vicente Juarez, Maria Elena Crespo Espindola
CLINICAL RHEUMATOLOGY
(2019)
Article
Immunology
Sebastian Udry, Jose Omar Latino, Cristina Belizna, Silvia Peres Wingeyer, Diego Santiago Fernandez Romero, Gabriela de Larranaga
IMMUNOLOGIC RESEARCH
(2019)
Article
Rheumatology
Jose Omar Latino, Sebastian Udry, Federico Aranda, Silvia Peres Wingeyer, Diego Santiago Fernandez Romero, Cristina Belizna, Gabriela de Larranaga
Article
Medical Laboratory Technology
Mauro Moiana, Federico Aranda, Gabriela de Larranaga
Summary: Histones were initially known as DNA packaging proteins, but later were found to have antimicrobial properties extracellularly and also potentially harmful effects on the body. They are involved in triggering inflammatory and coagulation responses in different cell types.
CLINICAL BIOCHEMISTRY
(2021)
Meeting Abstract
Rheumatology
Sabrina Porta, Silvia Peres, Federico Aranda, Maria Femanda Eguez Del Pozo, Mauro Moiana, Ana Lucero, Ana Canizares, Marina Micelli, Eduardo Kerzberg, Gabriela De Larranaga
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2020)
Meeting Abstract
Rheumatology
Sebastian Udry, Omar Latino, Cristina Belizna, Silvia Peres Wingeyer, Diego Fernandez Romero, Gabriela de Larranaga
Meeting Abstract
Gastroenterology & Hepatology
Alicia M. Sambuelli, Gabriela F. de Larranaga, Paula Chavero, Silvia Peres, Antonio Carrera Silva, Andrea Errasti, Lisina Tessone, Silvia Negreira, Anibal H. Gil, Sergio P. Huernos, Maricel I. Bellicoso, Silvina A. Goncalves, Pablo Tirado, Carla V. Rothlin
Meeting Abstract
Gastroenterology & Hepatology
A. Sambuelli, P. Chavero, G. de Larranaga, A. Errasti, S. Peres, L. Tessone, S. Negreira, N. Silvia, M. Bellicoso, S. Huernos, S. Goncalves, P. Tirado, E. A. Carrera Silva, C. Rothlin
JOURNAL OF CROHNS & COLITIS
(2018)
Article
Medicine, General & Internal
Jose M. Ceresetto, Cristina Duboscq, Jorge Korin, Carlos Fondevila, Patricia Casais, Andrea Rossi, Alejandra Scazziota, Marta Martinuzzo, Maria Esther Aris Cancela, Claudio Rosa, Gonzalo Pombo, Carla Guimelli, Yolanda Adamczuk, Alejandra Marti, Diana Penchasky, Dardo Riveros, Dolores Puente, Lucia Celebrin, Soledad Molnar, Susana Meschengieser, Miguel Castro Rios, Alicia Blanco, Hector Hendler, Andres Brodsky, Analia Sanchez Luceros, Pedro Negri Aranguren, Jose Luis Fedele, Claudio Merlo, Pablo Rana, Carina Gumpel, Cecilia Colorio, Beatriz Grand, Virginia Canonico, Eleonora Rossi, Paulo Colimodio, Sergio Orlando, Daniel Fassi, Mirta Arias, Laura Viudez, Roberto Farreras, Pablo Martinez, Hugo Ferro, Claudia Casali, Alejandra Baques, Guillermo Arbesu, Susana Vinuales, Fernanda Medina, Veronica Cortes, Maria Del Carmen Gallo, Ludmila Ehelou, Luis Barrera, Irene Rey, Gabriela De Larranaga, Flavia Figueroa, Alicia Vilaseca, Isabel Kuri, Alberto Maneyro, Maria Otaran, David Luis Xavier, Susana Garbiero, Julieta Salviu, Patricia Fontenla, Andrea Eckhardt, Carolina Bomparola, Laura Fornasiero
MEDICINA-BUENOS AIRES
(2020)