Article
Radiology, Nuclear Medicine & Medical Imaging
Zhijun Mai, Qiuxia Yang, Jiahui Xu, Hui Xie, Xiaohua Ban, Guixiao Xu, Rong Zhang
Summary: This study aimed to summarize the MRI manifestations of hepatocellular carcinoma (HCC) with and without progression after stereotactic body radiation therapy (SBRT) and evaluate the treatment effect using the modified Liver Reporting and Data System (LI-RADS). The results showed that the signal intensity and enhancement patterns of HCCs exhibited a temporal evolution after SBRT. Tumor growth, arterial phase hyperenhancement (APHE) and wash-out, and increased signal intensity on T2WI/DWI indicated tumor progression.
ABDOMINAL RADIOLOGY
(2023)
Article
Oncology
Thomas B. Brunner, Dominik Bettinger, Michael Schultheiss, Lars Maruschke, Lukas Sturm, Nico Bartl, Ivana Koundurdjieva, Simon Kirste, Hannes P. Neeff, Christian Goetz, Nils Henrik Nicolay, Gabriele Ihorst, Fabian Bamberg, Robert Thimme, Anca-Ligia Grosu, Eleni Gkika
Summary: The study findings indicate that SBRT is an effective and well-tolerated local treatment for patients with hepatocellular carcinoma, providing high rates of local control and maintaining quality of life for patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Pablo Munoz-Schuffenegger, Aisling Barry, Eshetu G. Atenafu, John Kim, James Brierley, Jolie Ringash, Anthony Brade, Robert Dinniwell, Rebecca K. S. Wong, Charles Cho, Tae Kyoung Kim, Gonzalo Sapisochin, Laura A. Dawson
Summary: This study investigated the long-term outcomes of patients with HCC and MVI treated with SBRT, showing promising results in terms of local control and overall survival. Patients who received sorafenib treatment after SBRT had longer survival, but some patients experienced adverse events like gastrointestinal bleeding.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Isaure Roquette, Emilie Bogart, Thomas Lacornerie, Massih Ningarhari, Jean-Emmanuel Bibault, Marie-Cecile Le Deley, Eric F. Lartigau, David Pasquier, Xavier Mirabel
Summary: This study describes the treatment efficacy and safety of stereotactic body radiation therapy (SBRT) in patients with hepatocellular carcinoma (HCC). The analysis of data from 318 patients showed that SBRT is efficient for the management of HCC with a favorable toxicity profile.
Article
Oncology
Alexander Piening, Anand Swaminath, John Dombrowski, Ryan M. Teague, Noor Al-Hammadi, Jeevin Shahi
Summary: The study found that advanced hepatocellular carcinoma patients who received ST+SBRT had better overall survival compared to those who received ST alone. This suggests that combination therapy plays a positive role in improving survival in patients with advanced HCC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Marie Cantaloube, Florence Castan, Morgane Creoff, Jessica Prunaretty, Karl Bordeau, Morgan Michalet, Eric Assenat, Boris Guiu, Georges-Philippe Pageaux, Marc Ychou, Norbert Ailleres, Pascal Fenoglietto, David Azria, Olivier Riou
Summary: The study demonstrates that stereotactic body radiation therapy (SBRT) using volumetric modulated arc therapy (VMAT) and real-time adaptive tumor gating for hepatocellular carcinoma (HCC) is effective with optimal local control and low toxicity, especially in patients not eligible for other local therapies. Additionally, the diameter of lesions and the volume of PTV were found to be associated with disease-free survival and overall survival in HCC patients receiving SBRT with VMAT.
Article
Oncology
Luca Boldrini, Angela Romano, Silvia Mariani, Davide Cusumano, Francesco Catucci, Lorenzo Placidi, Gian Carlo Mattiucci, Giuditta Chiloiro, Francesco Cellini, Maria Antonietta Gambacorta, Luca Indovina, Vincenzo Valentini
Summary: Hepatocellular carcinoma in early stages can benefit from local ablative treatments such as radiofrequency ablation or transarterial chemoembolization. Radiotherapy has shown promising results for HCC treatment. Magnetic resonance-guided radiotherapy may represent a significant improvement in stereotactic body radiotherapy for liver tumors.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Seo Yeon Youn, Bohyun Kim, Dong Hwan Kim, Ho Joong Choi, Pil Soo Sung, Joon-Il Choi
Summary: This study evaluated the factors predicting recurrence-free survival and overall survival after curative surgery in HCC patients treated with LRT. The study found that the LR-TR viable category at the time of surgery, preoperative AFP level, number of LRT sessions, and resection surgery independently predicted recurrence. A risk score categorized patients into different risk groups, predicting the 1-year recurrence rate. Postoperative recurrence and failure to meet the Milan criteria predicted death in patients.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tao Quan, Yanan Ren, Jinyi Li, Xiaojie Fu, Yazhou Jin, Yuncai Ran, Sheng Guan, Jingliang Cheng, Haowen Xu
Summary: This study aimed to compare the efficacy of enhanced 3D T1-weighted black-blood fast-spin-echo vessel wall magnetic resonance imaging (eVW-MRI) and time-of-flight magnetic resonance angiography (TOF MRA) for follow-up evaluation of aneurysms treated with flow diversion (FD). The results showed that eVW-MRI outperforms TOF MRA as a reliable noninvasive and nonionizing radioactive imaging method for evaluating aneurysm remnants and parent artery patency after FD.
EUROPEAN RADIOLOGY
(2023)
Article
Medicine, General & Internal
Judith Herrmann, Saif Afat, Andreas Brendlin, Maryanna Chaika, Andreas Lingg, Ahmed E. Othman
Summary: The study evaluated a novel abbreviated 20-min WB-MRI for oncologic follow-up imaging in patients with melanoma, demonstrating its feasibility, high image quality, and diagnostic confidence with reliable reproducibility.
Article
Radiology, Nuclear Medicine & Medical Imaging
Himanshu Kumar Sharma, Christopher Kyriakakos, Tony El Jabbour, Stephen Ward, Michael Buckstein, Bachir Taouli, Sara Lewis
Summary: This case series demonstrates that HCC lesions treated with SBRT undergo decreased size, persistent arterial phase hyperenhancement, and incomplete pathologic necrosis during liver transplant.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Oncology
Changchen Jiang, Shenghua Jing, Han Zhou, Aomei Li, Xiangnan Qiu, Xixu Zhu, Zetian Shen
Summary: The combination of TACE and CyberKnife SBRT demonstrated optimal efficacy and tolerable toxicity in treating BCLC stage B HCC. Results indicated high rates of local control and survival among patients in the study.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Sumin Lee, Jinhong Jung, Jin-Hong Park, So Yeon Kim, Jonggi Choi, Danbi Lee, Ju Hyun Shim, Kang Mo Kim, Young-Suk Lim, Han Chu Lee, Hee Hyun Park, Jong Hoon Kim, Sang Min Yoon
Summary: This study evaluated the clinical outcomes of patients with single viable hepatocellular carcinoma (HCC) who received stereotactic body radiation therapy (SBRT) after incomplete transarterial chemoembolization (TACE). The results showed that SBRT could be considered a feasible salvage treatment option for HCC, with high rates of local control and overall survival.
Article
Clinical Neurology
Pierre-Yves Borius, Anne Christine Januel, Jean Yves Plas, Pierre Duthil, Jean Albert Lotterie, Igor Latorzeff, Jean Sabatier
Summary: A long-term study was conducted on patients who received overexposure radiation treatment for arteriovenous malformation. The study found a high obliteration rate and some radiation-induced changes, but with moderate clinical consequences. Long-term follow-up is necessary.
JOURNAL OF NEUROSURGERY
(2023)
Article
Gastroenterology & Hepatology
Sayo Tsumura, Shigeo Shimose, Takashi Niizeki, Eri Kuboyama, Hideki Iwamoto, Masatoshi Tanaka, Etusko Moriyama, Tomotake Shirono, Kota Takaki, Yu Noda, Masahito Nakano, Mitsutoshi Inoue, Kazuki Tsustumi, Ryoko Kuromatsu, Hironori Koga, Kyoko Higuchi, Takumi Kawaguchi
Summary: This study aimed to investigate whether telephone follow-up by clinical pharmacists contributes to improved adherence and treatment duration for unresectable hepatocellular carcinoma (HCC) patients treated with lenvatinib (LEN). The results showed that the telephone follow-up group had a significantly higher progression-free survival and longer treatment duration compared to the non-telephone follow-up group. Telephone follow-up with a hospital family-pharmacist further reduced self-interruption and adverse-event discontinuation.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrea S. Kierans, Kyle J. Lafata, Daniel R. Ludwig, Lauren M. B. Burke, Victoria Chernyak, Kathryn J. Fowler, Tyler J. Fraum, Katrina A. McGinty, Matthew D. F. McInnes, Mishal Mendiratta-Lala, Guilherme Moura Cunha, Brian C. Allen, Elizabeth M. Hecht, Tracy A. Jaffe, Kevin R. Kalisz, Damithri S. Ranathunga, Benjamin Wildman-Tobriner, Diana M. Cardona, Anum Aslum, Sonia Gaur, Mustafa R. Bashir
Summary: This study compared overall survival and progression free survival between patients with LR-M hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA), and evaluated factors associated with prognosis. The results showed similar overall survival in patients with LR-M HCC and LR-M iCCA, suggesting that LR-M imaging features may be more accurate predictors of patient outcomes than histology.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Oncology
Lise Wei, Josiah Simeth, Madhava P. Aryal, Martha Matuszak, Randall K. Ten Haken, Kyle Cuneo, Theodore S. Lawrence, Yue Cao
Summary: The purpose of this study was to investigate the relationship between direct radiation dose-related and inflammation-mediated regional hepatic function losses after stereotactic body radiation therapy (SBRT) in patients with hepatocellular carcinoma (HCC) and poor liver function. The results showed that regional hepatic function losses after SBRT in patients with HCC include both direct radiation dose-dependent and inflammation-mediated effects.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Review
Gastroenterology & Hepatology
Andrea S. Kierans, Victoria Chernyak, Mishal Mendiratta-Lala, Claude B. Sirlin, Elizabeth M. Hecht, Kathryn J. Fowler
Summary: The Organ Procurement and Transplantation Network (OPTN) has updated its liver transplantation allocation policy to align with the Liver Imaging Reporting and Data System (LI-RADS) for the diagnosis of hepatocellular carcinoma (HCC). However, further refinements may be needed for the OPTN allocation policy despite this significant milestone.
LIVER TRANSPLANTATION
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Anne Sailer, Pejman Ghanouni, George R. Schade, Alessandro Napoli, Joan Vidal-Jove, Steven S. Raman, Mishal Mendiratta-Lala, Sangeet Ghai, Andre Abreu, Karthik M. Sundaram, Antonio Westphalen, Sandeep Arora
Article
Biotechnology & Applied Microbiology
Wei Zhang, Ibrahim Oraiqat, Dale Litzenberg, Kai-Wei Chang, Scott Hadley, Noora Ba Sunbul, Martha M. Matuszak, Christopher J. Tichacek, Eduardo G. Moros, Paul L. Carson, Kyle C. Cuneo, Xueding Wang, Issam El Naqa
Summary: Ionizing radiation acoustic imaging (iRAI) enables real-time monitoring and adaptive feedback for cancer treatments by visualizing the interaction between radiation and tissues. A volumetric imaging system using a 2D matrix array transducer and a multi-channel preamplifier board was developed to map the 3D radiation dose distribution in complex clinical radiotherapy. The feasibility of temporal 3D dose accumulation and semiquantitative iRAI dose measurements were validated in tissue-mimicking phantom and in vivo rabbit model, respectively. Real-time visualization of 3D radiation dose delivered to a patient with liver metastases was achieved using a clinical linear accelerator, demonstrating the potential of iRAI in improving radiotherapy treatment efficacy.
NATURE BIOTECHNOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lise Wei, Madhava P. Aryal, Kyle Cuneo, Martha Matuszak, Theodore S. Lawrence, Randall K. Ten Haken, Yue Cao, Issam El Naqa
Summary: The study aimed to develop NTCP models using DGAE-MRI for individualized adaptation of RT in HCC patients receiving SBRT. The results showed successful development of NTCP models using DGAE-MRI k1 maps, demonstrating feasibility in a small patient cohort.
Article
Engineering, Biomedical
Stephen F. Mee, Daniel F. Polan, Yuni K. Dewaraja, Kyle C. Cuneo, Joseph J. Gemmete, Joseph R. Evans, Theodore S. Lawrence, Janell S. Dow, Justin K. Mikell
Summary: This study introduces a method for treating underdosed hepatocellular carcinoma lesions using stereotactic body radiation therapy (SBRT) following post-selective internal radiation therapy (SIRT) dosimetry. It demonstrated that selectively targeting these lesions with SBRT could reduce normal tissue toxicity and improve treatment outcomes.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Dipesh Niraula, Wenbo Sun, Jionghua Jin, Ivo D. Dinov, Kyle Cuneo, Jamalina Jamaluddin, Martha M. Matuszak, Yi Luo, Theodore S. Lawrence, Shruti Jolly, Randall K. Ten Haken, Issam El Naqa
Summary: This study developed an artificial intelligence-based decision-making framework to assist in dynamic treatment regimes (DTR) for oncology. The framework utilizes advanced machine learning analytics and information-rich multi-omics data to overcome the challenges posed by various variables, treatment response uncertainty, and patient heterogeneity. The framework, demonstrated in Knowledge Based Response-Adaptive Radiotherapy (KBR-ART) applications, consists of two main components and has shown promising results in improving clinical decision-making and treatment outcomes.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Laila A. Gharzai, Chang Wang, Ming Tang, William C. Jackson, Christopher Maurino, Matthew M. Cousins, Mishal Mendiratta-Lala, Neehar D. Parikh, Charles S. Mayo, Randall K. Ten Haken, Dawn Owen, Kyle C. Cuneo, Matthew J. Schipper, Theodore S. Lawrence
Summary: The study concludes that irradiation for metachronous hepatocellular carcinoma (HCC) offers low rates of local failure with acceptable toxicity and overall survival similar to patients receiving a first course of treatment.
PRACTICAL RADIATION ONCOLOGY
(2023)
Article
Oncology
Rishi Das, Madeline R. Abbott, Scott W. Hadley, Vaibhav Sahai, Filip Bednar, Joseph R. Evans, Matthew J. Schipper, Theodore S. Lawrence, Kyle C. Cuneo
Summary: This study is an exploratory analysis of patients with pancreatic cancer undergoing chemoradiation therapy to investigate acute and chronic side effects. The study found that metallic biliary stents may be associated with an increased risk of upper gastrointestinal bleeding and mortality, while intensity modulated radiation therapy (IMRT) is associated with less nausea and short-term toxicity.
ADVANCES IN RADIATION ONCOLOGY
(2023)
Review
Oncology
Yue Cao, Kyle C. C. Cuneo, Joseph Evans, Randall K. K. Ten Haken, Daniel T. T. Chang, Theodore S. S. Lawrence
Summary: In this article, the available reports on magnetic resonance imaging apparent diffusion coefficient (ADC) changes in hepatocellular carcinoma (HCC) in response to stereotactic body radiation therapy are reviewed. The comparison of various diffusion image acquisition methods, ADC analysis methods, HCC response assessment methods, and statistical methods for predicting local tumor progression by ADC metrics are discussed, along with the pros and cons of these studies. Based on the detailed analyses of existing investigations, the conclusion that ADC is established as an imaging biomarker for stereotactic body radiation therapy assessment in HCC cannot be drawn.
Article
Oncology
Daniel J. Herr, Chang Wang, Mishal Mendiratta-Lala, Martha Matuszak, Charles S. Mayo, Yue Cao, Neehar D. Parikh, Randy Ten Haken, Dawn Owen, Joseph R. Evans, Teodor Stanescu, Michael Yan, Laura A. Dawson, Matthew Schipper, Theodore S. Lawrence, Kyle C. Cuneo
Summary: Optimizing stereotactic body radiotherapy (SBRT) based on individual patient's probability for tumor control and risk of liver injury can decrease treatment-related toxicity while maintaining tumor control in patients with impaired liver function or tumors not amenable to thermal ablation.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Theodore S. Lawrence, Madhava P. Aryal, Joseph R. Evans, Kyle C. Cuneo, Daniel T. Chang, Mathew J. Schipper, Yuhang Zhang, James M. Balter, Randall K. Ten Haken, Yue Cao
Summary: There is debate about why SBRT is more effective in controlling HCC compared to fractionated treatment. Classic biological explanation suggests that the higher BED of SBRT causes more DNA damage and tumor cell kill. However, recent preclinical evidence supports a new biology involving radiation-induced vascular collapse, which leads to increased tumor cell death. This study found that vascular collapse does not typically occur after standard SBRT for HCC.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Oncology
Kyle C. Cuneo, Daniel J. Herr
SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA
(2023)
Meeting Abstract
Oncology
Daniel J. Herr, Chang Wang, Mishal Mendiratta-Lala, Martha Matuszak, Charles S. Mayo, Yue Cao, Neehar Parikh, Randy Ten Hanken, Dawn Owen, Teodor Stanescu, Michael Yan, Laura A. Dawson, Matthew Schipper, Theodore S. Lawrence, Kyle C. Cuneo