Article
Oncology
Xiaohong Liu, Dedong Cao, Hui Liu, XiaoKang Ke, Xin Liu, Ximing Xu
Summary: This study retrospectively analyzed and compared upper aerodigestive tract (UAT) and non-upper aerodigestive tract (NUAT) NKTCL patients. The majority of the lesions were UAT-NKTCL, while NUAT-NKTCL patients had advanced stage and poor prognosis. The 3-year overall survival rate was significantly higher in the initial complete remission group compared to the non-complete remission group. For advanced stage patients, KI67% and bone marrow involvement were independent factors affecting overall survival. The study aims to improve the initial complete remission rates and find new predictive models for the whole population.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Biology
Che-Hong Chen, Wen-Lun Wang, Ming-Hung Hsu, Daria Mochly-Rosen
Summary: The upper aerodigestive tract (UADT) is highly susceptible to multiple primary cancers. Head and neck cancer (HNSCC) patients are at high risk of developing esophageal cancer (ESCC) and vice versa. The ALDH2*2 missense mutation is a genetic risk factor for UADT cancer and is associated with increased incidence, faster progression, and poorer prognosis. Alcohol use is a major lifestyle risk factor in ALDH2*2 carriers and the genotoxic agent acetaldehyde likely plays a role in tumorigenesis. Precision medicine-based strategies integrating lifestyle and genetic risk factors, such as alcohol consumption and ADH1B and ALDH2 genotypes, are needed for better screening, surveillance, and treatment outcome.
Article
Medicine, General & Internal
Dalan Jing, Debo You, Ziyuan Liu, Wei Wang
Summary: Extranodal natural killer/T-cell lymphoma, nasal type can occur primarily in the orbit without involvement of the nasal cavity. Early discovery, biopsy, diagnosis, and appropriate treatment can successfully control tumors and improve prognosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Taku Sato, Rumi Ueha, Takao Goto, Akihito Yamauchi, Kenji Kondo, Tatsuya Yamasoba
Summary: The study identified co-expression of ACE2 and TMPRSS2 proteins in various tissues of rats, with TMPRSS2 showing more distinct expression in peripheral alveoli. These findings correspond to clinical symptoms of COVID-19 and hint at a possible exacerbation of symptoms due to TMPRSS2 expression, offering potential clues for further investigation into the pathogenesis of COVID-19.
Article
Biochemistry & Molecular Biology
Marco Fiore, Antonio Minni, Luca Cavalcanti, Giammarco Raponi, Gianluca Puggioni, Alessandro Mattia, Sara Gariglio, Andrea Colizza, Piero Giuseppe Meliante, Federica Zoccali, Luigi Tarani, Christian Barbato, Marco Lucarelli, Flavio Maria Ceci, Silvia Francati, Giampiero Ferraguti, Mauro Ceccanti, Carla Petrella
Summary: Alcohol consumption is associated with oxidative stress and an increased risk of upper aero-digestive tract (UADT) carcinoma. Microorganisms in the oral cavity can metabolize ethanol and form acetaldehyde, a carcinogenic metabolite. A study was conducted on UADT cancer patients to estimate their alcohol consumption and analyze the presence of acetaldehyde-producing bacteria. The study found that heavy drinkers had a higher presence of these bacteria, which correlated with increased oxidative stress.
Article
Health Care Sciences & Services
Huei-Tzu Chien, Chi-Chin Yeh, Chi-Kuang Young, Tzu-Ping Chen, Chun-Ta Liao, Hung-Ming Wang, Kai-Lun Cho, Shiang-Fu Huang
Summary: Head and neck cancer patients who are habitual drinkers and carriers of certain genetic factors are at higher risk of developing multiple primary tumors. Establishing a polygenic scoring model can effectively predict the risk of multiple primary cancers. Routine screening of the upper digestive tract is recommended for patients with high scores in the polygenic model to detect new primary tumors early.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Mariana Toledo Goncalves Moreira, Patricia Ribeiro Pereira, Adriano Aquino, Carlos Adam Conte-Junior, Vania Margaret Flosi Paschoalin
Summary: Aldehydes, especially acetaldehyde, are carcinogenic molecules that should be controlled in food to prevent UADT and liver cancers. Aged beer consumption exposes drinkers to acetaldehyde, which can be increased due to post-brewing reactions. Aldehydes are formed during beer aging, causing off-flavors. This systematic review explores volatile compound profiles and suggests methods to reduce aldehyde accumulation and flavor instability in beer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Zhuangzhuang Shi, Xin Li, Xinhua Wang, Lei Zhang, Ling Li, Xiaorui Fu, Zhenchang Sun, Zhaoming Li, Xudong Zhang, Mingzhi Zhang
Summary: The nasal microbiota in NKTCL showed significantly decreased alpha diversity and increased beta diversity compared to CRS and healthy controls. The genus Corynebacterium was significantly depleted, while genus Staphylococcus was the most abundant in NKTCL. Nasal microbial community differed significantly between UAT-NKTCL and non-UAT NKTCL, with a potential for classification between UAT-NKTCL and CRS. Additionally, the alpha diversity of the nasal microbiota was associated with clinical covariates of NKTCL.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Otorhinolaryngology
Christian Fritz, Karthik Rajasekaran
Summary: This study searched a national legal database and found that 86.9% of medical malpractice claims related to upper aerodigestive tract cancer involved allegations of failure to diagnose or delay in diagnosis. Tongue, larynx, and nasopharynx cancers were more frequently litigated than expected. The average payout for diagnosis failure lawsuits was $2,840,690. Increased awareness of litigation on upper aerodigestive tract cancers can improve patient care and help otolaryngologists minimize potential litigation risks.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Public, Environmental & Occupational Health
I Kuzmickiene, R. Everatt
Summary: The study analyzed the trends in UADT and stomach cancer mortality rates in Lithuania from 1987 to 2016, identifying significant cohort effects in both sexes. The findings suggest that effective strategies targeting known risk factors could reduce the burden of cancer in Lithuania. Further research is needed to understand the reasons behind unfavorable trends in younger cohorts.
Article
Oncology
Peng Yeh, Tzu-Yu Li, Po -Wen Cheng
Summary: Narrow-band imaging (NBI) is used to enhance mucosal neovascularization and its role in detecting nasal lymphomas is not well-established. This case report presents a 91-year-old male with persisting nasal obstruction, whose nasal lymphoma was detected with the aid of NBI.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Hematology
Moo-Kon Song, Joo-Seop Chung, Sung-Yong Oh, Sung-Nam Lim, Won-Sik Lee, Sang-Min Lee, Do-Young Kim
Summary: In patients with limited-stage UAT NK/T cell lymphoma, elevated lactate dehydrogenase level, short distancemax, and chemotherapy combined with radiotherapy have independent predictive value for progression-free survival and overall survival. Evaluating lymphatic spread and local control is essential for these patients.
Article
Oncology
Ziyuan Shen, Xicheng Chen, Cai Sun, Tianyi Lu, Yuye Shi, Hao Zhang, Jingjing Ye, Ling Wang, Taigang Zhu, Yuqing Miao, Xudong Zhang, Liang Wang, Guoqi Cai, Wei Sang
Summary: The clinicopathologic characteristics and prognosis of nasal and nonnasal ENKTL patients are different, with nasal forms patients having superior overall survival (OS) than nonnasal patients, especially in the era of asparaginase.
Article
Medicine, General & Internal
Yi Duan, Juan Huang, Johannes Haybaeck, ZhiHui Yang
Summary: Primary extranodal natural killer (NK)/T-cell lymphoma (ENKTL) rarely occurs in childhood and adolescence, especially in the gastrointestinal (GI) tract. It is important to consider ENKTL in the differential diagnosis for patients with GI symptoms, and to differentiate it from GI T-cell lymphomas through morphology and immunohistochemistry. This case emphasizes the need for increased awareness and timely diagnosis of ENKTL in the GI tract in children.
Article
Materials Science, Multidisciplinary
Oisin Bugter, Yue Li, Anouk H. G. Wolters, Vasundhara Agrawal, Amil Dravid, Andrew Chang, Jose Hardillo, Ben N. G. Giepmans, Robert J. Baatenburg de Jong, Arjen Amelink, Vadim Backman, Dominic J. Robinson
Summary: The study found significant differences in chromatin packing density and organization between cancer patients and controls, suggesting potential novel strategies for cancer risk assessment and diagnosis.
MICROSCOPY AND MICROANALYSIS
(2021)